Upcoming Webinar
Instrumentl Fall Launch: Grant Work, Leveled Up.
Thu, Oct 29 or Wed, Nov 4 @ 2PM ET

Skip to main content
Main content

Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

32,000+

Available grants

$9.00B

Total funding

$6K

Median grant

32,000+ grants
$9.00B total
$6K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

32,423 Results based on applied filters

The Women's Fund of Central Ohio Grants

The Women's Fund of Central Ohio
Private
Delaware County, Ohio, Fairfield County, Ohio +5 more
Unspecified amount
The Women's Fund of Central Ohio supports organizations that empower women and girls through various initiatives, including civic engagement, health education, leadership development, and economic security. By prioritizing trust-based and participatory grantmaking, the Fund aims to dismantle gender norms and promote equitable solutions. Grants are awarded annually to innovative programs focused on these areas, ensuring that the voices of those most affected by systemic inequity are elevated and heard.
Women's Rights & Equality Reproductive Rights Reproductive Education +2 more

Aquatic Invasive Species Grant Program

Montana Department of Natural Resources & Conservation
State/Local Government
Montana
Up to US $50,000
The Aquatic Invasive Species Grant Program, managed by the Montana Department of Natural Resources and Conservation, provides funding to combat aquatic invasive species in Montana. With an annual budget of $278,580, the program supports projects aimed at prevention, control, and education. Eligible projects can receive up to $50,000 and may include monitoring, outreach, and applied research. Local proposals addressing state-wide priorities will receive preference during the evaluation process.
Invasive Species Control

INTESOL Wendy Wildman Long Scholarship

Central Indiana Community Foundation
Private
Indiana
Unspecified amount
The INTESOL Wendy Wildman Long Scholarship, established by Indiana Teachers of English to Speakers of Other Languages, supports current or former English learners from Indiana. It aims to provide educational funding for college or vocational training, with preference given to students of color. Eligible applicants must have a minimum GPA of 3.0 and demonstrate financial need, ensuring access to opportunities for historically marginalized communities in Central Indiana.
Education - Higher Education Vocational & Trade Education Education - High School +3 more

RSLAAIS Leadership Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The RSLAAIS Leadership Award, presented by the American Academy of Allergy, Asthma & Immunology (AAAAI), honors exemplary leaders within state, regional, or local allergy societies. This prestigious award recognizes individuals for their significant contributions to community involvement, clinical education, and the advancement of the AAAAI's mission. Candidates are nominated by the RSLAAIS Board of Governors and must demonstrate a commitment to enhancing their local allergy societies and the broader medical community.
Asthma Vaccines & Immunizations Immune System Diseases

AAAAI Special Recognition Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The AAAAI Special Recognition Award honors individuals who significantly contribute to the allergy and immunology community. Offered by the American Academy of Allergy, Asthma & Immunology, this prestigious award recognizes outstanding efforts in advancing care and research in the field, promoting optimal patient outcomes. The AAAAI, with over 7,000 members worldwide, is a leading authority in allergy and immunology, dedicated to enhancing the knowledge and practice of these critical health areas.
Immune System Diseases Allergies & Allergic Diseases Vaccines & Immunizations

AAAAI Distinguished Scientist Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The AAAAI Distinguished Scientist Award recognizes exceptional contributions in allergy and immunology research, honoring those who have significantly advanced the field and demonstrated leadership. This prestigious award is presented by the American Academy of Allergy, Asthma & Immunology, a leading organization for over 7,000 professionals dedicated to improving patient care and promoting research in allergic diseases. The award highlights the commitment to excellence and innovation within the specialty.
Immune System Diseases Allergies & Allergic Diseases Vaccines & Immunizations

Nature Conservation Grants: Agriculture

The Turing Foundation
Private
Burkina Faso, Cameroon +6 more
Unspecified amount
The Turing Foundation focuses on enhancing sustainable practices in agriculture and nature conservation, specifically targeting the protection and sustainable management of marine ecosystems in developing countries. It emphasizes the importance of coral reefs and mangroves while working to combat climate change. Organizations directly invited by the Foundation can contribute to these crucial efforts, ensuring that current needs are met without compromising future generations' ability to thrive.
Climate Change Resilience & Equity Coastal Conservation

