Best Operating Grants for Nonprofits

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For more mature concepts aimed at workflow refinement, performance optimization, and generation of proof-of-concept and validation data in relevant public-health use cases in LMICs.

The REALTORS Housing Opportunities Fund Grant, initiated by the Charleston Trident Association of Realtors in 2003, aims to support affordable housing projects in Berkeley, Charleston, and Dorchester counties. With over $1 million invested, the grant prioritizes nonprofits focused on education, development, or repair of affordable housing. Interested organizations must register to apply, allowing two business days for processing. This competitive funding opportunity promotes community development and addresses housing needs.

The Paul Jorgensen Conservation Research Grant, offered by the Anza-Borrego Foundation, supports undergraduate and graduate students conducting ornithological field studies in Southern California's Colorado Desert and Peninsular Ranges. Grants of up to $2,500 are available to assist with fieldwork costs, honoring Paul D. Jorgensen's legacy. Special consideration is given to research conducted within state parks, fostering a deeper appreciation and understanding of California's unique desert ecosystems.

The Indiana Department of Health is inviting local health departments to apply for the Naloxone Grant to distribute opioid overdose reversal kits, including naloxone nasal spray. This initiative aims to increase the availability of life-saving medication in communities, especially in collaboration with organizations such as county jails. Education on the use of naloxone and legal protections for responders is also a key component of the program, fostering a safer environment for overdose interventions.

Overlake Corporate Sponsorship aims to support local organizations that enhance community well-being. With a focus on non-profits in the Eastside area, we prioritize partnerships addressing healthcare access, mental health, and homelessness. Our criteria emphasize valid 501(c)(3) status and alignment with our community health goals. While we value every sponsorship request, we must judiciously allocate resources to ensure maximum community impact.

The PATH 1.4 Community Care Hub initiative by the Utah Department of Health and Human Services aims to enhance coordinated care for chronic disease management in rural Utah. By establishing a data-driven Community Care Hub, the project will connect local organizations and individuals to address health and social needs effectively. This initiative aligns with federal goals to improve health outcomes and ensure a seamless system of support for communities in need.

The VHCF Health Access Grants aim to enhance healthcare access for uninsured Virginians and those in underserved areas. This funding supports initiatives to expand care capacity, establish broader services, and address the mental health crisis exacerbated by the COVID-19 pandemic. Eligible organizations include public agencies and 501(c)(3) nonprofits. The program prioritizes projects that create coordinated systems of care to improve health outcomes for vulnerable populations.

The BJA FY 2026 Second Chance Act Community-based Reentry Program aims to support community organizations and tribal governments in providing essential mentoring and transitional services for individuals returning from correctional facilities. This initiative targets those assessed as moderate to high risk for recidivism, addressing their needs both pre-and post-release. By fostering successful reintegration into society, the program contributes to public safety and reduces recidivism rates, aligning with the mission of the U.S. Department of Justice.

The Music Industry Mental Health Fund’s FireAid Grants aim to support music industry professionals and their families affected by the LA wildfires. By providing up to $2,000 for outpatient mental health services, along with recommendations for qualified providers and follow-up care, this initiative addresses the urgent need for mental health resources in the wake of personal loss and financial hardship. The fund emphasizes continuity of care to ensure that recipients receive comprehensive support as they navigate their recovery.

The 1890 Institution Teaching, Research, and Extension Capacity Building Grants Program aims to enhance the capabilities of eligible institutions by fostering collaboration with federal and non-federal entities. This initiative supports the White House's commitment to promote excellence at Historically Black Colleges and Universities (HBCUs). By strengthening institutional teaching, research, and extension capacities, the program helps ensure that HBCUs can effectively contribute to innovative solutions in education and community development.

The Cancer Prevention and Control Programs aim to enhance cancer outcomes by funding partnerships among national, state, territorial, and tribal organizations. These initiatives focus on evidence-based strategies for cancer surveillance, prevention, and control, specifically targeting breast and cervical cancer screening for underserved populations. Through collaboration, the program seeks to improve clinical services and cancer survivorship, ultimately striving towards the vision of 'All People Free of Cancer' by leveraging resources and community involvement.

The North Carolina Forest Service Urban and Community Forestry Financial Assistance Program aims to empower municipalities in achieving sustainable urban and community forestry management. By providing financial support and expertise, the program enhances community living quality through effective forestry practices. It uses specific standards to classify community management levels, fostering progress and celebrating achievements. This initiative encourages collaboration among stakeholders to further urban forestry goals and improve local environments, ultimately contributing to healthier, greener communities.

Greater Opportunities for Affordable Living (GOAL)

The GOAL program provides grants, federal tax credits and zero-interest federal loans to developers and project sponsors who build affordable rental housing for low- to moderate-income families and seniors.

