Best Large Grants for Nonprofit Organizations

The Water & Waste Disposal Loan & Grant Program in California provides essential funding for rural areas to enhance clean drinking water systems, sewage disposal, waste management, and storm drainage. Eligible applicants, including local governments and nonprofits, can use the funds for construction, improvements, and related activities like legal fees and land acquisition. This program aims to ensure access to reliable water services and promote public health in underserved communities.

The Water & Waste Disposal Loan & Grant Program in Arkansas offers essential funding for rural areas to establish and improve drinking water systems, sewage disposal, and storm water drainage. Eligible applicants, including state and local governments and nonprofits, can utilize funds for various projects including construction, legal fees, and maintenance. This initiative aims to ensure access to clean water and effective waste management in underserved communities.

The Enhancement Dam Removal Design and Implementation Block Grant, administered by Watersheds United Vermont, aims to support community-driven dam removal projects that enhance water quality and habitat. This funding initiative, backed by the Vermont Department of Environmental Conservation, encourages proposals for the design and implementation of effective dam removal strategies, fostering ecological resilience and community engagement across the state.

The Water & Waste Disposal Loan & Grant Program in Arizona provides essential funding for clean drinking water systems, sewage disposal, solid waste management, and storm water drainage in eligible rural areas. It supports local governments, non-profits, and tribes with financing for projects that ensure reliable services. Funds can cover construction, engineering costs, and necessary equipment, promoting healthier communities and sustainable development in rural settings.

The Water & Waste Disposal Loan & Grant Program in Alaska provides essential funding for rural areas to develop clean drinking water systems, sewage disposal, and storm water management. This program supports local governments, nonprofits, and tribes lacking commercial credit options. Eligible projects include the construction and improvement of water treatment facilities, sewer systems, and solid waste management. The initiative aims to enhance public health and environmental quality while ensuring access to vital resources for communities.

The Water & Waste Disposal Loan & Grant Program in Alabama aims to provide essential funding for clean drinking water systems and sanitary waste management in eligible rural areas. This initiative supports the construction and improvement of water sourcing, sewer systems, and stormwater drainage, ensuring reliable services for households and businesses. Eligible applicants include local governments, nonprofits, and federally-recognized tribes, promoting access to crucial resources in underserved regions.

Cambia Health Foundation seeks to improve health care through focused investments in the health care workforce. They aim to expand, diversify, and train professionals to address behavioral health provider shortages. By enhancing both paid and unpaid workforce sectors, Cambia fosters wellness, reduces stigma, and promotes collaborative care models. Their commitment to health equity reflects in their strategic areas of investment, ensuring everyone has the opportunity for better health outcomes.

The W. W. Smith Charitable Trust provides funding for basic medical research focusing on heart disease, cancer, and AIDS. Grants are available to 501(c)(3) nonprofit organizations located in the Greater Philadelphia area and Camden, NJ. Each grant typically ranges from $100,000 to $125,000 for a one-year term. The Trust aims to support unique and promising research projects that can lead to larger awards, ensuring a direct impact on health outcomes.

The United Way of Southeast Louisiana is launching its second cycle of collaborative grants aimed at eradicating poverty through community-driven initiatives. The grants focus on five priority areas aligned with their Blueprint for Prosperity, which addresses stability, prosperity, wellness, and vibrant communities. Eligible applicants must operate within specific parishes and demonstrate a commitment to systemic change and equity. Funding supports planning, implementation, and continuous improvement efforts to foster long-term community impact.

The James Marston Fitch Mid-Career Fellowship offers research grants up to $15,000 for mid-career professionals in fields like historic preservation, architecture, and urban design. Applicants must demonstrate a commitment to innovative research and a clear dissemination plan. The fellowship encourages impactful projects that contribute significantly to the field, ensuring that only qualified individuals can apply, as it does not fund organizational projects or dissertation research.

The CFES Mini Grants program, offered by the Community Foundation of the Eastern Shore, supports local 501c3 nonprofits and certified schools with funding under $1,000 for diverse programs. These grants address crucial community needs in areas like health, arts, and education, enhancing services for vulnerable populations. Applications are accepted monthly, but first-time applicants may require a consultation. The program emphasizes collaboration and aims to empower organizations making a positive impact in Somerset, Wicomico, and Worcester counties.

