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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

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$8.25B

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$6K

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$8.25B total
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32,483 Results based on applied filters

Klamath Water Quality Improvements Grant Program

Oregon Watershed Enhancement Board (OWEB)
State/Local Government
Klamath County, Oregon
Unspecified amount

Klamath Water Quality Improvements Grant Program

Interim Measure 11 from the Amended Klamath Hydroelectric Settlement Agreement (KHSA), includes funding to address water quality improvements in the Klamath River via restoration and conservation actions in the Klamath Basin in Oregon. The emphasis of Interim Measure 11 (IM11) is nutrient reduction projects. PacifiCorp, in consultation with the Interim Measures Implementation Committee, developed a list of project categories to be implemented to fulfill the objective of IM11. PacifiCorp has provided funding of up to $6,433,500 for design/engineering and implementation of projects. This funding is administered through the Klamath Water Quality Improvements Grant Program.

After two grant cycles, a total of $4.9 million remains for future restoration and technical assistance projects. The next solicitation for grant applications will be in February 2026.

A Steering Committee, facilitated by the Oregon Department of Environmental Quality (ODEQ), was established to assist OWEB with the program implementation. OWEB is the Fiscal Agent and will award IM11 funds for projects approved by the Steering Committee until the funds are exhausted.

The Steering Committee is comprised of members from the following organizations: Oregon Water Resources Department, ODEQ, Oregon Department of Agriculture, Oregon Department of Fish and Wildlife, National Oceanic Atmospheric Administration, US Fish and Wildlife Service, US Bureau of Reclamation, Yurok Tribe, Karuk Tribe, Klamath Tribes, California Department of Fish and Wildlife, California North Coast Regional Water Quality Control Board and Aquatic Ecosciences.

Funding

  • ​Total Remaining Available: $4.9 million
  • ​Max Request:​ None
  • ​Required Match: 5% Technical Assistance & Restoration (25% is encouraged for Restoration)
Freshwater Conservation Environmental Contamination & Pollution Water Resource Management

Appalachian Regional Commission NOFO

Georgia Department of Community Affairs
State/Local Government
Banks County, Georgia, Barrow County, Georgia +35 more
Up to US $2,000,000

Appalachian Regional Commission NOFO

DCA is making available infrastructure funding in Georgia’s Appalachian Regional Commission footprint.  Funding limit per project is $2,000,000 and all applicable match requirements apply.    

Water Resource Management Pedestrian & Bike-Friendly Infrastructure

NSEDC: Water and Sewer Fund Grant

Norton Sound Economic Development Corporation
Private
Kusilvak Census Area, Alaska, Nome Census Area, Alaska
Up to US $1,000,000
The NSEDC Water and Sewer Fund Grant provides critical financial support for water and sewer projects in Norton Sound communities, allocating $1 million for upgrades or new construction. Additionally, it offers emergency funding up to $300,000 for urgent health and infrastructure needs. This program, renewed in 2024 and set to expire in 2029, aims to enhance community health and financial stability through essential water and sewer improvements.
Water Resource Management Waste Management

Minnesota's Coastal Program Grants: Small Grants

Minnesota Department of Natural Resources
State/Local Government
Carlton County, Minnesota, Cook County, Minnesota +2 more
US $1,000 - US $4,500
Minnesota's Coastal Program Grants offer funding for projects aimed at enhancing the management of Lake Superior's coastal areas. Managed by the Minnesota Department of Natural Resources, these small grants (up to $10,000) support short-term initiatives that promote planning, outreach, technology advancement, and youth education. Eligible projects include developing plans, hosting conferences, and creating educational resources for youth. The program prioritizes sustainability and community engagement in coastal management efforts.
Land / Habitat Conservation Freshwater Conservation Water Resource Management

Partners for Conservation - Illinois Soil and Water Conservation District Grants

Illinois Environmental Protection Agency
State/Local Government
Illinois
US $39,000 - US $500,000

Partners for Conservation - Illinois Soil and Water Conservation District Grants (FY26)

The Illinois Department of Agriculture (the “Department” or “IDOA”) is issuing this Notice of Funding Opportunity (“NOFO”) to provide grants to cover ordinary and contingent administrative expenses under the Soil and Water Conservation Districts program per the Soil and Water Conservation Districts Act (70 ILCS 405) and Partners for Planning and Conservation 30 ILCS 105/6z-32) Sec. 6z-32.