AAAAI/ Elliot and Roslyn Jaffe Third-Year Fellowship Food Allergy Research Award at Icahn School of Medicine at Mount Sinai

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
New York
Up to US $130,000
The AAAAI/ Elliot and Roslyn Jaffe Third-Year Fellowship Food Allergy Research Award supports third or fourth-year allergy/immunology or gastroenterology fellows at Icahn School of Medicine at Mount Sinai. This fellowship aims to foster academic careers in food allergy research by funding educational and research activities. Eligible candidates must be in training, conduct research at Mount Sinai, and be AAAAI In-training members. Priority is given to those with a documented career plan for future research funding.
Digestive System Health & Diseases Immune System Diseases Allergies & Allergic Diseases

Jurgens, Virgil, Scholarship

Beatrice Educational Foundation
Association/Society
United States
US $375
The Jurgens, Virgil Scholarship, funded by the Beatrice Educational Foundation, offers a $375 award to a Beatrice High School senior who excels in baseball and ranks in the top 25% of their class. The Foundation, established in 1987, provides financial support for educational opportunities. This scholarship aims to assist deserving students in pursuing higher education, emphasizing the importance of academic achievement and community involvement.
Education - Higher Education Academic Scholarship Programs Baseball & Softball +2 more

Hays, Karla, Loving Heart, Scholarship

Beatrice Educational Foundation
Association/Society
United States
Up to US $1,000
The Hays, Karla, Loving Heart Scholarship offers financial support to graduating seniors of Beatrice High School, with one to three scholarships available totaling up to $1,000. Administered by the Beatrice Educational Foundation, this initiative aims to assist deserving students in pursuing higher education. The foundation, established in 1987, supports academic achievement and civic involvement in the community. Eligible students must maintain a minimum GPA of 3.0 and demonstrate ethical scholarship application practices.
Education - Higher Education Academic Scholarship Programs Music +2 more

Connection, Assistance, Resources and Education Grant for Dementia Caregivers in DC (CARE DC)

District of Columbia Department of Health
State/Local Government
District of Columbia
US $70,000 - US $80,000
The Connection, Assistance, Resources and Education Grant for Dementia Caregivers in DC (CARE DC) aims to enhance the quality of life for dementia caregivers by establishing a coordinated network of resources. This initiative seeks to increase caregiver support and reduce the long-term health impacts associated with caregiving. By facilitating access to dementia navigation services, CARE DC promotes wellness and equity among caregivers in the District, addressing critical health risks and enhancing community collaboration.
Dementia & Alzheimer’s Disease Caregiver Support / Respite Care

Mastercard Innovation Fund

Mastercard Center for Inclusive Growth
Corporate
United States
US $200,000 - US $250,000
The Mastercard Strive USA 2025 Innovation Fund aims to enhance the financial health of small businesses across the U.S. by providing up to $250,000 in grants to organizations developing innovative solutions. This initiative focuses on addressing challenges such as limited access to financial resources and vulnerability to economic shocks, ultimately fostering resilience and growth within the small business sector.
Entrepreneurship Business Education Business Development +2 more

North Sound Health Equity Scholarship

Chuckanut Health Foundation
Private
Island County, Washington, San Juan County, Washington +2 more
Unspecified amount
The North Sound Health Equity Scholarship, funded by the Chuckanut Health Foundation, aims to enhance diverse representation in healthcare by supporting students from Whatcom, Skagit, Island, and San Juan Counties. This scholarship not only alleviates financial burdens but also empowers those who have faced systemic barriers, fostering a community committed to health equity. Join us in investing in the future of healthcare and ensuring that everyone has access to excellent care.
Educational Access & Equity Minority Services Health Care Access & Delivery +4 more

Abuse Survivors: Sue Cook Winfrey Fund Grant

Hampton Roads Community Foundation
Private
Accomack County, Virginia, Chesapeake City, Virginia +4 more
US $5,000 - US $65,000
The Sue Cook Winfrey Fund, managed by the Hampton Roads Community Foundation, supports organizations aiding abuse survivors, focusing primarily on domestic violence and providing essential services for both children and adults. Established in a region with a rich philanthropic history, the Fund prioritizes residential facilities for children, ensuring they receive the care and support needed. The Hampton Roads Community Foundation, active since 1950, has contributed over $344 million to local nonprofits, showcasing its commitment to community welfare.
Domestic Violence Child Abuse & Neglect Supportive Housing & Shelters

