Best Operating Grants for Nonprofits

The Williamsburg Health Foundation (WHF) offers the Responsive Grant to enhance health in Greater Williamsburg. This private foundation supports nonprofit organizations and government agencies focused on improving opportunities for uninsured and underinsured populations. Priority is given to proposals that align with WHF's mission, demonstrate collaboration, and create stronger health systems. For more details, visit their Strategic Plan online.

The Crail-Johnson Foundation focuses on enhancing the well-being of children and families in Los Angeles through grants aimed at Health, Human Services, and Education. It supports non-profit organizations that provide essential services, prioritizing communities such as San Pedro and Watts. The Foundation emphasizes mental health, access to care, and innovative programs for disadvantaged youth. Grants are typically one-year, with a focus on systemic change and proven approaches to community health and education.

The High-Need Healthcare Career Scholarship Program, offered by the District of Columbia Department of Health, aims to support local residents pursuing careers in high-demand healthcare roles. This initiative addresses critical workforce shortages for positions such as Home Health Aides, Certified Nurse Aides, and Emergency Medical Technicians. Funding is available for training programs that prepare individuals to meet these urgent healthcare needs, enhancing community health services.

The Julie Hayes Performing Arts Grants aim to support organizations dedicated to the performing arts, including dance, music, opera, and theatre, in Gilroy and surrounding areas. This grant prioritizes programs that demonstrate community impact, sustainability, and strong local involvement. Eligible applicants must be established organizations with a board and financial controls, ensuring accountability. The Foundation avoids funding capital improvements and budget shortfalls, focusing instead on projects that benefit the wider community without discrimination.

GO Virginia Program Overview

GO Virginia is a collaborative economic development initiative, that provides project-based incentives to encourage collaboration between private industry, higher education and local government in each region to produce results that will grow and diversify the regional economies and ultimately the commonwealth.

To achieve the program goals, the GO Virginia State Board has created nine regional councils. These councils are responsible for developing regional Growth and Diversification Plans and implementing those plans through the submission of project applications. Applications approved at the regional level are advanced to the GO Virginia State Board for funding.

The GO Virginia State Board has identified four primary investment strategies to achieve the program goals. The four priority investment strategies are:

• Workforce Development – building talent pipelines aligned with business needs that increases the pool of qualified workers
• Site Development and Infrastructure - preparing a regional portfolio of business-ready sites that attract private investment
• Entrepreneurship & Innovation (Startup Ecosystem) - creating a resource-rich environment for scalable start-ups and early-stage companies 
• Cluster Scale-Up -  helping existing regional industries grow and compete at a larger scale

All successful projects should align with at least one of these strategies and demonstrate a clear connection to a region’s Growth & Diversification Plan. See the GO Virginia Program Manual for details.

• GO Virginia is not an economic development incentive program. Individual private businesses may not receive funding, nor can any project provide exclusive benefits to a single private business.

• GO Virginia funds must support new and expanded efforts — not ongoing operations. Funding cannot be used to continue, sustain, or supplement the operating costs of existing programs. Projects must clearly demonstrate added value and represent new activity that advances GO Virginia’s mission. Proposals must fill a documented gap, scale a proven model, or introduce a new approach that supports regional priorities.

Virginia Growth and Opportunity Fund (GO Virginia) Competitive Grants

Competitive Grants are designed for projects that involve two or more GO Virginia regions (multi-regional) or go beyond what a single region’s annual allocation can support. They give regions the ability to collaborate or pursue initiatives that deliver substantial economic impact. To qualify, a project must present an extraordinary economic opportunity—one that is transformative in scale.

Competitive Grants allow regions to scale their ideas, tackle challenges that cross boundaries, and pursue transformative projects leverage regional strengths aiming to expand opportunities that benefit multiple localities and industries.

Application Types

Competitive Grants can support planning or implementation projects. The type of application depends on whether your project is multi-regional or single region. Competitive Grants include: Multi-Regional Planning Grants; Multi-Region Implementation Grants; and Single Region Implementation Grants.

Single Region Implementation Grants

Single-Region Implementation Grants are available for extraordinary opportunities within one region that cannot be fully supported by that region’s annual allocation. These projects are intended to address unique, high-impact needs where the scale of investment exceeds local resources but still delivers outcomes consistent with the goals of GO Virginia.

