Best Large Grants for Nonprofit Organizations

The Birth Equity Innovation Seed Grants in Illinois aim to support community organizations working to reduce disparities in maternal and infant health. Funding will be available for programs tied to communities most affected by these inequities, facilitating access to essential maternal care services. The Illinois Department of Public Health encourages innovative approaches that establish or maintain programs focused on improving birth equity, particularly for marginalized populations. Grants range from $0 to $1,000,000.

The Innovative Water Infrastructure Workforce Development Grant, offered by the U.S. Environmental Protection Agency (EPA), aims to enhance career pipelines in the water utilities sector. This funding opportunity supports institutions and organizations in expanding access to water utility jobs through apprenticeship, education, and training programs. By fostering collaborations and increasing public awareness, the initiative seeks to address the workforce needs of water systems, contributing to community health and environmental protection.

The CHCF Innovation Grant supports organizations in the Capitol Hill community with funding between $5,000 and $15,000. This grant is aimed at fostering innovative programming and outreach to serve new audiences. Applications are accepted biannually, with deadlines in September and March, encouraging creative proposals that align with core community areas such as education, arts, and social services. This initiative promotes collaboration and enhances community impact.

The Water & Waste Disposal Loan & Grant Program in Arkansas offers essential funding for rural areas to establish and improve drinking water systems, sewage disposal, and storm water drainage. Eligible applicants, including state and local governments and nonprofits, can utilize funds for various projects including construction, legal fees, and maintenance. This initiative aims to ensure access to clean water and effective waste management in underserved communities.

The Installation and/or Replacement of Utilities Grant by the Illinois Department of Commerce and Economic Opportunity (DCEO) aims to enhance the quality of life in Illinois through funding for permanent capital improvements. This includes installation or replacement of utilities like water and electrical systems, fire hydrants, and drainage improvements. Eligible entities can apply for bondable costs associated with these projects, contributing to a cleaner environment and improved infrastructure.

The Rudolph J and Daphne A Munzer Core Grants focus on community-level support, primarily in Long Beach, CA. The Foundation aims to enhance family support systems, provide educational opportunities for underserved children, and improve access to healthcare for vulnerable populations. Grants range from $10,000 to $125,000, targeting high-priority needs in nonprofit organizations. Eligible organizations must be tax-exempt and serve identified communities, ensuring impactful initiatives that align with the Foundation's mission.

The CAL FIRE Forest Health Program aims to enhance the resilience of California's forests against wildfires, drought, and pests caused by climate change and land management practices. Funding supports large-scale projects focused on restoring forest health, protecting watersheds, and promoting carbon storage through reforestation. Grants range from $750,000 to $7 million, targeting projects that yield climate benefits and further state forest management goals.

The Water & Waste Disposal Loan & Grant Program in California provides essential funding for rural areas to enhance clean drinking water systems, sewage disposal, waste management, and storm drainage. Eligible applicants, including local governments and nonprofits, can use the funds for construction, improvements, and related activities like legal fees and land acquisition. This program aims to ensure access to reliable water services and promote public health in underserved communities.

The UP Sustainable Forest & Wildlife Grant supports projects that enhance the quality of life in the Upper Peninsula of Michigan. It aims to fund initiatives focused on research, education, and wildlife habitat improvement, prioritizing collaborative efforts that benefit the public. Grants typically do not exceed $1,000 and are exclusively available to non-profit organizations that serve the local community. Political purposes and operational expenses are ineligible for funding.

The ACT on Health Equity Community Solutions Challenge Grant, backed by the Astrazeneca Foundation, aims to enhance health equity by funding community-based nonprofit programs. Since its inception in 2021, it has allocated over $2.6 million to initiatives addressing nutrition, healthcare access, and lung health for historically marginalized populations. Eligible US-based 501(c) organizations can apply, with a focus on projects serving underserved communities and improving health outcomes through targeted support.

The Water & Waste Disposal Loan & Grant Program in Connecticut offers essential funding for the development of clean drinking water and sanitary waste management systems in rural areas. Eligible applicants include state and local governments, nonprofits, and tribes who cannot access commercial credit. This program supports various projects, including water sourcing, sewage treatment, and stormwater management, ensuring safe and sustainable environmental practices for communities in need.

The RIC Foundation's Catalyst Grants program aims to support innovative initiatives that catalyze change in Rhode Island. By prioritizing collaborations among organizations, the program addresses essential community priorities while emphasizing diversity, equity, inclusion, and access. Grants are available to state and local governments, academic institutions, and nonprofit organizations, focusing on systemic inequities. Applications are accepted annually, with a single grant awarded per cycle, fostering impactful partnerships for lasting progress.

The Regional Impact Grants for Norwich Youth aim to support youth development programs targeting economically and socially disadvantaged youth in Norwich. Funded by generous legacy gifts, these grants prioritize initiatives that enhance early childhood education, mentoring, mental health access, and educational opportunities. With grants of up to $15,000 available, eligible applicants include 501(c)(3) organizations and educational institutions committed to fostering youth empowerment and social change.

