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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

33,000+

Available grants

$8.25B

Total funding

$6K

Median grant

33,000+ grants
$8.25B total
$6K median

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32,600 Results based on applied filters

Dell Scholars Program

Michael & Susan Dell Foundation
Private
United States
Unspecified amount
The Dell Scholars Program, established by the Michael & Susan Dell Foundation, provides scholarships and support to empower students in their journey towards college graduation. It offers flexible funding for tuition, housing, and essential expenses, ensuring students can focus on their education. Alongside financial aid, scholars receive academic coaching, career guidance, and mental health resources, fostering resilience and success. Since 2004, it has helped over 6,000 scholars, including 4,500 graduates, achieve their academic goals.
Mental Health & Psychiatric Diseases Career / College Preparation Financial Literacy +3 more

Rob Schorling Memorial Fund

Greater Salina Community Foundation
Private
Saline County, Kansas
Up to US $2,000
The Rob Schorling Fund, managed by the Greater Salina Community Foundation, offers financial support for individuals and families facing expenses related to leukemia and lymphoma treatments. This fund aims to alleviate the burden of medical costs and travel for residents within a 25-mile radius of Saline County, Kansas. Grants are awarded on a first-come, first-served basis, ensuring timely assistance for those in need.
Lymphoma Leukemia Organ And Tissue Banks

Tri-City Community Foundation Grant

Community Foundation of South Alabama
Private
Baldwin County, Alabama, Colbert County, Alabama
Up to US $25,100
The Tri-City Community Foundation Grant aims to enhance the quality of life in Foley, Gulf Shores, and Orange Beach by funding local nonprofits. Established in 2018, this grant supports initiatives in arts, mental health, education, and economic opportunity. Eligible organizations must be IRS-recognized 501(c)(3) entities serving the Tri-City community. The Foundation prioritizes proposals that demonstrate community support and articulate measurable outcomes, with a total of $25,100 available for the grant cycle.
Art & Culture Education Mental Health & Psychiatric Diseases +4 more

Nonpoint Source Program - Municipal Sewer Connections Grants

Montana Department of Natural Resources & Conservation
State/Local Government
Montana
Up to US $100,000
The Municipal Sewer Connections Grants, offered by the Montana Department of Natural Resources & Conservation, aim to protect water resources by funding projects that facilitate the transition from individual septic systems to municipal sewer connections. This program, which operates on a first-come, first-served basis, is designed to alleviate the financial burden of such transitions for homeowners, thereby promoting improved water quality and sustainability in Montana.
Freshwater Conservation Waste Management Sanitation & Clean Drinking Water +1 more

Project Bread: School Breakfast Grant Program

Project Bread - The Walk for Hunger Inc.
Private
Massachusetts
Unspecified amount
Project Bread's School Breakfast Grant Program aims to ensure that all students in Massachusetts have access to nutritious meals through innovative breakfast solutions. By starting or expanding programs like Breakfast After the Bell, schools can significantly increase breakfast participation. The program provides essential support and resources to help schools assess their needs and implement effective strategies for enhancing breakfast accessibility, ultimately fostering a healthier school community.
Food Delivery & Distribution Services Food Access & Hunger Food Security

Lundbeck US Charitable Fund: Charitable Donations

Lundbeck Us Charitable Fund
Private
United States
Unspecified amount
The Lundbeck US Charitable Fund focuses on enhancing brain health through impactful donations. Established to support organizations dedicated to brain health, it addresses pressing needs by funding innovative strategies and community collaborations, particularly for at-risk populations. The Fund aims to transform lives and improve mental health care, with a commitment to responsible giving. With over 20 organizations supported in 2023, it drives meaningful change in communities affected by brain disorders.
Neurological Diseases & Disorders Mental Health & Psychiatric Diseases Cognitive Intervention & Therapy +4 more

Lundbeck US Charitable Fund: Sponsorships

Lundbeck Us Charitable Fund
Private
United States
Unspecified amount
The Lundbeck US Charitable Fund focuses on enhancing brain health through sponsorships that support various initiatives. These sponsorships are available to both non-profit and for-profit organizations, provided they align with Lundbeck's mission. Funds are primarily allocated for educational or awareness events, with an emphasis on community outreach and collaboration to address gaps in care, especially for vulnerable populations. By fostering innovative strategies, the Fund aims to drive meaningful change in the field of brain health.
Military & Veterans Services Cognitive Science Neuroscience +4 more

