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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

33,000+

Available grants

$8.25B

Total funding

$6K

Median grant

33,000+ grants
$8.25B total
$6K median

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32,600 Results based on applied filters

Drinking Water Source Protection Grant Program (OR)

Oregon Watershed Enhancement Board (OWEB)
State/Local Government
Oregon
Up to US $3,000,000
The Drinking Water Source Protection Grant Program (OR) provides crucial funding for public water suppliers to enhance, restore, or protect drinking water sources. Established by Oregon's HB 2010, this program allocates $5 million, with individual grants capped at $3 million, to support land acquisition and conservation efforts. It particularly focuses on serving rural and lower-income communities, ensuring access to clean water while promoting environmental stewardship and community health.
Water Resource Management Land / Habitat Conservation

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) (357604)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $475,000
This funding opportunity encourages applications for clinical observational studies focused on musculoskeletal, rheumatic, and skin diseases. It aims to gather essential data for designing future clinical studies, enhancing understanding of disease symptoms, progression, and patient outcomes. Observational studies supported by this initiative will contribute to the development of objective biomarkers and effective outcome measures. Applicants are invited to address key challenges in clinical project design, ensuring a robust foundation for subsequent clinical trials.
Musculoskeletal Diseases Neurological Diseases & Disorders Skin Diseases & Dermatology +1 more

Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required) (357602)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
The Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required) aim to support clinical trials that can be completed within a limited timeframe. This funding opportunity encourages a variety of exploratory studies that align with the NIAMS mission, focusing on interventions such as drugs, biologics, devices, and various therapies. Applications are due by 5:00 PM local time of the applicant organization.
Musculoskeletal Diseases Neurological Diseases & Disorders Skin Diseases & Dermatology +1 more

Goldberg, Joseph and Ruth, Scholarship

Beatrice Educational Foundation
Association/Society
United States
Unspecified amount
The Goldberg, Joseph and Ruth Scholarship, offered by the Beatrice Educational Foundation, aims to support students pursuing medical professions, such as nursing, dental, and physical therapy. Established in 1987, the Foundation provides over $55,000 annually in scholarships to Beatrice High School seniors. Eligible applicants must be in the top quarter of their class and complete the application independently. This scholarship is part of the Foundation's commitment to enhancing educational opportunities in the Beatrice School District.
Academic Scholarship Programs Education - Higher Education Medical Education & Professional Training +4 more

Equity Workforce Training Implementation Grants (MA)

Massachusetts Clean Energy Center (MassCEC)
State/Local Government
Massachusetts
Up to US $1,200,000
The Massachusetts Clean Energy Center (MassCEC) offers Equity Workforce Training Implementation Grants to enhance access to training for individuals from underrepresented communities. Grants of up to $1,200,000 are available over two to three years for projects that create career pathways in climate-critical occupations. Applicants can propose initiatives focused on employment training, pipeline preparedness for adult learners, or capacity planning for effective training programs, aiming to address existing barriers and foster employer engagement.
Workforce Preparation & Job Readiness Green Economy & Jobs Climate Change Resilience & Equity

Lifetime Contribution to the AAAAI and Allergy / Immunology Specialty Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The Lifetime Contribution to the AAAAI and Allergy/Immunology Specialty Award honors individuals who have made significant and enduring contributions to the AAAAI and the allergy/immunology field. Awardees are recognized for exemplary service, leadership in professional organizations, impactful research, and mentorship of trainees. This prestigious accolade underscores the recipient's dedication to advancing the specialty and improving patient care, emphasizing the importance of community engagement and leadership in the field.
Immune System Diseases Allergies & Allergic Diseases Asthma

CFNV: Environment Fund

The Community Foundation for Northern Virginia
Private
Alexandria City, Virginia, Arlington County, Virginia +7 more
US $5,000 - US $20,000
The Environment Fund, launched in 2018 by The Community Foundation for Northern Virginia, aims to protect and enhance the natural environment of Northern Virginia. It fosters collaboration among nonprofits, businesses, and educational institutions to promote awareness and citizen engagement in environmental protection. In 2025, funding will support nonprofit organizations providing educational programs in conservation, energy efficiency, sustainability, watershed management, and workforce climate initiatives, specifically targeting areas within Arlington, Fairfax, Loudoun, and Prince William Counties.
Environmental Conservation Environmental Health Natural Resources +3 more