The Ohio Environmental Protection Agency is offering grants under the Clean Water Act Section 319(h) to support projects that improve water quality in Ohio streams. With a total funding of $2.5 million, eligible applicants include local governments and nonprofit organizations. Projects aimed at reducing nonpoint source pollution and restoring impaired stream segments are prioritized. This initiative provides 100% funding for projects lasting up to three years, enhancing habitats and reducing pollutants.

The Baker Foundation Grant supports 501c3 non-profit organizations primarily in Pierce County, Washington. Established in 1987 by the Baker family, it aims to enhance community welfare through funding for youth programs, arts, and education. Grants range from $2,500 to $10,000 for programs and $25,000 for capital projects. The Foundation honors its founder's legacy by fostering a vibrant cultural and educational landscape, ensuring the community continues to benefit for generations.

The Foundation for Pennsylvania Watersheds offers Convening Grants to nonprofit organizations for collaborative projects aimed at protecting and restoring water resources. Grants, capped at $2,000, are available to groups with 501(c)(3) status in areas from the Ohio border to the Susquehanna River. By leveraging local and federal funds, the foundation supports efforts to ensure clean water for future generations, addressing both pristine and polluted waterways in Pennsylvania.

The Prevent Cancer Foundation is dedicated to cancer prevention and early detection, funding vital research grants and fellowships across the U.S. Its mission is to empower individuals to combat cancer, aiming to reduce cancer deaths by 40% by 2035. The grants provide up to $100,000 over two years to innovative projects that enhance cancer prevention and early detection efforts, supporting a future where cancer is preventable and manageable for everyone.

The Charles A. King Trust Postdoctoral Research Fellowship Program supports postdoctoral fellows and clinician scientists engaged in clinical and implementation research, aiming to enhance their skills and independence in biomedical research. Established in 1936, this program offers two-year grants ranging from $194,100 to $215,000, including a flexible expense allowance. The upcoming awards will be granted on October 1, 2025, fostering innovation in health services and population health.

The Proposition 68: Fish and Wildlife Improvement Grant Program provides funding to enhance fish and wildlife habitats across California. This initiative aims to restore rivers and streams, acquire water resources, and improve wetland conditions. Eligible projects include water transfers, habitat improvements, and land acquisitions that support aquatic and riparian ecosystems. With a total budget of up to $30 million, this program plays a critical role in maintaining biodiversity and resilience against climate change.

The North Central Michigan CF: NCMCF Youth Advisory Council (YAC) Grants empower local youth from Crawford, Ogemaw, and Oscoda Counties to promote philanthropy by awarding grants to non-profit organizations benefiting individuals under 18. Prioritizing projects addressing pressing youth issues such as mental health, substance use, and bullying, the YAC fosters community improvement while enhancing members' understanding of grant-making. This initiative, supported by the W.K. Kellogg Foundation, ensures impactful contributions to youth-centric programs.

The Isnardi Foundation Grant aims to support 501(c)(3) charitable organizations in Fresno, California, focusing on education, poverty reduction, health advancements, city beautification, and care for the elderly. The Foundation seeks proposals from qualified nonprofits, but does not fund salaries or employee benefits. This initiative reflects a commitment to community welfare and the advancement of Italian heritage in the region, fostering a better quality of life for all residents.

About Us

The Texas Commission on Environmental Quality is the environmental agency for the state. We have approximately 2,800 employees, located in our central office in Austin and 16 regional offices around Texas.

Nonpoint Source Water Quality Grants

TCEQ and the Texas State Soil and Water Conservation Board (TSSWCB) nonpoint source (NPS) programs administer federal grants for activities that prevent or reduce nonpoint source pollution. The grants are made available through a federal program authorized under Section 319(h) of the Clean Water Act. Funds are appropriated by Congress.

The grant will reimburse 60% of the cost of selected projects; applicants provide the other 40% of the cost as match, which may include in-kind services by volunteers or partner organizations.

Types of Projects Prioritized

You can find descriptions of past projects funded through the TCEQ’s Nonpoint Source Program on our Projects webpage. Agricultural and silvicultural projects addressing nonpoint source pollution are funded through the TSSWCB Section 319(h) Grant Program. The types of projects that are prioritized include those that:

• lead to water quality improvements
• develop and implement EPA-accepted watershed protection plans (WPPs).

Requirements Related to Stormwater Activities

Projects that implement Municipal Separate Storm Sewer System (MS4) permit requirements are not eligible for funding. However, projects within areas covered by MS4 permits might be eligible for assistance if the proposed management measures are not required or used for permit compliance. For example, low impact development practices and retrofits of storm water control structures on developed properties are outside the scope of most MS4 permits in Texas and thus are usually eligible for 319(h) funding.