The Partners for Conservation Program is a long-term, state-supported initiative to protect natural resources and enhance outdoor recreational opportunities in Illinois. Several state agencies share responsibility for administering the Partners for Conservation Fund. The Illinois Department of Agriculture oversees the program's agriculture-related components. Under the Illinois Department of Agriculture, the program implements strategies for maintaining the viability of Illinois' soil and water resources. Soil and Water Conservation Districts assist landowners in natural resource management by providing technical assistance in such areas as soil conservation, water quality protection, wetlands management, flood control, soil erosion control at urban construction sites, stream bank stabilization, recycling, soil interpretation, land use and site suitability, and conservation education.

Local County Soil and Water Conservation Districts in Illinois that provide natural resource management technical assistance to landowners in such areas as soil conservation, water quality protection, wetlands management, flood control, soil erosion, stream bank stabilization, recycling, soil interpretation, land use and site suitability, and conservation education are eligible to apply.

Awards will be made to applicants meeting all eligibility criteria. Applications will be accepted until April 15, 2026. District funding will be awarded on a competitive basis and determined on base operations support and technical training level of District staff according to completion of planner level certification and technical supplemental support. Funding is also established to cover the cost of health insurance. Awards will range from $39,000 to $500,000. The Illinois Department of Agriculture anticipates distributing this amount across 98 awards.

Freshwater Conservation Land / Habitat Conservation Water Resource Management +1 more

The Jane Deming Fund Grant

Orange County Community Foundation
Private
Orange County, California
Unspecified amount
The Jane Deming Fund Grant, managed by the Orange County Community Foundation, focuses on supporting musical activities and education for under-served youth in Orange County. The grant is dedicated to projects that involve stringed instruments, provide tuition for music camps, purchase instruments for promising students, and produce performances that reach new audiences. This fund reflects Jane Deming's commitment to enhancing community engagement through music.
Music Music Education Symphony / Orchestra

Texas Health Community Impact Grants: Collin Region

Texas Health Resources
Private
Collin County, Texas
Up to US $900,000

Texas Health Community Impact

A Department of Community Health Improvement

We invest in community health and well-being through grantmaking and strategic collaborations. From data-driven, home-grown regional strategies to technical assistance, Texas Health Community Impact collaborates with community leaders to offer creative grant opportunities to North Texas organizations with a mutual desire to transform health and well-being in innovative ways.

Texas Health Community Impact Grants (Request for Proposals)

Texas Health Community Impact requests proposals to fund local organizations collaborating on innovative solutions that address barriers to community health and wellbeing. Up to $5 million is available across nine counties for the 2027-2028 grant cycle.

These community health improvement grants are made possible by Texas Health Resources—a faith‑based, nonprofit health system that cares for more patients in North Texas than any other provider.

Key Requirements

Applications must fulfill four key requirements: 1. Propose an innovative approach. 2. Demonstrate a collaborative effort between two or more organizations. 3. Align with strategic priorities. 4. Promote sustainability. Read Grant Key Requirements.

Project Implementation

Applicants must demonstrate the ability to begin implementing activities within four months of the execution of the MOU. Exceptions may be considered on a case-by-case basis.

Prior Applicants

Organizations that applied for a previous Texas Health Community Impact grant cycle and were not awarded are eligible to apply. 

Request for Proposals by Region

The Texas Health Community Impact Grant requests proposals by regions: 1) Collin Region; 2) Dallas and Kaufman Region; 3) Denton, Wise and Parker Region; 4) Southern Region; and 5) Tarrant Region.

Texas Health is investing a total of $5 million in grants across its five regions, which spans nine counties. Groups seeking to work collaboratively on innovative upstream approaches to address priorities identified in each region are encouraged to apply for this competitive funding opportunity.

