Upcoming Webinar
Instrumentl Fall Launch: Grant Work, Leveled Up.
Thu, Oct 29 or Wed, Nov 4 @ 2PM ET

Skip to main content
Main content

Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

33,000+

Available grants

$8.25B

Total funding

$6K

Median grant

33,000+ grants
$8.25B total
$6K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

32,600 Results based on applied filters

Massachusetts Food Ventures Program

Massachusetts Department of Agricultural Resources (MDAR)
State/Local Government
Massachusetts
US $25,000 - US $250,000
The Massachusetts Food Ventures Program (MFVP) aims to enhance access to healthy, affordable food and bolster economic opportunities for low to moderate income communities. By providing grants for food ventures in areas like Gateway Cities and rural regions, MFVP supports local agricultural enterprises and aligns with the Massachusetts Local Food Action Plan. Key investment areas include food processing infrastructure and improved distribution systems, ensuring equitable access to fresh local food and promoting healthy eating.
Food Access & Hunger Food Delivery & Distribution Services Food Security

Senior Citizens Housing of Ann Arbor (SCHAA) Grant Program

Ann Arbor Area Community Foundation
Private
Washtenaw County, Michigan
Unspecified amount
The Senior Citizens Housing of Ann Arbor (SCHAA) Grant Program, established by the Ann Arbor Area Community Foundation, aims to support organizations and programs that assist older adults and their caregivers. For 2025, the focus will be on technology and transportation initiatives within Washtenaw County. This program reflects the foundation's commitment to community empowerment, equity, and collaboration, ensuring that all residents have access to vital resources and support.
Senior Services Aging / Gerontology Health Disparities & Social Determinants of Health +2 more

Science Policy Fellowship

American Chemical Society
Association/Society
United States
Unspecified amount
The Science Policy Fellowship, offered by the American Chemical Society, provides a unique opportunity for trained scientists to engage in public policy. This program enhances understanding of the policy-making process, allowing Fellows to work alongside experienced Government Affairs staff. The Fellowship focuses on key areas such as federal research funding, education in STEM, and environmental policies. Candidates with a strong background in chemical sciences or engineering are encouraged to apply, regardless of holding a doctorate.
Environmental Chemistry & Toxicology Environmental Justice & Advocacy Environmental Policy

John Muir Community Health Fund (CHF) Grant

John Muir Health
Private
Contra Costa County, California
Unspecified amount
The John Muir Community Health Fund (CHF) Grant focuses on enhancing health care access for underserved populations in Central and East Contra Costa County. As part of John Muir Health's commitment to improving community well-being, the CHF provides financial support to nonprofit organizations addressing critical health needs. By fostering innovative health initiatives and filling service gaps, the grant aims to create lasting health improvements and ensure equitable care for vulnerable groups.
Workforce Preparation & Job Readiness Nutrition & Healthy Eating Health Care Access & Delivery +2 more

Loretta Morris Memorial Grants

BreatheStrong CF
Association/Society
United States
Up to US $750
The Loretta Morris Memorial Grants support individuals with cystic fibrosis in California who wish to engage in physical activities such as swimming, horseback riding, dance, or golf. Established in memory of Loretta Morris, this fund aims to help recipients enjoy the benefits of an active lifestyle. Applications are welcomed from both children and adults, promoting inclusivity and well-being within the CF community. Note that certain items, like memberships or accessories, are not eligible for funding.
Dance Cystic Fibrosis Swimming +2 more

Dr. John M. Anderson Excellence in Mental Health Award - Community Mental Health Provider (MO)

St. Louis County Children's Service Fund
Private
Bond County, Illinois, Calhoun County, Illinois +13 more
Unspecified amount
The Dr. John M. Anderson Excellence in Mental Health Award recognizes outstanding mental health professionals in the St. Louis area who significantly contribute to reducing stigma and promoting mental health in the African American community. This award, presented by the St. Louis County Children’s Service Fund, honors individuals who demonstrate a commitment to improving access to mental health services and advocate for the well-being of children and families. Nominations are evaluated through a rigorous scoring process.
Black American Services Health Disparities & Social Determinants of Health Children’s Mental Health +1 more