The WSRCO Community Forests Grant Program empowers Washington communities to safeguard their working forest heritage. It balances ecological preservation with recreational opportunities, ensuring that forestlands remain resilient against development pressures. Eligible applicants include cities, tribes, and nonprofit organizations, enabling diverse groups to engage in vital conservation projects. Typical initiatives include purchasing land for forest conservation and enhancing habitat health. This program plays a crucial role in maintaining the environmental and cultural integrity of Washington's forests for future generations.

The TruStage Foundation focuses on fostering economic mobility through education and housing initiatives. By supporting K-12 literacy, mentoring, and affordable housing projects, the foundation aims to uplift marginalized communities. With a commitment to addressing racial and socioeconomic disparities, TruStage seeks to empower individuals and families to build a brighter future. Their funding is directed towards impactful programs that align with their mission, while avoiding causes that do not meet their criteria for economic mobility.

The Food Waste Reduction Grant aims to assist local governments, non-profits, and businesses in minimizing food waste sent to landfills. Administered by the North Carolina Department of Environmental Quality, this program encourages proposals that enhance food donation networks or composting operations. Funds are to be allocated towards developing infrastructure for food waste reduction, ensuring excess food is redirected to those in need through food banks and composting facilities.

The Birth Equity Innovation Seed Grants in Illinois aim to support community organizations working to reduce disparities in maternal and infant health. Funding will be available for programs tied to communities most affected by these inequities, facilitating access to essential maternal care services. The Illinois Department of Public Health encourages innovative approaches that establish or maintain programs focused on improving birth equity, particularly for marginalized populations. Grants range from $0 to $1,000,000.

The Gold Beach Community Fund Grant, administered by the Oregon Community Foundation, offers financial support for various projects aimed at enhancing Central Curry County. Eligible applicants include 501(c)(3) non-profits and public entities. The fund prioritizes initiatives in recreational activities, cultural enhancement, and youth-related projects. However, individuals and certain expenses like travel and payroll are ineligible for funding. Special preference is given to projects benefiting youth in the Gold Beach area.

The Intermountain Community Care Foundation aims to enhance healthcare access and promote healthy behaviors among low-income and underrepresented populations in Utah and Southeast Idaho. It funds innovative projects that yield measurable results, focusing on significant and lasting changes in community health. Successful applicants must demonstrate a clear need, include a financial audit, and adhere to specific eligibility criteria. The foundation specifically excludes funding for political campaigns, operational deficits, and large equipment purchases.

The Cooperative Agreement to Support Activities Related to Analgesics, Anesthetics, and Addiction (U01) aims to enhance research in Anesthesia, Addiction Medicine, and Pain Medicine. It focuses on critical areas such as clinical trial endpoints for chronic pain, outcome measures in stimulant use disorders, and neurodevelopmental assessments in pediatric patients. The initiative encourages applicants to propose comprehensive, evidence-based plans to improve the prescribing of analgesic and anesthetic drug products, with multiple awards available.

The Caroline Alexander Buck Foundation focuses on enhancing the lives of children in the greater Philadelphia area through educational and social service programs. Established in 1960, this private foundation provides one-year grants to public charities with 501(c)(3) status, aiming to foster productive community members. Funding is limited to specific geographic areas and eligibility criteria, ensuring that support is directed towards initiatives that genuinely benefit children and their families.

The North Wilkesboro Grant Program, managed by Speedway Children's Charities, aims to support nonprofits focused on children in Wilkes County. In 2024, over $320,000 was distributed to local organizations. The program prioritizes aid for homeless individuals, orphans, foster youth, and victims of sex trafficking, alongside critical medical and educational services. Eligible applicants must be 501(c)(3) organizations with a focus on children's welfare, ensuring equitable opportunities for all.

The Clean Vessel Act Grant Program, initiated by the Georgia Department of Natural Resources, provides essential funding for constructing and maintaining sewage pumpout stations for recreational boaters. With 75% of project costs covered, the program aims to improve environmental protection by preventing sewage discharge into waterways. Grant recipients must ensure facilities are accessible and operational during reasonable hours, promoting public awareness and use of these crucial waste management systems.

The Ka Papa O Kakuhihewa Fund, part of the Community Grants Program by the Hawai‘i Community Foundation, aims to support nonprofit organizations focused on resource conservation. It prioritizes projects that promote environmental education, energy conservation, and stewardship initiatives, particularly benefiting the Wai‘anae Coast and Kapolei communities. The fund emphasizes youth engagement and local economic support, advocating for partnerships with community organizations to enhance conservation efforts and instill a sustainable mindset among future generations.

