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Best Puerto Rico Grants for Nonprofits

Find the perfect Puerto Rico grants for nonprofits on Instrumentl. 9,000+ Puerto Rico grants for nonprofits in the United States.

9,000+

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$2.55B

Total funding

$5K

Median grant

9,000+ grants
$2.55B total
$5K median

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8,987 Results based on applied filters

Water & Waste Disposal Grant Program in Puerto Rico

USDA: Rural Development (RD)
Federal Government
Puerto Rico
Unspecified amount
The Water & Waste Disposal Loan & Grant Program in Puerto Rico provides essential funding for rural communities to ensure access to clean drinking water, sanitary sewage disposal, and effective storm water drainage. Eligible applicants include state and local governments, nonprofits, and federally-recognized tribes. The funds can be utilized for construction, improvement, and financing of water systems, as well as related activities like legal fees and land acquisition, supporting sustainable community development.
Sanitation & Clean Drinking Water Water Resource Management Waste Management

NCAA Postgraduate Scholarship - Winter Sports

National Collegiate Athletic Association
Private
Canada, Puerto Rico +2 more
US $10,000
The NCAA Postgraduate Scholarship for Winter Sports awards up to 126 scholarships of $10,000 annually to outstanding student-athletes who excel both academically and athletically. Eligible candidates are in their final year of NCAA competition and must have a minimum GPA of 3.2. The scholarships are available for men and women in various winter sports and are intended for use in accredited graduate programs, emphasizing the importance of academic achievement and community involvement.
Sports & Athletics Hockey Swimming +2 more

Catalyze Product Definition Medical Device prototype design/testing and disease target identification and assay development (R61/R33 - Clinical Trial Not Allowed)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Up to US $4,466,000
The NHLBI Catalyze program aims to transition basic science discoveries into effective treatments for diseases under the NHLBI mission. This initiative supports early-stage product definition, prototype design, and assay development for HLBS disorders. The R61 phase focuses on initial designs and experimental setups, while the R33 phase extends support for prototype testing and user feedback. Successful completion prepares products for in vivo testing, enhancing health and societal outcomes with NIH and other support.
Respiratory Diseases & Systems Sleep Medical Technology, Devices, and Equipment

Republic Services: Community Grant Program

Republic Services Charitable Foundation
Corporate
Puerto Rico, United States
Unspecified amount
The Republic Services Community Grant Program supports local nonprofit organizations focused on neighborhood revitalization, safety, disaster relief, and social services. Eligible 501(c)(3) organizations can apply once annually through an online application process. The program emphasizes a non-discrimination policy, ensuring services are provided without bias. However, funding is not available for individuals, government entities, schools, or religious organizations. This initiative reflects Republic Services' commitment to community engagement and support.
Disaster Relief / Humanitarian Aid Community / Public Safety Human & Social Services

NINDS Alzheimers Disease-Related Dementias (ADRD) Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NINDS Alzheimer’s Disease-Related Dementias (ADRD) K99/R00 program promotes diversity by supporting new independent investigators from underrepresented backgrounds in AD/ADRD research. This award facilitates a transition from mentored postdoctoral positions to independent faculty roles, providing essential NIH research support. Applicants must propose research that does not involve leading a clinical trial but may include participation in trials led by mentors. Key deadlines for applications span from October 2024 to June 2027.
Dementia & Alzheimer’s Disease Diversity, Equity & Inclusion Medical Education & Professional Training

Disability Inclusion Fund Grant

Borealis Philanthropy
Private
American Samoa, Guam +4 more
US $75,000 - US $150,000
The Disability Inclusion Fund Grant, managed by Borealis Philanthropy, aims to support organizations advocating for disability inclusion, rights, and justice. As a partner in philanthropy, Borealis facilitates donor collaboratives to maximize impact across various communities and movements. Organizations interested in applying for this grant are encouraged to review the detailed FAQ for further information. This initiative is a vital step towards fostering inclusivity and promoting the rights of individuals with disabilities.
Disability Care & Services Disability Rights & Justice Diversity, Equity & Inclusion

Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed) (357838)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant supports institutions in developing clinical and translational science training programs. This program aims to enhance the research training of postdoctoral individuals holding doctoral degrees, ensuring a diverse pool of scientists equipped to tackle critical health challenges. Applications must be submitted by 5:00 PM local time of the applicant organization, and non-U.S. entities are not eligible.
Science Health & Medicine Medical Education & Professional Training

Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Predoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed) (357836)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Ruth L. Kirschstein National Research Service Award (NRSA) offers predoctoral training grants aimed at enhancing clinical and translational science. Administered by the NCATS, this program supports institutions in training aspiring researchers for a PhD or equivalent, ensuring a diverse cohort of scientists equipped to tackle pressing health challenges. The ultimate goal is to cultivate a skilled workforce capable of advancing biomedical research and addressing community health needs effectively.
Science Health & Medicine Medical Education & Professional Training

Rauschenberg Medical Emergency Grants

New York Foundation for the Arts
Private
American Samoa, District of Columbia +6 more
Up to US $5,000
The Rauschenberg Medical Emergency Grants, administered by the New York Foundation for the Arts, provide one-time funding up to $5,000 for artists facing unexpected medical emergencies. This program aims to alleviate financial burdens caused by medical costs, ensuring that artists can receive necessary care without delay. Eligible applicants must be practicing artists in visual arts, film, or choreography, and demonstrate financial need. This initiative supports artists of color, LGBTQ+ individuals, and those outside major coastal cities.
Emergency Medical Care & Services

Charlie's Heart Foundation Annual Grant Program

Charlie's Heart Foundation
Private
Africa, American Samoa +11 more
US $5,000 - US $30,000
Charlie's Heart Foundation Annual Grant Program supports small nonprofits focusing on mental well-being for families in underserved communities. Grants between $5,000-$30,000 are available, prioritizing organizations based in North Carolina. Eligible applicants must be 501(c)(3) tax-exempt and demonstrate alignment with the Foundation's mission, organizational need, and program sustainability. The Foundation does not fund individuals, private foundations, or religious organizations, ensuring a strong focus on impactful community programs.
Family Services Human & Social Services

ACT on Health Equity Community Solutions Challenge Grant

Astrazeneca Foundation
Private
California, Connecticut +15 more
Up to US $30,000
The ACT on Health Equity Community Solutions Challenge Grant, backed by the Astrazeneca Foundation, aims to enhance health equity by funding community-based nonprofit programs. Since its inception in 2021, it has allocated over $2.6 million to initiatives addressing nutrition, healthcare access, and lung health for historically marginalized populations. Eligible US-based 501(c) organizations can apply, with a focus on projects serving underserved communities and improving health outcomes through targeted support.
Health Care Access & Delivery Community Health Education Health Disparities & Social Determinants of Health +4 more

Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
The National Center for Complementary and Integrative Health (NCCIH) is inviting research applications focusing on mind and body interventions like mindfulness meditation and yoga that promote emotional well-being and whole person health. This initiative supports innovative studies that validate mechanisms of emotional well-being, utilizing a phased funding approach (R61/R33) to ensure rigorous clinical trials. Preliminary data comparable to R01 applications are required, emphasizing the importance of research quality.
Mindfulness, Meditation & Yoga

HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed) (357655)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $100,000
The HEAL Initiative aims to identify new druggable targets for pain within the understudied proteome. This funding opportunity invites applications for pilot projects that generate preliminary data and tools for exploring these targets. The initiative seeks to enhance research on understudied proteins related to pain management, providing essential funding for biochemical and biological work. This NOFO is part of the NIH's broader effort to develop novel medications that address various aspects of opioid addiction and its consequences.
Chronic / Acute Pain Anesthesia and Pain Medicine Drug Use Disorder +1 more

DOJ FY 2026 Bridging Immigration-Related Deficits Experienced Nationwide (“BIDEN”) Program Round 2

Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The DOJ's FY 2026 BIDEN Program aims to address immigration-related challenges by providing funding to eligible state and local governments. This initiative focuses on enhancing law enforcement's capacity to apprehend criminal aliens, investigate gang activities, and manage court operations related to crimes committed by aliens. By supporting these critical efforts, the program aims to improve public safety and uphold the rule of law in communities across the nation.
Domestic / Homeland Security Crime & Justice

