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Get operating grants for nonprofits covering essential expenses, staffing, program delivery, and organizational sustainability.
32,000+
Available grants
$8.26B
Total funding
$6K
Median grant
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About Patient Advocate Foundation
Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.
Who we are and our impact
Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.
Eosinophilic esophagitis
Help with healthcare costs for eosinophilic esophagitis
This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.
About the disease
Eosinophilic Esophagitis (EoE) is a disorder of the esophagus and is increasingly recognized as a major cause of swallowing difficulties in children and adults. It is a chronic disease of the immune system and can be triggered by a food allergy, acid reflux, or an airborne allergy. An allergic trigger causes the immune system to overact which causes many white blood cells, or eosinophils, to collect in the esophagus. This causes the esophagus to become inflamed and not contract properly. The esophagus can also narrow and develop rings or abscesses. This condition can become worse over time.
About Patient Advocate Foundation
Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.
Who we are and our impact
Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.
Multiple sclerosis (MS)
Help with healthcare costs for Multiple sclerosis (MS)
This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.
About the disease
Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.
About Patient Advocate Foundation
Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.
Who we are and our impact
Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.
Multiple sclerosis (MS) health equity
Help with healthcare costs for multiple sclerosis (health equity)
This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.
Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code.
About the disease
Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.
Truist Foundation
The Truist Foundation is committed to Truist Financial Corporation's (NYSE: TFC) purpose to inspire and build better lives and communities. Established in 2020, the foundation makes strategic investments in nonprofit organizations to help ensure the communities it serves have more opportunities for a better quality of life. The Truist Foundation's grants and activities focus on building career pathways to economic mobility and strengthening small businesses.
Inspire Awards
This year’s Inspire Awards seeks nonprofits supporting the career navigation and workforce development needs of workers across the United States. The challenge seeks applications that help individuals gain the skills, guidance, and support needed to access quality jobs, advance in their careers, and build long-term stability in an evolving world of work.2026 Truist Foundation Inspire Awards Challenge Question
How are nonprofits providing innovative direct services, training programs, and career navigation supports for adult workers in the age of AI?
Challenge Dimensions
Nonprofit organizations have long been critical advocates and service providers for workers in the United States. Nonprofits provide workers necessary upskilling opportunities, AI literacy training, career navigation support, and wraparound services in conjunction with career pathways programming. All necessary for the modern workforce. Meeting the moment, Truist Foundation and MIT Solve want to hear the ways in which nonprofits headquartered in the Truist operating footprint are providing innovative career pathway programming in the age of AI. Although solutions don’t need to focus on generative AI specifically, teams should demonstrate how their career pathways programming align with the following dimensions:
Here are the grants for this challenge
Minnesota Department of Health
Mission: Protecting, maintaining and improving the health of all Minnesotans.
Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.
Rural Health Transformation Program Funding
The federal Rural Health Transformation Program (RHTP) was created by H.R.1 (Section 71401 of Public Law 119-21) on July 4, 2025. It is a federal initiative to help states support rural communities in improving health care access, quality, and outcomes by transforming the health care delivery ecosystem. The RHTP focuses on promoting innovation, strategic partnerships, infrastructure development, and workforce investment in rural communities. Minnesota has outlined their initiatives online (learn more about Minnesota's Rural Health Transformation Program).
Grant recipients will select activities from broad RHTP initiatives designed to advance the overarching goals of improving health outcomes and access to care for rural Minnesotans, sustainably expanding the rural health care workforce, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments.
Entity Type: Certified Community Behavioral Health Clinics (CCBHCs) and Community Mental Health Centers (CMHCs)
Estimated Number of Awards: 16
Estimated Maximum Award in Budget Period 1: $240,000
Applicants may request up to the maximum award.
Our mission is to enhance quality of life, today and in the future, by:
Richard and Lou Ann Bergen Scholarship in the Creative Arts
Amount
Minimum $1,000
Geographic Limitations
Saline County high school seniors attending either Bethany College, Kansas City Art Institute, Kansas State University, Kansas Wesleyan University, University of Kansas or Wichita State University.
