Best Large Grants for Nonprofit Organizations

The BCBSAZ Foundation for Community and Health Advancement supports charitable events that align with health improvement initiatives in Arizona. Eligible applicants include non-profit organizations and academic institutions. The foundation focuses on critical health issues such as mental health, chronic conditions, and health equity. Sponsorship applications must be submitted 60 days prior to the event date, with reviews conducted monthly. The foundation aims to enhance community health through strategic partnerships and impactful funding.

The Zero Suicide Initiative aims to enhance suicide prevention within Indian health systems by implementing the Zero Suicide framework. This program focuses on culturally informed strategies to empower Tribal health systems, fostering leadership, workforce development, and effective suicide risk identification. It emphasizes timely engagement and evidence-based treatment, ensuring continuity of care and quality improvement, ultimately enhancing outcomes for American Indian and Alaska Native individuals at risk for suicide.

The ME Project Canopy Assistance Grants support community forestry projects focused on tree planting and maintenance. Applicants, including local governments and non-profits, must attend a grant workshop prior to submission. The program emphasizes sustainable practices, enhancing community health, and improving air and water quality. A 50/50 matching requirement applies to federal funds, encouraging local financial commitment. This initiative aims to foster collaboration and share expertise for long-term forestry success in Maine.

The Bay Area Lyme Foundation Grant supports innovative research aimed at improving diagnostics and treatments for Lyme disease. With a revised granting schedule, proposals can be submitted year-round, with reviews conducted three times annually. The foundation welcomes applications from universities, hospitals, and independent entities across the U.S., emphasizing the importance of addressing challenges in diagnosing and treating Lyme disease, especially for difficult cases.

The Garden Club of America Board of Associates Centennial Pollinator Fellowship offers funding for research on pollinator decline, specifically targeting bees, bats, butterflies, and moths. This fellowship, established in 2013, supports graduate students in U.S. institutions with annual funding typically around $4,000. It aims to enhance knowledge in pollinator science while fostering a new generation of scientists dedicated to conservation. Recipients may reapply for additional funding in subsequent years.

The Policy Campaign Grants by the Deaconess Foundation empower organizations to drive systemic change through policy advocacy and grassroots efforts. With funding up to $100,000, these grants aim to support urgent campaigns that enhance voter engagement and community organizing. By strengthening local movements, the foundation seeks to address racial and structural inequities in Eastern Missouri and Southern Illinois, fostering a path towards liberation and community well-being.

Purpose

CalRecycle's Waste Tire Cleanup Grant, a competitive grant program to provide funding for collection, removal, transportation, recycling, & disposing of California waste tires from tire piles & illegal dumping areas along public rights-of-way or private property. California cities, counties, special districts, Qualifying Tribal Entities & joint powers authorities are eligible to apply. This grant has a 2-year grant term. 

Description

CalRecycle oversees the Waste Tire Cleanup Grant, a competitive grant program to provide funding for collection, removal, transportation, recycling, and disposing of California waste tires from tire piles and illegal dumping areas along public rights-of-way or on private property. California cities, counties, special districts, Qualifying California Native American tribes and joint powers authorities are eligible to apply. Funding:  $1,500,000 available for fiscal year (FY) 2026–27 - $100,000 for individual grant awards and $250,000 for regional grant awards.

Funding

Funds are limited to the removal of waste tires:

• Along public rights-of-way
• On private property.
• This grant has a 2-year grant term and is offered in even years. 

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Breast Cancer Screening & Prevention Initiative

The Breast Cancer Screening & Prevention Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to expand access to lifesaving breast cancer screening and prevention services for uninsured and medically underserved. Through this initiative, the NAFC will provide $30,000 grants to members to establish or strengthen breast cancer screening programs in alignment with evidence-based guidelines from the U.S. Preventive Services Task Force and the American Cancer Society. Funding will support activities such as improving patient identification and referral systems, increasing access to mammography services through partnerships or mobile units, strengthening staffing and technology capacity, and providing patient education and case management to ensure follow-through with recommended screenings. By enhancing early detection and preventive care, the initiative seeks to reduce barriers to care and improve health outcomes for women who might otherwise go without critical cancer screening services.

McCullough-Hyde Memorial Hospital

Community Grants

The McCullough-Hyde Foundation is excited to announce the launch of the Community Granting Program, as part of the expanded philanthropic mission of the Foundation. It is anticipated that more than $200,000 in funding will be available annually through this grant-making program.

