Best Large Grants for Nonprofit Organizations

CVS Health Foundation: Hometown Fund

The CVS Health Foundation’s Hometown Fund was created to support local nonprofits across Hartford, Connecticut, and the state of Rhode Island – places where our CVS Health teams live, work and care deeply about community health. Through this fund, we support organizations that are making a real difference by expanding access to health care and addressing the everyday factors that shape people’s well‑being, like nutritious food and stable housing.

In 2025, the Hometown Fund awarded $2 million in general operating support grants – $1 million to 20 organizations in Greater Hartford and another $1 million to 20 organizations across Rhode Island. These investments continued our commitment to improving local health and strengthening community support systems, bringing the amount of Hometown Fund grants awarded since 2022 to $8 million. 

The Philippine Cultural Foundation of Hawaii Scholarship Fund supports Hawaii residents of Filipino ancestry pursuing higher education in Hawaii. Established in 2004, this fund prioritizes students who demonstrate financial need, maintain a minimum GPA of 3.5, and intend to study fields related to culture, arts, or communications. The foundation encourages applications from previous recipients in good standing, ensuring continued support for eligible students committed to their academic and cultural studies.

The Hanna H. Gray Fellows Program, funded by the Howard Hughes Medical Institute, aims to enhance diversity in the scientific community by supporting early-career researchers. The program provides funding for postdoctoral training and early faculty years, promoting an inclusive academic culture. Fellows receive an initial salary of $80,000 and a $20,000 annual expense allowance. This initiative helps develop future leaders in biological and biomedical sciences, ensuring equitable opportunities for all backgrounds.

The American Association of Law Libraries (AALL) Research Fund Grant supports projects that enhance legal information services and law librarianship. With a funding cap of $5,000 per round, the grant encourages diverse scholarship in legal research. Eligibility includes individuals with relevant research experience, while preference is given to AALL members. Applications are reviewed biannually by a jury, ensuring that the most impactful projects receive support. This initiative aims to foster innovation and collaboration within the legal information community.

The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.

The Brian D. Johnson Mechanical Engineering Scholarship at Montana State University provides financial assistance to deserving students pursuing degrees in Mechanical and Industrial Engineering. This scholarship, varying in amount, aims to support those demonstrating financial need and maintaining a minimum GPA of 3.0. Montana State University is committed to offering a robust educational experience, ensuring students achieve academic success while managing their financial responsibilities.

The FY 2027 Department of War Multidisciplinary Research Program of the University Research Initiative (MURI) aims to fund U.S. academic teams conducting innovative research to tackle complex challenges for the Department of War. Established in 1985, MURI promotes collaboration among diverse scientific disciplines, enhancing the defense workforce and addressing critical areas of interest through multidisciplinary research efforts at U.S. universities.

The PLTW Gateway program, in partnership with Arrow Electronics, aims to enhance STEM education in public and charter schools across the U.S. Funded by Lockheed Martin, this initiative provides $10,000 for schools to expand their existing PLTW Gateway programs. Eligible activities include adding new units and training teachers. Since its inception, over 300 programs have been established, reaching over 77,000 students and addressing the growing need for skilled engineers and computer scientists.

The PLTW Gateway program, supported by Lockheed Martin, offers grants for schools to implement STEM and CTE-aligned curricula. Aimed at enhancing educational access for students, it provides funding of $10,000 for the 2026-2027 academic year. Eligible schools include public and charter institutions across the U.S. This initiative, part of a long-standing partnership since 2007, addresses the critical need for future engineers and scientists, benefiting over 77,000 students through innovative coursework.

The Duke Endowment's Rural Church Grants aim to empower rural United Methodist Churches in North Carolina to effectively respond to changing community demographics. By providing resources and fostering collaboration among church leaders, the program enhances congregational capacity and community engagement. Key strategies include supporting pastoral leaders, reimagining church real estate for community use, and implementing impactful programs, especially for children. This initiative reflects a commitment to ensuring equitable opportunities across diverse rural populations.

FC Cincinnati Foundation

FC Cincinnati is committed to leaving a legacy, creating something bigger than ourselves, and being the embodiment of a rising Cincinnati. Through our own programs and initiatives, and the support of key partners, we aim to improve the lives of children through the game of soccer and will continue to do our part to create an inclusive community.

