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Best Puerto Rico Grants for Nonprofits

Find the perfect Puerto Rico grants for nonprofits on Instrumentl. 9,000+ Puerto Rico grants for nonprofits in the United States.

9,000+

Available grants

$2.55B

Total funding

$5K

Median grant

9,000+ grants
$2.55B total
$5K median

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8,987 Results based on applied filters

Mutual Self-Help Housing Technical Assistance Grants in Puerto Rico

USDA: Rural Development (RD)
Federal Government
Puerto Rico
Unspecified amount
The Mutual Self-Help Housing Technical Assistance Grants in Puerto Rico provide essential support to organizations aiding low-income families in constructing their own homes. These grants enable recipients to offer technical guidance and supervision, facilitating community-driven housing projects. Eligible entities include government non-profits and federally recognized tribes, while funding cannot be used for direct construction labor or purchasing materials. This program fosters self-sufficiency and strengthens community ties in rural areas.
Real Estate & Housing

ABE Opportunity Grants

American Bar Endowment
Private
American Samoa, Guam +4 more
Up to US $25,000
The American Bar Endowment's Opportunity Grant Program provides funding for innovative, boots-on-the-ground initiatives that address urgent legal needs of the public. This grant focuses on increasing access to justice for underserved populations, improving the justice system, and enhancing public understanding of legal rights. Eligible applicants include public charities and organizations directly impacting local communities, with a strong emphasis on projects that leverage technology and address immediate legal challenges.
Law Legal Services

NIMH Career Transition Award for Tenure-Track Intramural Investigators (K22 Independent Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
The NIMH Career Transition Award (K22) supports tenure-track intramural investigators at NIMH in their transition to independent research faculty positions. This program aims to foster innovative research in mental health, encouraging applicants with a strong record of research excellence. Key deadlines for applications vary, including those for standard and renewal submissions, emphasizing the importance of timely applications to secure funding and advance mental health research initiatives.
Biology Health & Medicine Medical Education & Professional Training +1 more

Jazz Road Tours Grants

South Arts, Inc.
Private
American Samoa, Guam +5 more
Up to US $15,000
Jazz Road Tours Grants provide financial support for emerging and mid-career jazz artists to develop tours across communities in the U.S. Grants up to $15,000 facilitate three-to-six site tours, focusing on underserved areas. This program, funded by the Doris Duke Charitable Foundation and the Mellon Foundation, aims to enhance artists' income opportunities while promoting jazz in diverse venues. Applications are encouraged from individual artists, with deadlines throughout 2024 and 2025 for various tour periods.
Music Festivals

Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional) (357572)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Interventions to Reduce Sleep Health Disparities (R01) grant aims to fund non-pharmacological strategies that enhance sleep health and address disparities in sleep among affected populations. The program emphasizes innovative approaches to examine sleep as a crucial element in mitigating health disparities across various health outcomes. Deadlines for applications range from February 2025 to June 2027, supporting both standard and renewal submissions under the National Institutes of Health.
Health Disparities & Social Determinants of Health Sleep

Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) (357568)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $375,000
The Research Enhancement Award Program (REAP) aims to boost basic and clinical research at health professional and graduate schools that have historically received limited NIH funding. By supporting small-scale research projects led by faculty, REAP fosters student engagement in significant research endeavors, enhancing their educational experience. Eligible institutions must grant advanced degrees in health professions and have received under $6 million in NIH support in four of the last seven years, promoting broader participation in the nation's biomedical research efforts.
Medical Education & Professional Training Biology Health & Medicine

Rural Business Development Grants in Puerto Rico

USDA: Rural Development (RD)
Federal Government
Puerto Rico
US $10,000 - US $500,000
The Rural Business Development Grants in Puerto Rico aim to enhance small rural businesses through technical assistance and training. With no maximum grant amount, priority is given to smaller requests, and funds can be utilized for various projects including training, land development, and pollution control. Eligible applicants include rural public entities and nonprofits that serve communities outside urban centers. This initiative fosters economic growth and innovation in underserved areas, ensuring sustainable development for local businesses.
Rural Development

NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01 Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,050,000
The NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01) invites applications for clinical trials focusing on complementary and integrative health approaches. This funding opportunity emphasizes the importance of multisite feasibility trials to gather essential data for planning future efficacy studies. Deadlines for standard and AIDS-related applications range from February 2024 to November 2026, underscoring the urgency for innovative research in high-priority areas.
Integrative & Alternative Health

Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required) (351620)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This funding opportunity invites applications for investigator-initiated clinical trials focused on complementary and integrative health interventions delivered remotely or via mobile health technologies. The trials must be fully powered, with no in-person contact, and require justification for this approach. Preliminary data on feasibility and safety must be provided, alongside evidence of clinical benefit. A Plan for Enhancing Diverse Perspectives is mandatory for submission. Key deadlines range from February 2024 to June 2026.
Integrative & Alternative Health Telemedicine & Telehealth

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) (357604)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $475,000
This funding opportunity encourages applications for clinical observational studies focused on musculoskeletal, rheumatic, and skin diseases. It aims to gather essential data for designing future clinical studies, enhancing understanding of disease symptoms, progression, and patient outcomes. Observational studies supported by this initiative will contribute to the development of objective biomarkers and effective outcome measures. Applicants are invited to address key challenges in clinical project design, ensuring a robust foundation for subsequent clinical trials.
Musculoskeletal Diseases Neurological Diseases & Disorders Skin Diseases & Dermatology +1 more

NCI Continuing Umbrella of Research Experiences (CURE) Mentored Clinical Scientist Research Career Development Award (K08 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NCI CURE Mentored Clinical Scientist Research Career Development Award (K08) aims to support individuals with clinical doctoral degrees in developing research careers that address national health-related needs. This program focuses on enhancing the research capabilities of underrepresented clinical scientists in cancer research, including health disparities. Awardees receive protected time for supervised research training, preparing them to compete for future research project grants. Key deadlines for applications span from February 2025 to October 2027.
Cancer / Oncology Medical Education & Professional Training

NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) (357493)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $350,000
The NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) grant invites applications for mid-phase clinical trials focusing on natural products such as botanicals and dietary supplements. It aims to advance scientific knowledge by determining optimal dosing and patient responses. Applicants must provide preliminary data demonstrating bioavailability and measurable impacts on target engagement. This initiative will not support efficacy trials for cancer treatments and encourages early contact with NCCIH scientific contacts.
Food Safety Drug Safety

NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) (357492)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,050,000
The NCCIH Natural Product Early Phase Clinical Trial Award supports innovative clinical trials of natural products, such as botanicals and dietary supplements, with a strong scientific basis. Applications are encouraged to explore optimal delivery methods and combinations with other treatments. Funding is available for up to three years to assess the impact on target engagement and clinical outcomes, aiming to translate basic science findings into practical clinical applications.
Food Safety Drug Safety

NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required) (357490)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33) invites research proposals for early phase clinical trials of natural products, including botanicals and dietary supplements, emphasizing scientific validity for further testing. Applicants may receive up to three years of funding for pharmacokinetics and bioavailability studies, with potential for an additional three years to evaluate clinical outcomes. This initiative aims to optimize natural product delivery through innovative study designs.
Food Safety Drug Safety

Ryan White HIV/AIDS Program (RWHAP) Integrated HIV/AIDS Planning Resource Allocation Cooperative Agreement

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Up to US $700,000
The Ryan White HIV/AIDS Program (RWHAP) Integrated HIV/AIDS Planning Resource Allocation Cooperative Agreement aims to enhance the effectiveness of HIV prevention and care planning for RWHAP Parts A and B recipients. Through the provision of training, tools, and technical assistance, this initiative seeks to optimize resource allocation and strengthen the overall system of HIV care and treatment, ultimately improving health outcomes for those affected by HIV.
HIV / AIDS