The expectation is that single-region projects will demonstrate the same level of rigor as multiregional efforts—clear economic impact, measurable outcomes, and long-term sustainability—while making the case for why Competitive Grant support is essential. In some cases, the request may use a mix of per-capita funds and Competitive Grant funds; in other cases, it may rely entirely on Competitive Grant funds.

The National Institutes of Health (NIH) is inviting applications for the Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV and HBV (MRA-HBV) program. This initiative aims to enhance understanding of hepatitis B persistence and pathogenesis, identify biomarkers, validate drug targets, and create non-invasive diagnostics. It supports observational cohorts paired with multidisciplinary teams utilizing existing clinical data, contributing to innovative research in hepatitis B cure strategies.

The Bloom-Hays Ecological Research Grant and Zembal Wetland Research Grant support ecological research in Southern California, focusing on avian species and coastal wetland habitats. Grants ranging from $250 to $2,500 are awarded to graduate and outstanding undergraduate students, promoting innovative research that benefits native species and habitats. Preference is given to projects directly related to local ecology, ensuring that funding addresses critical habitat issues in the region.

Department of Administration

​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​The Department of Administration is the flagship agency of the State of Wisconsin. We help the Office of the Governor with the biennial state budget, provide centralized purchasing and financial management for state agencies, and work with the 11 federally recognized Native Nations in Wisconsin on gaming, coastal programs, and other key areas. Our mission is to provide effective and efficient services at the best value to government agencies and the public.

CDBG - Emergency Assistance Program (EAP)

​Program Overview

The Community Development Block Grant -Emergency Assistance Program CDBG-EAP (PDF) is administered by the Wisconsin Department of Administration, Division of Energy, Housing, and Community Resources (DEHCR) under Title I of the Housing and Community Development Act of 1974, as amended. CDBG-EAP funds are used to assist local units of government in addressing emergency housing, public facility, infrastructure, and business assistance needs that occur as a result of natural or manmade disasters.  

The CDBG - Emergency Assistance Program includes funding for: Public Facility/Infrastructure Assistance; Housing Rehabilitation Assistance; and Business Assistance.

Housing Rehabilitation Assistance

CDBG-EAP housing assistance is available to eligible homeowners and tenants whose primary residence has been damaged by a natural or manmade disaster. Funds are awarded as a grant.

Individual homeowners or tenants must apply directly through their local municipal government. 

Eligible repair projects include:

• Foundations, façades, and roofs
• Electrical and HVAC repairs and replacements
• Water, sewer system, and water heater repairs

GO Virginia Program Overview

GO Virginia is a collaborative economic development initiative, that provides project-based incentives to encourage collaboration between private industry, higher education and local government in each region to produce results that will grow and diversify the regional economies and ultimately the commonwealth.

To achieve the program goals, the GO Virginia State Board has created nine regional councils. These councils are responsible for developing regional Growth and Diversification Plans and implementing those plans through the submission of project applications. Applications approved at the regional level are advanced to the GO Virginia State Board for funding.

The GO Virginia State Board has identified four primary investment strategies to achieve the program goals. The four priority investment strategies are:

• Workforce Development – building talent pipelines aligned with business needs that increases the pool of qualified workers
• Site Development and Infrastructure - preparing a regional portfolio of business-ready sites that attract private investment
• Entrepreneurship & Innovation (Startup Ecosystem) - creating a resource-rich environment for scalable start-ups and early-stage companies 
• Cluster Scale-Up -  helping existing regional industries grow and compete at a larger scale

All successful projects should align with at least one of these strategies and demonstrate a clear connection to a region’s Growth & Diversification Plan. See the GO Virginia Program Manual for details.

• GO Virginia is not an economic development incentive program. Individual private businesses may not receive funding, nor can any project provide exclusive benefits to a single private business.

• GO Virginia funds must support new and expanded efforts — not ongoing operations. Funding cannot be used to continue, sustain, or supplement the operating costs of existing programs. Projects must clearly demonstrate added value and represent new activity that advances GO Virginia’s mission. Proposals must fill a documented gap, scale a proven model, or introduce a new approach that supports regional priorities.

Virginia Growth and Opportunity Fund (GO Virginia) Competitive Grants

Competitive Grants are designed for projects that involve two or more GO Virginia regions (multi-regional) or go beyond what a single region’s annual allocation can support. They give regions the ability to collaborate or pursue initiatives that deliver substantial economic impact. To qualify, a project must present an extraordinary economic opportunity—one that is transformative in scale.

