Best Large Grants for Nonprofit Organizations

The Patricia Ann Emberg Charitable Trust Grant provides funding for educational programs in northeastern Minnesota and northwestern Wisconsin. Established in 2014, it focuses on supporting tax-exempt nonprofit and governmental vocational, technical, and trade school programs. The trust aims to enhance workforce development in key industries such as forestry and aircraft maintenance. Applications are accepted year-round, with a deadline of May 5 for consideration in the annual grant meeting.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5409 - Smarter Water Governance with AMI: Conservation, Affordability, and Rate Design

Grant Information

• Evaluate how utilities are currently leveraging advanced metering infrastructure (AMI) data to inform pricing, conservation programs (including emergency curtailment practices), affordability programs, and plans for future implementation.
• Analyze AMI data and assess how the data can be leveraged to develop and/or enhance conservation programs, policies, rates, and affordability programs.
• Investigate the potential for advanced analytics, including machine learning, of AMIdatasets to support adaptive or dynamic rate structures, early detection of hardship or atrisk households, categorization of customer classes, dynamic tiering based on household size, and better targeting of affordability and conservation interventions.
• Identify the obstacles utilities and regulators face when balancing conservation, equity, and revenue stability, and how improved AMI data can clarify tradeoffs.

The Takoma Foundation offers grants to enhance the social, environmental, and cultural vitality of Takoma Park. These grants, capped at $5,000 for small nonprofits and $1,000 for larger organizations, support initiatives in community connection, youth empowerment, anti-racism, and assistance for vulnerable populations. Eligible organizations must align with the Foundation's mission and primarily serve the Takoma Park area, ensuring equitable opportunities for all community members.

The Murphy Family Foundation, established in 1986, focuses on combating poverty in the greater Cleveland area. It primarily supports organizations that provide food, shelter, and educational services to the disadvantaged. The foundation's mission stems from a long-standing commitment by the Murphy family, who have been involved in manufacturing specialty chemical products for generations. While it has a strict policy on grantmaking, it may consider proposals outside its primary mission based on individual family interests.

Greater Toledo Community Foundation

Greater Toledo Community Foundation transforms generosity into lasting impact. With over $510 million in assets across 1,000+ funds, we've granted more than $370 million to strengthen education, health, arts, and social services throughout our region.

We connect donors with causes they care about while bringing together leaders, organizations, and resources to tackle our community's biggest challenges. What began with Walter E. Terhune's vision in the 1920s continues today as we help individuals, families, and businesses create positive change that will benefit our region for generations.

Healthy Aging Fund

The Community Foundation is funding programs that help older adults (60+) stay healthy, connected and independent.

This initiative follows the Ohio Department of Aging's State Plan, shaped with input from the Area Office on Aging of Northwestern Ohio. Priorities of the plan include cognitive health, chronic disease reduction, mental health, social inclusion, and nutrition access, plus engagement opportunities, physical activity, and preventive screenings. The plan is built on research and input from content-area experts.

The Foundation’s Focus

The Healthy Aging Fund is seeking proposals aligned with the State Plan and the Community Foundation's place-based priorities: programs that promote physical and mental health, reduce social isolation and strengthen community connections for older adults.

The Community Foundation seeks to identify collaborative approaches that work well enough to scale. This is a chance for northwest Ohio providers to test new approaches and collaborations: the kind with real potential to increase impact for participants and move the needle on broader community goals.

Funding Priorities

• Multiple partners with complementary expertise, prioritizing diversity of resources across agencies
• Programs delivered through or including senior centers, community centers or long-term care facilities
• Diverse programming that reaches more participants
• Accommodations for specific needs — memory care, vision loss, etc.
• An educational component

The Community Foundation is seeking cross-agency partnerships that expand access to diverse programming and have real potential to scale. Available for projects up to two years. See more in the Grant Guidelines. 

Hungry for Music

The Hungry for Music story began in 1992, when Founder and Director Jeff Campbell (in photo) organized a street musician concert to benefit the homeless. Within three years, he formed a 501(c)(3) nonprofit organization, dedicated to expanding opportunities in music for children.

Since then, Hungry for Music has placed more than 27,000 instruments into the hands of aspiring musicians. Children whose trajectory has been altered by the uplifting and life-changing gift of music.

We've delivered everything from guitars and trombones to violins and xylophones to kids in 50 states and 35 countries.

We collect and redistribute more than 2,000 instruments annually and, in our 31-year journey, we've become a full-time force for good in the musical community.

Request an Instrument

Hungry for Music collects and distributes instruments including brass, woodwinds, strings, electric keyboards, drums and other percussion, as well as amps and accessories.

Who Hungry for Music Helps

• Music teachers at Title One schools who identify children who cannot participate because of lack of funding.
• Music directors at innovative after-school music programs.
• Social workers who have young clients who would benefit from music therapy.

