Best Large Grants for Nonprofit Organizations

About Us

The Community Mental Health Fund makes grants to 501(c)(3) mental healthcare organizations. We are a public fund and services are audited. Care must meet standards set by the Board of Trustees and the State of Missouri. We also support multi-agency initiatives, including cultural competence and trauma-informed care. Services assist our community’s most vulnerable citizens. Abused children, battered women, and homeless families are among those we serve.

Our Mission

Our Mission is to support a network of quality mental health services for persons with mental illness that are equitably accessible and responsive to the varied and unique needs of Jackson County Missouri residents.

2027 Fee-for-Service Applications

CMHF request for 2027 funding proposals

The Board of Trustees requests mental health fee-for-service funding applications from agencies currently funded in these funding categories:

• Safety Net
• Children's Treatment Centers
• Community-Based Mental Health
• Families and Children
• Domestic and Sexual Violence
• Support Services

Empire State Development

The mission of Empire State Development (“ESD”) is to promote a vigorous, inclusive and growing state economy, encourage business investment and job creation, and support diverse, local economies across New York State through the efficient use of loans, grants, tax credits, real estate development, marketing, and other forms of assistance. 

New York State Career Readiness Entertainment Workforce (CREW) Diversity Grant Program

Objective

The New York State Career Readiness Entertainment Workforce (CREW) Diversity Grant Program (formerly known as the New York Entertainment Workforce Diversity Grant Program) provides financial assistance in the form of grants for job creation and training programs that support efforts to recruit, hire, promote, retain, develop and train a diverse and inclusive workforce for the motion picture and television production and post-production industries in New York State.

Eligible programs include training in film and television editing and development. Proposed programs must address the Grant Program’s goals of providing opportunities for diverse workers and/or those located in economically distressed areas of New York State.

The Sewer Overflow and Stormwater Reuse Municipal Grant (NJ) provides up to $12 million in funding for municipalities to address combined sewer overflows, sanitary sewer overflows, and stormwater management. Prioritization is given to financially distressed communities and projects that utilize green technology. Grants can cover up to 100% of eligible project costs, with a maximum project cap of $2 million. This initiative aims to enhance infrastructure while promoting environmental justice.

The City of Spokane is inviting proposals for projects aimed at addressing the affordable housing crisis within its limits. With a total funding of $7,856,000 from various sources, the goal is to increase and preserve affordable housing options for extremely low and low-income households. Applicants can request up to 25% of the total project cost, ensuring compliance with AMI and population requirements set by funding sources.

Over our more than 100-year history, we've been fighting heart disease and stroke, striving to save and improve lives.

Our Mission

To be a relentless force for a world of longer, healthier lives.

Rapid Impact Research Award

Purpose

The American Heart Association continuously seeks innovative ideas to address the most pressing issues impacting cardiovascular and brain health. To that end, the Association is pleased to announce the Rapid Impact Research Award program, which will support early and mid-career investigators proposing innovative research that aligns with the Association’s mission. Novel basic, clinical and/or population health proposals are invited in the following three priority areas of research.

• Sudden cardiac arrest/resuscitation science
• Cardiovascular Kidney Metabolic Syndrome
• Stroke and/or vascular dementia

Applicants will be asked to indicate alignment of their proposal with one or more of the topic areas listed above. 

The Used Oil Collection Gift Grant Program, managed by the New Hampshire Department of Environmental Services, provides gift grants to municipalities for establishing and improving used oil collection centers. These grants aim to support Do-It-Yourselfers in properly recycling their used oil at licensed facilities. Eligible entities include towns, counties, and registered inspection stations, with most grants not exceeding $2,500, while multi-town centers may qualify for up to $5,000.

The Arctic Slope Community Foundation offers grants to enhance the quality of life in Arctic Slope communities. With a focus on food security, education, and cultural preservation, these grants support 501(c)(3) organizations, government entities, and tribes. The application process requires a pre-interview and aims for projects that address community needs. Funds are allocated based on structured models, ensuring sustainability and meaningful impact in the region. Applications are accepted year-round, promoting ongoing community development.

The Redemption Innovation Grant Program, managed by the California Department of Resources Recycling and Recovery, aims to support innovative recycling initiatives by funding start-up costs for various recycling projects. Eligible applicants include certified recycling centers and new businesses looking to establish themselves in California. Projects must address unserved zones and comply with existing regulations, contributing to California's commitment to a circular economy by increasing recycling rates and reducing waste.

The Jeanette Zaichkin NRP Nursing Grant for Excellence and Innovation in NRP Education supports nurses dedicated to enhancing neonatal resuscitation training. This grant, offered by the American Academy of Pediatrics, provides up to $10,000 for innovative projects addressing key gaps in transitional physiology and evidence-based practices. Eligible applicants must be current NRP Instructors and work in neonatal care settings. The initiative aims to empower nurses in teaching essential skills for successful newborn resuscitation.