Adaptive IPM For Invasive Agricultural Pests RFP

California Department of Food & Agriculture
State/Local Government
California
Up to US $500,000
The California Department of Food and Agriculture is inviting proposals for the Adaptive IPM for Invasive Agricultural Pests grant program. This initiative aims to develop integrated pest management strategies that can be implemented swiftly when new invasive pests threaten California's agriculture. With $500,000 available for one award, the program seeks to enhance existing IPM strategies and explore new control measures to combat pesticide resistance and ensure a sustainable agricultural environment.
Insect Pest Control Agricultural Pest Management

Training Program in Neurodevelopmental Disabilities

The Childrens Hospital Of Philadelphia
Private
Pennsylvania
Unspecified amount
The Training Program in Neurodevelopmental Disabilities at The Children's Hospital of Philadelphia Research Institute offers advanced training for individuals pursuing careers in neuroscience and neurodevelopmental research. Established in 1998, it emphasizes the understanding of disabilities linked to chromosomal defects and trauma. Trainees engage in hands-on research, develop critical skills, and collaborate with esteemed scientists, aiming to become leaders in their field. The program actively encourages applications from underrepresented minority groups to foster diversity in scientific research.
Neuroscience Neurological Diseases & Disorders Learning Disabilities +3 more

Mayer and Morris Kaplan Foundation Environment Grant

Mayer And Morris Kaplan Foundation
Private
United States
Unspecified amount
The Mayer and Morris Kaplan Foundation Environment Grant aims to support initiatives that combat climate change, prioritizing efforts to reduce fossil fuel consumption and enhance climate education for young adults. The foundation emphasizes innovative solutions and partnerships to address both immediate and long-term environmental challenges. Areas of focus include climate and clean energy policy, as well as providing scientifically accurate climate change education. By leveraging data and research, the foundation seeks to empower organizations dedicated to creating impactful change.
Climate Change Resilience & Equity Environmental Contamination & Pollution Green Infrastructure

Foundation for Health Equity (f4HE): Food Insecurity Grant

Foundation for Health Equity
Private
Philadelphia County, Pennsylvania
Unspecified amount
The Foundation for Health Equity (F4HE) focuses on combating food insecurity in Northwest Philadelphia by supporting tax-exempt organizations. Grants aim to address immediate needs and systemic inequities, funding programs that provide food assistance and promote healthy aging. F4HE prioritizes nonprofits that exemplify both direct service and systemic change, ensuring a fair opportunity for all community members to achieve optimal health. This initiative seeks to empower local organizations and enhance community resilience against hunger.
Food Access & Hunger Food Delivery & Distribution Services Food Security

Black Giving Collective Grant

Rochester Area Community Foundation
Private
Genesee County, New York, Livingston County, New York +6 more
US $5,000 - US $15,000
The Black Giving Collective (BGC) champions Black-led initiatives in the eight-county region of Rochester, New York, addressing systemic disparities within the Black community. Guided by the 2024 State of Black Rochester report, BGC provides grants ranging from $5,000 to $15,000, focusing on program support, capacity building, technology, and community engagement. Organizations must have Black leadership or membership to apply, ensuring that funding directly impacts and uplifts the community.
Black American Services Black American Culture & Heritage Economic Services & Development +5 more

Women & Girls’ Fund

Main Street Community Foundation
Private
Hartford County, Connecticut, Litchfield County, Connecticut +1 more
Unspecified amount
The Women & Girls’ Fund, established by the Main Street Community Foundation in 2001, supports organizations that empower women and girls in Connecticut. With a focus on senior services, confidence building, and mental health, the fund prioritizes projects that enhance self-sufficiency and promote leadership skills. Collaborations among organizations are encouraged, fostering community connections and addressing critical needs. Grants are available for program and capacity-building initiatives that align with these goals.
Women & Girl Services Senior Services Mental Health & Psychiatric Diseases +4 more

MMS Giving Foundation Grant

Mms Giving Foundation
Private
King County, Washington
Unspecified amount
The MMS Giving Foundation Grant aims to enhance the lives of individuals and communities in the Pacific Northwest through support for education, arts, and community programs. Focused on the Puget Sound region, the Foundation prioritizes funding specific tasks or projects that address pressing needs. Eligible applicants include 501(c)(3) public charities in good standing that are located in King County or neighboring areas. The Foundation does not fund religious or political activities.
Environmental Education Performing Arts Workforce Preparation & Job Readiness +3 more

