Best Operating Grants for Nonprofits

The RFP 0323 - Agricultural Nonpoint Source Pollution Abatement and Control Program invites Soil and Water Conservation Districts to propose projects aimed at reducing nonpoint source pollution from agriculture in New York State. Eligible projects focus on planning (AEM Tier III) or implementing (AEM Tier IV) Best Management Practices. This program supports initiatives that contribute to cleaner watersheds and sustainable agricultural practices.

Maine Historic Preservation Commission

In 1971 the Legislature established the Maine Historic Preservation Commission to implement State policy to "preserve the architectural, historic and environmental heritage of the people of the State, and to develop and promote the cultural, educational and economic benefits of these resources." The Commission is an independent agency within the Executive branch of state government that functions as the State Historic Preservation Office.

Its Director serves as the State Historic Preservation Officer (SHPO) upon appointment by the Governor. The office administers the programs of the National Historic Preservation Act of 1966 in Maine, which includes the identification, evaluation, and protection of the state’s significant cultural resources.

Historic Community Buildings Grant Program

In the November 2024 general election, Maine voters approved a $10,000,000 bond issue to restore historic buildings owned by governmental and nonprofit organizations. The bond requires a 25% matching share from either private or nonprofit sources, and the program is administered by the Maine Historic Preservation Commission (Commission). 

Eligible buildings are those Historic Community Buildings that have been listed in the Register or that have been nominated for listing in the Register by the Commission. They must be open to the general public and support the social, educational, or cultural life of Maine people. They may include libraries, museums, educational and governmental buildings, social meeting halls, churches, and entertainment venues. 

The Maine Healthy Soils Program offers a Soil Health Implementation Grant to support projects that mitigate barriers to soil health on farms. Applicants can receive up to $100,000 for expenses related to soil amendments, cover cropping, and equipment purchases. This initiative aims to enhance soil health, improve agricultural yields, and encourage sustainable practices. Eligible applicants must be enrolled in the Maine Healthy Soils Program to apply. This grant helps promote healthier farming practices across Maine.

The Hebert Memorial Scholarship, established by Jacquelyn and Donald Hebert, aims to support Saginaw County residents pursuing higher education. With a minimum GPA requirement of 3.0, this scholarship is available to graduating high school seniors and current college students enrolled full-time. The Heberts, who valued education and community service, created this fund to help students achieve their academic goals, reflecting their commitment to enhancing the lives of local youth.

The Joanna Orr Memorial Scholarship, supported by the JWCC Foundation, honors the legacy of Joanna Orr, a dedicated nurse. Established for aspiring nurse assistants, this scholarship emphasizes compassion and care in healthcare. Since its inception in 1984, the JWCC Foundation has aimed to empower students through various scholarships, helping them become future leaders in their fields. The scholarship amount varies, reflecting the Foundation's commitment to supporting education and community service.

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Margaret and Dr. Paul Borton Music Scholarship

This scholarship has been made possible by the generosity of Dr. Paul Borton, who established the Margaret and Dr. Paul Borton Music Scholarship of the Community Foundation for Muskegon County in memory of his wife, Margaret Borton. Margaret "Maggie" Borton arrived in Muskegon in the late 40s, bringing with her the rich heritage and culture of South Carolina. Not having had the opportunity in her youth to pursue music, she sought ways to include it in her daily life, enjoying the many concerts and festivals available in our area. Maggie always admired the talented youth she met in Muskegon's musical community. Knowing of her dream, her love for people and her passion for music, Maggie's husband, Paul established the Margaret Borton Music Scholarship Fund in her memory to provide scholarship assistance to Muskegon County students who will major in music in college.

The Arthur L. and Elaine V. Johnson Foundation Grants, established in 1990, aim to support organizations that assist individuals with physical disabilities through guide dogs and other assistance animals. The foundation also prioritizes wildlife conservation efforts, particularly for endangered species and their habitats. Grants are awarded to charitable organizations under specific IRS classifications, focusing on long-term impactful projects. Applications for ongoing operational funding are discouraged, and priority is given to conservation activities that are science-based.

Florida Cancer Innovation Fund

The Florida Legislature created the Florida Cancer Innovation Fund in 2024 within the Casey DeSantis Cancer Research Program, with oversight by the Florida Cancer Connect Collaborative, to support innovative cancer research and treatment models, including emerging trends that may serve as catalysts for further research and treatments.

In fiscal year 2026-27, a total of $70 million is available for Florida cancer innovation research.

