Best Operating Grants for Nonprofits

The Kathryn E. and John P. Doyle Scholarship Fund, established by John P. Doyle in 2015, supports female students pursuing degrees in science at the University of Alaska Fairbanks. This endowed scholarship aims to empower Alaskan women in their educational endeavors, reflecting the founders' belief in the transformative power of education. Awards are typically given annually, with the possibility of accumulating funds if no suitable candidates are found. Financial need is a preference in selection.

Helpers Community Grants

Helpers Community cares deeply about nonprofits that enrich the lives of individuals with developmental disabilities. Helpers Community is dedicated to supporting nonprofit agencies and individuals that help those who provide residential care, recreation, and job training programs to Adults with developmental disabilities. Helpers Community grants fund 501(c)(3) organizations that serve individuals with developmental disabilities, with priority given to those in the state of California.

Organizations that qualify through their commitment to serve Adults with developmental disabilities can apply for grants for infrastructure and materials for specific programs or projects, including facility improvement projects, but not for general operating support and/or salaries.

The amount of funding requested, keeping in mind our typical grant awards range from $15,000 to $25,000, and if any other potential funders have been approached or have committed to fund a portion of this infrastructure need.

The Greenway Ecological Fund Grant, supported by the NY Power Authority, allocates $1 million annually until 2057 to fund ecological projects in the Niagara Greenway. Projects must align with the Niagara River Greenway Plan and can include land acquisition, habitat restoration, and ecological stewardship. Eligible applicants include non-profits and local government entities. This initiative aims to enhance environmental sustainability and foster community engagement in ecological preservation efforts.

Loene Pooler Guthrie Scholarship Fund

The Loene P. Guthrie Scholarship fund benefits music students in Benton, Linn, and Lincoln counties who plan to engage in the teaching of piano, voice, and orchestral music.

This scholarship fund promotes the teaching of piano, voice and orchestral music by aiding music students in Benton, Linn, and Lincoln Counties who plan to engage in the teaching of piano, voice, and orchestral music. Students who will graduate from Linn, Benton, or Lincoln County high schools or graduates of those high schools currently studying music at an institution of higher learning may apply. The Linn-Benton Chapter of the Oregon Music Teachers Association reviews the applications and selects individuals to perform at an audition open to the public.

The BCBSND Impact Grants aim to enhance the health and well-being of North Dakotans by supporting innovative community initiatives. Funded by the Blue Cross Blue Shield of North Dakota Caring Foundation, these grants focus on whole-person health, emphasizing behavioral health and social determinants of health. Eligible organizations can receive up to $10,000 to implement projects that promote healthier lifestyles and address critical health issues, ensuring a lasting impact in local communities.

The Barney Family Foundation Grant focuses on improving early education and advancing medical research, particularly in cancer and Alzheimer’s. It supports organizations that demonstrate a clear plan to enhance children's life experiences and educational opportunities for those in grades K-8. Grants typically range from $5,000 to $50,000, prioritizing established entities while welcoming startups. Eligible applicants must have 501(c)(3) status, and the Foundation does not fund individual requests or political activities.

Grants to Organizations Providing Emergency Assistance to Bostonians

Grant Description

The Trustees of Charitable Donations for Inhabitants of Boston (TOCD) is a public charitable trust. It is made up of small private funds that have been entrusted to the City of Boston to help residents facing financial hardship. 

The Trust Office works with partner organizations to efficiently distribute the TOCD funding and provide wraparound services and support to grantees. The TOCD Board is seeking qualified organizations for the regranting program. 

This application will determine which local non-profit charitable organizations are interested in and qualified to partner with TOCD and receive funds for emergency assistance grants to Bostonians for a one or three year period. These are not organizational grants; the majority of the funding should go directly to people in need, and will need to be closely tracked and reported on. Many of the funds making up TOCD have legal restrictions for both the purpose for which the funds are used and for characteristics of the recipients. 

The Minnesota Youth at Work Competitive Grant supports workforce development for economically disadvantaged youth aged 14-24. Administered by the Minnesota Department of Employment and Economic Development (DEED), it prioritizes programs that provide career education, serve under-represented communities, and assist youth with disabilities. Applicants can request up to $850,000 annually, with potential for continued funding based on performance in the first year.

The Herb Kohl Philanthropies Homegrown Grants support local initiatives aimed at strengthening communities in Wisconsin. These grants are designed for organizations that empower children and youth, promote financial stability, and provide essential resources. Eligible applicants include nonprofit organizations with federal tax-exempt status that actively engage with their communities. The program emphasizes innovative solutions to local needs, ensuring funds are used effectively to enhance well-being and skills. Collaboration with local partners is encouraged to maximize impact.

