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Best St. Louis city Grants for Nonprofits in Missouri

Discover active funding opportunities in St. Louis city Grants for Nonprofits. 37,000+ grants are available for a wide range of missions and programs with additional grants in St. Louis County, Jackson County, and St. Charles County.

9,000+

Available grants

$2.60B

Total funding

$5K

Median grant

9,000+ grants
$2.60B total
$5K median

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9,406 Results based on applied filters

Ameren Missouri Grant Program

Ameren Corporation
Corporate
Adair County, Missouri, Adams County, Illinois +149 more
Unspecified amount
The Ameren Missouri Grant Program supports local organizations and community events in Missouri and Illinois, enhancing the quality of life for residents. Grants vary in amount and are typically awarded during a mid-year cycle lasting 30 days. Eligible applicants must be nonprofits serving communities where Ameren operates, while ineligible entities include individuals and for-profit organizations. This initiative reflects Ameren's commitment to community development and engagement.
Education Economic Services & Development Civic Engagement & Education +1 more

Tilles Fund Grant

Rosalie Tilles Nonsectarian Charity Fund 313743
Private
Bond County, Illinois, Calhoun County, Illinois +14 more
Unspecified amount
The Tilles Fund Grant focuses on innovative charitable investments in the Greater St. Louis Area, aiming to support children with developmental, intellectual, and physical disabilities. The foundation seeks to partner with effective non-profit organizations that demonstrate measurable outcomes in education and community impact. Since 1926, the Tilles Foundation has been committed to providing essential services and educational opportunities, ensuring disadvantaged children have the tools they need for a brighter future.
Children With Disabilities Education - K through 12 Education - Higher Education

The Pettus Foundation Grants

St Louis Community Foundation
Private
St. Louis City, Missouri, St. Louis County, Missouri
US $5,000 - US $25,000
The Pettus Foundation Grants focus on enhancing self-reliance and productivity in underserved communities through targeted funding in St. Louis. They support nonprofit initiatives in workforce development, youth development, and education, with a keen interest in early childhood education and job training programs. Applications are by invitation only, facilitated by the St. Louis Community Foundation, emphasizing robust governance and collaboration with multiple funding partners. Typical grants range from $5,000 to $25,000.
Workforce Preparation & Job Readiness Education - K through 12

DEW Foundation Grant

DEW Foundation
Private
Adair County, Missouri, Adams County, Illinois +189 more
Unspecified amount
The DEW Foundation Grant supports tax-exempt charitable organizations globally, aiming to promote the common good through financial contributions and personal involvement. The foundation prioritizes charities where family members are actively involved and focuses on ministries, health, education, and community service. While it may fund its own projects, it typically does not exceed 10% of an organization's operating budget and avoids supporting politically affiliated causes or normal church operations. Innovative and effective organizations are especially welcome.
Health & Medicine Disaster Relief / Humanitarian Aid Human & Social Services +4 more

Jean Griswold Foundation Scholarship Program ( Winter )

Jean Griswold Foundation (Griswold Cares Foundation)
Private
Acadia Parish, Louisiana, Adams County, Colorado +385 more
US $500 - US $2,000

The Jean Griswold Foundation

The Jean Griswold Foundation (JGF) is a non-profit organization dedicated to supporting Caregivers through educational opportunities and scholarships. 

Our Mission

The mission of the Jean Griswold Foundation is to support Caregivers by providing educational scholarships* to enable them to further their training, enhance their careers, and better assist the clients they serve.

By offering educational scholarships*, our Foundation will not only make a positive impact on the Caregivers themselves, but also the clients they assist and the home healthcare agencies where they are employed, as well as help advance the overarching home-care industry.

Scholarships will be paid directly to the federally accredited educational institutions of the winning Scholars’ choosing.

Empowering Caregivers Through Education

The Jean Griswold Foundation Scholarship Program awards scholarships to deserving Caregivers who wish to further their education in a care-related field. Applicants do not have to be associated with Griswold in any way, and the funds will be paid directly to the institution where the caregiver will be receiving education.  

Our Winter 2026 Scholarship Application period is now open! Applications will be accepted until 11:59pm ET August 31, 2026. Join our email list to get the first notice of all Scholarship happenings.  

Where would we be without Caregivers? 

Their selflessness is astounding, yet they are often overlooked and underappreciated. 

The Jean Griswold Foundation is dedicated to supporting Caregivers, the backbone of the care industry. We provide educational scholarships so Care Professionals can further their training, enhance their skills, elevate their careers, and better assist the people they serve.