Willamette Health Council: Community Event Sponsorships

Willamette Health Council
Private
Marion County, Oregon, Polk County, Oregon
US $500 - US $2,500
The Willamette Health Council offers Community Event Sponsorships to enhance local initiatives in the Marion-Polk region. Grants typically range from $500 to $2,500. Organizations may receive one sponsorship per calendar year, provided their events align with the Council's mission to improve community health. Applications are accepted on a rolling basis, with specific deadlines for review. This funding supports efforts to tackle health disparities and promote equity in healthcare access.
Healthy Habits & Behaviors Health Disparities & Social Determinants of Health Addiction & Substance Use Disorders +2 more

Columbus Realtors Foundation - Community Grant

Columbus Realtors Foundation
Private
Ohio
Unspecified amount
The Columbus Realtors Foundation supports real estate-related initiatives in central Ohio through its community grants. With over $600,000 invested since 2008, the foundation aids organizations that address homelessness, repair homes for low-income families, and promote affordable housing. Established in 1991, it aims to enhance the real estate environment while empowering local nonprofits and government entities to foster healthy communities.
Equitable & Affordable Housing Homelessness Services Supportive Housing & Shelters

David Kelby Johnson Memorial Foundation Grants

David Kelby Johnson Memorial Foundation
Private
United States
US $5,000 - US $100,000
The David Kelby Johnson Memorial Foundation offers grants to 501(c)(3) organizations focused on sight preservation, children's services, and environmental conservation, primarily in Utah. Established in memory of David Kelby Johnson, who tragically lost his life at a young age, the foundation aims to honor his legacy by supporting impactful charitable initiatives. Grants range from $5,000 to $100,000, with a commitment to improving communities both locally and globally.
Eye Diseases & Disorders Vision Impairment Care & Services Senior Services +4 more

Chartercare Behavioral & Mental Health for Adults & Children Grant

Chartercare Foundation
Private
Rhode Island
Up to US $50,000
The Chartercare Behavioral & Mental Health Grant offers up to $50,000 for proposals aimed at improving mental health services for children and adults in Rhode Island. The grant seeks innovative programs that address critical gaps in care, ensuring timely access to mental health professionals and effective treatment for issues like anxiety and depression. Eligible applicants include 501(c)(3) nonprofits in good standing, with a preference for new initiatives or enhancements to existing programs.
Mental Health & Psychiatric Diseases Children’s Mental Health Depression / Anxiety

Green Acres Local & Nonprofit Program (NJ)

State of New Jersey Department of Environmental Protection
State/Local Government
New Jersey
Unspecified amount
The Green Acres Nonprofit Grant in New Jersey supports tax-exempt organizations aiming to enhance public access to open space for recreation and conservation. This grant fosters the development of outdoor recreational facilities and the stewardship of natural resources. Eligible nonprofits can receive matching funds to acquire land, develop parks, or manage conservation projects, thus ensuring a lasting impact on community well-being and environmental sustainability.
Natural Resources Land / Habitat Conservation Outdoor Recreation +3 more

Earth Rising Foundation Grants

Earth Rising Foundation
Private
United States
US $200 - US $20,000
The Earth Rising Foundation Grants provide financial support ranging from $200 to $20,000 for grassroots climate initiatives. The foundation emphasizes empowering Indigenous communities, advocating for sustainable agricultural practices, and addressing social justice issues linked to climate change. By fostering youth involvement and supporting innovative projects, the foundation aims to create a vision for a sustainable future that respects both people and the planet. Applications must be submitted through a US-based nonprofit organization.
Youth Services Climate Change Resilience & Equity Diversity, Equity & Inclusion +3 more

The Kansas City Royals Foundation Grants Program

Royals Charities Inc.
Private
Bates County, Missouri, Caldwell County, Missouri +12 more
Unspecified amount
The Kansas City Royals Foundation Grants Program has distributed over $25 million since 2001, focusing on Literacy and Education, Healthy and Active Communities, and Military and Veteran Support. Key initiatives include scholarships for underrepresented students, youth engagement through sports, and veteran recognition at games. Organizations within the greater Kansas City area are encouraged to apply, particularly those with budgets under $5 million. The foundation prioritizes projects aligning with its strategic pillars, fostering community growth and support.
Child Welfare Services Children With Disabilities Special Needs Education +4 more