Health Promotion and Disease Prevention Research Centers: 2027 Special Interest Project Supplements (SIPS)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
The Health Promotion and Disease Prevention Research Centers are offering supplemental funding for Special Interest Projects (SIPs) aimed at enhancing public health practices. These projects will focus on innovative health promotion and disease prevention strategies to mitigate leading health risks in the U.S. The initiative supports ten specific SIPs, including studies on cancer care, alcohol use reduction, and emergency preparedness, thereby fostering research that translates into real-world health improvements.
Cancer / Oncology

Expanded Surveillance for Pediatric Infectious Diseases

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $850,000 - US $1,140,000
This funding opportunity aims to establish a U.S. network for active surveillance of pediatric acute respiratory illnesses and gastroenteritis. The initiative will focus on respiratory and enteric viruses, assessing the effectiveness of prevention products such as vaccines. Recipients will follow CDC protocols to enroll patients and confirm viral infections, ultimately reducing hospitalizations and enhancing public health strategies for children's healthcare.
Infectious & Parasitic Diseases Children’s Health & Pediatrics

Improving Protection against Influenza and Other Respiratory Pathogens: the US Flu VE Network

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $1,350,000 - US $3,550,000
The US Flu Vaccine Effectiveness (VE) Network aims to enhance the effectiveness of vaccines against influenza and other respiratory pathogens, which are significant contributors to morbidity and mortality. This funding opportunity invites proposals for surveillance studies, including annual VE assessments, acute respiratory illness tracking, household transmission research, and immunogenicity studies. Applicants can apply for either Component A or B, with the option to include additional components based on their primary selection.
Respiratory Diseases & Systems

INCLUDE Project: Omics Phenotypes Related to Down Syndrome (X01 Clinical Trial Not Allowed)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The INCLUDE Project aims to enhance the health and quality of life for individuals with Down syndrome by generating comprehensive genomic and multi-omics data. This initiative encourages applicants to submit samples to NIH-supported resources, facilitating the exploration of molecular mechanisms related to health conditions associated with Down syndrome. The data will be shared via the INCLUDE Data Hub, promoting collaboration within the research community, though no direct funding is available to applicants.
Down Syndrome

Advanced Development and Sustainment of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
The National Cancer Institute (NCI) is set to release a Notice of Funding Opportunity (NOFO) aimed at advancing informatics technologies for cancer research. This initiative will support the development of tools that enhance data acquisition, management, and analysis throughout the cancer continuum. By focusing on technologies with proven impact, the NOFO seeks to optimize and sustain resources critical for cancer biology, diagnosis, treatment, and epidemiology.
Cancer / Oncology Biomedical informatics

The National Network of STI Prevention Training Centers (NNPTC)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $350,000 - US $1,000,000
The National Network of STI Clinical Prevention Training Centers (NNPTC) aims to enhance the education and training of clinicians and disease intervention professionals in STI patient care. This initiative focuses on improving the ability of healthcare providers and systems to effectively diagnose, manage, and counsel individuals at risk for STIs, ultimately reducing morbidity and enhancing public health outcomes on both local and national levels.
Sexually Transmitted Diseases

Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required) (357602)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
The Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required) aim to support clinical trials that can be completed within a limited timeframe. This funding opportunity encourages a variety of exploratory studies that align with the NIAMS mission, focusing on interventions such as drugs, biologics, devices, and various therapies. Applications are due by 5:00 PM local time of the applicant organization.
Musculoskeletal Diseases Neurological Diseases & Disorders Skin Diseases & Dermatology +1 more

Plant Protection Act Section 7721 Fiscal Year 2027 National Clean Plant Network (NCPN)

Animal and Plant Health Inspection Service
Federal Government
American Samoa, Guam +4 more
Up to US $3,500,000
The U.S. Department of Agriculture's Animal and Plant Health Inspection Service is offering at least $10 million in funding for the National Clean Plant Network (NCPN) program, aimed at supporting the production of pathogen-free plant material. This initiative focuses on establishing Clean Plant Centers across the U.S. to enhance competitiveness for specialty crop producers. Key priorities include optimizing clean plant distribution and advancing innovative technologies to increase awareness of clean plants' importance.
Plant Science Plant Pathology