The Community Granting Program is a philanthropic program that makes investments that address significant health needs of local communities. The Foundation will partner with and provide funding to local organizations that are leading the way to build healthier communities.

The McCullough-Hyde Foundation invites proposals from organizations for programs and projects that focus on education, prevention programs, awareness efforts, wellness opportunities and direct care in the following areas:

Programs and projects that prevent, manage, and reduce the burden of chronic conditions including, but not limited to, heart disease, hypertension, stroke, and diabetes. Eligible initiatives may focus on education, early detection, care coordination, wellness promotion, and access to treatment and support services.

Programs and projects that promote and sustain healthy lifestyle choices, including, but not limited to, physical activity, nutrition, tobacco cessation, and preventive care. Eligible initiatives should be community-centered and designed to empower individuals and families to take control of their health through activities, education, engagement, and improved access to wellness opportunities that support active living, particularly among youth and families.

Programs and projects that improve access to and quality of mental health and substance use services, reduce stigma, and promote emotional well-being across all age groups. Eligible initiatives may include, but are not limited to, prevention, early intervention, treatment, recovery support, education, and outreach related to conditions including, but not limited to, anxiety, depression, and addiction.

Programs and projects that address the underlying social and economic conditions influencing health outcomes, including, but not limited to, access to healthcare, food, housing, transportation, education and employment. Eligible initiatives should aim to reduce barriers to health and wellness by improving the environments where people live, work, and play.

The HIV Prevention and Alcohol R61/R33 funding opportunity aims to advance innovative HIV prevention strategies through a phased research approach. The R61 phase focuses on developing and pilot testing interventions, addressing key implementation questions for diverse populations. Following successful milestones, the R33 phase expands testing of these interventions and explores their effectiveness and sustainability, particularly in relation to alcohol use and related health issues.

The Circular Arizona Grant, formerly known as the Arizona Recycling Coalition, is a nonprofit initiative aimed at fostering an equitable circular economy in Arizona. With nearly $300,000 awarded since the 1990s, the program supports nonprofits, government agencies, and local businesses with grants up to $5,000. The focus is on measurable projects that enhance recycling efforts and reduce landfill waste, promoting sustainability and innovation throughout the state.

The Source Water Protection Assistance Program (SWPAP) aims to enhance public health by safeguarding drinking water supplies. It emphasizes the importance of protecting existing water sources over costly treatment solutions. Eligible applicants include public water systems and nonprofit organizations, while projects must focus on effective source water protection measures. The program encourages collaboration among various stakeholders to prevent contamination and improve water quality. Funding is available for projects that meet specific criteria, including timely completion and demonstrable impact.

The Kentucky Pride Fund Composting Grant, established under Senate Bill 50, aims to support eligible applicants in diverting materials from landfills towards composting, reuse, or recycling. This initiative, part of the Recycling and Household Hazardous Waste Management Grants Program, encourages sustainable practices and environmental stewardship in Kentucky. By providing financial assistance, the grant fosters innovative solutions to waste management challenges, ultimately contributing to a cleaner and more sustainable community.

The Kentucky Pride Fund Household Hazardous Waste Management Grant supports projects aimed at developing an integrated recycling infrastructure and managing household hazardous waste in Kentucky. Established in 2006, the program emphasizes regional projects with state-approved cooperative agreements and requires a 25% match. It serves as a crucial resource for public education on recycling and hazardous waste management, promoting efficient use of limited funds for maximum impact.

The Community Forestry Grants Program by Texas A&M Forest Service aims to foster sustainable urban forestry initiatives, enhancing community resilience against climate change while promoting health equity. Each grant, worth $50,000, supports projects that develop diverse tree cover and improve public access to green spaces, particularly in historically disadvantaged areas. Eligible entities include public and non-profit organizations, focusing on innovative solutions that integrate urban forestry into community planning and wellness strategies.

The ACA Conservation, Community, and Education Grants support projects that conserve and enhance Alberta's fish, wildlife, and habitats. Funded by anglers and hunters, these grants aim to promote awareness and appreciation for Alberta's natural environment. Projects eligible include those that align with ACA's mission and enhance community engagement in conservation efforts. While there is no maximum grant amount specified, requests over $40,000 require justification, with the average grant being around $12,000.