The SK27 Sickle Cell Initiative Continuation Solicitation, administered by the Ohio Department of Health, aims to enhance the quality and accessibility of comprehensive sickle cell services across Ohio. This initiative focuses on supporting individuals of all ages, promoting public awareness, and improving coordination of resources. By collaborating with Regional Sickle Cell Projects, the program emphasizes effective tracking, counseling, and education to address sickle cell-related health disparities and improve outcomes for affected communities.

GO Virginia Program Overview

GO Virginia is a collaborative economic development initiative, that provides project-based incentives to encourage collaboration between private industry, higher education and local government in each region to produce results that will grow and diversify the regional economies and ultimately the commonwealth.

To achieve the program goals, the GO Virginia State Board has created nine regional councils. These councils are responsible for developing regional Growth and Diversification Plans and implementing those plans through the submission of project applications. Applications approved at the regional level are advanced to the GO Virginia State Board for funding.

The GO Virginia State Board has identified four primary investment strategies to achieve the program goals. The four priority investment strategies are:

• Workforce Development – building talent pipelines aligned with business needs that increases the pool of qualified workers
• Site Development and Infrastructure - preparing a regional portfolio of business-ready sites that attract private investment
• Entrepreneurship & Innovation (Startup Ecosystem) - creating a resource-rich environment for scalable start-ups and early-stage companies 
• Cluster Scale-Up -  helping existing regional industries grow and compete at a larger scale

All successful projects should align with at least one of these strategies and demonstrate a clear connection to a region’s Growth & Diversification Plan. See the GO Virginia Program Manual for details.

• GO Virginia is not an economic development incentive program. Individual private businesses may not receive funding, nor can any project provide exclusive benefits to a single private business.

• GO Virginia funds must support new and expanded efforts — not ongoing operations. Funding cannot be used to continue, sustain, or supplement the operating costs of existing programs. Projects must clearly demonstrate added value and represent new activity that advances GO Virginia’s mission. Proposals must fill a documented gap, scale a proven model, or introduce a new approach that supports regional priorities.

Virginia Growth and Opportunity Fund (GO Virginia) Competitive Grants

Competitive Grants are designed for projects that involve two or more GO Virginia regions (multi-regional) or go beyond what a single region’s annual allocation can support. They give regions the ability to collaborate or pursue initiatives that deliver substantial economic impact. To qualify, a project must present an extraordinary economic opportunity—one that is transformative in scale.

Competitive Grants allow regions to scale their ideas, tackle challenges that cross boundaries, and pursue transformative projects leverage regional strengths aiming to expand opportunities that benefit multiple localities and industries.

Application Types

Competitive Grants can support planning or implementation projects. The type of application depends on whether your project is multi-regional or single region. Competitive Grants include: Multi-Regional Planning Grants; Multi-Region Implementation Grants and Single Region Implementation Grants.

Multi-Regional Planning Grants

Multi-Regional Planning Grants give regions the chance to work together on big ideas before moving into implementation. These grants support the research, coordination, and strategy development needed when challenges or opportunities cross regional boundaries.

The goal is to help regions align priorities, engage key industry partners, and produce a clear roadmap that positions them for a future implementation project. By investing in planning first, regions reduce risk, build stronger partnerships, and ensure that later projects are grounded in real data and regional consensus.

Only planning projects that demonstrate a clear path toward a future multi-region implementation project of extraordinary economic opportunity will be considered for funding. In addition to the attached PDF document, see also the Planning Grant Administrative Guidance.

The Mosaic Company Foundation Community Investment Grant aims to create a lasting impact in communities by supporting initiatives in three key areas: Food, Water, and Local Community. With an annual investment of approximately $12 million, the foundation addresses food security, promotes water conservation, and enhances community sustainability. Eligible applicants must be recognized charitable organizations, primarily in North America, committed to improving quality of life through innovative solutions and partnerships.

The 25 Squared Grant Initiative, in partnership with Square Financial Services, allocates $65,400 to support 25 Utah nonprofits dedicated to community development. Grants of at least $2,500 will be awarded, with an additional $5,000 for exceptional organizations in categories such as Best in Show and Small Business Excellence. This initiative promotes economic empowerment by focusing on small business development, affordable housing, and financial wellness, fostering a positive impact across the state.

The C.D. Besadny Conservation Grants support grassroots conservation and education projects in Wisconsin, with funding ranging from $500 to $5,000. The grants prioritize initiatives that engage marginalized communities, protect rare species, and enhance climate resiliency. Eligible applicants include public charities, governmental units, and accredited educational institutions. The total project budget cannot exceed $10,000, and matching contributions are encouraged. This funding opportunity aims to strengthen connections between people and Wisconsin's natural resources.

