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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

32,000+

Available grants

$9.00B

Total funding

$6K

Median grant

32,000+ grants
$9.00B total
$6K median

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32,423 Results based on applied filters

Rose Hills Foundation Grant

Rose Hills Foundation
Private
Imperial County, California, Los Angeles County, California +6 more
Unspecified amount
The Rose Hills Foundation Grant aims to foster a healthier and more equitable Southern California by funding nonprofits that address critical needs in the community. With a focus on education, arts, culture, and human services, the foundation supports organizations that empower at-risk youth and families. By providing essential resources, they strive to enhance the quality of life across Los Angeles County, ensuring that all individuals have access to opportunities that promote growth and well-being.
Art & Culture Education Youth Services +5 more

Specialty Crop Block Grant (SD)

South Dakota Department of Agriculture & Natural Resources
State/Local Government
South Dakota
Up to US $325,000
The Specialty Crop Block Grant Program in South Dakota, administered by the SD Department of Agriculture and Natural Resources, aims to enhance competitiveness for specialty crops. This includes fruits, vegetables, and flowers. Grants support initiatives to boost consumption, expand market access, improve food safety, and foster research. Eligible applicants include government entities, nonprofits, research institutions, and individual producers, promoting innovation and sustainability in the specialty crop sector.
Food Safety Sustainable Agriculture & Agroecology Agricultural Pest Management +1 more

F-gas Reduction Incentive Program (FRIP): Commercial & Industrial (C&I) Refrigeration Solicitation

California Air Resources Board
State/Local Government
California
Unspecified amount
The F-gas Reduction Incentive Program (FRIP) by the California Air Resources Board aims to promote the adoption of ultra-low-global warming potential refrigerants in commercial and industrial refrigeration. With a funding pool of $38.5 million, the program prioritizes facilities in disadvantaged communities and those facing challenges in transitioning to climate-friendly technologies. This initiative addresses financial barriers while supporting significant reductions in hydrofluorocarbon emissions, aligning with California's regulatory requirements.
Carbon / Greenhouse Gas Reduction

Allergic Respiratory Diseases Award

American Lung Association
Private
United States
Up to US $150,000
The Allergic Respiratory Diseases Award, supported by the American Lung Association and the American Academy of Allergy, Asthma & Immunology, aims to bolster research in allergic respiratory diseases. Designed for faculty in Clinical Allergy and Immunology at academic medical centers, this award offers $75,000 annually for up to two years. It seeks to empower researchers at pivotal points in their careers, enhancing understanding and treatment of these conditions while promoting lung health.
Respiratory Diseases & Systems Allergies & Allergic Diseases Immune System Diseases

Prevent Homelessness for Families with Young Children RFP

William Penn Foundation
Private
Philadelphia County, Pennsylvania
Up to US $800,000
The William Penn Foundation's RFP aims to prevent homelessness for families with young children, ages 0-8, by supporting projects that offer critical interventions. Eligible projects include eviction diversion, foreclosure prevention, and home repair services. The foundation encourages partnerships to enhance effectiveness and reserves at least $500,000 for organizations with budgets under $2 million or led by historically marginalized groups. Proposals for funding can span up to three years.
Homelessness Services Supportive Housing & Shelters Youth Services +1 more

Individual Artist Fellowship Awards

New Jersey State Council on the Arts
State/Local Government
New Jersey
US $3,000 - US $32,000
The Individual Artist Fellowship Awards, offered by the New Jersey State Council on the Arts, support practicing artists in New Jersey to pursue their artistic goals. With two application deadlines on July 2 and July 16, 2025, these fellowships are awarded based on the artistic quality of submitted work, evaluated by independent panels. Eligible artistic categories range from Film and Digital to Painting and Interdisciplinary works, fostering creativity across diverse disciplines.
Visual Arts Film Fine Art +2 more