We only accept requests from public school music teachers, administrators, after-school/summer music program directors, and social workers. 

In our history, we have supported music programs in 40 different countries through stateside sponsors (i.e. business, school, church). We do not accept requests directly from international programs.

After-School & Summer Programs

Hungry for Music supports more than three dozen after-school/summer music programs annually across the United States. To be added to our distribution, a site visit is required.

The Fall Grant Cycle by the Community Foundation Serving Western Virginia supports organizations in Martinsville and surrounding areas that provide essential services to children, families, the elderly, and individuals with disabilities. This initiative focuses on enhancing health and quality of life through various charitable projects. Grants are awarded for specific purposes, typically not exceeding one year, and do not support deficit reduction or religious programs. This funding opportunity encourages impactful community engagement.

The Chartercare Wellness/Obesity Prevention/Nutrition Education Grant supports health initiatives in Rhode Island, offering up to $25,000 for programs aimed at enhancing wellness, nutrition education, and obesity prevention, particularly for disadvantaged groups. Eligible applicants are 501(c)(3) nonprofits in good standing. Proposals should detail program scope, patient impact, care improvement strategies, timely access to services, and outcome tracking methods. Preference is given to innovative solutions addressing critical needs.

The Winter Grant Cycle from the Thomas P. and Lewise S. Parsley Fund supports essential community initiatives in Western Virginia. Focused on providing prescription medications for the elderly and addressing substance abuse, the fund seeks to enhance the quality of life for financially needy individuals. Organizations in Martinsville, Roanoke, and surrounding counties are encouraged to apply, although the fund does not support deficit reduction or religious programs. This grant aims to foster impactful community outreach.

Impact San Antonio Grants empower nonprofit organizations in the region by providing funding for initiatives that focus on Arts & Culture, Education, Environment & Preservation, Family, and Health & Wellness. Since 2004, over $2.6 million has been awarded to impactful projects. Eligible applicants must be recognized 501(c)(3) organizations operating within designated Texas counties, ensuring a significant positive contribution to their communities.

The Community Foundation for Greater Atlanta is launching the 2025 Housing Stability Grant to support eviction prevention and services for individuals and families facing homelessness. Grants ranging from $20,000 to $50,000 will be awarded based on the applicant's needs and proposal quality. Emphasizing partnerships with community stakeholders, the foundation aims to promote safe and affordable housing in Clayton, Cobb, DeKalb, Fulton, and Gwinnett counties, enhancing overall community stability.

Disabled Veterans National Foundation

The Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability.

Guided by this commitment, DVNF developed its Health & Comfort programs, offering emergency financial assistance, housing transition support, food assistance, comfort kits, and wellness initiatives. These programs are designed to meet veterans where they are and to provide practical solutions that restore hope and stability. Today, DVNF continues to grow as a trusted national nonprofit. Every day, our team works with a clear purpose: to change lives for the men and women who have served our country.

Homeless To Housing Program - Financial Assistance

DVNF is dedicated to assisting disabled and at-risk veterans in their transition from homelessness to permanent housing. Recognizing that securing a home is a significant milestone, DVNF understands that true stability is achieved when a house becomes a home, furnished with essential items that provide comfort and functionality. We help cover essential costs related to securing and creating comfortable housing for at-risk veterans.

The H2H Program offers comprehensive support to veterans by providing: Financial Assistance of up to $2,000 to cover essential costs related to securing permanent housing, such as security deposits and initial rent payments.

For Financial Assistance: Payments are processed through two payment cycles each month, around the 15th and 30th. If your payment is delayed beyond the expected date, a Promissory Note of Payment will be issued to the vendor, confirming our organization's responsibility and requesting that no penalties be applied to the applicant.

The Barney Family Foundation Grant focuses on improving early education and advancing medical research, particularly in cancer and Alzheimer’s. It supports organizations that demonstrate a clear plan to enhance children's life experiences and educational opportunities for those in grades K-8. Grants typically range from $5,000 to $50,000, prioritizing established entities while welcoming startups. Eligible applicants must have 501(c)(3) status, and the Foundation does not fund individual requests or political activities.

The FY25-FY26 Advanced Transportation Technology and Innovation (ATTAIN) grant program aims to enhance transportation through the deployment of innovative technologies. It focuses on improving safety, mobility, and efficiency while fostering economic competitiveness. Projects funded will prioritize core infrastructure improvements and address roadway congestion, aligning with the Trump Administration's goals. The program emphasizes economic opportunities and community benefits, ensuring that selected projects contribute positively to families and communities, ultimately enhancing their quality of life.

The Rural Opioid Technical Assistance Centers program aims to provide essential training and technical assistance to combat opioid and stimulant misuse in rural areas. With 10 Regional Centers and a National Coordinating Office, the initiative focuses on high-quality prevention, treatment, and recovery support services for substance use disorders. This program anticipates awarding 11 new grants to enhance community health and safety in addressing polysubstance use challenges.

