Best Large Grants for Nonprofit Organizations

The El Paso Community Foundation Grant supports innovative philanthropic projects in the El Paso region, including far west Texas, southern New Mexico, and northern Chihuahua, Mexico. Established in 1977, the foundation has awarded over $167 million in grants to address community needs. Key focus areas include arts, education, health, and economic development. Priorities include collaboration and impactful projects, while avoiding grants for individuals, capital campaigns, or religious purposes.

The Opportunity Endowment Fund, managed by the East Tennessee Foundation, aims to enhance the effectiveness and sustainability of nonprofit organizations across a 25-county service area. Grants of up to $25,000 support collaborative projects focused on improving operational systems, fostering partnerships, and addressing community needs. Projects that demonstrate collective impact and leverage matching funds are prioritized, particularly those that tackle adverse childhood experiences and enhance early childhood education.

The Gratiot County Community Foundation offers competitive grants to enhance the quality of life for Gratiot County residents. With three grant cycles each year, funding is available for community development, arts, education, health, and more. Projects must serve the county's citizens and align with the Foundation's mission of addressing community needs creatively. Non-profit organizations within the area are encouraged to apply, ensuring broad benefits across diverse populations.

The Foundation for Sustainability and Innovation Grant aims to support projects that promote environmental restoration, preservation, and education, with a focus on sustainable resource use and community development. This grant encourages innovative approaches that connect urban and rural settings, enhance biodiversity, and foster creativity in addressing societal challenges. Eligible applicants include IRS-designated non-profits that align with the foundation's vision. The foundation also supports small presses and periodicals that creatively address sustainability issues.

The Mary E. Kwiatkowski Social Services Scholarship Fund, offered by the Erie Community Foundation, supports female and LGBTQIA+ students pursuing social sciences and public service careers. In 2023, over $800,000 was awarded to more than 500 students for post-secondary education. This scholarship aims to eliminate financial barriers for diverse talents in Erie County's social services sector, requiring applicants to submit an essay on their public service aspirations and challenges in the Erie region.

The Mathew A. and Mildred Hunter Charitable Trust Grant, established in 1997, aims to support religious, charitable, scientific, literary, or educational purposes. Priority is given to organizations assisting abused children and the mentally handicapped, as well as educational institutions providing scholarships. The average grant size ranges from $2,500 to $20,000. Eligible applicants must be tax-exempt under specific IRS codes and operate primarily in Lake County, Florida.

The NIAID aims to support four Clinical Trials Networks (CTNs) by funding Statistical and Data Management Centers (SDMCs) to enhance HIV research. These SDMCs will oversee study designs, data collection, and compliance with regulatory standards while ensuring data quality and integration. This initiative is a crucial step toward ending the HIV epidemic, fostering innovative methods, and adhering to NIH data sharing policies. Applications for the SDMCs are now being solicited.

The Plato George Eliades Law Scholarship Endowment, established in 2007, supports continuing education in legal and law enforcement fields. With a $1,000 scholarship, it is awarded to eligible seniors from local high schools who demonstrate financial need, academic excellence, and a commitment to their education. Applicants must submit a complete online application with necessary documentation. The John Randolph Foundation prioritizes confidentiality and reserves the right to revise scholarship criteria as needed.

The Permanente Medical Group's Delivery Science Fellowship Program provides a unique opportunity for health professionals and PhD researchers to engage in impactful delivery science research. Fellows work closely with experienced mentors and Kaiser Permanente physicians to address critical healthcare delivery issues, enhance their research skills, and contribute to innovative solutions that improve patient care. This two-year program includes individualized mentorship, access to extensive data resources, and opportunities for publication and presentation at national conferences.

Education Forward Arizona, in partnership with Freeport-McMoRan, is launching a scholarship program aimed at providing education and training in critical technical fields. The initiative targets recent high school graduates and adult learners, starting recruitment for Fall 2025. Participants will gain skills for rewarding careers in mining, essential for the energy transition. Eligible candidates should be 18 or older, willing to enroll in community college programs, and participate in internships, ensuring a pathway to employment with Freeport-McMoRan.

The Marshall and Ellen Peters Family Foundation, established by Ellen Bookman Peters, supports charitable organizations primarily in Brazos County, Texas. With a strong commitment to community service, the Foundation funds initiatives in various program areas, including arts, education, health, and human services. Mrs. Peters, a dedicated Presbyterian and community leader, left a lasting legacy through her philanthropic efforts. The Foundation continues to honor her memory by contributing an average of $50,000 annually to enhance local community well-being.

The Richard Hayes "Career Technical Education" Grant, offered by the Gilroy Foundation, supports transformative educational initiatives in technology, design, and vocational training. With over 40 years of impactful grantmaking, the foundation allocates 5% of year-end balances to eligible 501(c)(3) organizations. This grant specifically aims to enhance skills in technical drawing, graphic technology, engineering studies, and film production, thereby empowering the community through education.