David J. Morafka Memorial Research Award

Desert Tortoise Council
Private
Clark County, Nevada, Esmeralda County, Nevada +21 more
US $3,000
The David J. Morafka Memorial Research Award, established by the Desert Tortoise Council, offers $2,500 to support research on gopher tortoise species in the southwestern U.S. and Mexico. This award honors Dr. David J. Morafka's contributions to herpetology. Applicants must be affiliated with recognized institutions and present their findings at a Desert Tortoise Council symposium. Evaluation criteria include research significance, originality, and feasibility, ensuring impactful conservation efforts.
Herpetology Herpetological Conservation

Mumford & Keller Grant and Scholarship Program

Indiana Audubon Society Inc.
Private
United States
US $500 - US $5,000
The Mumford & Keller Grant and Scholarship Program, initiated by Indiana Audubon in 2010, offers financial support for projects focusing on natural resources and Indiana's birdlife. With grants ranging from $500 to $5,000, it aims to promote conservation, research, and education. Priority is given to initiatives targeting key species and habitats within Indiana. This program honors the legacy of Russell Mumford and Charles Keller, enhancing bird conservation efforts for future generations.
Ornithology Ornithological Conservation

Social & Economic Mobility Grant

Community Foundation of Broward
Private
Broward County, Florida
Unspecified amount
The Social & Economic Mobility Grant, offered by the Community Foundation of Broward, supports 501(c)(3) nonprofits providing services in Broward County. Eligible organizations must have a Gold Seal of Transparency from Candid. Grants are awarded twice a year across four focus areas, including Social & Economic Mobility. Specific areas, such as Strong Nonprofit Community, accept applications by invitation only. Detailed eligibility criteria can be found in the Focus Area Grant Guide.
Economic Services & Development Workforce Preparation & Job Readiness Entrepreneurship +2 more

Nesting Bird Habitat Incentive Program Public Lands Funding

California Department of Fish and Wildlife
State/Local Government
California
Up to US $850,000
The Nesting Bird Habitat Incentive Program (NBHIP) supports the restoration and maintenance of habitats for nesting waterfowl and game birds on public lands. Established in 2018, it is funded through hunting validation fees, generating approximately $2 million annually. For FY 2025-26, up to $850,000 is allocated for habitat projects, divided into maintenance of existing perennial grass ($150,000) and restoration/enhancement of habitats ($700,000), promoting biodiversity and ecological health.
Ornithology Ornithological Conservation

Large PWS Lead Service Line Inventory Grant

New Hampshire Department of Environmental Services
State/Local Government
New Hampshire
Up to US $60,000
The New Hampshire Department of Environmental Services has launched the Large PWS Lead Service Line Inventory Grant program to assist water systems with over 1,000 service connections in identifying service lines marked as 'unknown'. This initiative is part of compliance with the EPA Lead Copper Rule Improvements, requiring annual service line inventories. Grants of up to $60,000 are available, with no community match required, to facilitate the identification and replacement planning of lead service lines.
Sanitation & Clean Drinking Water Water Resource Management

Research and Development Grant Program

Ohio Water Development Authority (OWDA)
State/Local Government
Ohio
US $200,000
The Research and Development Grant Program by the Ohio Water Development Authority (OWDA) supports innovative projects in wastewater, water management, solid waste, and energy resource development. Eligible applicants include local government agencies and higher education institutions. Priority is given to proposals that enhance water quality, technology, equity, and resilience. Grants are contingent upon available funding, and applicants are advised to review the Participation Agreement before applying.
Waste Management Green Infrastructure Sanitation & Clean Drinking Water

Community-Drive Outreach for Hypertension Management and Diabetes Prevention Short Term Project Funding Opportunity