The rating and award criteria outlined herein has been prepared by the Alaska Housing Finance Corporation (AHFC) to establish the criteria which will be used to award Greater Opportunities for Affordable Living (GOAL) Program funds. This program contains four primary funding sources:

• Low-Income Housing Tax Credits (LIHTC),
• Home Investment Partnership Program (HOME) funds,
• Senior Citizen’s Housing Development Fund (SCHDF)*
  • Additional capital development funds available for senior housing development, provided by AHFC’s funding partners, will be synonymously treated as SCHDF requests for the purpose of this Qualified Allocation Plan.
• National Housing Trust Fund (NHTF).
  • In years where a sub-grant is awarded to the Municipality of Anchorage from AHFC, NHTF awards made through the GOAL program will only be issued to proposals located outside of the Municipality of Anchorage.
• Other sources that may become available through new programs or partner investments.

The OK Southern Pine Beetle Prevention Cost-Share Grant Program aims to assist landowners in eastern Oklahoma in managing their pine forests, particularly those at risk from the Southern Pine Beetle (SPB). The program provides financial support for practices that promote healthy forest conditions and reduce infestation risks. Priority is given to landowners in LeFlore, McCurtain, and Pushmataha counties, but funding is also available for high-risk stands outside these areas, ensuring comprehensive protection against SPB threats.

About Us

The Washington State Department of Health (DOH) is Proud to Serve All People in the Great State of Washington. The Evergreen State was named the “Best State” by U.S. News to measure how states are performing on behalf of their residents. The state of Washington boasts unparalleled natural beauty, from volcanoes and rain forests to wineries and beaches. Washington State is divided in to 39 counties that reflect the wide cross section of life in America -urban, suburban, and rural. Washington is home to 29 federally recognized tribes, independent nations within our great state, with the 8th largest Native American population in the U.S. People we serve. Over the past decade Washington’s population grew by nearly one million people to 7.75 million. We also grew more diverse with U.S. Census reporting Washington becoming 10 percent more diverse during this decade. DOH works continuously to reduce health disparities among vulnerable and underserved communities to achieve health equity throughout Washington.

Healthy Environment for All (HEAL) Community Capacity Grant

The Healthy Environment for All (HEAL) Act was passed in 2021. The HEAL Act helps to reduce environmental and health disparities and improve the health of all people in Washington state.

This grant program focuses on building climate resilience and enhancing community-led decision-making to advance environmental justice (EJ). This funding provides communities most impacted by environmental hazards with the resources needed to collaborate with state agencies on environmental health decisions. Those communities include (but are not limited to):

• Native Nations
• Urban natives
• Black and BIPOC communities
• Rural communities
• Youth
• Low- income
• Unhoused
• Disabled
• LGBTQ+
• Other communities most vulnerable to climate impacts

The legislature required the Department of Health (DOH) to base the grant program on the Environmental Justice Council (EJC) Climate Commitment Act’s (CCA) funding recommendations and budget priorities. This grant program is funded by the CCA, which creates a cap-and-invest program to limit carbon emissions.

Grantees received 2 funding opportunities to build capacity for engaging in HEAL activities:

• Project funding: DOH awarded $100,000 grants to 4 projects. An organization may have applied on its own or in partnership with other organization(s) for funds. These funds can help organizations and community provide input on:
• The Environmental Justice Council implementation of the HEAL Act.
• DOH updates to the Environmental Health Disparities Map.
• State agencies’ implementation of the HEAL Act. This includes environmental justice assessments, budgeting and funding, community, and Tribal engagement.
• Passthrough funding: DOH awarded $500,000 grants to 2 passthrough applicants. We invited community-based organizations to sub-grant or award funds to other community-based organizations working with overburdened communities and vulnerable populations across Washington state.  

The Climate Justice Fellowship, funded by NYSERDA, invites organizations to host a full-time fellow for one year to advance climate justice and clean energy initiatives in Disadvantaged Communities. Eligible fellows, who must be NYS residents from Priority Populations, will receive a salary and professional development support. NYSERDA aims to fund approximately 150 fellowships by 2026, with a total budget of $6 million. Host employers must apply to confirm eligibility and facilitate fellows' projects.

The USA Dry Pea and Lentil Council (USADPLC) invites research proposals for pulse crops, focusing on breeding, nutrition, crop management, and product development for the 2023-24 fiscal year. Projects should adopt a transdisciplinary approach to tackle complex challenges, with average awards around $30,000. Researchers are encouraged to leverage industry funding for matching grants. Note that equipment purchases over $10,000 are not eligible. Compliance with specific proposal guidelines is essential.