StopWaste

StopWaste is a public agency serving the 1.7 million diverse residents of Alameda County. Formed in 1976, we work on behalf of 17 member agencies—the County, 14 cities, and 2 sanitary districts—committed to advancing environmental sustainability and building healthy, equitable, climate resilient communities in Alameda County.

Our Current Goals

StopWaste's work is guided by three long-term goals: building a healthy local food system that eliminates waste, advancing a thriving circular economy, and accelerating innovation in the built environment. We prevent wasted food, recover surplus food to nourish communities, and keep materials in circulation through reuse, repair, recycling, and composting—while helping communities across Alameda County cut pollution, save money, and meet California’s climate and waste goals.

Reusable Foodware Mini-Grants

Up to $500 for Alameda County restaurants, cafes, and retail food businesses to purchase reusable foodware for dine-in service.

What You Get

• Up to $500 in reusable foodware (plates, cups, utensils, etc.)
• Free hands-on support during your transition
• No complicated paperwork required.

What's Covered

Reusable items for dine-in service, including:

• Plates and bowls
• Cups and mugs
• Utensils (forks, knives, spoons, chopsticks)
• Serving trays and baskets

The Joseph A. Coolidge Award provides scholarships and awards for Northeastern University honors students. It supports tuition, global experiences, and research initiatives. Eligible students must be enrolled in a major within the Physical Sciences or Mathematics, demonstrating academic excellence and community involvement. Applications will open in Spring 2026, offering resources to enhance honors studies and foster academic achievement.

The Allegheny County Community Development Block Grant (CDBG) program supports vital community development projects aimed at benefiting low- to moderate-income individuals. Funded by the U.S. Department of Housing and Urban Development, the program encompasses a wide range of initiatives, including housing development, infrastructure improvements, and workforce development. Eligible applicants include local governments, authorities, and both nonprofit and for-profit organizations. All projects must align with HUD’s objectives and contribute to community revitalization efforts.

The Boo Grigsby Foundation, established in 2007, supports 501(c)(3) organizations in Baton Rouge and across Louisiana, focusing on education, health services, arts, human services, community initiatives, and conservation. With over $2,500,000 donated, the foundation aims to enhance community welfare through diverse programs and initiatives, ensuring all residents have access to vital resources and opportunities for growth.

The John H. and Wilhelmina D. Harland Charitable Foundation Grant focuses on supporting effective organizations that enhance opportunities for low-income youth, particularly in Atlanta and DeKalb County, Georgia. The foundation prioritizes programs in arts education, community services, and child development. Grants are available to public charities with a minimum two-year operational history. Applications are accepted annually, and only by invitation for arts education programs, ensuring a concentrated impact on community needs.

The Western Balkans Program, supported by The Rockefeller Brothers Fund, aims to advance democracy and peace in a region undergoing transformation. With a focus on Serbia, Montenegro, Kosovo, and Bosnia and Herzegovina, the program encourages transparency in governance and sustainable development. Despite challenges from historical conflicts, the Fund promotes inclusive societies and civil engagement to foster reconciliation and support a European future. Organizations seeking grants must be tax-exempt and focused on educational or charitable initiatives.

Levine Impact Lab

The Levine Impact Lab powers equitable transformation by investing in nonprofit leadership, building community organizations’ capacities, and building their capacity to accelerate positive social and environmental change.

We combine venture-capital expertise and inspired philanthropic thinking to radically amplify the value of giving.

Levine Impact Lab Operational Support Program

The Levine Impact Lab’s Operational Support Program is an 18-month, high-engagement operational partnership designed to help environmental organizations move strategic and financial priorities forward.

At the core of the program is hands-on operational support: our team works side-by-side with your leaders to drive progress on a critical project, whether it’s strengthening your financial infrastructure, increasing earned revenue, or planning for growth.

This is a working partnership. The grant funding and peer-learning community are designed to support and accelerate your momentum.

We are the best fit for organizations that:

• Operate at the intersection of environmental impact and social enterprise
• Are past the startup phase but still in a critical growth stage
• See LIL as a thought partner in unlocking strategy, scale, and sustainability
• Show up with clear goals and a commitment to moving the work forward

More information about participation commitments here.

What is Operational Support?

To get the most out of this program, organizations must come prepared with a specific project, workstream, or organizational challenge they want to tackle over the 18 months with operational support. 

Potential Area(s) of Support: 

• Financial strategy and planning
• Fundraising, development and donor engagement strategy
• Cost structure analysis
• Program development or expansion
• Corporate partnership strategy 
• New location or geographic expansion
• RFP support/capital planning
• Strategic planning
• Board engagement

Find examples of what past cohorts have worked on here.

People

The success of this program relies on having the right organizational leaders at the table. Each organization must commit two senior staff members who are equipped to make key decisions, drive implementation, and stay closely involved throughout the 18-month engagement. These leaders must:

• Have clear decision-making authority and/or strong backing from the Executive Director or CEO
• Be directly involved in the project or challenge the organization is addressing
• Be able to commit time, energy, and focus to move the work forward

There will also be opportunities to include additional staff members in operational projects, as needed, to ensure the right voices and expertise are present. 

