Best Large Grants for Nonprofit Organizations

The HIV Prevention and Alcohol R61/R33 funding opportunity aims to advance innovative HIV prevention strategies through a phased research approach. The R61 phase focuses on developing and pilot testing interventions, addressing key implementation questions for diverse populations. Following successful milestones, the R33 phase expands testing of these interventions and explores their effectiveness and sustainability, particularly in relation to alcohol use and related health issues.

The Truancy Reduction Service Grant, offered by the District of Columbia Department of Human Services, focuses on providing essential services to combat truancy among youth aged 10-17 in selected schools. This initiative, aimed at enhancing mental health, mentorship, and family support, emphasizes the importance of culturally competent strategies and outreach. Applicants must demonstrate experience with at-risk youth and ensure services are accessible in Spanish, targeting diverse populations, including those facing housing instability and special needs.

The Ella B. Cleveland Trust Grant supports charitable medical research organizations focusing on leukemia, muscular dystrophy, and cerebral palsy. Established in memory of Ella B. Cleveland, the trust prioritizes 501(c)(3) entities and has no geographic limitations, though it often funds organizations in Georgia. Applications are accepted year-round, with an average grant size of $5,000, and total annual giving ranging from $10,000 to $15,000.

The GLS Campus Suicide Prevention program aims to enhance behavioral health services for college students, addressing critical issues such as suicide, depression, and substance use disorders. By fostering a culture of help-seeking and reducing stigma, this initiative ensures that at-risk students receive timely intervention and support. The program represents a vital investment in the mental well-being of students, promoting a healthier campus environment through evidence-based strategies and comprehensive public health approaches.

The Employees Community Fund (ECF) of The Boeing Company empowers employees to make a significant impact through pooled donations. Established over 60 years ago, this employee-managed fund supports charitable organizations in communities where Boeing operates. The Potomac Region Chapter, formed in 2000, focuses on education, veterans, and low-income communities, with over 130 members contributing to the cause. Grants are available to nonprofits that align with these focus areas, fostering community engagement and support.

The Anthony F. Cordeiro Charitable Foundation Grant aims to support nonprofit organizations in southeastern Massachusetts and Rhode Island that enhance the lives of families and children. Established in 2017, the foundation focuses on providing essential resources such as health services, mental health support, food, and shelter. Eligible applicants include 501(c)(3) organizations that align with the foundation's mission, ensuring no discrimination in hiring or service provision.

The A Fund for Women Grant, offered by the Madison Community Foundation, aims to empower women and girls in Dane County by supporting projects focused on economic empowerment and education. Eligible 501(c)3 organizations can apply for funding to enhance accessibility to education, promote financial literacy, and advocate for policy changes that support women's rights. The deadline for full applications is June 25, 2025, and multi-year grants may be considered.

The Susquehanna Riverlands Conservation Landscape Mini-Grant Program offers competitive grants ranging from $2,000 to $20,000 for projects enhancing habitat connectivity, sustainable river access, and community collaboration. This initiative is part of a collaborative effort to protect natural resources and improve quality of life along the Susquehanna River in Pennsylvania. Applications are accepted until July 1, 2025, encouraging local nonprofits and municipalities to apply for funding that aligns with the program's goals.

The Diminished Tree Species Grant Program focuses on restoring native tree species crucial for biodiversity and forest health. By funding scientific research, seed orchard development, and land preservation, the program aims to combat climate change through effective tree restoration projects. The Oak Hill Fund, a private entity, encourages project-specific applications, prioritizing organizations that meet eligibility criteria under Section 501(c)(3) of the IRS. This initiative is vital for sustaining healthy ecosystems and mitigating environmental impacts.

The Shredder’s Studio Art Scholarship is designed to assist Nantucket High School graduates pursuing degrees in fine arts or art therapy. This fund aims to cover college tuition costs, ensuring students have the support they need to excel in various artistic disciplines including painting, sculpture, photography, and graphic design. By investing in the artistic development of local talent, the scholarship fosters creativity and innovation within the community.