Collin-Specific Content

Problem Statement

Based on extensive community feedback and analysis of data in the 2025 CHNA, as well as input from the Collin Leadership Council, the following non-medical drivers of health (NMODH) have been identified as top concerns in Collin County: Healthcare Access, Navigation & Literacy and Connectedness. Therefore, the Collin Leadership Council will seek innovative proposals to reduce barriers related to NMDOH in Healthcare Access, Literacy & Navigation, as well as Connectedness, through enhanced access to nutrition, chronic disease management, primary care, and social connectedness in 4 high need zip codes: East McKinney (75069), Farmersville (75442), Princeton (75407), and Blue Ridge (75424).

Health Disparities & Social Determinants of Health Literacy Nutrition & Healthy Eating +4 more

Montana AmeriCorps State Formula Program Grant

Montana Governor’s Office of Community Service
State/Local Government
Montana
Unspecified amount

Governor’s Office of Community Service aka ServeMontana

Established in 1993, Montana’s Commission on Community Service administers grants under the National and Community Service Trust Act of 1993, amended by the Edward M. Kennedy Serve America Act of 2009 and the Montana Community Service Act of 1994 (MCA 90-14-103). In partnership with the Montana Commission on Community Service, a primary function of the Governor’s Office of Community Service (GOCS) is administering funds to AmeriCorps State programs. 

AmeriCorps Montana

AmeriCorps State grants aid programs in addressing critical community needs, including Education, Disaster Services, Health, Environmental Stewardship, Economic Opportunity, and service to Veterans and Military Families. Grants must align with priorities in the Montana State Service Plan.

Eligible organizations may apply for the following AmeriCorps grants to address pressing needs in Montana: Competitive Program Grants; and Formula Program Grants.

Formula Program Grants

Implement or continue a Formula AmeriCorps State program.

This Notice is the first step an applicant must complete to apply for and receive AmeriCorps State Formula funding. ServeMontana’s role is to solicit, screen, and rank applications. All applications cleared through screening will be ranked and submitted to AmeriCorps for funding determination.

Organizations proposing a new AmeriCorps State program or continuing a currently formula funded program that places AmeriCorps members and operates only in Montana must apply to this competition.

Expectations of All Applicants

  • Address rural, Tribal, underserved, or areas of poverty not currently served by AmeriCorps programs;
  • Clearly connect proposed activities to the needs and priorities in the Montana State Service Plan;
  • Take a collaborative approach to program planning, design, and delivery;
  • Recruit Montanans to serve in their local community; and
  • Design and deliver an inclusive program that is accessible to individuals with disabilities
Military & Veterans Services Environmental Conservation Land / Habitat Conservation +5 more

Ben B. Cheney Foundation Grant

Ben B Cheney Foundation Inc
Private
Clallam County, Washington, Clark County, Washington +18 more
Up to US $40,000
The Ben B. Cheney Foundation Grant supports community improvement projects in areas where Mr. Cheney's lumber company operated. Focused on one-time project grants, the foundation emphasizes sustainability and local support. Eligible applicants include public charities and government units primarily in Washington, Oregon, and California. The foundation prioritizes projects that invest in long-lasting community needs and demonstrate innovative solutions. Since 1975, it has supported over 1,200 organizations, making a significant impact in local communities.
Basic Human Needs Disability Care & Services Education - Higher Education +8 more

Montana AmeriCorps State Competitive Program Grant

Montana Governor’s Office of Community Service
State/Local Government
Montana
Unspecified amount

Governor’s Office of Community Service aka ServeMontana

Established in 1993, Montana’s Commission on Community Service administers grants under the National and Community Service Trust Act of 1993, amended by the Edward M. Kennedy Serve America Act of 2009 and the Montana Community Service Act of 1994 (MCA 90-14-103). In partnership with the Montana Commission on Community Service, a primary function of the Governor’s Office of Community Service (GOCS) is administering funds to AmeriCorps State programs. 

AmeriCorps Montana

AmeriCorps State grants aid programs in addressing critical community needs, including Education, Disaster Services, Health, Environmental Stewardship, Economic Opportunity, and service to Veterans and Military Families. Grants must align with priorities in the Montana State Service Plan.

Eligible organizations may apply for the following AmeriCorps grants to address pressing needs in Montana: Competitive Program Grants; and Formula Program Grants.

Competitive Program Grants

Implement or continue a Competitive AmeriCorps State program.