FC Cincinnati Foundation’s mission is accomplished primarily through five key programs: Club Ambassadorship through In-School and Out-of-School Programming, Mini Pitch Soccer Builds, West End Pride and Learning Is Cool. These programs help promote and encourage strong academic performance, and serve as catalysts to reinforce character values and improved health for children in the Greater Cincinnati region. The Foundation also serves as FC Cincinnati’s philanthropic arm, making donations and investments to Cincinnati-area organizations that have similar goals and ambitions for the area’s youth.

Donation Request

Donations are a way for FC Cincinnati to give back to local non-profit's as they are hosting fundraisers and events. These donations include, but are not limited to FCC signed merchandise items, FCC apparel items, and on special occasion, tickets to matches. Donations allow FC Cincinnati to show up across the city and support causes that are important to our fans, allowing us to connect with fans in a way that is meaningful to them. These items allow non-profits to use the donation for fundraising efforts and supporting their organization to raise money for a specific cause.

The Hahl Proctor Charitable Trust Grant provides financial assistance to charities focusing on children, families, arts, and education. Established by Hahl Proctor, a generous community member, the trust aims to support worthwhile causes with grants typically ranging from $2,000 to $20,000. This initiative reflects her commitment to enhancing community life through charitable endeavors.

The PLTW Gateway Program Expansion, in partnership with Lockheed Martin, aims to enhance STEM education in schools across the United States. With a total grant of $10,000 for the 2026-2027 academic year, this initiative focuses on expanding existing PLTW Gateway programs, allowing schools to introduce new units and train additional teachers. Since 2007, Lockheed Martin's support has enabled over 300 programs, providing critical skills to more than 77,000 students nationwide.

The Evelyn W. Preston Memorial Fund Grant supports music concerts in Hartford's public spaces during the summer months. Established in 1978, it is open to nonprofit organizations, including arts groups and cultural centers. Eligible projects must feature at least two instruments and be accessible to the general public. The fund emphasizes community engagement and artistic collaboration, aiming to enrich the cultural landscape of Hartford while ensuring concerts are free for all attendees.

The St. Joseph's Home Legacy of Care Fund, established by the Community Foundation for the Land of Lincoln, supports various programs and charitable initiatives in Central Illinois. This fund encourages eligible nonprofit organizations, including 501(c)(3) charities and faith-based entities, to apply for funding throughout the year. The foundation aims to adapt and respond to the evolving needs of the community, ensuring that support reaches those who need it most.

This funding opportunity invites applications for Testing Centers focused on evaluating somatic cell genome editing technologies for translational applications. These centers will provide essential resources and testing services to researchers, ensuring the efficacy and safety of novel genome editing methods. By developing innovative in vivo and in vitro models, the centers aim to enhance scientific rigor and reproducibility in biomedical research, ultimately supporting the advancement of therapeutics for human diseases.

About

The Chester County Community Foundation connects people who care with the causes that matter, so their philanthropy makes a difference now and forever.

As you are aware, there is ongoing uncertainty around federal and state funding that significantly impacts nonprofit organizations. The Community Foundation is committed to supporting a strong and resilient sector, and we encourage all organizations to be proactive in their planning.

We strongly encourage every nonprofit to engage in scenario planning, examine cash flow projections and assess funding risks. We have seen nonprofits explore a variety of pathways forward, such as adapting program design, reducing or merging operations and significantly diversifying revenue streams .

Capacity Building: Coping with Cutbacks Grant

These grants are specifically designed to strengthen the sustainability and effectiveness of nonprofits serving Chester County.

• Funding may support efforts in contingency planning, strategic restructuring, partnerships and collaborations, marketing and communications, resource development, technology improvements, and more.
• Volunteer grant panels and CCCF staff review proposals.

 Wayne Community Foundation

The Wayne Community Foundation is an organization designed to assist and benefit the citizens of Wayne County. The goal is to provide an efficient entity to accept and administer funds in the manner prescribed by each donor.

Wayne Community Foundation is affiliated with the Community Foundation of Greater Des Moines, a nationally certified foundation.

Seeds for Success Grant

The Wayne Community Foundation plays a key role in providing significant funding to projects that strengthen the Wayne County community. We have intentionally created this grant making cycle to award a grant that will have a major significant impact in the Wayne County community. Seeds of Success projects must demonstrate how they will serve as a catalyst, go above and beyond, and bring innovation to all of Wayne County.

The Seeds for Success Grant is awarded to help large projects get started or completed. 