Renewals
Scholarship is renewable up to four years.
About Us
Texas Health and Human Services, also known as the Texas Health and Human Services Commission (HHSC), helps more than 7.5 million Texans every month. The agency supports the needs of mothers, children and families through programs such as Medicaid, CHIP, SNAP, women’s health and behavioral health services.
HHSC provides long-term services and supports for seniors and people with disabilities, and operates state supported living centers for residents with intellectual and developmental disabilities and state psychiatric hospitals. HHSC also regulates health care providers, professions and facilities to protect the health and safety of Texans.
Preparation for Adult Living (PAL) Transition and Financial Support Services
Executive Summary
The State of Texas, by and through the Texas Health and Human Services Commission (HHSC) on behalf of the Texas Department of Family and Protective Services (DFPS) Child Protective Services (CPS) Program seeks Applicants to provide Preparation for Adult Living (PAL) Transition and Financial Support Services in an effective and efficient manner in DFPS Regions 1 to 5 and Regions 7 to 11 ( Refer Section 2.4, DFPS Regions) to DFPS Youth and Young Adults to help them successfully transition to adulthood.
WHO ARE WE?
In 2020, Jackson County was home to more than 165,000 children and youth under 18 years of age, and ranked 75th out of 114 Missouri counties for child welfare. Thirty-two percent of our county’s children under 6 years of age live in poverty. Twenty-five percent of our older kids do, too. Hundreds are victims of abuse or neglect. Thousands require clinical psychiatric care. A prior needs assessment of funding for children’s services in Jackson County revealed an annual funding gap of over $21M. CSF exists to change this story. Uniting care, connection, and creativity, we are providing opportunities to give hope to Jackson County kids.
CSF is an innovative way to support child well-being projects. While we are funded by a Jackson County sales tax, we are a stand-alone organization led by an independent board. We are committed to community equity. Our board is balanced to reflect our county, and we work to educate and support all applicants, so everyone—including small organizations and first-timers—has a fair shot at funding. We believe in fresh solutions, constant progress and collaboration. Our work allows us to see the whole-county picture, so we can connect like-minded partners and promote new collaborations.
CSF Core Funding
Core Funding is at the heart of our mission to make transformative investments in the mental health and emotional well-being of children in Jackson County. It supports organizations dedicated to improving the lives of children and families, enabling them to provide essential services that strengthen protective factors, mental health and social-emotional well-being. This funding is central to creating lasting impact, ensuring that every child has the opportunity to thrive.
Organizations can access Core Funding through two different funding cycles to best meet the needs of the organization. For traditional non-profit organizations, calendar year funding (January 1 – December 31) is the intended option to provide support. For schools and school-based/school-adjacent services, academic year funding (July 1 – June 30) is available. Both cycles follow a clear and structured process for requesting and awarding funds, with flexibility to suit different program needs. The application process has been streamlined to allow for more equitable access, with applicants now engaging in in-person presentations rather than submitting lengthy applications. This change fosters stronger relationships between the CSF and funded partners and levels the playing field for all organizations.
CSF can fund:
Canvas Foundation
Canvas Foundation is made up of volunteers from across Canvas Credit Union who give their time, knowledge, and heart to further our goals. We are a fully independent 501(c)(3) non-profit. Most importantly: we're you. Your neighbors, your friends, your community.
Canvas Foundation Grants
Are you a local 501(c)(3) organization supporting Colorado schools, families, military members, or first responders? If so, we invite you to apply for a grant from Canvas Foundation. We'd love to learn about your mission and the impact you're making in your community.
Schools, Families, Military, and First Responders
Our goal is to support and nurture these critical areas and leave a lasting footprint in our communities. We achieve that by providing financial grants, charitable activities and programs that reflect the communities we serve. These funds are intended to create long-term relationships between Canvas Foundation and the recipients so we can create thriving communities together.