The Steve Stricker American Family Insurance Foundation Grant supports nonprofit organizations in south-central and southeastern Wisconsin that promote strong families and healthy children. Each August, eligible organizations can apply for funding to help empower youth to achieve their dreams. This initiative not only strengthens community ties but also fosters a healthier future for generations to come, with award notifications sent out in November.

The Cavaliers Community Foundation (CCF) is a charitable organization established in 1993 that supports local non-profits focused on youth development in Northeast Ohio. With over $25 million granted, CCF prioritizes programs that enhance education, health, and wellness for at-risk youth. Eligible organizations must be 501(c)(3) charities with a minimum of three years of operation. Grants typically average $10,000, aiming to foster community impact and support for young people.

The OR Feasibility Study Grants program, managed by the Oregon Water Resources Department, aims to support water conservation, reuse, and storage projects across the state. With around $750,000 available for the 2023-2024 funding cycle, eligible applicants include local governments and tribes. The funding is intended for studies assessing project feasibility, ensuring communities can effectively address their unique water challenges before proceeding with implementation.

The Saint Luke's Foundation Community Grant aims to enhance local health by providing financial support to residents in Buckeye – Shaker, Mt. Pleasant, and Woodland Hills. Grants of up to $6,000 are available for health-improving projects led by community members, such as community gardens and mentoring programs. The Resident Advancement Committee awards these grants from March to September annually, empowering local leaders to address health equity and foster positive change within their neighborhoods.

The Region Grants Open Grant Round: Community Vitality, supported by Land O'Lakes Foundation, aims to enhance the vibrancy of dairy communities in the East and West Regions. With a total investment of $500,000 annually, grants ranging from $1,000 to $20,000 are available for organizations focused on rural development, education, and community resources. Eligible applicants must have a 501c3 status and serve specific geographic areas, ensuring support reaches those in need.

The Cancer-Related Behavioral Health Fund, established by the HealthWell Foundation, provides financial assistance to individuals diagnosed with cancer for behavioral health treatments. This fund covers costs associated with prescription drugs, counseling services, and transportation. Aiming to alleviate financial burdens, it ensures that underinsured patients can access necessary care without delay. In 2024, the foundation awarded over $1.2 billion, emphasizing its commitment to improving health outcomes for cancer patients across the United States.

The BCF Community Grant, offered by the Barry Community Foundation, aims to enhance community welfare by connecting resources with needs. This grant supports nonprofit, educational, and governmental initiatives that foster sustainable change in Barry County. Prioritizing alignment with the Seven Elements of a Healthy Community, these grants address vital areas such as Arts and Culture, Basic Needs, and Health and Wellness. The foundation is committed to making a positive impact through strategic grantmaking.

The Adelaide Dawson Lynch Trust Grant, established in 1993 in memory of Adelaide Dawson Lynch, aims to support charitable organizations in Rhode Island providing essential food and shelter to economically disadvantaged citizens. Grants typically range from $1,000 to $5,000, with larger amounts available for special initiatives. Eligible applicants must serve the Rhode Island community, focusing on housing, shelter, and human services.

The Thalassemia Patient Incentive Award, sponsored by the Cooley’s Anemia Foundation, aims to support thalassemia patients in pursuing their educational and career aspirations. Awards ranging from $250 to $2,000 will be granted to students at various academic levels, with applications due in March 2026. This initiative not only encourages academic growth but also fosters a positive outlook among patients living with thalassemia, underscoring the Foundation's commitment to improving their quality of life.

The Educational Incentive Award Application by the Cooley’s Anemia Foundation aims to support children of individuals with severe thalassemia in pursuing their educational and career aspirations. With a total funding of $10,000 for the 2025-2026 school year, awards range from $500 for two-year programs to $1,000 for higher degree studies. Eligible applicants must be diagnosed with specific thalassemia types and provide necessary documentation, including a 250-word essay detailing their educational goals.

The Mid-Hudson Valley Designated Grants program, funded by the Dyson Foundation, supports nonprofit organizations in Columbia, Dutchess, Greene, Orange, Putnam, and Ulster counties. It focuses on addressing essential human needs like housing and healthcare for marginalized communities. Grants are available for specific purposes, including youth programs and economic development efforts, ensuring a direct impact on local communities and promoting equitable access to resources.

The Mother Cabrini Health Foundation's Basic Needs Grant Program aims to address the essential needs of New Yorkers facing challenges such as food insecurity, inadequate housing, and economic instability. This initiative supports organizations that provide access to social services, promote economic mobility, and ensure stable housing and nutrition for underserved communities. Grants of $75,000 or more are available for programs that align with the foundation's mission of fostering health and well-being in New York State.