This Notice is the first in a multistep process an applicant must complete to apply for and receive AmeriCorps State Competitive funding. ServeMontana’s role is to solicit, screen, and rank applications. This process is only for ranking; no funding will be awarded from this solicitation. All applications cleared through screening will be ranked and submitted to compete nationally for funding. 

Organizations continuing a competitively funded program or proposing an AmeriCorps State program that operates only in Montana must apply to this competition.

Expectations of All Applicants

  • Address rural, Tribal, underserved, or areas of poverty not currently served by AmeriCorps programs;
  • Clearly connect proposed activities to the needs and priorities in the Montana State Service Plan;
  • Take a collaborative approach to program planning, design, and delivery;
  • Recruit Montanans to serve in their local community; and
  • Design and deliver an inclusive program that is accessible to individuals with disabilities.
Land / Habitat Conservation Disaster Preparedness Health Disparities & Social Determinants of Health +5 more

Black Philanthropy Fund

The Cleveland Foundation
Private
Cuyahoga County, Ohio, Geauga County, Ohio +1 more
US $10,000 - US $25,000

The Cleveland Foundation

The Cleveland Foundation is the community's trust—a collective savings account dedicated to making the lives of Greater Clevelanders better.

The Cleveland Foundation is the world's first community foundation and one of the largest today. The foundation was established in 1914 by Frederick Harris Goff, a well-known lawyer and banker at the Cleveland Trust Company. Goff sought a solution for people who wanted to give back to their community in a lasting and impactful way. Unlike a one-time donation to a specific cause or organization, a gift to the Cleveland Foundation is invested to grow over time and meet the changing needs in the community across generations.  

Black Philanthropy Fund

The Cleveland Foundation’s Black Philanthropy Fund is an endowed affinity fund dedicated to advancing healthy communities and long‑term prosperity for Greater Cleveland’s Black community.

Harnessing the strength of collective giving, the fund convenes bold voices and sparks joyful collaboration to drive systemic change. Through strategic grantmaking and community partnerships, the fund invests in organizations creating pathways to opportunity, building wealth and advancing holistic well‑being.

Impact Areas

  • Opportunity Access: Grants support organizations leading initiatives that open doors to meaningful careers, entrepreneurial ventures and civic leadership, creating inclusive pathways for Black communities to thrive and lead boldly. 
  • Economic Investment & Wealth Building: Grants support organizations equipping individuals with the tools, knowledge and resources to build financial security and generational wealth through education, collaborative investment opportunities and innovative strategies for personal growth.
  • Physical & Mental Health: Grants support organizations advancing holistic well‑being by strengthening mental resilience, promoting physical health and creating joyful spaces for connection and community care. 

Entrepreneurship Civic Leadership Development Financial Literacy +4 more

SCCF: Health & Human Services Grant

Steuben County Community Foundation
Private
Steuben County, Indiana
US $3,000 - US $10,000
The Steuben County Community Foundation offers the Health & Human Services Grant Cycle to support projects that enhance physical and mental health, provide essential healthcare services, and address basic human needs like hunger and homelessness in Steuben County. Nonprofits serving the area are eligible, with a focus on collaborative initiatives that improve quality of life and tackle root causes. This funding seeks to empower organizations committed to making a meaningful impact in the community.
Human & Social Services Health & Medicine Mental Health & Psychiatric Diseases +6 more

Wayne Willis Foundation Scholarship Fund

Central Kansas Community Foundation
Private
Anderson County, Kansas, Barton County, Kansas +23 more
Unspecified amount

About Us

Mission

The mission of CKCF is Building Stronger Communities Through Charitable Giving. Located in Newton, CKCF is a host foundation to 18 affiliates in the central Kansas region, supporting rural philanthropy.

History

The CKCF based in Newton, Kansas is thriving as a viable community foundation serving Newton while also being host to numerous affiliate community foundations throughout central Kansas. The Central Kansas Community Foundation was originally founded in 1994. Following a stable history serving a tri-county area the foundation merged in 2009 with the well-established Greater Newton Community Foundation. Today, the CKCF continues to demonstrate a commitment to strengthening communities across the entire Central Kansas region.

Wayne Willis Foundation Scholarship Fund

The scholarship was established to provide financial assistance to current graduating high school seniors or college/graduate students who are furthering their careers through a degree in wildlife management or conservation of natural resources.