Strategic Alliance Matching Grant - Division II

National Collegiate Athletic Association
Private
Alabama, Alaska +45 more
Unspecified amount
The Strategic Alliance Matching Grant - Division II offers financial support to enhance ethnic minority and gender representation in mid- to senior-level athletics administration roles across NCAA Division II institutions. With an annual budget of $860,000, the grant aims to fund up to 20 schools and conferences each year. Eligible applicants must be active Division II members and are encouraged to collaborate with their human resources departments during the proposal process, ensuring compliance with grant requirements.
Minority Services Women & Girl Services Sports & Athletics +1 more

Coaching Enhancement Grant - Division II

National Collegiate Athletic Association
Private
Alabama, Alaska +45 more
US $48,000
The Coaching Enhancement Grant - Division II aims to enhance diversity in NCAA coaching by providing financial support for new assistant coaching positions. This grant specifically targets increased representation of ethnic minorities and women in athletics. Selected schools receive funding for three years to cover salaries and benefits, totaling $370,000 annually for up to 21 institutions. Eligible schools must be active NCAA Division II members committed to these diversity efforts.
Sports & Athletics Minority Services Women & Girl Services +1 more

NCAA Jim McKay Graduate Scholarship

National Collegiate Athletic Association
Private
Canada, Puerto Rico +2 more
US $10,000
The NCAA Jim McKay Graduate Scholarship honors the legacy of journalist Jim McKay by awarding a one-time $10,000 scholarship to one male and one female student-athlete annually. Eligible candidates must have a minimum GPA of 3.5, demonstrate integrity, and show interest in sports communication. There is no limit to the number of nominations from institutions, highlighting the NCAA's commitment to supporting student-athletes in their academic and professional pursuits.
Sports & Athletics News Media & Communications Journalism

NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $177,000
The NIH HEAL Initiative PainCare Clinician Training Program (PCTP) offers Mentored Clinical Scientist Development Awards (K08) to support emerging independent researchers in pain management. This program aims to develop a new generation of skilled investigators by providing essential NIH research funding during their early careers. Notable deadlines for grant applications range from October 2024 to June 2027, ensuring ample opportunity for applicants to submit their proposals and enhance their research capabilities.
Medical Education & Professional Training Chronic / Acute Pain Anesthesia and Pain Medicine

NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Patient-Oriented Research Career Development award (K23 - Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $177,000
The NIH HEAL Initiative PainCare Clinician Training Program (PCTP) aims to develop a new generation of independent investigators in patient-oriented research focused on pain management. This K23 award provides essential funding to support early-career researchers, enabling them to establish independent research programs aligned with the NIH HEAL Initiative. Key application deadlines span from October 2024 to June 2027, ensuring opportunities for renewals and resubmissions. This program is vital for advancing pain management research.
Medical Education & Professional Training Chronic / Acute Pain Anesthesia and Pain Medicine

NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Basic Experimental Studies with Humans (BESH) Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $177,000
The NIH HEAL Initiative PainCare Clinician Training Program (PCTP) offers Mentored Clinical Scientist Development Awards (K08) aimed at nurturing a new generation of independent investigators. This program provides essential NIH research funding during the early-career phase, enabling awardees to establish their independent research programs focused on pain management. Key application deadlines span from October 2024 to June 2027, ensuring ample opportunities for interested candidates to apply.
Chronic / Acute Pain Anesthesia and Pain Medicine

PLTW Engineering - New Program (Arconic Foundation)

Project Lead The Way Inc
Private
American Samoa, Guam +4 more
US $20,000
The PLTW Engineering grant, supported by the Arconic Foundation, aims to enhance STEM education by funding the implementation of PLTW Engineering courses in schools. This initiative prepares students for future careers by igniting their passion for engineering. Grants will cover startup costs for new programs or expansions of existing ones. Eligible schools must offer PLTW's Advanced Manufacturing course for the 2026-2027 school year, ensuring access to essential resources and training for educators.
Engineering