The US Dept. of Health & Human Services, through the Eunice Kennedy Shriver National Institute of Child Health and Human Development, is set to announce a funding opportunity focused on HIV research for pediatric and maternal populations. This initiative aims to foster innovative clinical trials addressing critical research areas in HIV, inviting collaborations from experts in various fields. Applications are not currently solicited, but potential applicants are encouraged to prepare for this opportunity.

The Peter and Elizabeth C. Tower Foundation is dedicated to empowering children and young adults affected by substance use disorders, learning disabilities, mental illness, and intellectual disabilities. Their Programs & Services Grants support initiatives within Erie and Niagara Counties in New York and parts of Massachusetts, focusing on enhancing community capabilities and improving quality of life. Note that applications for certain grant cycles are paused for the remainder of 2025 as the foundation shifts towards emergency response funding.

The MPPEP Phase 3 program aims to enhance processing capabilities for invasive, wild-caught catfish, benefiting both processors and fishers. By increasing processing capacity and volume, the initiative seeks to create fair wages and stable job opportunities, fostering economic growth in rural areas. This grant will support innovative strategies that ensure sustainable practices and elevate incomes within the community, thus contributing to the overall development of the meat and poultry sector.

The Bay Area Lyme Foundation Grant supports innovative research aimed at improving diagnostics and treatments for Lyme disease. With a revised granting schedule, proposals can be submitted year-round, with reviews conducted three times annually. The foundation welcomes applications from universities, hospitals, and independent entities across the U.S., emphasizing the importance of addressing challenges in diagnosing and treating Lyme disease, especially for difficult cases.

The Urban Act Grant Program in Connecticut provides financial assistance to municipalities identified as economically distressed or public investment communities. This initiative aims to enhance community conservation, urban development, and improve quality of life for residents. Local officials must submit a letter to the Office of Policy and Management to apply, as there is no formal application process. The funds can support various projects, including economic development, housing, and public safety.

Who We Are

Community Foundation of North Louisiana brings people and resources together to solve problems and enhance our community. Our mission is to promote philanthropy and improve the quality of life in the North Louisiana community by serving as a permanent and growing resource of expertise and funds.

Established in 1961, the Foundation oversees more than $200 million in assets for the benefit of North Louisiana. The funds managed by the Foundation are invested for the community’s benefit and then are returned to the community in the form of grants to a wide variety of charitable endeavors. Since inception, the Community Foundation has granted over $150 million in grants to nonprofit organizations.

WPN Grants

The Women’s Philanthropy Network (WPN), a fund of the Community Foundation of North Louisiana, is seeking applications from programs with clearly defined outcomes that address one or more of the following areas: school readiness, student achievement, attendance, literacy, numeracy, mental health, behavioral health, nutrition, and physical well-being.

The WPN plans to award one large grant in the range of $50,000 – $75,000, and one or two small grants in the range of $5,000 – $15,000.

The John W. Alden Trust Grant supports organizations in Eastern Massachusetts that provide care and services to children and youth (ages 0-24) with disabilities or those at risk due to social factors. Grants can fund capacity building, program support, and more, but applicants must demonstrate a focus on high-risk youth and meet specific criteria. The Trust emphasizes sustainability and may require matching funds for grant approval.

The Tennessee Housing Trust Fund Competitive Grants support the development and preservation of rental housing for low- and very-low income households, including the elderly and special needs populations. Eligible projects can receive funding between $100,000 and $600,000, focusing on those with incomes at or below 80% of the area median income. Priority is given to projects in rural areas and those serving the most vulnerable populations, ensuring access to safe and affordable housing.

The Dayton Foundation's Basic Human Needs Grants provide essential financial support to 501(c)(3) nonprofit organizations in Greater Dayton, focusing on vital necessities like food, shelter, healthcare, and clothing. Grants are awarded quarterly to eligible organizations that demonstrate a commitment to diversity and collaboration in addressing the needs of the homeless, poor, and hungry. This funding also covers operational costs and infrastructure improvements, ensuring organizations can effectively serve their communities.

The Clean Water State Revolving Fund (CWSRF) Program in California has been vital for financing projects aimed at enhancing water quality since 1989. The State Water Resources Control Board outlines its plans for SFY 2025-26 in this Intended Use Plan, highlighting significant updates and objectives for funding. This program not only supports environmental health but also fosters sustainable development across the state.

Morris Animal Foundation invites Established Investigators to submit pre-proposals for research focused on reptile and amphibian health. This initiative emphasizes the importance of animal health and welfare while facilitating impactful conservation efforts. Proposals must demonstrate clear animal health needs, collaborative strategies, and potential benefits to wildlife populations. Funding for these projects is anticipated to average around $100,000 over a maximum duration of 36 months, fostering innovative solutions for pressing health challenges in these species.