The Alabama State University Anniston/Calhoun County Alumni Scholarship Fund aims to support African American graduating seniors from Calhoun County who plan to attend Alabama State University. Established by the ASU Alumni, this fund reflects a commitment to education and community enhancement. It provides one-time scholarships for students pursuing associate or bachelor’s degrees, or approved workforce training programs, ensuring they receive necessary financial assistance for their educational journey.

The RMEF Grant Program lies at the core of advancing our mission.

RMEF established the program in 1986 to provide financial and logistical support to projects that align with our priorities and goals. Grant funds raised by RMEF members, volunteers and generous donors from across the country translate into significantly more conservation accomplishment when matched with partner funds. The RMEF Grant Program also aims to build recognition for RMEF’s work, grow engagement, and boost local fundraising efforts.

Governed by clear guidelines and criteria, the RMEF Grant Program seeks to foster meaningful collaborations and long-term impacts in the conservation of natural resources and outdoor traditions. Grant project partners include federal, state, local, and tribal wildlife and land management agencies, private landowners and local stakeholders, sportsmen and women, and conservation organizations, universities, foundations and the outdoor industry. Eligible projects primarily focus on habitat stewardship, land conservation and access, wildlife management, and hunting heritage.

We support organizations recognized by the Internal Revenue Service (IRS) as a 501(c)3 entity, federal, state, local, or tribal government entities, sportsmen’s organizations, or educational institutions. All applicants must have a Federal Employer Identification Number (EIN) issued by the IRS. RMEF does not offer grants to individuals.

Hunting Heritage

Ensuring our hunting heritage is central to RMEF’s mission. Hunters—America’s first conservationists—remain the driving force behind wildlife conservation. RMEF funds hunting heritage and conservation education to help more people experience the outdoors, learn the skills of hunting, and carry forward the traditions that define big game country, including outdoor skills programs/events, hunter or conservation outreach, mentored hunts, and other similar activities.

The Swindells Charitable Foundation Grant supports the relief of sick, suffering, and indigent aged individuals, as well as public and charitable hospitals. Established in 1993, the foundation offers grants that have a duration of one year. Priority is given to organizations serving economically disadvantaged children and older adults. Note that applicants cannot receive funding for more than three consecutive years. This grant is a vital resource for enhancing health human services.

Emergency Solutions Grant Program

What Is the ESG Program?

The Emergency Solutions Grant program (ESG) provides any individual experiencing homelessness with emergency shelter and essential supportive services as well as homelessness prevention and rapid re-housing. Additionally the ESG program supports the activity of street outreach with the goal of connecting those individuals and families living on the streets or in areas not meant for human habitation to emergency shelter or housing options. For those unwilling or unable to access shelter, outreach workers will provide these most vulnerable individuals with portable shelter, food, clothing, and more.

West Virginia Community Advancement and Development’s (WVCAD) goal is to enable those experiencing homelessness, or at-risk of being homeless to get back on their feet by providing stable housing environments throughout the State of West Virginia. The ESG program is by no means a “hand out”, but instead a “hand up” in providing housing and supportive services with hopes that the end result is self-sustainability with no return to homelessness.

To achieve this, WVCAD provides funding and resources to multiple agencies throughout the State with dedicated staff having the local reach and knowledge necessary to serve those experiencing homelessness, or at risk of becoming homeless in their communities. This includes individualized case management, equitable provisions of supportive services, housing and utility assistance, housing information, and any additional referrals as needed. These funds are made possible through an annual funding allocation from the U.S. Department of Housing and Urban Development.

ESG services are a vital component to the stability and economic development of communities throughout West Virginia by assisting individuals and families who without this program’s assistance could become or remain homeless.

What Can the ESG Program Do for You? 

ESG provides emergency shelter, including domestic violence shelter options, for individuals who are living in a place not meant for human habitation. This includes facilities that provide shelter during the day or overnight and are dedicated to providing clients with the necessary tools and services to help them get back on their feet. These agencies are staffed by employees and volunteers dedicated to improving the lives of the most vulnerable and chronically homeless individuals in their communities.

The program rapidly rehouses individuals who, by no fault of their own, find themselves in a situation where they are literally homeless and are living in a place not meant for human habitation. This can be due to loss of income tied to a job loss, being trapped in a domestic violence situation, or being forced out of a residence. Agencies who provide this service follow a ‘housing first’ approach to ending homelessness in West Virginia, by getting clients into a stable housing environment as quickly as possible while providing essential services to help individuals get back on their feet. 