ROSES25: D.8 Habitable Worlds Observatory Precursor Science Investigation

National Aeronautics and Space Administration (NASA)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Habitable Worlds Observatory (HWO) is a pioneering space mission concept aimed at discovering life beyond our solar system, as highlighted in the Astro2020 survey. The HWO-PSI program seeks to reduce risks for future missions by advancing scientific investigations that inform mission design. As HWO enters its pre-formulation phase, it addresses significant astrophysical questions and technical challenges, ultimately striving for groundbreaking discoveries in our understanding of the universe.
Astronomy & Astrophysics Space Science

NIOSH Exploratory/Developmental Grant Program (R21) (363327)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Up to US $300,000
The NIOSH Exploratory/Developmental Grant Program (R21) aims to enhance understanding of occupational diseases and injuries. It focuses on identifying risks, developing prevention strategies, and translating scientific discoveries into effective measures. Applicants are encouraged to describe the health burdens addressed, outline research activities, and demonstrate potential impacts on occupational safety. This initiative supports innovative concepts, model systems, and technologies that can significantly improve workplace health outcomes.
Occupational Health & Safety

Teaching Health Center Graduate Medical Education (THCGME) Program (363324)

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
US $160,000 - US $960,000
The Teaching Health Center Graduate Medical Education (THCGME) Program aims to equip residents with the skills to deliver exceptional healthcare, especially in rural and underserved areas. By funding the training of residents in HRSA-supported primary care residency programs, it fosters a diverse healthcare workforce capable of meeting the needs of various populations. This initiative not only enhances the quality of care but also strengthens community health systems.
Medical Education & Professional Training Rural Health Care

Direct-to-Consumer Distribution of HIV and other STI Self-Tests

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This funding opportunity aims to enhance a web-based ordering portal for distributing 1.5 million HIV and STI self-tests to high-burden communities. By optimizing access to these self-tests, the initiative seeks to raise awareness, prevent new infections, and improve the health outcomes of users, thereby contributing to better overall public health and wellbeing.
HIV / AIDS

Early Detection, Response, and Control of Global Rabies Outbreaks and Associated Threats to America's Dog-Rabies Free Status

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $150,000 - US $400,000
This funding opportunity aims to enhance the global response to rabies through innovative, cost-effective tools. The initiative focuses on reducing human rabies cases and advancing canine rabies elimination, particularly in high-burden regions. Research areas include tracking vaccination efforts, managing rabies exposure investigations, improving laboratory systems, and assessing the economic impact of interventions. Ultimately, it seeks to develop strategies that protect public health and ensure the sustainability of rabies-free status in the U.S.
Infectious & Parasitic Diseases

Puerto Rico Grants for Nonprofits Highlights

Puerto Rico grants for nonprofits provide funding to support education, disaster recovery, public health, and cultural preservation. The following grants empower organizations to address critical challenges, promote resilience, and foster sustainable development across Puerto Rico.


Search Instrumentl's Puerto Rico Grants Database


Find 834 funding opportunities for nonprofits in Puerto Rico, with $698M available. Instrumentl helps organizations discover funding sources through automated deadline tracking, curated grant searches, and research-driven funder insights to drive local progress.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Puerto Rico Grants for Nonprofits

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

800+ Puerto Rico grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

500+ Puerto Rico grants for nonprofits over $25K in average grant size

400+ Puerto Rico grants for nonprofits over $50K in average grant size

16 Puerto Rico grants for nonprofits supporting general operating expenses

500+ Puerto Rico grants for nonprofits supporting programs / projects

400+ Grants on Instrumentl focused on Disaster Relief / Humanitarian Aid

200+ Grants on Instrumentl focused on Cardiovascular Diseases & Systems

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Puerto Rico grants for Nonprofits?

Most grants are due in the first quarter.

Q1
31.5%
Q2
23.7%
Q3
19.8%
Q4
25.0%

Typical Funding Amounts

What's the typical grant amount funded for Puerto Rico Grants for Nonprofits?

Grants are most commonly $318,750.

$375 $375 Min.
$318,750 $318.8 K Median
$1,385,019 $1.4 M Average
$80,000,000 $80 M Max.

Browse Grants by Other Territories and Regional Locations