The United Way KGC Impact 100 Grant seeks proposals from local nonprofit organizations that address critical health and human service needs in the Kansas City region. Selected organizations will receive a one-year unrestricted grant, enhancing their visibility and connections within the United Way network. This initiative emphasizes diverse approaches in Health, Education, and Financial Stability, ensuring a comprehensive impact across various community sectors. Organizations are encouraged to apply based on alignment with United Way's funding goals and community needs.

MH263036 - Delivering Sources of Strength OMH Suicide Prevention Center of New York (SPCNY)

The New York State Office of Mental Health (OMH) through its Suicide Prevention Center of New York (OMH SPCNY) is pleased to announce the availability of funds dedicated to the implementation of Sources of Strength, a suicide prevention program, in New York State high schools (grade 9-12).

The organization awarded this RFP will be responsible for onboarding new schools statewide into Sources of Strength by providing both Adult Advisor and Peer Leader trainings conducted by a certified Sources of Strength trainer. In addition, the organization would maintain ongoing technical assistance and support for schools that have completed their initial Sources of Strength training within the previous three years. By the third year of support, offboarding must be offered to help schools build the capacity needed to sustain the program independently. The awardee shall train peer leaders to initiate and conduct a series of systematic peer-to-peer prevention activities under the supervision of trained adult advisors. Messaging activities are to directly target and modify the helpseeking attitudes and behaviors of youths throughout each school, so that students are better able to manage distress, including anxiety, depression, and stress, and draw on positive coping resources including capable adults in their community. The organization shall report these activities to OMH on a regular frequency in the form of a report.

The Goodwin Family Memorial Trust Grant supports the moral, physical, and intellectual development of needy males under 21 in California. Established by Mabel Frankie Goodwin, the trust focuses on education, health, and human services. Grants range from $10,000 to $35,000, with 35 grants awarded annually, totaling up to $600,000 in yearly giving. Organizations must be 501(c)(3) public charities and wait one year after four consecutive grants before reapplying.

Cytokinetics is dedicated to supporting local communities in the San Francisco Bay Area and Greater Philadelphia Region by providing access to essential services that address food and housing insecurity. Their funding initiatives aim to foster stability and resilience among at-risk populations, emphasizing charitable donations to qualified 501(c)(3) organizations that align with their corporate giving priorities. This support helps build strong connections between Cytokinetics and the communities they serve.

The Linnean Macleay Fellowship, established in 1905 by the Linnean Society of New South Wales, supports research in Natural History and related sciences. Funded by a bequest from Sir William Macleay, the Fellowship is available to members of the Society who reside in New South Wales and hold a Science degree from the University of Sydney. It is tenable for one year but can be renewed for up to five years, contingent on satisfactory progress.

The FY25 Vitality Fund, initiated by the Deputy Mayor for Planning and Economic Development, aims to encourage business relocation and expansion in Washington, DC, particularly in the central business district. The program offers grants to businesses that commit to significant capital improvements and job creation. Preference is given to companies occupying at least 15,000 square feet and creating new jobs. The fund supports economic growth and aims to have a positive impact on the local community.

Governor’s Office of Volunteer Services

The Governor’s Office of Volunteer Services works to increase an ethic of service and volunteerism in the State of Alabama, strengthen the capacity of Alabama’s faith and community-based organizations, and promote collaboration among individuals and organizations striving to meet some of the greatest needs in our state.

Alabama AmeriCorps State Notice of Funding Opportunity

Grant Information

The Governor’s Office of Volunteer Services is seeking grant applicants to operate or develop AmeriCorps programs solely within Alabama. The AmeriCorps programs will enroll AmeriCorps volunteers (members) to address community-identified needs in one or more focus areas during their term of service: Disaster Services, Economic Opportunity, Education, Environmental Stewardship, Healthy Futures, or Veterans and Military Families. The Governor’s Office of Volunteer Services (GOVS) is the legal applicant to the federal AmeriCorps agency, and applicants applying under this notice are subgrantees of GOVS. Applicants will initially submit their grant to GOVS via email and successful applicants will enter the final grant application in eGrants for submission (when required) to the AmeriCorps agency. All program proposals will be required to align with and adhere to President Trump’s Executive Orders and directives: Executive Orders – The White House

The Summer Lea Hillman Foundation Grant focuses on enhancing the quality of life for vulnerable children, animals, and communities in the Portland metro area. The foundation prioritizes animal health and safety, child and youth development, homeless services, and environmental sustainability. Eligible organizations must be recognized as tax-exempt public charities. The foundation does not fund individuals, ensuring support is directed towards impactful community initiatives.