The NSF NCAR Advanced Study Program (ASP) Graduate Visitor Program (GVP) Fellowship provides an enriching opportunity for graduate students to collaborate with NSF NCAR scientists on their research projects. It supports visits of 2 to 3 months, covering travel and housing costs. Eligible candidates include advanced Master’s and Ph.D. students focused on atmospheric sciences and related fields. The program encourages professional development through workshops and allows for potential extensions with co-sponsorship. Applications for the 2026 program are now open.

The Fiscal Year 2027 Department of War Multidisciplinary Research Program aims to fund innovative research teams from U.S. universities. Established in 1985, this initiative addresses complex challenges faced by the Department of War, fostering collaboration across various scientific disciplines. By integrating world-class faculty and graduate students, the program seeks to cultivate a skilled workforce poised to enhance the U.S. defense capabilities and contribute to the advancement of the defense industrial base.

The George J. & Effie L. Seay Foundation Grant supports nonprofit organizations in Virginia, focusing on arts, culture, education, and human services. Established in 1957, the foundation promotes various charitable programs and prefers funding specific projects over general operating grants. Grants are typically one year in duration, and organizations may not apply for another grant until three years after receiving funding. The foundation encourages collaboration with other funding sources to maximize support.

The Perry Dean and Alice Graham Charitable Foundation Grant supports 501(c)(3) organizations in Texas, with a special focus on Navarro County. Established in 1987, the foundation aims to enhance community welfare through grants in Arts, Culture, Education, and Human Services. Organizations must have operating budgets under $20 million to qualify for funding, ensuring that support reaches smaller, impactful entities dedicated to charitable purposes.

The CERSP Grant Program, administered by Harlem CDC, aims to provide financial assistance for initiatives and events that align with the mission of Harlem CDC. Funded through contributions from Columbia University, this program supports community and economic revitalization efforts in New York State, promoting local economic growth and job creation. With a focus on inclusivity and development, CERSP seeks to enhance the quality of life and opportunities within diverse neighborhoods.

The Hamer Foundation

Our Mission:

The mission of The Hamer Foundation is to provide support to nonprofit organizations within a 100-mile radius of State College PA in the following areas: 

• Environmental Support – 50% of donations 
• Community Support – 35% of donations 
• Educational Support – 15% of donations 

The Air Force Basic Research Sciences Conference and Workshop Support program encourages proposals from U.S. institutions of higher education and nonprofit organizations for conferences and workshops that promote research and technology interchange. These events are vital for sharing recent findings and educational techniques in key scientific areas. The program specifically invites Historically Black Colleges and Universities, Minority-serving Institutions, and Tribal Colleges to participate, aiming to foster collaboration and knowledge exchange among researchers.

The Lenoir County Community Foundation Grant Program, established in 1993, supports local charitable initiatives through competitive grants. It primarily serves organizations that are tax-exempt under Section 501(c)(3) or local government units, including public schools. Grants typically range from $500 to $3,000 and are aimed at enhancing community life in Lenoir County. This program encourages diverse organizations to apply, excluding those that engage in political lobbying or faith-based exclusivity.

Oklahoma Department of Career and Technology Education

For more than 100 years, Oklahoma’s system of career and technology education has focused on improving Oklahoma’s economy by offering individuals the training and skills necessary to be successful in the workplace and providing companies with the workforce necessary to compete globally.

Oklahoma's CareerTech system significantly contributes to the state's economic development and quality of life. Vision: We are securing Oklahoma’s future by developing a world-class workforce. Mission: We prepare Oklahomans to succeed in the workplace, in education and in life.

Competitive Technology Center Lottery Grant

The Oklahoma Department of Career and Technology Education requests proposals from technology centers for funding the implementation and/or upgrading of instructional and training technology for the purpose of (1) innovative “cutting edge” hardware and software, (2) curriculum materials, (3) machinery and equipment for new technologies, and/or (4) instructor training.

All proposed expenditures, including instructor training/professional development, must be related directly to the approved proposal. Curriculum materials purchased should support the technology requested in the proposal and could include digitally delivered curriculum and assessments. The request should not supplant current curriculum expenditures. For the purpose of this grant request, technology refers to any use of innovative processes, equipment and software that will enhance and/or advance instructional techniques or an advanced interactive learning environment to provide for the needs of the students and clients of the district, including business and industry.

Any and all technology equipment purchased with these funds will become the sole property of the local school district and will be placed on the local school district inventory. However, technology/equipment purchased with the grant must remain located at the technology center and in the specific Career Tech program to which it is awarded.