Artists & Scholars Project Grant

Arts and Humanities Council of Montgomery County
Private
Montgomery County, Maryland
US $1,000 - US $5,000
The Artists & Scholars Project Grant supports individual artists and scholars residing in Montgomery County, MD, for projects in diverse arts and humanities disciplines. Aimed at fostering creativity and enhancing skills, the grant encourages innovative work that reflects the multicultural essence of the community. By promoting strategies for Diversity, Equity, Inclusion, and Access (DEIA), the Arts & Humanities Council of Montgomery County aims to nurture talent and support distinctive artistic endeavors between May 1, 2026, and April 30, 2027.
History Writing & Literature Philosophy +7 more

Lead Service Line Inventory Grant Program

Illinois Department of Environmental Protection
State/Local Government
Illinois
US $20,000 - US $50,000
The Lead Service Line Inventory Grant Program offers funding to local government units for creating a comprehensive lead service line inventory as mandated by Illinois law. Eligible applicants can receive between $20,000 and $50,000, with applications reviewed on a first-come, first-served basis until funds are exhausted. Additional financial support may be sought through low-interest loans for line replacements. Reporting requirements include quarterly updates and annual financial evaluations, ensuring transparency and accountability in project progress.
Sanitation & Clean Drinking Water Water Resource Management

Implementing Gatekeeper Training within the Illinois Department of Corrections and Juvenile Detention Centers in Disproportionately Affected Communities

Illinois Department of Public Health
State/Local Government
Illinois
Approximately US $168,903
This grant opportunity focuses on implementing Gatekeeper Training in Illinois' correctional facilities to address suicide prevention in communities that are disproportionately affected by mental health issues. The initiative aims to enhance public health strategies aligned with the Illinois Suicide Prevention Strategic Plan 2020. By training gatekeepers, the program seeks to mitigate suicide risks and improve outcomes in vulnerable populations, contributing to a comprehensive approach to mental health support.
Suicide Prevention Correctional Systems & Prisons

NIHCM: Research Grants

The National Institute for Health Care Management
Private
United States
US $50,000 - US $60,000
The NIHCM Foundation is seeking innovative research proposals that address critical issues in U.S. health care, particularly focusing on drug pricing, provider consolidation, health care delivery, chronic disease management, and the role of artificial intelligence. Projects should aim to improve affordability and quality of care. We welcome submissions from a variety of researchers and organizations, with a preference for studies that can be completed within one year.
Health Policy & Advocacy Health Care Access & Delivery Health Disparities & Social Determinants of Health +4 more

Evolve Houston’s eMobility Grants

Evolve Houston
Private
Austin County, Texas, Brazoria County, Texas +7 more
Up to US $15,000
Evolve Houston’s eMobility Grants offer vital funding to community leaders and organizations, enabling them to launch innovative projects that enhance access to clean transportation in underserved neighborhoods. With grants up to $15,000, these initiatives focus on electric mobility solutions, including infrastructure development, education, and workforce training. Since 2022, Evolve Houston has supported over 50 community-led projects, continuing its mission to create a cleaner, more connected Houston through sustainable mobility options.
Electrification Workforce Preparation & Job Readiness Public Transportation & Mass Transit Systems +1 more

Montana DNRC: Hazardous Fuels Reduction Grant Program

Montana Department of Natural Resources & Conservation
State/Local Government
Montana
Up to US $100,000
The Montana DNRC Hazardous Fuels Reduction Grant Program aims to mitigate the risk of wildland fires and protect communities in high-priority areas adjacent to National Forest System lands. Funded by USFS resources, this program supports projects that reduce hazardous fuels through various methods like thinning and burning. Eligible applicants include non-profits, local governments, and tribal entities. Projects must align geographically and be initiated within three years of planned USFS treatments, ensuring community safety and environmental stewardship.
Waste Management Firefighting & Fire Prevention Fire Ecology