This year’s grant funding represents an expanded commitment to comprehensive cancer prevention and treatment innovation, including dedicated support for clinical trials, nutrition-based prevention research, and generic drug repurposing initiatives.

The purpose of this effort is to energize collaborations between oncologists, cutting edge researchers and cancer facilities and to provide a plausible route for expedited funding to bolster competitiveness for extramural cancer research funding. The aim is to provide opportunities to break down longstanding silos between researchers, cancer facilities, and medical providers to improve cancer research and treatment through rapid (12-month) innovative approaches to cancer research.

This opportunity supports groundbreaking research and innovative approaches aimed at combating cancer and improving patient outcomes across Florida. Don’t miss your chance to be part of the next wave of cancer innovation.

The William Stretesky Foundation Grants support public and educational initiatives in Sedgwick County, Colorado. Established to honor William Stretesky's legacy, the foundation focuses on enhancing community welfare through various categories, including arts, education, and medical emergency services. Grants are available only to 501(c)(3) entities, with a commitment to benefiting local residents. However, funding is not provided to individuals or for lobbying activities, ensuring resources are directed towards charitable purposes.

Who We Are

The GHACF is a team of dedicated individuals passionate about improving the lives of everyone in our community – connecting people, resources and solutions that create a lasting impact.

The GHACF is your partner. We can’t succeed alone – our work is possible only through the combined efforts of our nonprofit partners, community members, and passionate individuals. We are a bridge to help you make things happen and impact our community, together. We will walk alongside you to support and assist you in your philanthropic goals, now and forever.

Floto-Peel Family Fund

Medicine.

Checks are made payable to and mailed directly to the college after you have returned the required scholarship acceptance paperwork, thank you note, and photo. This is usually by early August.

The Barry Community Foundation supports programs and organizations that support and strengthen our community.

S.C. Blood Family Fund Grant

To fund projects dedicated to the agricultural heritage of the lives of Barry County residents, celebrating or supporting the legacy of family farms and our close-knit communities. Initiatives that benefit the Irving, Carlton, Woodland, and Castleton area will be considered.

The Community Development Block Grant – Disaster Recovery Multifamily Housing Program (DR-MHP) in California offers approximately $120.8 million for new multifamily housing construction in communities affected by 2020 disasters. This funding aims to support developers, including Tribal Entities, by streamlining the application process. Eligible project costs include property acquisition, construction, and related fees, ensuring effective recovery efforts in the most impacted areas.

The Low Income Worker Training Program, offered by the Minnesota Department of Employment and Economic Development, provides essential job-specific training grants of up to $200,000 for entities helping low-income individuals. This initiative aims to enhance workforce development by enabling individuals earning at or below 200% of federal poverty guidelines to acquire skills necessary for higher-paying jobs. The program supports training-related materials and certification fees, promoting economic self-sufficiency in Minnesota.

The Intervention Research to Improve Native American Health initiative aims to enhance health outcomes in Native American communities through innovative research. This program supports studies focused on health promotion, disease prevention, and culturally informed treatment strategies. Key deadlines for grant applications are October 21, 2025, and January 7, 2026. By addressing health disparities and leveraging community strengths, the initiative fosters sustainable interventions tailored to specific cultural contexts.

Community Foundation for Southwest Washington

The Community Foundation for Southwest Washington is a public charitable organization dedicated to strengthening communities across Southwest Washington by connecting people, resources, and philanthropic goals. The Foundation works to inspire giving, steward charitable funds, and invest in programs and initiatives that address local needs and opportunities. Through donor-advised funds, scholarships, grants, and community partnerships, the Foundation supports education, economic opportunity, health, and quality of life throughout the region. Guided by values of integrity, collaboration, equity, and long-term impact, the Community Foundation for Southwest Washington serves as a trusted partner for donors and nonprofits committed to building resilient and thriving communities.

Church at the Grove Scholarship

This scholarship supports higher education and vocational training opportunities for Christian young adults, primarily—though not exclusively—for members of Church at the Grove in Vancouver, Washington (formerly Walnut Grove Community Church). Each year, two scholarships are awarded, typically ranging from $1,000 to $1,500. Awards may be renewable for up to four years, provided recipients maintain a minimum 2.25 GPA and submit an application annually.

The Intervention Research to Improve Native American Health (R34) aims to support research that enhances health interventions for Native American populations. This includes studying the efficacy of health promotion and disease prevention strategies, culturally informed treatments, and addressing existing health disparities. The initiative encourages community-based solutions that are sustainable and adaptable to various Native American tribes. Key deadlines for grant applications are set for October 2025 and 2026, with additional dates for AIDS-related proposals.