Who this might include: Executive Director and Finance Director, Business Development Manager and Operations Lead, or Marketing Manager and Development Director, depending on the nature of your project.

What We Offer

• Tailored 1:1 operational support and strategic advising
• A national cohort of up to 10 organizations
• Peer network of strategic thought partners
• Virtual and in-person workshops and events
• Private Slack channel
• Exclusive alumni programming
• Grant funds over two years
• Supportive peer-learning community
• Accelerated organizational growth and momentum through strategic partnership with LIL

View Program Flyer here.

The Professional Formation of Engineers: Research Initiation in Engineering Formation (PFE: RIEF) program aims to foster research in the Professional Formation of Engineers (PFE) while expanding the community of researchers in this field. It targets early-career Principal Investigators (PIs) with limited experience in social science or education research, enabling them to develop expertise in engineering education research and address critical challenges in engineering formation.

About Madison Community FoundationSince 1942, Madison Community Foundation (MCF) has been building a stronger, more generous community and helping people like you make a lasting impact through charitable giving. Mission : MCF will engage Greater Madison in philanthropy to advance a more vibrant and equitable community.About Portage Area Community Fund (PACF) GrantPACF is dedicated to enhancing the quality of life in the greater Portage area for present and future generations.Key interest areas include:

• Civic and cultural enrichment,
• Natural and historic preservation,
• Parks and recreation,
• Community development,
• Youth and educational resources, and
• The needs of the community in the Portage area.

New Hanover County offers financial assistance through its Non-County Agency Funding program to support nonprofit organizations that align with its strategic objectives outlined in the 2024-2028 Strategic Plan. This annual funding, with a maximum allotment of $50,000, focuses on key areas such as economic development, community safety, and environmental stewardship. Eligible applicants include nonprofits with 501(c)(3) or 501(c)(6) status and governmental entities, fostering transparency and accountability in the funding process.

The Atherton Family Foundation Grants support charitable activities in Hawai‘i, focusing on areas such as arts, education, health, and community development. Capital requests over $25,000 are only accepted in July, while program requests are accepted in January, April, and October. Organizations must have a 501(c)(3) status or a fiscal sponsor. The foundation prioritizes collaborative approaches to address community issues and typically funds grants for one year, with specific guidelines for larger capital projects.

Borsheims

Few other stores have a history like Borsheims. From our humble beginnings in Omaha, Nebraska to becoming a Berkshire Hathaway company with worldwide clientele, our past helps propel us into the future. For more than 150 years, we've been honored to help our customers celebrate their special moments, and we look forward to celebrating many more.

Borsheims Gives

As an Omaha institution for more than 155 years, Borsheims is proud to give back to the community that has given us so much. Corporate citizenship and social responsibility are values that are intrinsic to our business. Borsheims is honored to support local non-profits every year with our Big Impact Grant donations, team member volunteerism, social responsibility, and through our Borsheims Gives program.

Borsheims Gives Big Impact Grant Program

Our Big Impact Grant program allows us to create new partnerships and expand our community giving to benefit a multitude of organizations across the Omaha area. Our focus areas for giving:

• Women's Initiatives
  • As a female-led company, Borsheims is committed to empowering women and creating opportunities for them to thrive. Through partnerships with non-profit organizations that support safety, education, career development, and personal growth, we champion programs and initiatives that help strengthen and uplift women to build brighter futures for themselves and for our community.
• Children's Support
  • Supporting children has long been at the heart of Borsheims’ philanthropic efforts. By providing essential resources and mentorship to local organizations dedicated to children’s well-being, we are committed to helping young people reach their full potential. By investing in the next generation, we help create stronger communities for years to come.
• Community Interests
  • We support the organizations, initiatives, and community leaders who help make our city vibrant, welcoming, and strong. Whether partnering with long-standing institutions or emerging non-profits, we are dedicated to investing in the people and causes that shape Omaha’s future.

The Alice E. and Joseph C. Blewett Foundation Grant supports charitable organizations, primarily in Dallas, Texas, focusing on education, arts, health, and human services. Organizations must be 501(c)(3) exempt to qualify. The foundation places a strong emphasis on local community engagement, aiming to enhance educational and cultural opportunities for youth. While there are no strict geographic limitations, preference is given to initiatives that align with the Blewetts' legacy of civic involvement and support for community welfare.

The LCCF Micro Grants aim to support nonprofit organizations in La Crosse County by providing funding between $250 and $3,000 for innovative projects. With a total allocation of $70,000 for this year, the La Crosse Community Foundation encourages applications from groups enhancing community life. Applications are ongoing until funds are exhausted, with approval notifications expected within three weeks. This initiative promotes growth and improved strategies to meet local needs.

The LCCF Nonprofit Capacity Building Grant Program, funded by the La Crosse Community Foundation, aims to enhance the sustainability and effectiveness of nonprofit organizations in La Crosse County. With $300,000 available, grants of $50,000 to $90,000 will support infrastructure investments, especially for those addressing disparities in historically marginalized communities. This program emphasizes ongoing technical assistance, fostering partnerships, and sharing best practices among grantees to build a more equitable community.