The Federal STOP Violence Against Women Formula Grant Program, administered by the Pennsylvania Commission on Crime and Delinquency, aims to enhance community responses to domestic violence, sexual assault, and stalking. By fostering collaboration among law enforcement, prosecution, and victim services, this program ensures a comprehensive approach to address these issues. With a focus on effective strategies and accountability for offenders, the grant encourages innovative solutions to protect and support victims, ultimately aiming to improve safety across communities in Pennsylvania.

The City of Bellingham invites organizations to apply for the First Steps to Develop Affordable Housing or Shelter Grant, aimed at enhancing housing options for low-income residents. Interested parties should submit an Expression of Interest Form, followed by a Statement of Intent to ensure proper coordination with funding opportunities. Predevelopment funding up to $60,000 is available for projects with a known site, supporting sustainable development efforts in the community.

Tipton County Foundation

Since its founding in 1986, the civic-spirited volunteers responsible for TCF’s Board leadership, fund-raising, investment decisions, and grantmaking have built a substantial endowment that will never be spent. The income earned from investments is used to help meet Tipton County’s charitable needs– from social services for youth and senior citizens, to art, culture, education, recreation, historical preservation, animal welfare, and community development projects of all types. TCF is also a conduit for individual support of organizations, receiving non-endowed contributions that are earmarked and sometimes matched for local needs.

Education Grants

The Foundation's Education Grantmaking cycle is available to projects or programs which advance the educational outcomes for Tipton County residents.

Teachers and administrators at either public school system are welcome to apply, as are those leading non-profit educational programs at local churches, homeschool associations, and pre-k organizations.

The Lilly Endowment Community Development Grant aims to enhance the quality of life in Indianapolis and across Indiana, supporting initiatives that foster strong neighborhoods, arts, and human services. With a focus on charitable entities, the Endowment prioritizes projects that address societal challenges, especially for communities of color. Organizations interested in funding must submit a preliminary letter detailing their project and funding needs, adhering to guidelines that emphasize local community impact.

The Vitality Grants aim to enhance arts and culture in the eight-county region of New York by supporting nonprofit organizations. This initiative focuses on fostering access to cultural opportunities in underserved communities, ensuring sustainability for local organizations, and celebrating the region’s diverse cultural heritage. With a new grant cycle starting in early 2025 for educational programs, these grants are crucial for enriching the community's cultural landscape.

The Residential Curbside Recycling Cart Grant Program, offered by The Recycling Partnership, supports communities in enhancing their recycling efforts through grant funding and technical assistance. It encourages the implementation of cart-based recycling systems, conversion from bins to carts, and expansion of service areas to ensure equitable access. This initiative also includes vital education and outreach support, helping residents improve their recycling habits and ultimately achieve higher recycling rates.

The Division of Boating and Waterways offers a Public Beach Restoration Program aimed at the restoration and enhancement of public beaches. This program provides funding for the engineered placement of sand on beaches or in the nearshore environment, covering up to 85% of nonfederal project costs for nonstate beaches. Eligible applicants include public agencies, ensuring support for vital coastal infrastructure and community access to healthy beach environments.

The Integrated Pest Management Program Grants, awarded by the New Hampshire Department of Agriculture, Markets & Food, aim to promote sustainable pest management practices. Since 1998, these grants support projects that incorporate biological, cultural, and chemical tactics to minimize environmental risks. The program is open to various applicants, including private citizens and organizations, focusing on education and reducing pesticide use to enhance public health and environmental quality. Priority is given to diverse applications, including educational initiatives and urban projects.

The City of Bellingham Preservation and Production Housing and Shelter Grant provides funding for the creation and preservation of rental housing, particularly for households earning under 60% of the area median income. With up to $3.5 million available, this program focuses on multifamily housing and transitional shelters, ensuring that vital housing resources are maintained and developed to meet community needs.

Small Community Grant Program (SCG)

What is the Purpose?

The Small Community Grant Program provides grants to municipalities to help replace malfunctioning septic systems that are polluting a waterbody or causing a public nuisance. An existent pollution problem must be documented to qualify for funding.

Grants can be used to fund from 25% to 100% of the design and construction costs, depending upon the property owners' income and the property's use. The municipality receives the grant as a reimbursement for eligible costs of the replacement septic system after substantial completion of the construction.

What are the program priorities?

When funds are available, grants are awarded based on financial need of the property owner, as well as the negative environmental impacts of a system. The program prioritizes and awards funding to replace systems which are:

Contaminating a public drinking water supply,

polluting a shellfishing area

discharging into a body of water, or

creating a public nuisance condition.

The Department of Environmental Protection (DEP) grants are not available to provide septic systems for new homes or for the replacement of a septic system that was constructed after July 1, 1974 and was not constructed in compliance with the Maine Subsurface Wastewater Disposal Rules at that time. Grant applications must be submitted by the municipality in which the property owner resides.