State of Rhode Island Department of Health
State/Local Government
Providence County, Rhode Island
Up to US $4,999
The Rhode Island Department of Health is offering a Short-Term Project Funding Opportunity aimed at promoting hypertension management and diabetes prevention in Providence communities. Eligible organizations can apply for up to $4,999 to create culturally relevant outreach events and materials that encourage the use of preventive health services. This initiative emphasizes community engagement, aiming to address social determinants of health through effective messaging and resource navigation, with project activities expected to run from April to August 2025.
Cardiovascular Diseases & Systems Diabetes Preventative Healthcare +1 more

Development of Medications to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional) (358937)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $3,000,000
This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.
Pharmacology Addiction & Substance Use Disorders Drug Use Disorder

Knight Foundation Advised Fund

Central Carolina Community Foundation
Private
Richland County, South Carolina
Unspecified amount
The Knight Foundation Advised Fund supports innovative projects that enhance democracy and community engagement in Columbia, SC. With grant amounts typically not exceeding $75,000, it focuses on revitalizing downtown areas and riverfront development. Eligible organizations must be 501(c)(3) charities or similar entities serving Columbia or Richland County. The foundation prioritizes civic engagement, smart design, and the arts to foster inclusive public life, while avoiding funding for debt reduction, capital campaigns, or projects with discriminatory practices.
Civic Engagement & Education Parks & Public Spaces Community Development & Revitalization +7 more

MCAN: Innovative Program Grants

Michigan College Access Network
Private
Michigan
Up to US $10,000
The Michigan College Access Network (MCAN) offers Innovative Program Grants to enhance college readiness and completion among low-income and first-generation students across Michigan. Grants of up to $10,000 are available to support innovative initiatives that align with MCAN's goal of increasing postsecondary attainment to 60% by 2030. Applicants are encouraged to partner with Local College Access Networks, ensuring a comprehensive approach to community-based educational support.
Career / College Preparation College Success / Persistence Education - K through 12 +2 more

RFA- Lead-Safe Homes Program- for a Lead Hazard Reduction

Wisconsin Department of Health Services
State/Local Government
Wisconsin
Unspecified amount
The Lead-Safe Homes Program (LSHP) invites local partner organizations to apply for grant funding aimed at reducing lead hazards in homes across Wisconsin. With up to $4 million available from October 1, 2025, to September 30, 2026, the program seeks to protect children and pregnant women eligible for Medicaid or BadgerCare. Organizations will be selected based on their ability to coordinate and execute lead hazard reduction efforts, ensuring safe environments for vulnerable populations.
Equitable & Affordable Housing Patient Safety Health Disparities & Social Determinants of Health

Eastern Illinois Foodbank Partnerships

Eastern Illinois Foodbank
Private
Champaign County, Illinois, Clark County, Illinois +15 more
Unspecified amount in in-kind support
Eastern Illinois Foodbank seeks to enhance its network of partner agencies dedicated to alleviating hunger. Organizations must be located within a specified 18-county area and possess 501(c)(3) tax-exempt status, or align with a qualifying umbrella organization. Partners are expected to maintain secure food storage, establish a budget for operational costs, and utilize the Link2Feed electronic system for record-keeping. This initiative ensures effective resource distribution and supports community members in need.
Food Delivery & Distribution Services Food Access & Hunger Food Security

RFA- Lead-Safe Homes Program- for a Program Administrative

Wisconsin Department of Health Services
State/Local Government
Wisconsin
Unspecified amount
The Lead-Safe Homes Program (LSHP), managed by the Wisconsin Department of Health Services, is offering grant opportunities to ensure homes are lead-safe for children, starting from October 1, 2025, to September 30, 2026. This initiative aims to partner with local organizations to provide lead hazard reduction services for Medicaid-eligible children and pregnant women. With up to $5 million available, multiple grants may be awarded to enhance children's health and safety across Wisconsin.
Equitable & Affordable Housing Residential Care & Nursing Homes Patient Safety