Respite for All Caregiver Support Enhancement Grants: Dorothy Rupe Caregiver Program

Arthur N Rupe Foundation
Private
California
Up to US $60,000
The Dorothy Rupe CNA Program Grant, offered by the Arthur N. Rupe Foundation, supports California Community Colleges in enhancing certified nursing assistant and home health aide programs. Grants of up to $50,000 aim to improve student outcomes through financial assistance for low-income students and instructional support, addressing workforce needs for compassionate healthcare professionals. This initiative fosters economic opportunities for underrepresented groups while ensuring quality training in essential healthcare skills.
Home Health Care Caregiver Support / Respite Care Nursing

Aylesworth Scholarship Award

Florida Sea Grant
State/Local Government
Florida
Unspecified amount
The Aylesworth Scholarship Award, offered by the Florida Sea Grant, supports full-time students at Florida universities conducting marine science research. This career award provides approximately $2,500 each semester to eligible students, ensuring they receive financial assistance until they achieve their educational goals. Established in 1984 by Ralph and Kitty Aylesworth, the scholarship aims to foster scientific knowledge and sustainable management of marine resources, benefiting both the economy and the environment.
Marine Biology Oceanography Fisheries +2 more

City of Bellingham: First Steps to Develop Affordable Housing or Shelter Grant

City of Bellingham
State/Local Government
Whatcom County, Washington
Unspecified amount
The City of Bellingham invites organizations to apply for the First Steps to Develop Affordable Housing or Shelter Grant, aimed at enhancing housing options for low-income residents. Interested parties should submit an Expression of Interest Form, followed by a Statement of Intent to ensure proper coordination with funding opportunities. Predevelopment funding up to $60,000 is available for projects with a known site, supporting sustainable development efforts in the community.
Equitable & Affordable Housing Supportive Housing & Shelters

Skutch Keystone Grant

Association of Field Ornithologists
Association/Society
Caribbean, Central America +2 more
Up to US $15,000
The Skutch Keystone Grant, established by Dr. and Mrs. Skutch, honors over sixty years of contributions to Neotropical ornithology. It supports research on birds in Mexico, Central America, South America, and the Caribbean, encouraging local scholars, including students and professionals, to conduct field studies. Grants of up to $15,000 are awarded annually to promote ecological and conservation efforts, enhancing our understanding of birds in their natural habitats.
Ornithology

A.F. Skutch Medal

Association of Field Ornithologists
Association/Society
Caribbean, Central America +1 more
US $1,000
The A.F. Skutch Medal, awarded by the Association of Field Ornithologists, honors outstanding contributions to Neotropical ornithology. Established in 1997, it recognizes achievements in research, mentoring students, and public engagement through publications. The award consists of a silver medal featuring the Fiery-billed Aracari and a monetary prize of $1,000. Nominations are accepted annually until July 31, with an emphasis on candidates' impactful contributions to the field.
Ornithology

Great Ownership Transfer Grant Opportunity

NY Small Business Funders Collective (SBFC)
Association/Society
Bronx County, New York, Kings County, New York +3 more
US $100,000 - US $150,000
The Supplier Diversity Partnership Grant Opportunity, led by the NY Small Business Funders Collective, aims to enhance supplier diversity for historically excluded entrepreneurs in NYC. This initiative focuses on innovative procurement solutions, fostering partnerships between buyers and sellers, and empowering Black, Latinx, AAPI, Indigenous, and women-owned businesses. The grant supports initiatives that address barriers in accessing contracts and promotes community-driven approaches to economic development, with funding ranging from $100,000 to $250,000.
Entrepreneurship Business Development Microfinance +3 more

