Best Large Grants for Nonprofit Organizations

The Focus Grant Cycles provide vital support to organizations in southwest Washington addressing intergenerational poverty. With awards ranging from $25,000 to $50,000, the program prioritizes initiatives that tackle systemic inequities affecting marginalized communities. Focus Grants emphasize collaboration, community engagement, and innovative strategies, ensuring that organizations with lived expertise can create sustainable pathways to prosperity. By investing in educational attainment, basic human needs, and asset-building, the program aims to disrupt poverty cycles and foster long-term stability.

The CSHF: Fostering Collaboration Grant Opportunity encourages innovative partnerships among diverse organizations to tackle complex community health challenges in El Paso and Teller Counties, Colorado. This grant prioritizes collaborative efforts that align with the Foundation's focus areas, including healthcare access and trauma prevention. Applicants must demonstrate commitment to evidence-based practices and transformative potential. Engaging with CSHF staff prior to application is essential for consideration.

The Southbury Community Trust Fund Grant aims to support programs benefiting Southbury residents through collaboration and partnerships. Priority is given to initiatives in social services, health education, youth development, and community enhancement. Eligible applicants include 501(c)(3) nonprofits and municipal entities. The fund does not support political or religious requests and encourages projects that serve the local community and promote advocacy efforts. This grant fosters community resilience and cultural heritage.

The Akron Community Foundation's Health & Human Services Grant focuses on enhancing the quality of life in Summit County. It supports approved 501(c)(3) organizations addressing essential needs such as food, shelter, and medical care. Grants prioritize systemic impact, organizational strength, and inclusiveness, aiming for sustainable solutions that benefit the community. The foundation seeks to empower nonprofits and ensure ethical stewardship of donor investments, ultimately contributing to self-sufficiency and wellness for the county's most vulnerable residents.

The Clay County Community Foundation (CCCF) offers Standard Grants ranging from $3,001 to $10,000 for non-profit organizations and local governments in Clay County, Iowa. These grants aim to enhance the quality of life through projects in areas such as economic development, cultural activities, and health services. The foundation prioritizes initiatives that connect donors with impactful causes, ensuring that funds are used effectively to address community needs and support innovative programs.

The Entergy Charitable Foundation Grant focuses on supporting initiatives that foster thriving communities through education, poverty solutions, and environmental programs. The foundation prioritizes funding for 501(c)(3) organizations and similar entities. Key areas include education development, innovative poverty solutions, and environmental restoration efforts, such as coastal wetland preservation. Organizations are encouraged to apply at least three months before funding is needed, ensuring timely support for impactful community projects.

The CCCF Impact Grant provides funding between $10,001 and $25,000 for projects that enhance quality of life in Clay County, Iowa. The grant prioritizes economic development, cultural activities, parks, and health services. Eligible applicants include 501(c)(3) non-profits and local government units. This initiative aims to support impactful community projects, fostering collaboration and growth within the county. For more details, contact the Clay County Community Foundation.

The Whidbey Climate Fund Grant supports innovative projects aimed at reducing greenhouse gas emissions and enhancing sustainability on Whidbey Island. Grants of up to $5,000 are available for non-profits, governmental entities, and individuals with non-profit sponsors. Projects should focus on educating the community, improving local ecosystems, and promoting environmental health. Applications will be reviewed by a committee of climate experts, ensuring credible and impactful initiatives for a sustainable future.

The Conservation, Food & Health Foundation Grant Program aims to enhance public health, food security, and environmental conservation in underfunded regions across Africa, Asia, the Caribbean, Latin America, and the Middle East. It supports innovative projects and applied research that promote local solutions, leadership development, and community capacity building. With grants typically ranging from $25,000 to $50,000, the program prioritizes initiatives that foster sustainability, replication, and systemic change beyond immediate project goals.

The Sapelo Foundation Grants focus on advancing environmental justice and protection in Georgia, aiming to empower marginalized communities. The foundation seeks partnerships that foster civic engagement, support sustainable practices, and advocate for effective environmental policies. With a commitment to statewide efforts, especially outside metro Atlanta, it emphasizes the importance of healthy environments for all Georgians. Two primary funding areas include water and climate/energy initiatives, with grants typically awarded biennially.

The VCF: Hills Fund Grant offers financial support ranging from $1,501 to $7,500 for projects that enhance educational opportunities and foster community sustainability in Poultney, Vermont. Eligible applicants include schools, municipal entities, and nonprofit organizations. The Hills Fund prioritizes initiatives that engage local residents and leverage additional community resources. Applications are accepted annually from January 1 to November 1, with a commitment to inclusivity and accessibility for all participants.