Substance Abuse Recovery Grant

Huntington County Community Foundation
Private
Huntington County, Indiana
Unspecified amount
The Substance Abuse Recovery Grant aims to combat substance abuse in collaboration with local entities like the City of Huntington and County Health Department. It supports prevention, education, intervention, and recovery initiatives, including Moral Reconation Therapy and transportation for recovery homes. This grant is available to non-profits and government organizations focused on helping individuals affected by substance abuse. By fostering a supportive environment, the grant seeks to improve community health and reduce substance-related issues.
Addiction & Substance Use Disorders Drug Use Disorder Life Skills Training & Rehabilitation

Kempner Fund: Core Grants: Empowered Youth

Harris & Eliza Kempner Fund
Private
Galveston County, Texas
US $20,000 - US $75,000
The Harris and Eliza Kempner Fund's Core Grants Program focuses on Empowered Youth, aiming to address significant challenges faced by Galveston's youth. With a commitment to enhancing mental health support, promoting civic engagement, and ensuring equitable access to resources, the fund seeks to empower young individuals, particularly those from marginalized backgrounds. Through targeted funding, the Kempner Fund strives to create a thriving community where every young person can reach their full potential.
Youth Services Children’s Mental Health Youth Development & Leadership +2 more

AISES Indian Motorcycle Academic Scholarship

American Indian Science and Engineering Society (AISES)
Association/Society
American Samoa, Canada +5 more
US $5,000
The AISES Indian Motorcycle Academic Scholarship offers $5,000 annually to support Native students pursuing degrees in STEM fields. Sponsored by the American Indian Science and Engineering Society, this scholarship aims to empower Indigenous students and enhance diversity in STEM. Eligible applicants must be current AISES members, full-time students, and enrolled citizens or descendants of recognized Native tribes. This scholarship not only provides financial assistance but also fosters community and innovation within the STEM landscape.
STEM / STEAM Education Minority Services Native American Services +4 more

Healthcare Workforce Development

Patterson Family Foundation
Private
Kansas, Missouri
Unspecified amount
The Patterson Family Foundation supports healthcare workforce development in rural communities across Kansas and western Missouri. The foundation encourages programs that enhance education, licensure, and retention of healthcare professionals. Organizations must register for grant consideration, and eligibility includes being a 501(c)(3) nonprofit or government entity. The foundation's mission focuses on strategic initiatives to ensure rural communities thrive, emphasizing collaboration and investment in essential services.
Health Policy & Advocacy Workforce Preparation & Job Readiness Health Care Access & Delivery +3 more

Bono Brothers Memorial Trust Grant

Bono Brothers Memorial Trust
Private
Marin County, California
US $5,000 - US $7,500
The Bono Brothers Memorial Trust Grant supports needy children in Marin County, California, through Catholic charitable organizations. Established in 1962 by Joseph Bono, the Trust awards an average of four grants annually to eligible 501(c)(3) organizations. The funds are intended for the care, support, maintenance, and education of these children, ensuring they receive necessary assistance and resources for a better future.
Basic Human Needs Poverty Alleviation & Services Child Welfare Services +5 more

Advanced and Specialized Course Access

Patterson Family Foundation
Private
Kansas, Missouri
US $50,000 - US $500,000
The Patterson Family Foundation offers funding for advanced and specialized course access, aiming to enhance educational opportunities for rural students in Kansas and western Missouri. Organizations can apply after registering through the Grants Portal. The foundation focuses on collaborative initiatives that ensure thriving rural communities by providing essential resources like dual-credit and STEM courses. Eligible applicants include 501(c)(3) organizations, school districts, or government entities, while projects outside the foundation's catchment area are ineligible.
STEM / STEAM Education Educational Access & Equity Education - High School +3 more

Water & Waste Disposal Grant Program in Virginia

USDA: Rural Development (RD)
Federal Government
Virginia
Unspecified amount
The Water & Waste Disposal Loan & Grant Program in Virginia provides essential funding for the development of clean drinking water systems, sewage disposal, solid waste management, and storm water drainage in eligible rural areas. This initiative supports local governments, nonprofits, and tribes to enhance public health and environmental sustainability by ensuring access to reliable water infrastructure. Funds can cover construction, legal fees, and other necessary costs, helping communities thrive.
Sanitation & Clean Drinking Water Water Resource Management

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.