The Clarence T.C. Ching Foundation Grant supports programs and capital projects primarily benefiting the people of Hawaii. Starting in 2025, applications will be accepted for six focus areas, including education and healthcare. Grants range from $3,000 to $100,000, with a preference for projects that have additional funding sources. Eligible applicants are non-profit organizations with 501(c)(3) status operating in Hawaii. The foundation does not fund projects outside Hawaii or general operating support.

The Nicor Gas Pillar Grants for Environmental Stewardship aim to support initiatives that enhance community engagement in conservation and sustainable practices. Grants up to $5,000 are available for 501(c)(3) organizations that focus on clean air, environmental protection, and green space preservation. Eligible organizations are encouraged to apply, particularly those that engage the public in environmental stewardship projects within Nicor Gas’ service area.

The Lawrence Fellowship offers a prestigious postdoctoral opportunity at Lawrence Livermore National Laboratory, inviting exceptional candidates from various technical disciplines. It emphasizes independent research within a collaborative environment, supported by experienced mentors. Fellows receive a competitive monthly salary of $11,204, fostering innovation in areas crucial for U.S. security and global stability. This fellowship not only provides financial support but also encourages groundbreaking scientific advancements.

The Inspire Change Grant, presented by ConocoPhillips and Coca-Cola Southwest Beverages, is a key initiative of the Houston Texans Foundation, established to promote social justice and racial equity in Houston. Since its inception in 2021, the grant has supported local organizations in their efforts to dismantle systemic barriers and create opportunities for youth. By leveraging the influence of football, the Foundation aims to foster a more inclusive community and empower the next generation.

The Americana Foundation offers grants aimed at supporting sustainable agriculture and community food systems in Michigan. Founded by Adolph and Ginger Meyer, the foundation emphasizes the importance of agriculture in American history and seeks to connect communities to local food sources. Eligible applicants include nonprofit organizations and municipal entities, with a focus on projects that enhance food access and promote ecological sustainability. The foundation prioritizes initiatives that empower underserved communities and address climate resilience.

The George and Mary Josephine Hamman Foundation, established in 1954, supports education, arts, scientific projects, and religious advancement in Texas. With over $132.2 million awarded in grants and scholarships, it aids qualified 501(c)(3) organizations and institutions. The Foundation is dedicated to enhancing community welfare through various initiatives, including scholarships for students and funding for medical and research institutions. Its commitment to charitable causes has made a significant impact over its 70 years of service.

The Blackford County Community Foundation Grant Program offers funding to enhance community life through various projects. Areas of interest include community development, health services, education, and human services. Grants are competitive and prioritize significant projects that benefit many people. Applications are evaluated based on collaboration, financial support, and potential for future sustainability. Note that grants do not support profit-making enterprises, political activities, or sectarian purposes.

The Buena Vista County Community Foundation offers small grants to not-for-profit organizations in Buena Vista County for capital investment projects. Grants of $2,000 or less are available with no required match. Eligible projects include youth education, arts, environmental initiatives, health services, and community betterment. The Foundation encourages applications during its annual funding cycles, typically held in Spring and Fall, and prioritizes projects that enhance community investment.

The Louis Padovano Grants, awarded by The Lotos Foundation, support not-for-profit organizations in New York City that provide free arts and science programs to middle and high school students. These grants aim to nurture talented individuals across diverse fields such as dance, film, music, theater, visual arts, writing, and the sciences. Eligible organizations must be 501(c)(3) tax-exempt and have not received funding for the past three consecutive years.