ESG also provides housing and utility assistance for homelessness prevention to keep individuals and families that are at imminent risk or at-risk of losing housing and have nowhere else to go gain the stability necessary to avoid experiencing homelessness. Agencies who provide homelessness prevention services can often assist individuals to keep their current housing arrangement, settle unpaid rent, provide utility assistance, or move individuals into a new location.

The Region Grants Open Grant Round: Community Vitality, supported by Land O'Lakes Foundation, aims to enhance the vibrancy of dairy communities in the East and West Regions. With a total investment of $500,000 annually, grants ranging from $1,000 to $20,000 are available for organizations focused on rural development, education, and community resources. Eligible applicants must have a 501c3 status and serve specific geographic areas, ensuring support reaches those in need.

The H-E-B Community Investment Program supports nonprofit organizations within its service area by providing monetary funding, volunteers, or in-kind donations. It prioritizes projects in arts, education, health, and social services. Eligible organizations must have valid 501c3 status and reapply annually for funding. Requests over $200 must be submitted online, while those under can be made at local stores. For further guidelines, visit their FAQs page.

Tobacco-Related Disease Research Program

A portion of California's tobacco product excise taxes are used to fund research grants. These grants are administered by TRDRP.

As one of three state agencies that work together towards a tobacco-free California, we aim to eliminate commercial tobacco use and tobacco-related diseases and to improve the health and well-being of all Californians. TRDRP works with the California Department of Public Health and Department of Education under the guidance of the Tobacco Education and Research Oversight Committee to ensure collaboration across all sectors of California's tobacco control community.

TRDRP is administered by the Research Grants Program Office (RGPO) at the University of California, Office of the President.

Cornelius Hopper Disparities Supplement

Purpose

The Cornelius Hopper Disparities Supplement (CHDS) supports California community members and student trainees who wish to pursue research training focused on tobacco priority populations. This Supplement award aims to build capacity by broadening the workforce and advancing efforts to end the commercial tobacco epidemic in California.

Summary:

• Maximum supplement amount per year: $20,000 (direct costs)
• Duration: 1 or 2 years
• Supplement funds are provided in addition to the parent grant award cap

This award is named after pioneer and trailblazer Dr. Cornelius L. Hopper, Emeritus Vice President for Health Affairs for the University of California, who helped establish TRDRP in 1988.

The Tribal Colleges Extension Program Special Emphasis (TCEP-SE) aims to enhance community engagement through pilot projects at 1994 Institutions, targeting issues like agricultural productivity, food systems, and public health. This program is open to a wide range of Tribal colleges and universities, promoting workforce development and youth involvement in agriculture. By addressing local needs, TCEP-SE fosters community vitality and prepares the next generation of Tribal agriculture leaders.

The Women’s 5K Classic Grants fund initiatives that educate and support women in preventing Breast and Gynecologic cancers while promoting fitness. Established in 1993, the program encourages women in the Lehigh Valley to engage in physical activities and raises awareness about cancer prevention and treatment. Grants support low-cost fitness programs, educational initiatives, and research efforts aimed at improving women's health and well-being, benefiting the community significantly.

The Arts in Social Service Grants from New Mexico Arts supports organizations focused on arts-based projects that tackle social issues affecting marginalized populations such as the incarcerated, homeless, and ill. With a two-year funding cycle starting in FY2026, eligible organizations can renew their applications for FY2027. This initiative fosters civic dialogues through artistic activities, encouraging community involvement in vital social discussions.

The Total Wireless + Empower Work: Working Students Pilot Grant aims to support working students in Dallas, Detroit, and Chicago through grants ranging from $50,000 to $150,000. Nonprofits will be selected to fund programs that provide job training, skill development, and host events to assist these students. This initiative encourages partnerships with organizations committed to fostering equitable workplaces and enhancing the educational journeys of working students.

The Philadelphia Chromosome Negative Myeloproliferative Neoplasms (MPN) Grant, offered by the Patient Advocate Foundation, provides crucial financial assistance to patients facing this cancer type. It covers out-of-pocket healthcare costs, including medication copays and insurance premiums, ensuring those affected can access necessary treatments. With a focus on personalized case management, the foundation has supported millions in navigating their healthcare needs, emphasizing the importance of timely and affordable care for patients diagnosed with MPN.

The Rockfall Foundation is accepting applications for its 2026 Annual Environmental Grants Program, aimed at non-profit organizations, municipalities, and schools. This program supports projects focused on environmental conservation, restoration, and education in the Lower Connecticut River Valley. Eligible expenses include materials, transportation, and program fees. Projects must demonstrate a clear benefit to the environment and align with the foundation's priorities, including environmental justice and youth engagement.