Education - Higher Education Wildlife Management Education - High School +2 more

The Children's Trust: Community Engagement Grant

The Children's Trust
Private
Miami-Dade County, Florida
Up to US $20,000
The Children's Trust Community Engagement Grant aims to enhance existing programs that support children and families in Miami-Dade County. This funding opportunity encourages organizations to address high-need populations and promote citizen engagement and advocacy. Nonprofits not currently funded by The Children's Trust can apply for grants typically under $20,000 to develop collaborative projects that foster community involvement. The grant focuses on improving access to essential services and empowering local communities.
Family Services Youth Services Child Welfare Services +5 more

Little Falls/Morrison County Grant

Laura Jane Musser Fund
Private
Morrison County, Minnesota
Up to US $30,000
The Little Falls/Morrison County Grant, established by the Laura Jane Musser Fund, aims to enhance community access and sustainability through support for nonprofit organizations in Morrison County, MN. Eligible organizations can apply for General Operating Support or Small Grants, with funding up to $10,000 for various projects. The grants prioritize measurable impacts in community engagement and organizational strength, ensuring that assistance is directed towards fostering meaningful community improvements.
Art & Culture Child Welfare Services Children’s Mental Health +5 more

Pennsylvania Infrastructure Investment Authority Grant Program

Pennsylvania Department of Community and Economic Development
State/Local Government
Pennsylvania
Up to US $20,000,000
The Pennsylvania Infrastructure Investment Authority Grant Program offers low-interest loans and grants for improvements in drinking water, storm water, and sewage treatment facilities. Eligible entities include municipalities, authorities, and private operators. Total project assistance can reach up to $11 million, or $20 million for multi-municipality projects. Applicants must consult with a PENNVEST Regional Project Specialist prior to submission. This program aims to enhance water management and pollution prevention practices across the state.
Sanitation & Clean Drinking Water Water Resource Management Environmental Contamination & Pollution

PDCED: Abandoned Mine Drainage Abatement and Treatment Program

Pennsylvania Department of Community and Economic Development
State/Local Government
Pennsylvania
Up to US $1,000,000
The Abandoned Mine Drainage Abatement and Treatment Program (AMDATP) is funded by the Marcellus Legacy Fund as established by Act 13 of 2012. This program aims to address the critical issue of Abandoned Mine Drainage (AMD), which significantly impairs over 5,500 miles of Pennsylvania's streams. Eligible projects can receive grants up to $1,000,000, requiring at least a 15% match, focusing on remediation, maintenance, and monitoring of AMD sites.
Water Resource Management Waste Management

Improving Chronic Disease Outcomes RFA - Activity 5.3b: Enhancing Rural Cancer-Focused Healthcare (ERCH)

New jersey department of health
State/Local Government
Atlantic County, New Jersey, Bergen County, New Jersey +12 more
Up to US $87,500

New Jersey Department of Health

The scope of work for the public health system is ever-expanding, and the Department is on the frontlines in leading the response to public health challenges. The Department has three primary branches – Public Health Services, Health Systems, and Integrated Health. All work collaboratively toward improving health by strengthening New Jersey’s health system.

Our Mission: Protect the public’s health, promote healthy communities, and continue to improve the quality of health care in New Jersey.

Rural Health Transformation Program: Improving Chronic Disease Outcomes in Rural New Jersey

The Division of Health Promotion, through its Community Health and Wellness Unit (CHWU), announces the availability of funding awarded to the State under the Rural Health Transformation (RHT) Grant Program. This funding opportunity is designed to support innovative and sustainable strategies that improve chronic disease outcomes, increase access to quality healthcare services, address health disparities, and strengthen healthcare systems in rural communities.

The grant seeks to advance community-driven solutions that promote health equity, improve health outcomes, and enhance care coordination across rural health systems.