Missouri Department of Natural Resources

Missouri’s air, land and water resources play an important role in our health and are essential to the environmental and economic vitality of our state. The department aspires to help Missouri citizens thrive by advancing environmental and economic sustainability. The department provides a range of services to help Missouri citizens, communities and businesses in these efforts. The department also provides opportunities to learn more about Missouri’s natural and cultural history at our state parks and historic sites.

Our Mission: We serve as stewards of our natural resources to benefit Missourians. The department's values and Strategic Initiative Plan guide the department as it moves. The department accomplishes its mission through its Division of Administrative Support, Division of Environmental Quality, Division of Energy, Missouri Geological Survey and Missouri State Parks. 

Drinking Water State Revolving Fund (DWSRF) Engineering Report Grant

Under the Drinking Water State Revolving Funds (DWSRF) program, the department provides Engineering Report Grants to small communities for developing plans or engineering reports related to the following:

• Compliance with new permit requirements
• Ability to provide safe drinking water

The community uses the funds to hire an engineer to produce a plan or report that either evaluates improvements to their drinking water system or consolidated or regionalized a nearby system. The report identifies the system’s needs, evaluates the existing facility or system, describes all the options to meet project goals, provides cost estimates and recommends the best alternatives. The report must strive to make reasonable and cost-effective recommendations for system improvements to meet Missouri Safe Drinking Water Law requirements. The final plan or report must be signed and sealed by a professional engineer registered in the State of Missouri.

United Way of Greater St. Louis

Our Mission: The United Way of Greater St. Louis mission is to mobilize the community with one goal in mind – helping people live their best possible lives. We unite people, resources and funding to help build strong and equitable communities where everyone can thrive.

Safety Net

United Way’s Safety Net is a collaborative network of agencies that deliver an array of essential direct services to address the region’s most pressing needs, helping families and individuals remain and work toward stability. Safety Net agencies provide direct services that address basic, urgent needs – such as access to food and housing— as well as supports that help move individuals and families toward stability, including education, health and well-being, workforce access, and financial mobility.

Safety Net Funding

United Way of Greater St. Louis is now accepting applications for its Safety Net Funding cycle and invites all eligible agencies across its 16-county region in Missouri and Illinois, including those not currently receiving United Way funding, to apply. United Way equips 160 local nonprofits with vital funding and training resources to support measurable impact across its five impact areas. Organizations selected will receive a three-year contract and become part of the UWGSL member agency network.

United Way’s Impact Areas

• Basic Needs 
• Community Stability and Crisis Response 
• Early Childhood and Youth Success 
• Health and Wellbeing 
• Jobs and Financial Mobility 

While needs are great across the five impact areas, United Way will use data derived from its landscape analysis of community needs to inform how service areas will be prioritized to ensure the region has access to a strong and resilient network as needs arise.

Community Foundation of Morgan County

The Community Foundation of Morgan County (CFMC) was founded on January 5, 2000, thanks to a grant from Lilly Endowment. CFMC was originally a partnership with the Mooresville Community Foundation and Morgan County Community Foundation. The historic Academy Building on the Newby Campus in Mooresville was CFMC’s original location.

After 25 years of service, the Community Foundation of Morgan County continues to grow our community endowment for purposes of enhancing the lives of all Morgan County citizens, now and for those in the future. We address community needs through grantmaking, including scholarships, connect donors to local needs, and provide leadership on key community issues.

Lilly Endowment GIFT IX Community Project Grant

The Community Foundation of Morgan County is committed to strengthening the long-term vitality of our community by addressing critical needs. The Community Project Grant Program, funded by Lilly Endowment Gift IX, provides strategic funding opportunities for transformative initiatives aligned with three key pillars:

• Affordable Housing- Temporary & Permanent
• Childcare Access & Affordability
• Food Insecurity & Poverty Relief

Up to $500,000 in funding is available per pillar to support high-impact, collaborative, and sustainable solutions that directly benefit residents of Morgan County.

Environmental Stewardship: Research Grants

FAO, through its Environmental Stewardship Pillar of Prosperity Fund, offers funding opportunities to advance conservation, environmental stewardship and the greater well-being of Appalachian Ohio.

FAO welcomes proposals for projects that result in scalable change, with a priority for projects that will impact multiple counties. FAO will consider funding requests between $5,000 and $50,000 per project, and at least $150,000 is available to award. We encourage applicants to propose research with the potential to significantly impact the understanding of aquatic biodiversity, water quality and threats to healthy habitats. The following examples illustrate eligible projects, but proposals are not limited to the listed areas.