Competitive Grants allow regions to scale their ideas, tackle challenges that cross boundaries, and pursue transformative projects leverage regional strengths aiming to expand opportunities that benefit multiple localities and industries.

Application Types

Competitive Grants can support planning or implementation projects. The type of application depends on whether your project is multi-regional or single region. Competitive Grants include: Multi-Regional Planning Grants; Multi-Region Implementation Grants; and Single Region Implementation Grants.

Multi-Region Implementation Grants

Multi-Region Implementation Grants are designed to turn collaborative plans into action. The goal is to deliver projects that create broad economic impact, strengthening targeted industry sectors, growing higher-paying jobs, and expanding opportunities across all participating regions. Because these projects represent a significant investment, applicants must demonstrate strong regional collaboration, clear economic outcomes, and a plan for sustaining results beyond the grant period.

Successful projects should create benefits that are shared across all participating localities, not concentrated in just one community. In other words, the project’s impact—such as new jobs, business growth, or expanded industry capacity—should be visible in each region that is part of the application.

The KCF Multiyear General Operations Grant, offered by the Kalamazoo Community Foundation, supports organizations in Kalamazoo County with a three-year funding commitment. Grants range from $25,000 to $175,000 annually, with an average of $50,000. This grant is ideal for organizations that have received KZCF funding within the past five years, enhancing community impact through support for wealth, housing, education, and vibrant neighborhoods.

The Women's Fund of Southwest Iowa, established by the Community Foundation for Western Iowa, aims to empower women and families in the region. Through strategic partnerships and community insights, the fund supports initiatives that enhance women's self-sufficiency, health, and engagement. Eligible projects must serve primarily women and align with focus areas like health, education, and childcare. This grant provides critical support for programs fostering positive change in southwest Iowa communities.

The Robert K. Dunn Perpetual Charitable Trust Fund Grant supports nonprofit organizations in the Greater Kankakee River Valley Area, focusing on projects that directly benefit youth. This year, over $42,000 will be awarded to initiatives that enhance youth services, emphasizing visibility, impact, and the ability to demonstrate measurable outcomes. The grant prioritizes organizations with 501(c)(3) status that address pressing community needs, ensuring sustainable benefits for Kankakee and Iroquois Counties.

The Adolph Coors Foundation's Youth and Adult Grant Programs support initiatives that promote self-reliance and integrity among Coloradans. Priorities include mentoring for youth, vocational training for adults, and fostering entrepreneurship. Organizations must be 501(c)(3) entities operating in Colorado, while special consideration is given to rural nonprofits. The Foundation aims for evidence-based results and transformational outcomes, focusing on programs that empower communities and enhance economic opportunities.

The Racial Equity Fund Grant, initiated by the York County Community Foundation in 2021, aims to promote equitable opportunities by funding projects that combat racism and inequity. Designed by a committee of community leaders of color, this grant prioritizes initiatives led by people of color, focusing on areas such as community leadership, education, health, and wellness. The committee reviews applications to ensure alignment with the fund's purpose, providing vital support to enhance community well-being.

The KCF Annual Responsive Grant supports organizations in Kalamazoo County with projects that align with community impact priorities, such as wealth, housing, education, and vibrant neighborhoods. It is ideal for first-time applicants, new organizations, and ongoing partners who haven’t received multiyear awards. Grants range from $5,000 to $50,000, empowering organizations to enhance their operations and community connections.

The McMillen Foundation Grants Program supports research in cardiology, lipids, and organ transplant, along with educational initiatives and social services in Washington and Alaska. With a single grant cycle annually, nonprofits certified under 501(c)(3) can apply for funding, preferably those benefiting children and promoting equity. The foundation emphasizes programs that leverage the arts to foster social change, impacting youth and disadvantaged communities. Applications must be submitted by July 31 to be considered for the current cycle.

The Arts Projects – Organisations Grants program, funded by the Australia Council for the Arts, supports diverse activities that enhance the arts sector and engage communities. With grants ranging from $20,000 to $100,000, eligible organizations can propose various initiatives including professional development, creative collaborations, and community engagement projects. Applications are open to organizations that benefit practicing Australian artists and audiences, fostering artistic innovation and cultural exchange.

The Carl C. Anderson Sr. & Marie Jo Anderson Foundation Grant supports organizations that assist low-income and vulnerable populations in New Mexico, Oklahoma, and Texas. The foundation emphasizes essential needs for children and youth, services for older adults, and enhancements for individuals with disabilities. They prioritize flexible, collaborative funding relationships and aim to improve community health and wellbeing. Please refer to their website for funding examples and additional guidelines.