Housing Justice Program Fellowship

Equal Justice Works
Private
Maryland, South Carolina +1 more
Unspecified amount
The Housing Justice Program Fellowship, offered by Equal Justice Works, addresses the urgent need for legal assistance among low-income individuals facing housing instability in Virginia, South Carolina, and Maryland. This two-year fellowship provides legal and organizational training, networking opportunities, and essential support for fellows dedicated to combating eviction and promoting housing justice. Ideal candidates possess strong communication skills and a commitment to community advocacy, making a significant impact in the lives of those at risk of displacement.
Homeownership Equitable & Affordable Housing Economic Rights, Justice, & Mobility +1 more

Aerie Real Foundation: Community Grant

The Aerie Real Foundation
Corporate
Canada, United States
Up to US $10,000
The Aerie Real Foundation™ Community Grant aims to enhance confidence, inclusion, and sustainability among young women while supporting non-profit organizations in the US and Canada. Grants of up to $10,000 are available to programs focused on mental well-being, fostering inclusive communities, and environmental protection. Applications are accepted from certified 501c3 nonprofits, with funding allocated for projects that align with the Foundation's mission. The goal is to empower the next generation and create a positive impact in local communities.
Women & Girl Services Environmental Conservation Environmental Stewardship +2 more

THCF: Community Grants - Wildlife Conservation

Truman Heartland Community Foundation
Private
Missouri
US $5,000 - US $10,000
The THCF: Community Grants for Wildlife Conservation supports initiatives across Missouri, encouraging proposals that enhance regional wildlife efforts. Starting in 2024, organizations can apply for funding for up to three consecutive years, promoting sustainability and impactful conservation projects. Eligible applicants include nonprofits dedicated to improving wildlife habitats and conservation strategies. This program aims to foster collaboration and maximize funding impacts to benefit the local ecosystem and communities throughout the state.
Wildlife Health Wildlife Management Wildlife Trafficking

Friends of the Drug Treatment Court Fund

Berks County Community Foundation
Private
Berks County, Pennsylvania
Unspecified amount
The Friends of the Drug Treatment Court Fund and Berks County Veterans Treatment Court provide essential financial support to participants in Berks County's treatment courts, enhancing their chances of program graduation. Assistance is directed towards participants facing uncovered expenses, ensuring resources for their rehabilitation journey. The fund also supports staff training and other court-related needs as identified by judges overseeing these programs. Submissions are accepted from January 1 to December 31, 2025, focusing on impactful community support.
Drug Use Disorder Reentry Services Military & Veterans Services

Forecast to Publish a Funding Opportunity Announcement for Copy of Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia Research Resource (U24) (Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA) aims to renew support for two research consortia focusing on the biological mechanisms of excessive alcohol consumption and Alcohol Use Disorder (AUD). By utilizing advanced technologies and fostering collaboration across multiple sites, this initiative seeks to standardize neurofunctional measures and enhance reproducibility in findings. Investigators are encouraged to prepare for future applications to this NOFO, which will utilize the U24 activity code.
Neuroscience Alcoholism

Schrafft Charitable Trust Grants for Returning Grantees (Youth Development)

William E Schrafft & Bertha E Schrafft Charitable Trust
Private
Bristol County, Massachusetts, Suffolk County, Massachusetts
Unspecified amount
The Schrafft Charitable Trust focuses on the growth of underserved youth (ages 6-21) through neighborhood-based education and economic independence programs in Boston and New Bedford. Eligible nonprofits can apply for Program or General Operating Grants, emphasizing community representation and impactful youth development initiatives. Returning grantees from the past three years may submit a full proposal directly. The Trust does not fund capital expenditures or scholarships, ensuring resources are directed towards meaningful educational opportunities.
After School / Summer Educational Programs Youth Development & Leadership Youth Services +3 more

Vegas Golden Knights Foundation Grant

Vegas Golden Knights Foundation Inc
Private
Clark County, Nevada
Up to US $20,000
The Vegas Golden Knights Foundation Grant supports local non-profits in Las Vegas, focusing on health and wellness, education, youth sports, and military and first responders. As a 501(c)(3) organization, it aims to make a sustainable impact through community programming and direct grants, awarding up to $20,000 per grant cycle. Eligible organizations must be qualified 501(c)(3) entities and may only submit one application per cycle, ensuring focused support for community-driven initiatives.
Education - K through 12 Youth Services Sports & Athletics +5 more

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.