• Flood resilience
• Watershed monitoring, analysis and management applications
• Application of innovative technologies and methodologies
• Collaborative research partnerships across disciplines and sectors
• Ecosystem services

The PTES Worldwide Conservation Insight Grants support scientific research and practical conservation efforts aimed at preserving endangered species. Grants range from £3,000 to £10,000 annually, up to a total of £20,000 over two years. Eligible applicants include researchers and conservationists working on critical conservation questions or local actions. The fund prioritizes projects with clear, sustainable outcomes that benefit endangered species and their habitats, particularly in low-income countries.

Cardinals Charities

Founded in 1990, Cardinals Charities supports programs designed to improve the quality of life and enhance opportunities for children, women, and minorities in the state of Arizona.

Cardinals Charities' grants are awarded on an annual basis in response to applications from various qualified non-profit organizations whose goals and programs align with the mission statement.

Since its inception, Cardinals Charities has distributed more than 9.1 million dollars to hundreds of worthy charitable organizations on behalf of the Arizona Cardinals and the National Football League.

Mission Statement​

The Arizona Cardinals Charities Fund supports programs designed to improve the quality of life and enhance opportunities for children, women, and minorities in the state of Arizona.

Grants are awarded on an annual basis in response to applications from non-profit 501(c)(3) qualified organizations whose goals and programs meet our mission statement. We make every effort to direct our contributions where they can have the greatest impact while addressing the most critical needs. Funding is limited to the success of Cardinals Charities' own fund-raising efforts during the year.

About the DNR

Preserving and enhancing the natural resources of Wisconsin

In keeping with our mission, the DNR is dedicated to working with Wisconsinites while preserving and enhancing the natural resources of Wisconsin. In partnership with individuals and organizations, DNR staff manage fish, wildlife, forests, parks, air and water resources while promoting a healthy, sustainable environment and a full range of outdoor opportunities.

Recycling Consolidation Grant to Responsible Units

The Recycling Consolidation Grant is available in addition to the Basic Recycling Grant. This grant program was created in the state 2011-13 Budget to offer supplemental assistance for Responsible Units (e.g. cities, towns, villages, counties, tribes or solid waste management system) that meet the eligibility criteria in s. 287.24, Wis. Stats. The sum of the awards may not exceed the total net eligible costs of recycling expenses.

About the DNR

Preserving and enhancing the natural resources of Wisconsin

In keeping with our mission, the DNR is dedicated to working with Wisconsinites while preserving and enhancing the natural resources of Wisconsin. In partnership with individuals and organizations, DNR staff manage fish, wildlife, forests, parks, air and water resources while promoting a healthy, sustainable environment and a full range of outdoor opportunities.

Basic Recycling Grant to Responsible Units

Recycling grant awards are made to responsible units (cities, towns, villages, counties, tribes or solid waste management systems) for residential recycling and yard waste program costs that are reasonable and necessary for planning and operating an effective recycling program. 

Eligible costs include those eligible recycling items associated ONLY with residential single family and 2–4-unit households.

If you are eligible to apply for this Basic Recycling Grant you may also qualify for the Recycling Consolidation Grant.

The Redwood Connect Grants, offered by Save the Redwoods League, aim to enhance equitable access to redwood parks by fostering meaningful connections between communities and nature. Targeting youth aged pre-K to 21, these grants prioritize low-income and marginalized groups, providing enriching park experiences that promote curiosity and stewardship. With over 300 grants awarded since 2000, the League seeks partners to inspire the next generation through direct engagement with the wonders of redwood forests.

Associated Bank Community Grants focus on enhancing the well-being of communities through charitable donations. Allocating 1% of annual pretax profits, the bank supports programs benefiting low- to moderate-income individuals and families. Philanthropic priorities include affordable housing, small business development, workforce development, sustainability, and racial/social equity. The bank collaborates with nonprofit organizations that align with its values, ensuring meaningful contributions to community growth and improvement.

The Dr. Bruce D. J. Batt Fellowship in Waterfowl Conservation honors the legacy of Dr. Bruce Batt, a leading figure in waterfowl research. This fellowship offers up to $5,000 annually to graduate students at North American universities conducting vital research on waterfowl and wetlands. Renewable for up to two additional years for PhD students, the fellowship promotes the integration of sound science in conservation efforts, supporting the next generation of waterfowl professionals.