Purpose and Goals

The purpose of the Rural Health Transformation Grant is to support projects that transform rural healthcare delivery by addressing systemic challenges and community-identified needs. Grant goals include, but are not limited to:

  • Improving access to healthcare services in rural and underserved areas
  • Strengthening rural healthcare infrastructure and workforce capacity
  • Enhancing care coordination and integration of services
  • Addressing SDOH impacting rural populations
  • Promoting preventive care, wellness, and chronic disease management

Proposed Grant Activities

  • Activity 5.2a: NJ Rural Southern Physical Activity and Nutrition Program (NJ R-SPAN)
  • Activity 5.2b: Umbrella Hub Organization
  • Activity 5.3b: Enhancing Rural Cancer-Focused Healthcare (ERCH)
  • Activity 5.3c: Rural Pharmacy Medication Management Therapy Program
  • Activity 5.3d: Rural Health Screening and Education
  • Activity 5.4b: Safe Communities: Youth Violence Prevention in Rural Communities

Activity 5.3b: Enhancing Rural Cancer-Focused Healthcare (ERCH)

Program Goals: The Enhancing Rural Cancer Healthcare program aims to implement sustainable policy, systems, and environmental change approaches across the rural areas of 8 Regional Chronic Disease Coalitions to reduce the burden of cancer and other chronic and reproductive diseases. There will also be a focus on supporting/providing cancer survivorship care to residents of rural areas. Residents of the rural areas served by this project will receive culturally specific cancer education, outreach, referrals to appropriate screening services, and survivorship care services. These project efforts may reduce cancer incidence and mortality in rural New Jersey.

  • Objective 1.1: Reduce cancer mortality and morbidity in New Jersey rural communities.
  • Objective 1.2: Establish PSE change strategies to improve the health and well-being of New Jersey rural communities with relation to cancer primary prevention, early detection, and survivorship.
  • Objective 1.3: Increased education, outreach, and screening within rural communities related to various cancer, chronic, and reproductive diseases.

Community Health Education Preventative Healthcare Chronic Illnesses +4 more

Health Foundation of South Florida Grants

Health Foundation of South Florida
Private
Broward County, Florida, Miami-Dade County, Florida +1 more
Unspecified amount
The Health Foundation of South Florida Grants aim to enhance the health of South Florida communities, particularly for vulnerable populations. The foundation invites nonprofit organizations and government agencies to submit proposals that align with its mission, focusing on access to care, social needs, and thriving communities. Preference is given to projects that demonstrate clear needs and measurable outcomes, especially those serving low-income and disadvantaged communities. Funding can support innovative collaborations and systems changes to improve healthcare access and outcomes.
Health Care Access & Delivery Health Disparities & Social Determinants of Health Community Development & Revitalization +5 more

NIHCM: Journalism Grants

The National Institute for Health Care Management
Private
United States
Unspecified amount
The NIHCM Journalism Grants support projects that enhance health reporting and education, targeting critical issues such as healthcare affordability, pharmaceutical pricing, provider market dynamics, and chronic disease management. This initiative emphasizes the importance of informing policymakers and the public on how to improve healthcare quality and access in the U.S. Proposals may also explore the role of artificial intelligence in healthcare delivery. Applications are welcome from journalists, nonprofits, and universities.
Journalism Health Information Technology Health Policy & Advocacy +5 more

Georgia Outdoor Stewardship Grant Program

Georgia Department of Natural Resources
State/Local Government
Georgia (US state)
US $500,000 - US $3,000,000
The Georgia Outdoor Stewardship Grant Program, established in 2018, provides funding for parks, trails, and conservation efforts across Georgia. Administered by the Georgia Department of Natural Resources, the program supports projects that protect wildlife and natural resources. Eligible applicants include local governments and conservation-focused organizations. This initiative, backed by strong voter support, aims to enhance outdoor recreation and safeguard critical lands for future generations.
Environmental Stewardship Trail Creation & Maintenance Wildlife Management +2 more

GFO-25-304 - Modeling and Monitoring Air Quality and Co-Benefits of Energy Interventions RFA

California Energy Commission
State/Local Government
California
US $2,900,000 - US $3,000,000

Modeling and Monitoring Air Quality and Co-Benefits of Energy Interventions

The purpose of this solicitation is to fund applied research and development projects that inform California's transition to an equitable, zero-carbon energy system that is climate-resilient and meets environmental goals. Applied research supported by this solicitation will improve existing ambient air quality modeling approaches, advance low-cost measurement technologies, and conduct analyses to quantify the air quality implications and related human health impacts of clean energy interventions across energy use sectors. Ultimately, this research will contribute to a foundation for accurate monetization of non-energy impacts of clean energy interventions.