Max W. Johnson Scholarship

Montgomery County Community Foundation Inc.
Private
Tippecanoe County, Indiana
Unspecified amount
The Max W. Johnson Scholarship, established by Max Johnson, supports students from Montgomery County, Indiana, enrolled in the Purdue University College of Agriculture. This educational scholarship recognizes achievements in soil and water conservation practices. The award is renewable for up to four years and covers tuition only. Eligible applicants must be graduates from local high schools and demonstrate a commitment to conservation efforts, enhancing the importance of sustainability in agriculture.
Academic Scholarship Programs Education - Higher Education College Success / Persistence +3 more

Robert and Joan Dircks Foundation Grant Program

Robert & Joan Dircks Foundation
Private
United States
US $1,000 - US $15,000
The Robert and Joan Dircks Foundation Grant Program supports non-profit organizations in New Jersey that provide opportunities for disadvantaged individuals. With grants ranging from $1,000 to $15,000, the foundation focuses on innovative programs that solve critical issues rather than operational needs. Eligible organizations must be tax-exempt under section 501(c)(3) of the Internal Revenue Code. The foundation does not fund political activities, cultural projects, or operating budgets, ensuring resources directly benefit those in need.
Children With Disabilities Poverty Alleviation & Services Disability Care & Services +3 more

Knight Fund Grant Program

Community Foundation of Grand Forks, East Grand Forks, and Region
Private
Grand Forks County, North Dakota
Unspecified amount
The Knight Fund Grant Program, managed by the Community Foundation of Grand Forks, aims to enhance connections between the University of North Dakota and the Downtown area through the University Avenue Corridor. This initiative focuses on improving community engagement, enhancing public spaces, and building on local assets to foster economic mobility and entrepreneurship. The fund specifically targets projects that unite diverse communities and support civic infrastructure, while excluding certain non-program expenses and individual applications.
Entrepreneurship Economic Services & Development Civic Affairs +4 more

NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed) (357995)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement invites applications for multi-center observational studies targeting high-risk diseases relevant to NIDDK's mission. The program encourages hypothesis-driven research involving multiple clinical centers. Key deadlines for application submissions are set for February, June, and October of 2025 and 2026. It is advised to consult with NIDDK staff prior to application submission to ensure alignment with grant expectations.
Diabetes Kidney Diseases Digestive System Health & Diseases

Physician of Tomorrow Scholarships: Lazarus Family Scholarship in Bioethics and Humanities

American Medical Association Foundation
Private
United States
US $10,000
The Lazarus Family Scholarship in Bioethics and Humanities, offered by the AMA Foundation, supports students engaged in bioethics or the humanities, including art, music, and literature. This scholarship aims to foster the next generation of physician leaders by providing financial assistance to those who are committed to advancing health equity and community service. By recognizing diverse fields of study, it emphasizes the importance of interdisciplinary approaches in medicine and the humanities.
Medical Ethics Music Theater +4 more

Arts in Rural Places Grant

South Arts, Inc.
Private
Alabama, Florida +7 more
Up to US $3,000
The Arts in Rural Places Grant, offered by South Arts, aims to enhance access to the arts in rural and isolated communities across nine southern states. Grants of up to $3,000 support public activities featuring Southern artists, requiring a dollar-for-dollar cash match. Eligible organizations must host at least two public events and engage a professional artist, promoting cultural engagement and artistic expression within these communities.
Writing & Literature Performing Arts Film +5 more

Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional) (358116)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $150,000
The Limited Competition Small Grant Program for NIDDK K01/K08/K23/K25 recipients offers funding opportunities for pilot studies and feasibility research. This program aims to support researchers transitioning to independent investigator roles by providing resources for small projects that can yield preliminary data for future R01 applications. Key deadlines for applications range from February 2025 through January 2028, with specific dates for standard, renewal, and AIDS-related applications.
Diabetes Kidney Diseases Digestive System Health & Diseases