PGE Foundation

The PGE Foundation, an independent philanthropic organization, aligns its grantmaking with Portland General Electric’s commitment to the communities it serves.

Founded in 1997, the Foundation was created through an endowment with the purpose of improving the quality of life for all Oregonians.

Since our inception, more than $33 million in investments has helped community-based organizations expand access to education, creative expression, and career pathways that strengthen long-term economic prosperity.

Climate Resilient Communities Fund

The PGE Foundation is pleased to announce the launch of its new Climate Resilient Communities Fund. Opening in March 2026, the Climate Resilient Communities Fund will help strengthen community preparedness, protect vulnerable populations, and support long-term environmental and economic vitality across Oregon. This new investment builds on extensive engagement with community partners and reflects the growing urgency of climate-related risks facing Oregon communities today, particularly those historically under-resourced.

Record-breaking wildfires, extreme heat, and other climate-related disasters are challenging our communities like never before—especially those in historically underinvested areas. We support locally driven, community-based programs that address some of the most pressing climate challenges facing Oregonians. We believe solutions rooted in local leadership are best informed by the needs and lived experiences of the communities most affected.

We prioritize organizations and programs that demonstrate elements of the following:

Core Mission

The mission of the organization prioritizes:

• Wildfire Hazard and Preparedness: Supporting community-driven strategies to reduce wildfire hazards, enable preparedness and response, and build long-term recovery capacity in fire-prone areas before fire comes.
• Nature-based Solutions: Investing in community stewardship through habitat restoration, tree canopy, and green infrastructure projects that cool communities, improve water and air quality, and protect ecosystems
• Parks and Public Spaces: Expanding, enhancing, and sustaining equitable access to safe, climate-resilient outdoor community gathering spaces where people connect and find refuge.

Outcomes

The proposed project will result in:

• Increased local community capacity and ongoing stewardship for resilience (especially for small and rural organizations)
• Measurable improvements in wildfire preparedness, canopy cover, restoration and green infrastructure
• Greater access to climate-resilient public spaces
• Stronger collaboration and learning networks across sectors

About VHCB

Our Mission: VHCB invests in the construction of affordable housing and conservation strategies that work together to ensure equity, resilience, and vitality for Vermont communities in perpetuity.

Clean Water Programs

VHCB administers two separate funding programs to support a healthy and clean Lake Memphremagog Basin—the Memphremagog Clean Water Service Provider, funded through the Vermont Department of Environmental Conservation, and the Leahy Memphremagog Clean Water Program, funded through the Great Lakes Fishery Commission.

Formula Grant Clean Water Projects in the Memphremagog Basin (Basin 17)

Introduction

The Vermont Housing & Conservation Board (VHCB), in its role as the Clean Water Service (CWSP) Provider for Basin 17, is accepting funding applications for projects that improve water quality in Basin 17, with a focus on projects that lead to a substantial reduction in phosphorus runoff into surface waters. Projects must be in line with the vision set forth by Act 76, the Clean Water Service Delivery Act, and policies and guidance set forth by the Vermont Department of Environmental Conservation (DEC) to implement the Act.

The Judy Dudziak Endowment for Community Music Organizations aims to enhance the cultural landscape in Los Alamos by providing up to $750 in unrestricted operating support to 501(c)(3) nonprofit organizations. These grants focus on promoting appreciation for various music genres, including classical, orchestral, and choral performances. The initiative reflects a commitment to fostering community engagement through the arts and ensuring that local organizations can thrive and sustain their programs.

The Coachella Valley - Proposition 68 Grant Program, administered by the California Coachella Valley Mountains Conservancy, provides funding to public agencies, nonprofits, and tribes for projects that enhance watershed health, land conservation, and community resilience. This initiative aligns with the 2018 California Drought, Water, Parks, Climate, Coastal Protection, and Outdoor Access Act, promoting public access to parks and encouraging water conservation efforts while addressing climate change impacts.

The Thornton S. Glide, Jr. and Katrina D. Glide Foundation provides grants to qualified 501(c)(3) organizations in California that focus on animal protection, land conservancy, agriculture, and civic endeavors. Established in 1995, the foundation prioritizes grants for specific capital acquisitions and does not support operational costs or direct aid to individuals. Emphasizing local impact, California-based organizations are favored over out-of-state counterparts.