Division of Boating and Waterways- Public Beach Restoration Program

California Department of Parks and Recreation
State/Local Government
California
Unspecified amount
The Division of Boating and Waterways offers a Public Beach Restoration Program aimed at the restoration and enhancement of public beaches. This program provides funding for the engineered placement of sand on beaches or in the nearshore environment, covering up to 85% of nonfederal project costs for nonstate beaches. Eligible applicants include public agencies, ensuring support for vital coastal infrastructure and community access to healthy beach environments.
Habitat & Ecosystem Restoration Coastal Conservation

Moody’s Community Impact Grant Program

Moody’s Investors Service, Inc.
Corporate
Argentina, Brazil +21 more
Unspecified amount
The Moody's Community Impact Grant Program supports organizations with tax-exempt status to foster social and economic equality. Established by Moody's Foundation, it prioritizes initiatives that empower underestimated communities and entrepreneurs, driving innovation and ecological restoration. The foundation focuses on inclusive growth, providing resources for small businesses and community resilience. Eligible organizations must be registered charities under U.S. IRS guidelines, while ineligible entities include individuals and those promoting unlawful discrimination.
Business Development Entrepreneurship Habitat & Ecosystem Restoration

WA RCO: Land and Water Conservation Fund

Washington State Recreation and Conservation Office
State/Local Government
Washington
US $200,000 - US $4,800,000
The WA RCO Land and Water Conservation Fund supports the acquisition and development of outdoor recreation resources, including parks and trails. Established in 1965, it aids states in enhancing public outdoor areas. The fund offers two programs: the State Program for all communities and the Legacy Program specifically for urban areas of 30,000+ residents, focusing on economically disadvantaged regions. Funding ranges from $200,000 to $4,800,000, promoting diverse project eligibility.
Habitat & Ecosystem Restoration Parks & Public Spaces Outdoor Recreation +1 more

Impact100 Crawford County

Community Foundation of the Ozarks Inc.
Private
Crawford County, Missouri
Unspecified amount
Impact100 Crawford County is a philanthropic organization focused on empowering local nonprofits through generous grants. With an emphasis on art, culture, education, health, and community betterment, they aim to enhance the lives of residents in Crawford County. Eligible organizations must meet specific criteria, such as being a recognized 501(c)(3) and having a minimum two-year operational history. This initiative fosters a spirit of giving and collaboration, ultimately strengthening the community.
Art & Culture Education Recreation +6 more

Career Development Award Program RFP- New Application

Melanoma Research Foundation
Private
United States
Up to US $50,000
The Melanoma Career Development Award (CDA) is offered by the Melanoma Research Foundation to support researchers dedicated to melanoma and its prevention. This award is designed for postdoctoral fellows with under five years of experience, research associates, scientists, staff scientists, assistant professors, and those focusing on melanoma prevention. The initiative promotes innovative research to advance understanding and treatment of melanoma, ultimately aiming to reduce its impact.
Cancer / Oncology Pediatric Cancers Skin Diseases & Dermatology

CARES Foundation Grant

Cares Foundation
Private
Sacramento County, California
Unspecified amount
The CARES Foundation Grant supports nonprofit organizations in California's Sacramento region that address the needs of individuals living with HIV. The foundation prioritizes HIV prevention, treatment, and support services, while also funding innovative projects that reduce stigma and discrimination against those affected by HIV. Eligible organizations must be 501(c)(3) nonprofits or government agencies primarily serving the local area, ensuring inclusivity and non-discrimination in their operations.
HIV / AIDS

Rasmuson Foundation: Community Support Grants

Rasmuson Foundation
Private
Alaska
US $35,000 - US $250,000
The Rasmuson Foundation's Community Support Grants provide funding for capital projects and initiatives that have a significant community impact, with awards ranging from $35,000 to $250,000. Eligible organizations must have a history of successful collaboration and project management. Applications are reviewed quarterly for capital projects and biannually for programmatic requests. Organizations can only hold one active grant at a time, ensuring focused community support and funding efficiency.
Architecture Historic Preservation Parks & Public Spaces +2 more