Ohio Water Development Authority

The Ohio Water Development Authority (OWDA) provides financial assistance for environmental infrastructure from the sale of municipal revenue bonds through loans to local governments in Ohio and from the issuance of industrial revenue bonds for qualified conduit projects in Ohio.

Mission Statement: To provide financial assistance for environmental infrastructure from the sale of municipal revenue bonds through loans to local governments in Ohio and from issuance of industrial revenue bonds for qualified projects in Ohio.

Un-Sewered Area Assistance Program

Program Description

The Ohio Water Development Authority created the Un-Sewered Area Assistance Program to provide grants for construction of a publicly owned sewer system for unsewered areas that have failing on-lot sanitary systems.

Please note, projects must be constructed using State of Ohio Prevailing Wage rates. Extension of an existing sewer system is not eligible for this program.     

The Morris Animal Foundation invites research pre-proposals for the Wildlife Health (Reptile and Amphibian) - First Award, aimed at enhancing the health and welfare of amphibians and reptiles. This initiative focuses on impactful research, particularly in chytrid disease. Eligible applicants include early career researchers with appropriate qualifications and a clear understanding of animal health challenges. Projects should demonstrate collaboration with relevant stakeholders and provide direct benefits to wildlife populations, emphasizing conservation through an animal health perspective.

The Alliance for Health Equity

The Alliance for Health Equity pursues its mission through grantmaking, providing scholarships, building partnerships and being catalytic to spark new initiatives where they are needed the most. Our ultimate goal is to improve the health, social, emotional, economic conditions among children, teens, and families in the Coatesville Area School District.

The Seed-And-Scale Match Fund

The Seed-And-Scale Match Fund is a signature funding initiative of The Alliance for Health Equity (AHE) that supports community-based organizations working to address key social determinants of health in Greater Coatesville. Seed-And-Scale is designed to help organizations launch new ideas, strengthen existing programs, and scale solutions rooted in community need and lived experience.

The Seed-And-Scale Match Fund supports both emerging initiatives and established models that reduce systemic barriers, expand access to essential resources, and strengthen pathways to long-term community impact. 

Focus on Social Determinents of Health (SDoH)

• Healthcare Access and Quality: Access to affordable, culturally responsive healthcare services including physical, behavioral, and preventive care that support wellness across the lifespan. 
• Education Access and Quality: Access to high-quality learning environments, academic support, and enrichment opportunities which enable children and youth to thrive. 
• Neighborhood and Built Environment: Safe, stable physical environments including housing and food access that support healthy living and community stability. 
• Social and Community Context: Strong relationships, supportive networks, and community engagement that foster belonging, resilience, and collective well-being. 
• Economic Stability: Strong relationships, supportive networks, and community engagement that foster belonging, resilience, and collective well-being. 

The Morris Animal Foundation is offering Pilot Study Awards focused on reptile and amphibian health and welfare, particularly for chytrid research. These awards aim to fund innovative, proof-of-concept studies that demonstrate a clear understanding of animal health issues and collaboration with stakeholders. Proposals must have a direct impact on wildlife populations and adhere to strict health study policies. The maximum funding is $20,000 for a duration of 12 months, ensuring significant contributions to wildlife health advancements.

The Matson Foundation, a corporate entity, emphasizes community involvement through charitable donations. They support a diverse range of areas including maritime conservation, education, human services, culture, and civic programs. Eligible organizations must be qualified non-profits, with a primary focus on community support where Matson operates. The foundation prioritizes projects that engage local communities, ensure sustainability, and demonstrate measurable impact, while adhering to specific eligibility and ineligibility criteria for funding.

Sewer Overflow and Stormwater Reuse Municipal Grants (OSG) Program

The DWQ has obtained grant funding for select stormwater projects through the Federal Sewer Overflow & Stormwater Grant Program (OSG). Applicants in financially distressed or rural communities (see Prioritization) will be prioritized. Projects must be stormwater projects which manage, reduce, treat, or recapture water through the use of green infrastructure. This money may not be used for any operation and maintenance expenses.

Project Type

Projects must use green infrastructure to manage, reduce, treat, or recapture stormwater and the funded portion of the project must meet Green Project Reserve requirements.

The New York State Conservation Partnership Grant Program, managed by the Land Trust Alliance and the Department of Environmental Conservation, supports land trusts through competitive grants. With over $34 million awarded, the program aims to boost organizational capacity, enhance stewardship efforts, and catalyze community engagement in conservation projects across New York. Grants are available in five categories, including Capacity & Excellence, Professional Development, and Stewardship & Resource Management, promoting sustainable conservation practices.