The Karen Kisslinger Fund, established by Karen's family, upholds her legacy of compassion and health in mind, body, and community. This unique charitable resource supports students from specific high schools in Connecticut and New York who are passionate about holistic health practices. Grants fund activities like yoga, mindfulness, and sustainable farming, ensuring that Karen's commitment to wellness and ethical living continues to inspire future generations.

The Pueblo Youth Action Council Grant, established in 2021 by the Caring for Colorado Foundation, supports youth-led initiatives in Pueblo County. This program empowers young leaders to engage in grantmaking, focusing on gang prevention, substance use disorder, and mental health. By participating, youth develop critical decision-making skills and gain insight into community needs. This innovative approach not only funds essential services but also nurtures a generation committed to social change and civic responsibility.

The WCF Community Emergency Response Fund Grant provides vital support for nonprofits in Flathead County facing unexpected emergencies. This flexible funding enables organizations to address immediate repairs essential for continued program delivery. Eligible applicants include 501(C)(3) nonprofits and government entities, with no maximum request amount specified. The foundation prioritizes urgent needs, ensuring that essential services remain operational during crises, while ineligible projects include recurring expenses and completed initiatives.

Florida Department of Health

Led by the State Surgeon General, the mission of the Florida Department of Health is to protect, promote, and improve the health of all people in Florida through integrated state, county, and community efforts.

The Live Like Bella Pediatric Cancer Research Initiative

The Florida Department of Health’s Live Like Bella Pediatric Cancer Research Initiative supports the pursuit of identifying cures for pediatric cancer.

The Live Like Bella Pediatric Cancer Research Initiative is established in section 381.922, Florida Statutes, works to advance progress toward curing pediatric cancer through grants awarded through a peer-reviewed, competitive process, to:

• Significantly expand pediatric cancer research capacity in Florida
• Improve both research and treatment through greater pediatric enrollment in clinical trials networks
• Reduce the impact of pediatric cancer on disproportionately impacted individuals

Research Focus

Applications submitted in response to this Funding Opportunity Announcement (FOA) must be responsive to one of the following areas of focus. 

• Prevention and Treatment
• Screening
• Obesity
• Treatment-Related Morbidities
• Technology Transfer Feasibility (TTF)
• Investigational New Drug or Investigational Device Exemption

Efforts to foster collaborations among institutions, researchers, and community practitioners should be included, when possible. Preference will be given to applications that address at least one of the cancers listed in the Research Priorities section of this FOA.

Funding Information

Applicants must request funding in the preceding grant categories to pursue research in the areas of focus outlined in the Research Focus section of this FOA. Preference will be given to applications that address the priorities listed in the Research Priorities section of this FOA. Specific grant funding amounts are available for each grant category.

Grant Categories

Applications in response to this FOA must align to a grant category (depending on the grant program) to pursue an area of focus from the Research Focus section of this FOA. Applications for research infrastructure grants that are reviewed and assigned exceptional scientific merit will be considered for preferential funding. 

The grant categories are: 1) Bridge; 2) Discovery Science; 3) Emerging Therapeutics and Technologies; 4) Equipment; 5) Multicenter Clinical Trials; 6) New Investigator Research (NIR); 7) High-Risk, High-Reward Clinical Research; 8) High-Risk, High-Reward Discovery Science; 9) Non-Typical Clinical Trials/Socio-Behavioral Research; 10) Research Infrastructure

Bella Initiative Grant Categories: Equipment

The solicitation is for infrastructure/resources to augment research equipment that advances the current and future cancer research capability. The expectation is that new equipment will be shared with other researchers as appropriate to support collaborative efforts. Reporting on the role of equipment in research studies will be required.

Maximum Duration: 12 months

Rainin Visionary Scientist Award 

The Kenneth Rainin Foundation believes that early support for innovative ideas can lead to improvements in preventing, predicting, diagnosing and treating Inflammatory Bowel Disease (IBD). Our Health grantmaking enables researchers worldwide to test ideas, gather and share data, and collaborate to advance the understanding of IBD.

The Rainin Visionary Scientist Award will provide grants of $300,000 each over two years to support three outstanding postdoctoral investigators whose work has the potential to advance the understanding of IBD and related biological systems. This award is designed to help postdocs based in the US who are actively preparing to transition to an independent faculty position develop innovative research programs and strengthen their trajectory toward independent scientific careers. By supporting promising scientists early in their careers, the Foundation seeks to accelerate discoveries that may ultimately improve the lives of people living with Crohn’s disease and ulcerative colitis.