Melanoma: Established Investigator Award

Melanoma Research Foundation
Private
United States
Up to US $125,000
The Melanoma Established Investigator Award offers up to $125,000 annually for two years, aimed at established melanoma researchers or senior researchers transitioning into melanoma research. Eligible applicants include Associate Professors or higher, with both tenured and non-tenured faculty encouraged to apply. U.S. citizenship is not a requirement for this funding opportunity provided by the Melanoma Research Foundation.
Cancer / Oncology Pediatric Cancers Skin Diseases & Dermatology

Suzanne & Walter Scott Foundation: Omaha Award

Suzanne And Walter Scott Foundation
Private
Cass County, Nebraska, Douglas County, Nebraska +6 more
Up to US $75,000
The Suzanne & Walter Scott Foundation's Omaha Award provides competitive grants to nonprofit organizations in the Omaha area focusing on food, personal care, shelter, and health. With a maximum grant request of $75,000 for general operations and $50,000 for capital projects, the foundation supports initiatives that address basic needs and promote community well-being. Organizations must be 501(c)(3) tax-exempt and located in the Omaha-Council Bluffs area to apply.
Basic Human Needs Food Access & Hunger Supportive Housing & Shelters +1 more

Urban Trees Mini Grant

Chesapeake Bay Trust
Private
Maryland
Up to US $10,000
The Urban Trees Mini Grant, funded by the Chesapeake Bay Trust, supports small tree planting projects in urban underserved areas across Maryland. Applications are accepted on a rolling basis until funds are exhausted, and projects can receive up to $10,000. This initiative is part of Maryland's broader goal to plant 5 million native trees by 2031, enhancing access to green spaces for communities in need.
Greening & Beautification Outdoor Recreation Outdoor Equity +2 more

MRF Breakthrough Consortium (MRFBC) Young Investigator Team Award to Advance the Field of Translational Immuno-Oncology

Melanoma Research Foundation
Private
United States
Up to US $150,000
The MRFBC Young Investigator Team Award supports innovative research in immuno-oncology for melanoma, offering up to $150,000 annually for two years. This funding targets U.S.-based researchers aiming to enhance clinical outcomes for melanoma patients or deepen the scientific understanding of immuno-oncology. The MRF collaborates with key institutions to address challenges in melanoma research, fostering partnerships that maximize research potential and impact.
Cancer / Oncology Skin Diseases & Dermatology Pediatric Cancers

Local Conservation Corps Grant Program

California Department of Resources, Recycling, and Recovery (CalRecycle)
State/Local Government
California
Unspecified amount
The Local Conservation Corps Grant Program, offered by the California Department of Resources Recycling and Recovery (CalRecycle), aims to promote environmental sustainability through the implementation of beverage container recycling, litter abatement, and the recovery of used oil and electronic waste. This initiative supports local conservation efforts and encourages community engagement in waste management practices, contributing to a cleaner and healthier environment for all.
Recycling

Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant

National Scleroderma Foundation
Private
United States
US $200,000
The Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant, provided by the National Scleroderma Foundation, aims to support research in scleroderma-related lung disease. With a funding amount of $200,000, the grant encourages established investigators to explore innovative solutions and enhance understanding of this condition, ultimately working towards improving the quality of life for affected individuals and advancing medical knowledge in the field.
Rare Diseases Immune System Diseases Interstitial Lung Disease

F. D. Rich Foundation Grants

F.D. Rich Company (The Rich Foundation)
Corporate
Fairfield County, Connecticut
Unspecified amount
The F. D. Rich Foundation Grants support charitable organizations in lower Fairfield County, Connecticut, focusing on arts, education, healthcare, and social services. Established under section 509(A) of the Internal Revenue Code, the foundation has contributed over $8 million to various non-profits since its inception. This funding aims to improve the quality of life for residents in the Stamford area and enhance community well-being through diverse initiatives.
Human & Social Services Media Arts Health Care Access & Delivery +6 more

Regional Water Plan Seed Grants (GA)