Quality Assurance Requirements

All project-related water quality data must be acquired, collected, and analyzed in accordance with an approved Quality Assurance Project Plan (QAPP). This includes all "environmental data operations" such as water quality sampling and analysis, flow measurement, acquisition or collection of rainfall data or geospatial data, and hydrologic or water quality modeling. QAPPs may take 3-6 months for final approval which must be obtained before any work specified in the QAPP can begin.

Funding for Septic Systems/On-Site Sewage Facilities

The TCEQ NPS grant program does not provide direct assistance to individual homeowners for septic systems. However, this grant program does fund projects managed by local entities, that provide septic system assistance and training on maintenance to homeowners. The Texas U.S. Department of Agriculture Rural Development offices , certain projects funded under TCEQ’s Supplemental Environmental Projects program, and other state and federal sources may offer technical and financial assistance with septic system repair and/or replacement in Texas. 

Bethany Legacy Foundation

For more than a century, the Bethany name has stood for compassion in action. Today, we carry that legacy forward by uniting the community around innovative, lasting solutions that strengthen well-being across Jefferson County, Indiana.

Bethany Legacy Foundation exists to build a healthier Jefferson County, IN. by listening first, collaborating widely, and investing wisely. Our mission is to bring people together to create sustainable change where it’s needed most.

Grants

Legacy 2030: Our Primary Focus Areas

Our six-year strategic plan aims to create a sustainable community where individuals of all ages can access the necessary resources and services to thrive. A strong workforce is the cornerstone, supported by ensuring youth, adults, and seniors have equitable access to transportation, mental health, and social services to promote well-being and independence. Our efforts and investments will focus on prevention, root causes, and initiatives that create a path to self-reliance.

The following outlines our Focus Areas, goals, and objectives for our Community and the People who live here:

Community

We aim for a Thriving Workforce that makes Jefferson County a desirable place to live and work and attracts and retains top talent.

To achieve this, we seek proposals, projects, and efforts that:

• Expand access and options for quality Childcare to improve outcomes for families and businesses
• Build stability through access to quality, safe and affordable Housing
• Expand Recreation options to promote health, connections, and a high quality of life
• Build skills and knowledge through Professional Development to enhance and advance careers

People

We aim for Strong Youth, Empowered Adults, and Stable Seniors in Jefferson County with the following outcomes if achieved:

• Kids that have a strong foundation and build resilience
• Adults that are healthy, educated, and productive citizens
• Seniors that are independent and Grow Old with Love and Dignity (GOLD)

To achieve this, we seek proposals, projects, and efforts that:

• Build Mental Health resilience and healing through holistic and preventative approaches
• Bridge distances by increasing options and access to Transportation
• Grow Social Services that strengthen and empower individuals and families

BLF uses an open application process to collect and review project ideas that align with BLF Focus Areas There are three types of applications: Long Application; Short Application; and Capacity Building Application.

BLF Grants: Short Application

• For requests of $50,000 or less in total funding, including multi-year requests
• Projects must support BLF Pillars and Focus Areas to be consider for funding
• Only one application form is submitted for review
• Approx 6-week process starting from application submission

United Health Foundation

The United Health Foundation was established by UnitedHealth Group in 1999 as a nonprofit, private foundation dedicated to improving health and healthcare. To date, the United Health Foundation has committed $880 million to programs and communities around the world, including a $100 million commitment to help support the healthcare workforce.

Grants

Our Philanthropic Partnerships

The United Health Foundation partners with local and national organizations to help build healthier communities. We focus on expanding access to care and improving health quality and outcomes by:

• Advancing and supporting the healthcare workforce
• Addressing mental and behavioral health
• Improving maternal and infant health outcomes
• Helping individuals manage chronic conditions

The State Street Foundation Grant supports nonprofits and NGOs that promote economic opportunity and reduce equity gaps in education and employability. Organizations seeking funding must operate in areas where State Street has a business presence and demonstrate a commitment to diversity and inclusion. The foundation prioritizes measurable outcomes and focuses on racial equity and social justice, ensuring that grants support initiatives that foster community engagement and sustainable impact.

The Mayo Clinic Community Contributions Program in Florida focuses on improving access to nutritious food. This grant supports registered 501(c)(3) organizations in northeast Florida, encouraging initiatives that align with community health needs. Eligible projects include health services, education, and youth enrichment, aiming to foster vibrant and sustainable communities. Organizations can apply for funding once per calendar year, with grants designed to enhance community engagement and address food insecurity.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Food as Medicine Initiative

The Food as Medicine Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to address food insecurity as a critical driver of health outcomes for uninsured and medically underserved patients. Research continues to demonstrate the strong connection between food insecurity and poor health, including increased risk of chronic conditions such as diabetes, hypertension, obesity, and certain cancers. Through this initiative, NAFC will provide $20,000 grants to member free and charitable clinics to implement or expand food insecurity screening and patient-centered interventions that improve access to healthy food and nutrition education as measured by the US Household Food Security Module or Hunger Vital Signs and patient education focused on food as medicine for eligible patients in order to increase the percentage of patients with improved food security scores within one year of project implementation.