PLTW Engineering - Program Expansion (Arconic Foundation)

Project Lead The Way Inc
Private
American Samoa, Guam +4 more
US $20,000
The PLTW Engineering program, supported by Arconic Foundation, aims to expand STEM education in public and charter schools across several states. This grant will help cover costs for necessary equipment and training, focusing on high-need student populations. Eligible schools must implement PLTW's Advanced Manufacturing course by the 2026-2027 school year. The initiative is designed to ignite student interest in engineering and increase enrollment in STEM disciplines.
Engineering

NCAA Postgraduate Scholarship - Fall Sports

National Collegiate Athletic Association
Private
Canada, Puerto Rico +2 more
US $7,000
The NCAA Postgraduate Scholarship for Fall Sports offers up to 126 scholarships annually, valued at $10,000 each, to student-athletes who excel academically and athletically. Eligible candidates must be in their final year of intercollegiate competition and maintain a minimum GPA of 3.20. Scholarships are awarded three times a year, with 21 available for men and 21 for women across various sports. This initiative promotes graduate education and recognizes the achievements of outstanding student-athletes.
Sports & Athletics Equestrian Sports Duathlons & Triathlons +2 more

Luce Indigenous Knowledge Fellowship

Henry Luce Foundation
Private
American Samoa, Guam +4 more
Up to US $75,000
The Luce Indigenous Knowledge Fellowship, launched by the First Nations Development Institute and the Henry Luce Foundation, supports Native knowledge holders and makers in their transformative work. With ten fellowships of $75,000 each, this two-year program fosters growth and collaboration across diverse fields such as agriculture, climate change, and cultural revitalization. Fellows will engage in community-building through required convenings, enhancing their leadership skills and professional networks to benefit Native communities.
Native American Culture & Heritage

NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $177,000
The NIH HEAL Initiative PainCare Clinician Training Program (PCTP) offers Mentored Clinical Scientist Development Awards (K08) to nurture new independent investigators. This program is pivotal in providing early-career researchers with the necessary NIH support to establish their research programs in pain management. Key deadlines for applications span from October 2024 to June 2027, including provisions for renewals and resubmissions, ensuring ongoing support for innovative research in this critical area.
Medical Education & Professional Training Chronic / Acute Pain Anesthesia and Pain Medicine

Puerto Rico Grants for Nonprofits Highlights

Puerto Rico grants for nonprofits provide funding to support education, disaster recovery, public health, and cultural preservation. The following grants empower organizations to address critical challenges, promote resilience, and foster sustainable development across Puerto Rico.


Search Instrumentl's Puerto Rico Grants Database


Find 834 funding opportunities for nonprofits in Puerto Rico, with $698M available. Instrumentl helps organizations discover funding sources through automated deadline tracking, curated grant searches, and research-driven funder insights to drive local progress.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Puerto Rico Grants for Nonprofits

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

800+ Puerto Rico grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

500+ Puerto Rico grants for nonprofits over $25K in average grant size

400+ Puerto Rico grants for nonprofits over $50K in average grant size

16 Puerto Rico grants for nonprofits supporting general operating expenses

500+ Puerto Rico grants for nonprofits supporting programs / projects

400+ Grants on Instrumentl focused on Disaster Relief / Humanitarian Aid

200+ Grants on Instrumentl focused on Cardiovascular Diseases & Systems

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Puerto Rico grants for Nonprofits?

Most grants are due in the first quarter.

Q1
31.5%
Q2
23.7%
Q3
19.8%
Q4
25.0%

Typical Funding Amounts

What's the typical grant amount funded for Puerto Rico Grants for Nonprofits?

Grants are most commonly $318,750.

$375 $375 Min.
$318,750 $318.8 K Median
$1,385,019 $1.4 M Average
$80,000,000 $80 M Max.

Browse Grants by Other Territories and Regional Locations