The Maine Health Access Foundation (MeHAF) offers the Systems Improvement and Innovation Responsive Grants Program to enhance health equity across Maine. This program, launched in 2020, complements previous grant initiatives by focusing on traditional systems-based organizations. It aims to improve access to healthcare in rural areas, support aging populations, address behavioral health issues, and promote maternal and child health. Community involvement is a key element, ensuring that those affected by health disparities have a voice in program development.

The Opportunity on the Plains Grant, provided by the United Way of the Plains, is a competitive funding initiative aimed at supporting health and human service programs in areas such as health, education, financial stability, and basic needs. By aligning with the social determinants of a strong community, this grant seeks to address pressing local needs. Eligible applicants must be 501(c)(3) organizations operating within specific counties and adhere to non-discrimination policies.

The Fund for Change Grants support organizations advocating for social change, focusing on underserved communities. With an average grant size of $10,000-25,000, it funds initiatives in housing, behavioral health, criminal justice reform, and environmental justice. Eligible organizations can apply annually, but multi-year commitments are not available. The fund does not support capital campaigns, indirect costs, endowments, or individual scholarships, ensuring that funds are directed towards direct program expenses.

The PHSKC Centering Diverse Healers in Youth Well-Being and Mental Health Grant Program aims to enhance youth mental health support by prioritizing BIPOC and LGBTQI+ organizations. This initiative seeks to increase access to resources, improve retention in youth-serving organizations, and support diverse mental health providers. Eligible applicants include nonprofits and community organizations focused on mental health and wellness in King County. The program encourages innovative proposals that address youth mental health needs and promote healing in the community.

Columbia Basin Trust

The Trust was created in 1995 to support efforts by the people of the Basin to create a legacy of social, economic and environmental well-being in the Canadian portion of the Columbia River Basin—the region most affected by the Columbia River Treaty.

Mission: The Trust supports efforts by the people of the Basin to create a legacy of social, economic and environmental well-being and to achieve greater self-sufficiency for present and future generations.

Non-profit SMART Grants

Non-Profit SMART Grants support Basin non-profits and First Nations to increase their energy efficiency, generate renewable energy, adapt to the impacts of climate change, and/or reduce their greenhouse gas emissions.

There are two streams for this grant: Stream One – Electric Vehicles and Charging Stations; and Stream Two – Renewable Energy and Improvements to Buildings

Stream Two – Renewable Energy and Improvements to Buildings

This stream supports solar photovoltaic arrays, energy efficiency retrofits or other building improvements to structures or property.

Environmental Stewardship: Community Grants

FAO, through its Environmental Stewardship Pillar of Prosperity Fund, offers funding opportunities to advance conservation, environmental stewardship and the greater well-being of Appalachian Ohio.

To support locally driven projects that preserve and enhance our natural environment.

Community grants empower local communities to preserve and enhance our natural environment.

We know relatively modest projects can make an outsized difference when they promote environmental stewardship and engage whole communities in conservation. More details about these grants and how to apply can be found on page 5. At least $50,000 is available to support community grants.

The Gordon Foundation for Children and Youth offers the Special Projects Grant Program to support initiatives that enhance the mental health and well-being of children and youth. This program funds a variety of projects, including sensory rooms for children with special needs, newsletters for youth in care, and educational trips for urban students to rural communities. Eligible applicants include individuals, schools, and organizations dedicated to improving youth mental health.

The McGlothlin Foundation Grant supports philanthropic initiatives in higher education, healthcare, and the arts, focusing primarily on projects in Southwest Virginia, Eastern Kentucky, and Northeast Tennessee. The foundation prioritizes proposals from tax-exempt non-profits, especially for capital projects and programmatic needs. While there are no fixed grant sizes, organizations are encouraged to apply after prior awards have concluded. The foundation does not fund individuals or political activities, ensuring its resources enhance community infrastructure and cultural development.

The CityArts Program Grants, offered by the Chicago Department of Cultural Affairs and Special Events, support local artists and cultural organizations by providing general operating grants based on average annual revenue. Eligible nonprofits can apply for grants ranging from equal to their revenue for smaller organizations to a maximum of $50,000 for larger ones. This initiative aims to enhance access to the arts across Chicago's diverse neighborhoods.