Caregiver Support / Respite Care

PLTW Launch - New Program (Ameren)

Project Lead the Way inc.
Private
Adair County, Missouri, Adams County, Illinois +143 more
US $15,000

PLTW Launch

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to schools interested in implementing and our expanding their PLTW Launch programs.

PLTW Launch's 43 interdisciplinary modules bring learning to life. The program empowers students to adopt a design-thinking mindset through compelling activities, projects, and problems that build upon each other and relate to the world around them. And as students engage in hands-on activities in computer science, engineering, and biomedical science, they become creative, collaborative problem solvers ready to take on any challenge.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Launch programs beginning in the next academic year.

PLTW Program Status

New Program

Grant Award and Distribution Schedule

  • Total Award: $15,000
    • First Year: $10,000
    • Second Year: $5,000

STEM / STEAM Education

PLTW Launch - Program Expansion (Ameren)

Project Lead the Way inc.
Private
Adair County, Missouri, Adams County, Illinois +143 more
US $5,000

PLTW Launch

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to schools interested in implementing and our expanding their PLTW Launch programs.

PLTW Launch's 43 interdisciplinary modules bring learning to life. The program empowers students to adopt a design-thinking mindset through compelling activities, projects, and problems that build upon each other and relate to the world around them. And as students engage in hands-on activities in computer science, engineering, and biomedical science, they become creative, collaborative problem solvers ready to take on any challenge.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Launch programs beginning in the next academic year.

PLTW Program Status

Program Expansion

STEM / STEAM Education

PLTW Gateway - Program Expansion (Ameren)

Project Lead the Way inc.
Private
Adair County, Missouri, Adams County, Illinois +143 more
US $10,000

PLTW Gateway

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a long-time supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to schools interested in implementing or expanding their PLTW Gateway programs.

Middle school is a time of exploration, a time when students are figuring out what they're passionate about today and how that relates to who they'll become tomorrow. During this transitional time, PLTW Gateway's 10 units empower students to lead their own discovery. The hands-on program boosts classroom engagement and excitement, drives collaboration, and inspires “aha! moments” and deep comprehension. And as students engage in PLTW's activities in computer science, engineering, and biomedical science, they see a range of paths and possibilities they can look forward to in high school and beyond.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Gateway programs beginning in the next academic year.

PLTW Program Status

Program Expansion

STEM / STEAM Education

Caesars Regional & Property Giving

The Caesars Foundation
Private
Amador County, California, Atlantic County, New Jersey +31 more
Unspecified amount
The Caesars Foundation supports community-focused organizations through monetary and in-kind donations, prioritizing strategic areas like social equity, climate action, and mental health. Eligible applicants include IRS-recognized nonprofits and educational institutions operating within the U.S. Requests must align with these focus areas to enhance community impact. Organizations that discriminate or operate outside the U.S. are ineligible. By fostering collaboration, the foundation aims to uplift vulnerable populations and promote sustainable practices.
Climate Change Resilience & Equity Food Security Human Trafficking +17 more

Creley Memorial Conservation Grant

ST LOUIS AUDUBON SOCIETY
Private
St. Louis City, Missouri
Up to US $7,000
The Creley Memorial Conservation Grant, established by the St. Louis Audubon Society, supports bird conservation and education projects in the St. Louis region. Funded by a generous family donation, the grant aims to strengthen collaborations and initiate partnerships that promote bird conservation. With an estimated $7,000 available for the 2025 grant cycle, this initiative reflects SLAS's commitment to fostering awareness and understanding of birds and their habitats, helping communities make informed ecological decisions.
Environmental Education Environmental Conservation Ornithology +2 more

PLTW Gateway - New Program (Ameren)

Project Lead the Way inc.
Private
Adair County, Missouri, Adams County, Illinois +143 more
US $20,000

PLTW Gateway

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a long-time supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to schools interested in implementing or expanding their PLTW Gateway programs.

Middle school is a time of exploration, a time when students are figuring out what they're passionate about today and how that relates to who they'll become tomorrow. During this transitional time, PLTW Gateway's 10 units empower students to lead their own discovery. The hands-on program boosts classroom engagement and excitement, drives collaboration, and inspires “aha! moments” and deep comprehension. And as students engage in PLTW's activities in computer science, engineering, and biomedical science, they see a range of paths and possibilities they can look forward to in high school and beyond.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Gateway programs beginning in the next academic year.