Georgia Department of Natural Resources
State/Local Government
Georgia (US state)
Up to US $150,000
The SFY2026 Regional Water Plan Seed Grants, provided by the Georgia Department of Natural Resources, aim to assist local governments and water users in their Regional Water Plan implementation efforts. Grants are capped at $75,000, with a project duration of up to 30 months. Interested applicants must attend a pre-application meeting with the Environmental Protection Division (EPD) and submit a full proposal online by the specified deadline.
Water Resource Management

Friends Foundation for the Aging Grant

Friends Foundation for the Aging
Private
United States
Unspecified amount
The Friends Foundation for the Aging Grant supports innovative and impactful programs aimed at addressing the needs of older adults, particularly within underserved populations. This Quaker foundation prioritizes collaboration and sustainability in its funding efforts. Eligible applicants must be 501(c)(3) public charities focused on enhancing the quality of life for aging individuals. Grants are typically awarded for one year and target organizations that align with the foundation's mission and values.
Aging / Gerontology Senior Services Protestantism +1 more

Single Ventricle Research Fund (SVRF) - Independent Investigator Track

Additional Ventures Foundation
Private
Countries
Up to US $600,000
The Single Ventricle Research Fund (SVRF) offers annual grants aimed at enhancing research and care for individuals with single ventricle heart defects. With awards of up to $600,000, the SVRF encourages innovative projects that align with the Additional Ventures Research Roadmap. This initiative not only supports novel treatments but also fosters collaboration across disciplines to address critical challenges in single ventricle heart disease management.
Cardiovascular Diseases & Systems Heart Disease Preventative Healthcare

IN Clean Water Act Section 319(H) Grants

Indiana Department of Environmental Management (IDEM)
State/Local Government
Indiana
Up to US $50,000
The Indiana Clean Water Act Section 319(H) Grants program aims to enhance water quality by addressing nonpoint source pollution, which is a major contributor to water quality issues in the state. Funded projects focus on educational outreach, developing watershed management plans, and implementing best management practices (BMPs). Eligible organizations include nonprofits, universities, and government agencies, with a required 40% match. The program promotes community-based solutions to foster sustainable water management.
Water Resource Management

Alzheimer’s Association: Center for Dementia Respite Innovation Grant (CDRI)

Alzheimer's Association
Private
United States
US $50,000 - US $100,000
The Alzheimer’s Association's Center for Dementia Respite Innovation Grant (CDRI) supports innovative respite care projects, aiming to improve person-centered dementia care across the U.S. With up to $20 million available over five years, the grant encourages local respite care providers to enhance their services through collaboration and innovative solutions. Recipients will receive training and assistance to ensure their programs are effective and sustainable, addressing the growing need for quality dementia care.
Dementia & Alzheimer’s Disease Caregiver Support / Respite Care

Herbert C. Kelman Fellowships

Weatherhead Center for International Affairs at Harvard University
Association/Society
Middlesex County, Massachusetts
US $3,000 - US $4,000
The Herbert C. Kelman Fellowships, offering $3,000–4,000, support research aimed at understanding and resolving international and ethnic conflicts, particularly the Israeli-Palestinian situation. Funded by the family of Professor Herbert C. Kelman, these grants encourage Harvard graduate students to engage in peacebuilding efforts. Eligible candidates may use the funding for dissertation-related travel, training, or data compilation throughout the summer or academic year, promoting vital research in conflict resolution.
International / Foreign Affairs International Security Violence Prevention +1 more

Local Health Department Naloxone Grant (IN)

Indiana Department of Health
State/Local Government
Indiana
Unspecified amount in in-kind support
The Indiana Department of Health is inviting local health departments to apply for the Naloxone Grant to distribute opioid overdose reversal kits, including naloxone nasal spray. This initiative aims to increase the availability of life-saving medication in communities, especially in collaboration with organizations such as county jails. Education on the use of naloxone and legal protections for responders is also a key component of the program, fostering a safer environment for overdose interventions.
Drug Use Disorder

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.34B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.7%
Q2
24.7%
Q3
23.5%
Q4
22.1%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $32,500.

$0 $0 Min.
$32,500 $32.5 K Median
$633,837 $633.8 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.7% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $32,500, while the average grant awarded is $633,837. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.