The Cemala Foundation Grant focuses on enhancing the quality of life in Greensboro by supporting strategic investments in community projects. With an emphasis on early childhood development, transformational spaces, and workforce training, the foundation aims to build a thriving community. Organizations promoting Continuous Quality Improvement are encouraged to apply for funding. This grant is vital for initiatives that address the evolving needs of Greensboro residents and foster sustainable growth.

About Us

Who We Are

We unite people, ideas, and resources to transform lives across Story County, working toward our vision of a connected and thriving community.

Making a Difference since 1953

Since 1953, United Way of Story County (UWSC) has been a trusted leader and convener, mobilizing our community to create lasting change. We believe transformation happens when neighbors, businesses, nonprofits, and volunteers unite around shared goals.

A connected and thriving Story County.

Unite people, ideas, and resources to transform lives in Story County.

Investing in You

We provide grants to local nonprofits that are dedicated to serving Story County in our focus areas of health, education, and financial security. These grants aim to empower organizations that are making a difference in our community, helping them to enhance their programs and reach more individuals in need.

Community Impact Grants

These grants support unanticipated, emerging, or other distinct under-funded needs that further the mission of UWSC.

Community Foundation of Greater Des Moines

The Community Foundation of Greater Des Moines improves quality of life for all by promoting charitable giving, connecting donors with causes they care about and providing leadership on important community issues…we’re simply better together. 

Greater Carlisle Community Foundation

Mission of the Greater Carlisle Community Foundation:

The mission of the Greater Carlisle Community Foundation is to educate citizens about opportunities for philanthropy and create partnerships to provide a better quality of life for individuals and families.

The Greater Carlisle Community Foundation is committed to improving the quality of life throughout Carlisle by investing in area nonprofits through our grant programs and by providing individuals, families and area businesses who love our community with a way to give back.  

Greater Carlisle Community Foundation Grants

The Greater Carlisle Community Foundation makes grants to IRS section 501(c)(3) ‘tax exempt’ organizations and IRS section 170(b) ‘unit of government’ organizations to assist in fulfilling the foundation’s mission to foster private giving, strengthen service providers and improve the conditions of the Greater Carlisle School Area. 

Project Area of Focus

• Arts/Culture/Humanities – Museums, Historic Preservation, Exhibits, etc.
• Education – Schools (all ages), Adult Learning Programs, etc.
• Environment/Animals – Environmental Protection, Beautification, Animal-Related Issues
• Health – General, Rehabilitative, Mental, etc.
• Human Services – Public Protection/Safety, Recreation, Youth Development, Social Support, General Human Services
• Public/Society Benefit – Community Improvement/Development, Philanthropy/Volunteerism, Capacity Building, Civil Rights, etc.

Project Type

• A capital-based request refers to the building of or the physical improvement of something.
• A program-based request refers to activity or general programmatic support.

Marshall Community Foundation: Mini Grant

Funding Amount

• Up to $750

The Marshall Community Foundation reviews/awards grants quarterly and yearly based upon the size of the grant request. (Grant applications can be submitted at any time.) Grants are awarded to agencies across Calhoun County that benefit residents of the City of Marshall and surrounding townships. Grants are intended to be a flexible local funding opportunity that can respond to community needs.

Application priorities include, but are not limited to:

• Yields substantial community benefits for the resources invested
• Facilitates cooperation and enhances collaboration among organizations
• Avoids duplication of services
• Benefits the greatest number of people in the community and attracts volunteer resources
• Strengthens or improves the self-sufficiency and efficiency in areas such as, but not limited to:
  • Capacity Building
  • Workforce Development
• Represents innovative, start-up efforts
• Supports low income/underserved populations with:
  • Access to Resources
  • Poverty Intervention
  • Food Insecurity
• Promotes youth development in areas such as, but not limited to:
  • Student Performance
  • Teacher Training
  • Supplemental Programs
  • Youth Mental Health
• Examines and addresses underlying causes of local challenges
• Seeks challenge or matching financial resources

The Marshall Community Foundation will only consider granting to organizations who have submitted final reports for all previous grants. Final reports must be approved by the Board of Trustees. The approval process may take up to three months.

The NFWF's Five Star and Urban Waters Restoration Grant Program aims to enhance community capacity for sustaining local natural resources through financial assistance for diverse partnerships. With approximately $2.5 million available, projects focus on improving water quality, restoring habitats, and engaging underserved communities. By promoting ecological improvements and community outreach, this program seeks to increase access to nature's benefits while addressing environmental hazards. A blend of urban and rural initiatives is expected for effective implementation.