The CAL FIRE Forest Health Research Program aims to enhance forest resilience in California by funding critical research in forest health and fire science. This initiative, part of the California Climate Investments, supports studies that address vital topics such as wildfire management, ecological impacts, and socio-economic factors. By prioritizing scientific research, the program ensures that actionable insights are available for forest management decisions to combat climate change effects and promote biodiversity.

The Thomas H. White Foundation offers grants to tax-exempt, non-profit organizations in Cuyahoga County, Ohio, focusing on programs that enhance early childhood education, promote educational success for K-12 students, and support workforce readiness. Eligible organizations must primarily serve residents of Cleveland and comply with specific requirements. Notably, capital campaign requests are ineligible. For more details, applicants are encouraged to contact the foundation directly.

The VCF: Hollows Fund Grant, established by the Vermont Community Foundation, supports educational opportunities and community sustainability in Poultney. Grants range from $250 to $1,500, aimed at schools and nonprofits addressing children's needs and fostering engagement. Eligible organizations must be tax-exempt and provide ADA-accessible programs. The fund prioritizes collaborative projects that enhance community connections and respond to local challenges, promoting a vibrant and inclusive environment for all residents.

The Forest Health Grant from CAL FIRE aims to enhance the resilience of California's forests against extreme disturbances such as wildfires and drought. This program supports landscape-scale projects focused on restoring forest health, protecting water resources, and promoting carbon storage. By funding activities that improve forest management and reforestation, CAL FIRE addresses climate change impacts while ensuring the sustainability of vital ecosystems. Eligible projects must demonstrate clear climate benefits through various management practices.

The Colorado AmeriCorp Operational Grant, administered by Serve Colorado, aims to enhance community service through AmeriCorps funding. It supports programs targeting workforce development, health care, and green infrastructure, focusing on underserved communities. Applicants must demonstrate a commitment to priority areas, ensuring high-quality program designs to improve lives and foster civic participation. This grant empowers organizations to engage AmeriCorps members in impactful service, promoting economic mobility and advancing racial equity, while addressing local community needs.

The Alfred N. Sanzari Family Foundation Grant aims to enhance community welfare in Northern New Jersey by focusing on healthcare, education, and support for disadvantaged populations. This includes initiatives for patient care related to Parkinson's Disease, educational programs for children, and services for women and children in need. With grants ranging from $500 to $10,000, the foundation seeks to make a significant impact in the lives of those it serves, continuing the legacy of generosity founded by Alfred N. Sanzari.

The Collaborative Health Sciences Program RFP by the University of Wisconsin aims to fund innovative research addressing complex health issues in Wisconsin. With a maximum award of $600,000 over three years, this initiative encourages interdisciplinary teams to explore new directions in health research. Eligible proposals should demonstrate potential for additional funding and focus on improving health equity, addressing diseases, clinical knowledge, and innovative training for health professionals, while ensuring collaboration among diverse disciplines.

The California Inflation Reduction Act Grants support Urban and Community Forestry projects aimed at enhancing tree canopy access and community engagement, particularly in disadvantaged areas. With a state allocation of $30.8 million, these grants promote climate resilience, combat extreme heat, and improve forest health. Funded by the USDA Forest Service, the initiative aligns with President Biden’s Justice40 Initiative, ensuring equitable access to the benefits of urban trees and fostering community involvement in environmental stewardship.

The East Missouri Foundation Grant supports 501(c)(3) organizations focused on providing essential services such as housing, healthcare, food, and transportation for vulnerable populations including seniors, persons with disabilities, and the homeless. The foundation issues one-time grants for specific purposes and does not fund individuals or organizations outside its defined priorities. Grants are determined by a board of directors committed to enhancing community welfare through targeted charitable initiatives.

The Heritage Partnership Program, managed by the Arizona Game and Fish Department, aims to foster collaboration on projects that deliver conservation and recreational benefits. Eligible entities include governmental agencies, Indian tribes, and 501c3 organizations. With specific funding categories for habitat management, public access enhancement, and urban wildlife conservation, projects must be completed within one year, following the state fiscal year. Note that no funding is available for FY26 as all funds are obligated.

The Fichtenbaum Charitable Trust, established in 2017, supports Texas charitable organizations in areas such as medical research for serious conditions, education for children with disabilities, and promoting fine arts. Grants typically range from $10,000 to $100,000, with an average of $35,000. The Trust prioritizes unique and necessary proposals that meet local community needs and do not duplicate existing services, particularly focusing on projects in Dallas County and surrounding areas.