Potts And Sibley Foundation Grant

Potts And Sibley Foundation
Private
Texas
Unspecified amount
The Potts and Sibley Foundation, established in 1967 by Effie Potts Sibley in memory of her husband, D.J. Sibley, is a private charitable foundation based in Midland, Texas. It provides grants to various charitable organizations, focusing on healthcare, food banks, mental health services, and support for the needy. The foundation aims to enhance the welfare of the community through initiatives in conservation education, domestic violence assistance, and senior programs.
Food Access & Hunger Mental Health & Psychiatric Diseases Supportive Housing & Shelters +2 more

Baseline Water Quality Data Grant Program

Pennsylvania Department of Community and Economic Development
State/Local Government
Pennsylvania
Up to US $250,000
The Baseline Water Quality Data Grant Program, established under Act 13 of 2012, aims to fund initiatives by the Commonwealth Financing Authority to collect and analyze baseline water quality data from private water supplies. Grants up to $250,000 are available, requiring a 15% match of the total project cost. This program seeks to improve understanding of groundwater quality conditions and enhance water resource management across Pennsylvania.
Sanitation & Clean Drinking Water Water Resource Management

Homelessness Solutions Program (HSP)

Maryland Department of Housing and Community Development
State/Local Government
Maryland
US $300,000 - US $4,200,000
The Homelessness Solutions Program (HSP) administered by Maryland's Department of Housing and Community Development aims to prevent and end homelessness by providing over $15 million annually to local Continuums of Care. HSP prioritizes funding to projects that divert at-risk households from homelessness, connect individuals to mainstream benefits and housing, serve vulnerable populations, implement evidence-based practices, and ensure equitable service delivery.
Homelessness Services Equitable & Affordable Housing Supportive Housing & Shelters

Proposition 68 Fish and Wildlife Improvement Grant Opportunities – Fish and Wildlife Improvement Grants

California Department of Fish and Wildlife
State/Local Government
California
Up to US $30,000,000
The Proposition 68 Fish and Wildlife Improvement Grant aims to enhance the resilience of communities against climate change impacts while improving fish and wildlife habitats. Funded by the California Department of Fish and Wildlife, these grants support projects that protect coastal and rural economies, promote agricultural viability, and develop recreational opportunities. Key objectives include improving water retention and landscape resilience, ensuring the sustainability of vital ecosystems across California.
Wildlife Management Freshwater Conservation Wildlife Health +1 more

Senior Citizens Grants - Wellness Grants

Pinellas Community Foundation
Private
Pinellas County, Florida
Unspecified amount
The Senior Citizen Services Grants, established by Senior Citizens Services, Inc. at the Pinellas Community Foundation, aim to support wellness programs for residents aged 55 and older in Pinellas County. Eligible organizations can request funding for services such as mental health counseling, adult day care, and caregiver support. Emphasizing competitive funding, these grants prioritize projects that directly benefit the senior population, enhancing their quality of life through various wellness initiatives.
Senior Services Wellness & Healthy Living Nutrition & Healthy Eating +2 more

Friends of Reservoirs: Mossback Grant

Friends of Reservoirs
Private
United States
US $1,000
The Friends of Reservoirs: Mossback Grant offers three grants of $1,000 in Mossback products to eligible members of Friends of Reservoirs organizations. Sponsored by Mossback Fish Habitat, these grants aim to enhance structural habitat in public waters. The total retail value is approximately $1,500. Applicants must cover freight costs, and a $25 application fee applies to each submission. This initiative supports habitat restoration efforts across member organizations.
Habitat & Ecosystem Restoration Fisheries Freshwater Conservation

Bass Pro Shops Large Grant

Friends of Reservoirs
Private
United States
Up to US $100,000
The Friends of Reservoirs: Large Grant supports fish habitat enhancement projects in manmade reservoirs, promoting conservation and partnerships. With approximately $250,000 in Federal funding and $500,000 from Bass Pro Shops, grants up to $75,000 are available. Projects must match funding and can be multi-year, with specific caps on subsequent funding. This initiative aims to address habitat impairments and enrich community quality of life through improved fishing opportunities.
Habitat & Ecosystem Restoration Fisheries Freshwater Conservation +1 more

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.