Improvements in air quality and related human health outcomes are important direct benefits of decarbonizing energy sectors that currently rely on fossil fuels. Capturing these impacts is important to motivate investments in decarbonization strategies but is also a challenging task. Robust air quality modeling and field measurements can help to accurately project the air quality-related benefits and ultimately monetize the human health impacts of clean energy interventions such as implementation of Senate Bill (SB) 100 (SB 100, De León, Chapter 312, Statutes of 2018), transportation electrification, and building electrification.

This solicitation addresses public interest research opportunities at the nexus of human health, air quality monitoring and modeling, and California’s decarbonizing electricity system. Existing ambient air quality simulation models require rigorous evaluation for accuracy of estimates, specific tailoring to California’s complex geography and meteorology, and expanded capability to simulate pollutants such as ozone and secondary particulate matter. Additionally, improvements in the spatial resolution and computational efficiency of existing models are critical to illuminate impacts of decarbonization strategies, and applied research is needed related to low-cost air quality sensors for in-situ household pollution measurement. While existing sensors enable collection of abundant data, they can be afflicted by performance issues and associated inaccuracies.

Projects must fall within the following project groups: 

  • Group 1: Advancing Ambient Air Quality Modeling Capabilities and Analysis; and
  • Group 2: Developing a Low-cost Air Quality Sensor to Assess Household Air Pollution.
Air Quality Carbon / Greenhouse Gas Reduction

Wild and Scenic Rivers Fund

Colorado Department of Natural Resources (CO DNR)
State/Local Government
Colorado
Up to US $400,000

Wild and Scenic Rivers Fund

In 2009, the Colorado General Assembly created the Wild and Scenic Rivers Fund to foster cooperative and collaborative processes aimed at the development of protections for river-dependent outstandingly remarkable values (“ORVs”). These protections would be intended as an alternative to wild and scenic river designation under the federal Wild and Scenic Rivers Act, while also protecting Colorado’s ability to fully use its compact and decree entitlements.

The Colorado General Assembly established the Colorado Water Conservation Board’s (CWCB’s) Wild and Scenic Rivers Fund (“the Fund”) in 20091. The legislature:

  • Provided that the Fund would be refreshed annually up to $400,000;
  • Stated that the Fund should be used to “work with stakeholders within the state of Colorado to develop protection of riverdependent resources as an alternative to wild and scenic river designation under the federal Wild and Scenic Rivers Act”; and,
  • Provided that the Board may adopt terms and conditions here called “guidelines” for fund disbursements.

The Fund is used for two primary purposes: 

  • To support local resource protection groups (“stakeholder groups”) that form to develop protection of river-dependent resources as an alternative to wild and scenic river designation under the federal Wild and Scenic Rivers Act, exploring different approaches that will most benefit the resource and the community, and 
  • For CWCB Staff operational expenses related to participation in such stakeholder groups.

These guidelines are designed to assure that the Fund is used to support the efforts of these various stakeholder groups in an equitable and efficient manner. It is the goal of the CWCB to ensure wise and effective use of monies from the Fund. The CWCB strongly encourages the use of this Fund for projects that result in the compilation of the best available data at the earliest stages of the federal agencies’ plan revisions and processes to evaluate streams and rivers for eligibility and suitability for Wild and Scenic designation. Colorado's Instream Flow Program offers a means to protect flow-related Outstandingly Remarkable Values (ORVs) without a Wild and Scenic designation; thus, stakeholder groups are encouraged to consider instream flows as a primary tool in the effort to protect such ORVs

Freshwater Conservation Water Resource Management Recreational Water Use & Boating

Safety Net Funding

United Way Of Greater St Louis Inc
Private
Calhoun County, Illinois, Clinton County, Illinois +14 more
US $50,000 - US $1,500,000

United Way of Greater St. Louis

Our Mission: The United Way of Greater St. Louis mission is to mobilize the community with one goal in mind – helping people live their best possible lives. We unite people, resources and funding to help build strong and equitable communities where everyone can thrive.