PLTW Program Status

New Program

Grant Award and Distribution Schedule

  • Total Award: $20,000
    • First Year: $10,000
    • Second Year: $10,000

STEM / STEAM Education

Seniors Community Revitalization & Development Fund

Deaconess Foundation
Private
Franklin County, Missouri, Jefferson County, Missouri +6 more
Up to US $30,000
The Seniors Community Revitalization & Development Fund, supported by the Deaconess Foundation, aims to enhance public health infrastructure for seniors aged 55 and older in the Greater St. Louis area. This initiative focuses on improving transportation, safety, and navigation support for seniors while promoting transparency and accountability. Organizations can apply for grants of up to $30,000 to address these priority areas, ensuring better access to essential services for the aging population.
Senior Services

Seeding the Future Grants

Deaconess Foundation
Private
Franklin County, Missouri, Jefferson County, Missouri +6 more
US $20,000
The Seeding the Future Grants, offered by the Deaconess Foundation, provide annual operating funds of $20,000 to organizations that align with the foundation's mission of enhancing community health in Eastern Missouri and Southern Illinois. These grants support initiatives that advocate for systemic change, public policy advancement, and the expansion of civic infrastructure, fostering partnerships for intergenerational health improvements. Eligible organizations must possess a 501(c)(3) status or work with a fiscal agent.
Public Policy Civic Engagement & Education Civic Affairs +1 more

Los Angeles Rams Donation Request

Los Angeles Rams Foundation
Private
Bond County, Illinois, Calhoun County, Illinois +14 more
Unspecified amount in in-kind support
The Los Angeles Rams Foundation supports local charitable organizations by providing autographed memorabilia for fundraising events. Each organization can request one donated item per year, with priority given to requests from the Los Angeles area. Although the Rams cannot fulfill requests for autographing merchandise, their contributions help raise significant funds through auctions and raffles, making a positive impact in the community. Please allow at least six weeks for processing.
All fields of work

PLTW Engineering - New Program (Ameren)

Project Lead the Way inc.
Private
Adair County, Missouri, Adams County, Illinois +143 more
US $30,000

PLTW Engineering

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a long-time supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to high schools interested in implementing or expanding their PLTW Engineering programs.

PLTW Engineering empowers students to step into the role of an engineer, adopt a problem-solving mindset, and make the leap from dreamers to doers. The program's courses engage students in compelling, real-world challenges that help them become better collaborators and thinkers. Students take from the courses in-demand knowledge and skills they will use in high school and for the rest of their lives, on any career path they take.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Engineering programs beginning in the next academic year.

PLTW Program Status

New Program

Grant Award and Distribution Schedule

  • Total Award: $30,000
    • First Year: $15,000
    • Second Year: $15,000

Engineering

PLTW Engineering - Program Expansion (Ameren)

Project Lead the Way inc.
Private
Adair County, Missouri, Adams County, Illinois +143 more
US $10,000

PLTW Engineering

Ameren has partnered with PLTW to inspire students and provide the hands-on STEM learning experiences necessary to thrive in life beyond the classroom. Ameren is a long-time supporter of K-12 STEM education in the region and is working with PLTW to provide grant support to high schools interested in implementing or expanding their PLTW Engineering programs.

PLTW Engineering empowers students to step into the role of an engineer, adopt a problem-solving mindset, and make the leap from dreamers to doers. The program's courses engage students in compelling, real-world challenges that help them become better collaborators and thinkers. Students take from the courses in-demand knowledge and skills they will use in high school and for the rest of their lives, on any career path they take.

Through this partnership, Ameren has committed funds to support PLTW grants to schools interested in starting or expanding PLTW Engineering programs beginning in the next academic year.

PLTW Program Status

Program Expansion

Engineering

Best Buy Teen Tech Center - Mini Tech Skills Workshop Grant

Best Buy Foundation
Private
Alameda County, California, Albemarle County, Virginia +47 more
Up to US $24,999
The Best Buy Teen Tech Center is offering a Mini Tech Skills Workshop Grant to support local and national non-profits in providing STEAM skills workshops for youth aged 13-19. These workshops, which include topics such as coding, filmmaking, and robotics, aim to enhance technical skills and career exploration. Funding can reach up to $24,999, with a focus on hands-on, facilitator-led experiences, and additional programming opportunities may be considered.
After School / Summer Educational Programs Youth Services Workforce Preparation & Job Readiness +2 more