Guidelines and Considerations
Boone County Community Foundation
The Boone County Community Foundation was formed in 2005 to coordinate and provide philanthropic support for community betterment projects in Boone County. The foundation is made up of community minded individuals who have the ability to assess community needs, implement asset development, evaluate area grant applications, encourage partnerships and initiate activities to enhance Boone County.
Mission: The Boone County Community Foundation is a charitable foundation created by and for local citizens to improve the quality of life right here in our communities. We are here to help donors make a positive, local impact by offering a variety of giving tools to help people achieve their charitable giving goals and do good work in our communities that lasts forever.
Grants
Each year the foundation makes grant awards to worthwhile projects located in the county that are identified through a community grants application process. Our foundation’s areas of emphasis include: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.
Three types of grants based on grant amount: Simple Grant; Standard Grant and Impact Grant
Simple Grant
$3,000 and under
Boone County Community Foundation
The Boone County Community Foundation was formed in 2005 to coordinate and provide philanthropic support for community betterment projects in Boone County. The foundation is made up of community minded individuals who have the ability to assess community needs, implement asset development, evaluate area grant applications, encourage partnerships and initiate activities to enhance Boone County.
Mission: The Boone County Community Foundation is a charitable foundation created by and for local citizens to improve the quality of life right here in our communities. We are here to help donors make a positive, local impact by offering a variety of giving tools to help people achieve their charitable giving goals and do good work in our communities that lasts forever.
Grants
Each year the foundation makes grant awards to worthwhile projects located in the county that are identified through a community grants application process. Our foundation’s areas of emphasis include: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.
Three types of grants based on grant amount: Simple Grant; Standard Grant and Impact Grant
Standard Grant
$3,001 - $15,000
Operating grants for nonprofits provide essential funding to support day-to-day operations, staff salaries, and infrastructure. The following grants help organizations build capacity, maintain sustainability, and focus on achieving their mission-driven goals.
Explore 8,000+ funding opportunities for operational support, with $3.50B in resources. Instrumentl helps nonprofits secure essential funding by offering grant discovery tools, deadline tracking, and strategic funder analysis to ensure long-term success.
How common are grants in this category?
Quite common — grants in this category are more prevalent than in others.
Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits?
Most grants are due in the first quarter.
Nonprofits of all types can apply for operating grants, but they are especially useful for organizations needing flexible funding to support the core work of their mission. Operating grants are ideal for nonprofits involved in general population well-being. Specific sectors include healthcare, education, social services, and the arts. Unlike project-based grants that fund specific initiatives, operating grants help with essential costs like staff salaries, rent, and general admin costs. Funders often look for groups with a clear mission who serve a meaningful purpose and have potential for long-term impact.
Based on Instrumentl’s live grant database for operating, grant deadlines are most common in Q1, accounting for 29.3% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.
Operating grants exist to help nonprofits function smoothly and grow effectively. The goal is to give organizations the financial means they need to focus on their mission, serve their communities, and support long-term stability. These grants allow nonprofits to improve everyday operations, invest in staff development, and expand programs. Funders want to see nonprofits thrive, not just survive, and providing operational support is a key element to making that happen.
Funding for operating grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $35,000, while the average grant awarded is $672,603. Understanding these funding trends can help nonprofits set realistic expectations when applying.
Operating grants are often funded by private foundations like the popular Ford Foundation. Some government agencies offer grants to strengthen nonprofit infrastructure, especially in sectors like health, education, and social services. Corporate giving programs may also support nonprofits that align with their values and create lasting impact.
To improve the chances of getting operating grants, nonprofits should:
For more advice on finding and winning operating grants, check out our step-by-step guide to general operating grants.
Instrumentl simplifies the process of applying for operating grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.
Check out how Habitat for Humanity delivered over 200% ROI within just a few weeks.