Safety Net

United Way’s Safety Net is a collaborative network of agencies that deliver an array of essential direct services to address the region’s most pressing needs, helping families and individuals remain and work toward stability. Safety Net agencies provide direct services that address basic, urgent needs – such as access to food and housing— as well as supports that help move individuals and families toward stability, including education, health and well-being, workforce access, and financial mobility.

Safety Net Funding

United Way of Greater St. Louis is now accepting applications for its Safety Net Funding cycle and invites all eligible agencies across its 16-county region in Missouri and Illinois, including those not currently receiving United Way funding, to apply. United Way equips 160 local nonprofits with vital funding and training resources to support measurable impact across its five impact areas. Organizations selected will receive a three-year contract and become part of the UWGSL member agency network.

United Way’s Impact Areas

  • Basic Needs 
  • Community Stability and Crisis Response 
  • Early Childhood and Youth Success 
  • Health and Wellbeing 
  • Jobs and Financial Mobility 

While needs are great across the five impact areas, United Way will use data derived from its landscape analysis of community needs to inform how service areas will be prioritized to ensure the region has access to a strong and resilient network as needs arise.

Early Childhood Development Disaster Relief / Humanitarian Aid Basic Human Needs +4 more

SD Workforce Education: Local Education Agency (LEA) Grant

South Dakota Department of Education
State/Local Government
South Dakota
Up to US $225,000

Career and Technical Education

The goal of the South Dakota Department of Education is for all students to graduate college, career, and life ready. The Division of College, Career and Student Success provides support for students' preparations for postsecondary education and the workforce. Services are connected to approved Career & Technical Education (CTE) programs, work-based learning, student organizations and more. In-line with the department's aspiration, DCCSS works to ensure students not only graduate from high school, but that they are prepared to navigate the transitions and life events that come after high school.

Workforce Education Grants

In 2013, the South Dakota Legislature established the Workforce Education Fund through SB 235. Part of that fund was designated to provide grants for Career & Technical Education (CTE) programs in secondary schools.

The Workforce Education Grants provide school districts and private, nonprofit entities who provide specialized training in South Dakota the opportunity to make transformative change in career and technical education programs. High quality CTE programs give students the knowledge, skills and experiences to be well prepared for postsecondary education and the workforce. Partnerships among secondary education, postsecondary education, and business & industry lay the foundation for modern CTE programs.

Grant Purpose & Eligibility

The Workforce Education Grants are designed to support and align secondary school CTE systems with South Dakota's postsecondary education programs and workforce needs, developing the state's talent pipeline for workforce development and economic growth. Projects are meant to serve middle and high school students.

Eligible applicants are Local Education Agencies (LEAs) with projects designed to serve middle and high school students. The LEAs who are awarded grants will serve as fiscal agents through the completion of their projects. All applications must demonstrate commitment by all grant partners to the grant project and its sustainability following the conclusion of the grant.

Education - Higher Education Workforce Preparation & Job Readiness Career / College Preparation +3 more

Arts & Culture – Small Arts Grants- Non-Profit Organizations

Fleishhacker Foundation
Private
Alameda County, California, Contra Costa County, California +1 more
US $5,000 - US $10,000
The Fleishhacker Foundation's Small Arts Grants program offers crucial financial support to small and mid-sized arts organizations in the Bay Area. Designed for nonprofits with budgets between $100,000 and $749,999, this program promotes the presentation of new works by local artists across various disciplines, including theater and visual arts. Grants, typically around $5,000, can be used for a range of operational costs, fostering creativity and cultural expression within communities.
Performing Arts Visual Arts Dance +4 more

Greenspring Grant Program

Greenspring Advisors
Corporate
Maryland, New Jersey +1 more
US $5,000 - US $20,000
The Greenspring Grant Program, established in 2012, focuses on supporting local non-profits dedicated to economic and workforce development. With $100,000 in grants ranging from $10,000 to $15,000, the program is entirely employee-run, allowing teams to select deserving organizations. Eligible entities include 501(c)(3) non-profits in Maryland, New Jersey, and Pennsylvania, while special consideration is given to local initiatives aimed at recovery, youth, and underserved populations.
Workforce Preparation & Job Readiness Job Creation Entrepreneurship +3 more

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.