Eva L. McKenzie Memorial Fund Grant

Eva L. McKenzie Memorial Fund
Private
California
US $5,000 - US $15,000
The Eva L. McKenzie Memorial Fund Grant supports California organizations focusing on the unique needs of blind individuals, and those affected by cerebral palsy or cancer. Established in 1961, the fund aims to provide charitable, scientific, and educational assistance. Eligible organizations must be 501(c)(3) exempt, operate within California, and directly address the challenges faced by these populations. Program areas include education, health, and human services.
Cerebral Palsy Cancer / Oncology Vision Impairment Care & Services

Legacy Disposal Site Abatement Partial Grant Program (CA)

California Department of Resources, Recycling, and Recovery (CalRecycle)
State/Local Government
California
Up to US $750,000
The Legacy Disposal Site Abatement Partial Grant Program, administered by CalRecycle, provides financial assistance to public entities in California for the cleanup of abandoned landfill sites. Grants of up to $750,000 are available to help cover eligible costs, ensuring compliance with state regulations and accelerating restoration efforts. This program aims to protect public health and the environment by facilitating the remediation of sites that pose risks due to improper disposal practices.
Waste Management Environmental Contamination & Pollution Environmental Health

Colon Cancer Coalition Get Your Rear in Gear Grants

Colon Cancer Coalition Foundation
Private
Bahamas, El Paso County, Texas +12 more
Unspecified amount
The Colon Cancer Coalition offers the Get Your Rear in Gear Grants to support local programs aimed at improving colon cancer screening and awareness. Open year-round, applications are reviewed biannually in February and August. Grants fund initiatives that educate the public about colon cancer and alleviate the financial burden on patients. By applying, organizations commit to promoting local events that raise funds for these important community programs.
Colon Cancer

Healthy Tree Canopy Grants For Cities- Step 1

Minnesota State Government - Hennepin County
State/Local Government
Hennepin County, Minnesota
US $1,000 - US $5,000
The Healthy Tree Canopy Grants for Cities aim to enhance the tree canopy in Hennepin County, Minnesota. Designed for city governments, these grants support projects that complete tree inventories and strengthen urban forestry efforts. Applicants can receive funding between $1,000 and $5,000, with a required match of 25% of project costs. The program seeks to engage communities in tree protection and management, addressing environmental challenges while improving public health and equity.
Forestry

Idaho Flood Management Grants

Idaho Department of Water Resources
State/Local Government
Idaho
Up to US $200,000
The Idaho Flood Management Grants program provides financial assistance for projects aimed at repairing flood-damaged stream channels and improving flood risk management across the state. Grants of up to $200,000 are available to eligible public entities, including municipalities and irrigation districts. Applicants must demonstrate the need for repairs and provide matching funds. Prioritizing projects with higher cost-share contributions can enhance competitiveness. This initiative aims to mitigate future flood risks in Idaho's waterways.
Water Resource Management

Florida's Future Forests Program Grant (FL)

Florida Department of Agriculture and Consumer Services
State/Local Government
Florida
Up to US $118,387
The Florida's Future Forests Program Grant supports landowners in establishing and maintaining healthy forests in Florida. Through cost-share payments, the program encourages approved forest management practices, including site preparation, seedling purchase, and planting. Administered by the Florida Department of Agriculture and Consumer Services, it aims to enhance forest acreage while ensuring sustainable ecosystem management. The grant funding, capped at $118,387.50 per agreement, is crucial for promoting effective tree establishment practices to combat environmental challenges.
Forestry

OREF/Musculoskeletal Transplant Foundation Research Grant Prgram

Orthopaedic Research and Education Foundation
Private
United States
US $100,000
The OREF/MTF Biologics Research Grant encourages innovative research in biologics, focusing on reconstruction, bone regeneration, and transplantation, including stem cells. It is open to licensed U.S. orthopaedic surgeons and PhD researchers with faculty appointments. The grant seeks clinically relevant projects that demonstrate practical applications and multidisciplinary collaboration, promoting excellence in research. New investigators are especially encouraged to apply, ensuring a commitment to advancing orthopaedic science.
Human Genome & Genetics Cell Biology Synthetic Biology +4 more

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.34B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.7%
Q2
24.7%
Q3
23.5%
Q4
22.1%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $32,500.

$0 $0 Min.
$32,500 $32.5 K Median
$633,837 $633.8 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.7% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $32,500, while the average grant awarded is $633,837. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.