Episcopal Presbyterian Health Trust Grant

St Louis Community Foundation
Private
Jefferson County, Missouri, Madison County, Illinois +4 more
Up to US $25,000
The Episcopal Presbyterian Health Trust Grant, managed by the St. Louis Community Foundation, focuses on enhancing health care access and addressing chronic diseases. Grants are awarded biannually, prioritizing maternal and infant health in the second cycle. Organizations are encouraged to submit one Letter of Intent (LOI) annually, ensuring their proposals align with the funding priorities to foster sustainable health solutions in the community.
Health Care Access & Delivery Preventative Healthcare Community Health Education +4 more

Saigh Foundation Grant

Saigh Foundation
Private
Clinton County, Illinois, Franklin County, Missouri +10 more
Unspecified amount
The Saigh Foundation Grant supports St. Louis-area non-profit organizations focused on improving the lives of children and youth through educational and healthcare initiatives. Applications are accepted electronically via the foundation's online portal. The foundation does not fund annual appeals, capital campaigns, or organizations outside the metropolitan St. Louis area, ensuring that resources are maximized for local impact.
Education - K through 12 Education - Preschool / Early Learning Children’s Health & Pediatrics

Giving Branch Scholarship

Giving Branch Foundation
Private
Arkansas, Clay County, Missouri +7 more
US $500 - US $5,000
The Giving Branch Scholarship, funded by Flat Branch Mortgage, Inc. employees, aims to support working adults in pursuing higher education within the communities served by Flat Branch. This scholarship offers financial assistance ranging from $500 to $5,000, targeting individuals aged 25 and older who meet specific employment, residency, and academic criteria. By investing in education, the Giving Branch Foundation seeks to empower local residents and contribute positively to the community.
Education - Higher Education Adult Education Academic Scholarship Programs

Bayer Fund: Health & Wellness Grant Program

Bayer Fund
Corporate
Alameda County, California, Allegheny County, Pennsylvania +50 more
Unspecified amount
The Bayer Fund Health & Wellness Grant Program aims to support organizations that provide education and resources for patients and caregivers facing cancer and cardiovascular diseases. Grants focus on assisting communities, particularly the African American population, in managing these health issues. Funding covers educational services, disease awareness, and access to care, with all activities to commence post-funding decisions. Eligible organizations must hold a 501(c)(3) status and operate within 55 miles of Bayer sites.
Cancer / Oncology Cardiovascular Diseases & Systems

ASSET Grant Program

United Way Of Greater St Louis Inc
Private
Calhoun County, Illinois, Clinton County, Illinois +14 more
Up to US $25,000
The ASSET Grant Program, developed in partnership with United Way of Greater St. Louis, provides vital financial education and asset building opportunities for low-income families with children. It aims to enhance financial literacy through goal setting, personalized counseling, and comprehensive coaching, including a savings match of $300. Supported by generous donations from Stifel Bank, U.S. Bank, and Wells Fargo, the program empowers families to achieve their financial goals and improve their overall economic stability.
Financial Literacy Family Services Economic Services & Development

Safety Net Funding

United Way Of Greater St Louis Inc
Private
Calhoun County, Illinois, Clinton County, Illinois +14 more
US $50,000 - US $1,500,000

United Way of Greater St. Louis

Our Mission: The United Way of Greater St. Louis mission is to mobilize the community with one goal in mind – helping people live their best possible lives. We unite people, resources and funding to help build strong and equitable communities where everyone can thrive.

Safety Net

United Way’s Safety Net is a collaborative network of agencies that deliver an array of essential direct services to address the region’s most pressing needs, helping families and individuals remain and work toward stability. Safety Net agencies provide direct services that address basic, urgent needs – such as access to food and housing— as well as supports that help move individuals and families toward stability, including education, health and well-being, workforce access, and financial mobility.

Safety Net Funding

United Way of Greater St. Louis is now accepting applications for its Safety Net Funding cycle and invites all eligible agencies across its 16-county region in Missouri and Illinois, including those not currently receiving United Way funding, to apply. United Way equips 160 local nonprofits with vital funding and training resources to support measurable impact across its five impact areas. Organizations selected will receive a three-year contract and become part of the UWGSL member agency network.

United Way’s Impact Areas

  • Basic Needs 
  • Community Stability and Crisis Response 
  • Early Childhood and Youth Success 
  • Health and Wellbeing 
  • Jobs and Financial Mobility 

While needs are great across the five impact areas, United Way will use data derived from its landscape analysis of community needs to inform how service areas will be prioritized to ensure the region has access to a strong and resilient network as needs arise.