Competitive proposals will demonstrate:

• A novel or creative scientific approach
• Strong potential to advance understanding of IBD biology or treatment
• Clear intellectual leadership from the applicant
• Feasible research aims that can be accomplished within two years
• A strong mentorship environment that supports career development

The Foundation particularly values projects that introduce new ideas, technologies or conceptual approaches to the study of IBD and relevant scientific disciplines.

Funds may be used for postdoctoral salary support, supplies, other direct research expenses necessary to complete the proposed work and travel to relevant scientific meetings. Awardees are expected to attend the Rainin Foundation Innovations Symposium during the award period. Economy/coach air travel costs for this meeting in San Francisco should be included in the budget.

The award provides $300,000 over two years. The grant period is October 1, 2026-September 30, 2028.

The Minnesota Department of Agriculture (MDA) offers the Cooperative Development Grant Program (CDG), a competitive funding opportunity aimed at assisting farmers in establishing new cooperatives. These cooperatives focus on operating agricultural product processing facilities or marketing agricultural products and services. With over 125 years of service, MDA is dedicated to enhancing the quality of life for all Minnesotans by ensuring a safe food supply and a robust agricultural economy.

The Stop & Shop School Food Pantry Program addresses childhood food insecurity by partnering with schools to establish or support food pantries. More than 9 million children in the U.S. face hunger, and this initiative ensures students from pre-K through college have access to meals, so they can focus on their education rather than their hunger. Currently, new applications are not accepted from schools in Boston or NYC boroughs due to capacity issues.

The AAUW Community Action Grant, administered by the Longmont Community Foundation, offers $3,000 to nonprofit organizations focused on promoting education and equity for women and girls. Eligible projects must be nonpartisan and located within the St. Vrain Valley School District. The grant aims to empower local initiatives that align with the mission of AAUW, fostering positive societal change and supporting diverse community needs.

Community Foundation of the Fox River Valley

The Community Foundation of the Fox River Valley is a public charitable foundation based in Aurora, Illinois, dedicated to improving quality of life across the Fox River Valley, including the Greater Aurora area and Kane and Kendall counties. The Foundation partners with donors to fulfill philanthropic goals by managing charitable funds and distributing grants and scholarships that address local needs in areas such as education, health and human services, arts and culture, and community development, while ensuring responsible stewardship of resources to create lasting community impact.

Robert J. & Mary Jayne Pooley Endowment Fund

The Robert J. and Mary Jayne Pooley Endowment Fund was created by the couple’s family and friends at the time of Mary Jayne’s passing. The fund provides scholarships to students entering the field of nursing. Robert J. Pooley, Sr. (1928-2016) was a lifelong resident of Aurora. He attended St. Mary Grade School and East Aurora High School. He was a graduate of Iowa State University where he received a degree in general engineering. After college, Mr. Pooley returned to Aurora and joined his father to form Leon B. Pooley and Son Builders (later Robert J. Pooley, Inc.), a company that constructed single family homes in the Aurora area for thirty years. He also was a member of the Illinois Realtors Association. Mary Jayne Pooley (1936-2011) was born in Hannibal, Missouri. At the age of nine, her family moved to Aurora. She was a graduate of Madonna High School and St. Joseph School of Nursing, both in Aurora. She reentered the workforce in 1982 as a nurse and addictions counselor. Before her retirement in 2007, she worked for twenty-two years at the Community Counseling Center in Aurora. In 1957, Mr. and Mrs. Pooley were married at Holy Angels Church. They made their home in Aurora, raising six children.

The Greenwall Foundation's Making a Difference in Real-World Bioethics Dilemmas Grant seeks proposals for innovative research addressing pressing bioethics issues in healthcare, policy, and practice. Projects should focus on topics such as trust in science, healthcare bias, public health crises, and healthcare access. The Foundation aims to support inclusive bioethics that incorporates diverse perspectives, promoting impactful solutions to real-world dilemmas while ensuring that bioethics remains central to decision-making in health-related fields.

The Woodman Family Foundation Housing Stability Grant for Artists provides $30,000 over three years to NYC-based visual artists facing housing instability. This initiative addresses the rising unaffordability of rental housing in New York City, aiming to enhance artists' housing security. The funds can be used for rent, security deposits, or utilities, allowing recipients to maintain focus on their artistic practices while ensuring stable living conditions. This grant supports five artists in its inaugural cycle.