Early Childhood Development Disaster Relief / Humanitarian Aid Basic Human Needs +4 more

QuikTrip Donations: At-Risk Youth and Early Childhood Education

QuikTrip
Corporate
Andrew County, Missouri, Arizona +100 more
Unspecified amount
QuikTrip is dedicated to supporting at-risk youth and early childhood education through strategic community investments. By donating 5% of annual net profits to qualified non-profits, QuikTrip aims to empower individuals and break the cycle of poverty. The company partners with organizations providing educational opportunities, ensuring that all youth, regardless of their backgrounds, can thrive as independent citizens. This initiative highlights QuikTrip's commitment to making a measurable impact in the communities where its employees live and work.
Youth Services Education - Preschool / Early Learning Early Childhood Development +1 more

Trio Foundation of St. Louis Grant

Trio Foundation of St. Louis
Private
St. Clair County, Illinois, St. Louis City, Missouri +1 more
Up to US $25,000
The Trio Foundation of St. Louis Grant aims to enhance community well-being and promote equity through its new funding framework. Established over two decades ago, the foundation focuses on empowering marginalized groups, particularly those facing discrimination based on race, gender, and socioeconomic status. The grant supports initiatives in women's economic empowerment, arts accessibility, and environmental justice, fostering authentic relationships with community partners to create lasting impact in the St. Louis region.
Arts / Culture Access & Participation Art & Culture Youth Services +17 more

Ferguson Cares Grant

Ferguson
Corporate
Abbeville County, South Carolina, Accomack County, Virginia +722 more
Unspecified amount
The Ferguson Cares Grant is an essential aspect of Ferguson's Sustainability strategy, focusing on social challenges and community wellbeing. This grant supports nonprofit organizations in the U.S. dedicated to affordable housing, skilled trades workforce development, clean water access, and enhancing local economic quality of life. Ferguson aims to create lasting partnerships that drive positive impact within their operational regions, reflecting their commitment to social responsibility and community support.
Equitable & Affordable Housing Community Development & Revitalization Sanitation & Clean Drinking Water +2 more

BJC Scholars Fund Scholarship

The Scholarship Foundation of St. Louis
Association/Society
Crawford County, Missouri, Madison County, Illinois +5 more
Up to US $12,000
The BJC Scholars Fund Scholarship, backed by BJC HealthCare, aims to support high school seniors from specific Missouri and Illinois counties pursuing higher education. Eligible students can receive up to $12,000 per academic year, renewable for up to ten semesters. This initiative addresses community needs highlighted by the Ferguson Commission, promoting educational opportunities for youth in the regions served by BJC hospitals, which are known for their commitment to healthcare excellence.
Academic Scholarship Programs

St. Louis city Grants for Nonprofits Highlights

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Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : St. Louis city Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

94 St. Louis city grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

15 St. Louis city grants for nonprofits over $25K in average grant size

6 St. Louis city grants for nonprofits over $50K in average grant size

21 St. Louis city grants for nonprofits supporting general operating expenses

77 St. Louis city grants for nonprofits supporting programs / projects

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

4,000+ Grants on Instrumentl focused on Academic Scholarship Programs

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for St. Louis city grants for Nonprofits?

Most grants are due in the fourth quarter.

Q1
23.6%
Q2
26.2%
Q3
20.9%
Q4
29.3%

Typical Funding Amounts

What's the typical grant amount funded for St. Louis city Grants for Nonprofits?

Grants are most commonly $10,000.

$500 $500 Min.
$10,000 $10 K Median
$29,618 $29.6 K Average
$775,000 $775 K Max.

Average Grant Size

What's the typical amount funded for Missouri?

Grants are most commonly $101,542.

$101,542

Total Number of Grants

What's the total number of grants in St. Louis city Grants for Nonprofits year over year?

In 2024, funders in Missouri awarded a total of 44,064 grants.

2022 39,922

2023 39,688

2024 44,064

Top Grant Focus Areas

Among all the St. Louis city Grants for Nonprofits given out in Missouri, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for St. Louis city Grants for Nonprofits changing over time?

Funding has increased by -15.61%.

2022 $4,698,402,122

2023 $5,287,874,816
12.55%

2024 $4,462,369,205
-15.61%

Missouri Counties That Receive the Most Funding

How does grant funding vary by county?

St Louis County, Jackson County, and St Louis City receive the most funding.

County Total Grant Funding in 2024
St Louis County $2,185,711,864
Jackson County $1,234,679,326
St Louis City $1,054,441,922
Greene County $223,079,775
Clay County $178,423,081

Related Grants in Missouri

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