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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

33,000+

Available grants

$9.00B

Total funding

$6K

Median grant

33,000+ grants
$9.00B total
$6K median

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32,545 Results based on applied filters

Workforce Development Training Fund (WDTF): Business Training Grants

Wyoming Department of Workforce Services (DWS)
State/Local Government
Wyoming
Up to US $75,000

Wyoming Department of Workforce Services

At the Wyoming Department of Workforce Services (DWS), we are committed to building stronger communities and empowering Wyoming’s workforce. We uphold legal employment practices, enforce labor laws, and promote safe and healthy working conditions. But our impact goes beyond policies—we support businesses, connect people with opportunities, and serve a diverse range of individuals, including employers, employees, job seekers, individuals with disabilities, veterans, families, healthcare providers, and more.

Our mission: To collaborate to support a thriving workforce and economy.

Workforce Development Training Fund

Unlock the Potential of Your Workforce with the Wyoming Workforce Development Training Fund (WDTF)

The Wyoming Workforce Development Training Fund (WDTF) is here to empower businesses and employees across Wyoming by providing professional development opportunities to enhance skills and foster growth.

The Workforce Development Training Fund (WDTF) is a unique Wyoming-based program that connects employers with professional development opportunities to increase employee skill attainment.

Before You Apply

Please ensure your business meets the following requirements to avoid delays in the registration process. 

Good Standing: Your business must be registered and in good standing with:

  • Wyoming Unemployment Insurance (UI)
  • Workers’ Compensation (WC)
  • Wyoming Secretary of State (SoS)
  • Workforce Development Training Fund (WDTF)

HireWyo: Your business must also be registered and in good standing with HireWYO. This process may take an additional 1-2 weeks, especially if your WC or UI accounts need to be updated.

Grant Opportunities Designed for Your Needs: 1) Apprenticeship Training Grants; 2) Business Training Grants; 3) Internship Grants; 4) Pre-Hire Economic Development Grant; 5) Pre-Obligation Grant

Business Training Grants

Invest in your current employees with training to correct an employee’s skill deficiency or upgrade their skill level in their current occupations.

Applications for events starting within the following month are prioritized. See more information on the Business Training Grants.

Business Development Workforce Preparation & Job Readiness Employment Services

Fish and Wildlife Resources Fund Grant Program

Colorado Department of Natural Resources (CO DNR)
State/Local Government
Colorado
Unspecified amount
The Fish and Wildlife Resources Fund Grant Program, administered by the Colorado Water Conservation Board, aims to support existing water supply facilities while ensuring the protection of Colorado's fish and wildlife. Grants can be utilized for water rights acquisition, river restoration projects, and a combination of both, enhancing environmental sustainability. Eligible applicants include operators of water facilities and the CWCB, with projects expected to be completed within three years. Contact CWCB staff for funding discussions and requirements.
Water Resource Management

MT Urban and Community Forestry: Program Development Grants

Montana Department of Natural Resources & Conservation
State/Local Government
Montana
Unspecified amount
The Montana Urban and Community Forestry program offers grants aimed at enhancing community forests' health. These grants support local governments in developing urban forestry programs through various projects such as tree inventory, urban forest management plans, and strategic tree planting. Eligible applicants include cities, counties, non-profits, and tribal governments in Montana. The program encourages innovative projects that promote biodiversity, climate change education, and workforce development, ensuring sustainable urban forestry practices.
Forestry

School Behavioral Health Services Comprehensive Expansion

District of Columbia Department of Behavioral Health
State/Local Government
District of Columbia
Up to US $600,000

School Behavioral Health Services Comprehensive Expansion

This RFA will deliver prevention, early intervention, and treatment services by Community Based Organizations (CBO) providers within the Comprehensive School Behavioral Health Model in 52 District of Columbia Public Schools (DCPS) and District of Columbia Public Charter Schools (DCPCS).

DBH will allocate funding to develop and further expand the District’s Comprehensive School Behavioral Health System in the District’s schools. The school behavioral health services will be aligned with the behavioral health unmet needs/gaps within the school. The array of services includes prevention, early intervention and treatment. Additionally, the selected CBOs will participate in the overall evaluation of the implementation.

Mental Health & Psychiatric Diseases Children’s Mental Health Healthy Habits & Behaviors

HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The HEAL Initiative aims to address the complex interplay between chronic pain and opioid use disorder (OUD), affecting 40-60% of OUD patients. Through the IMPOWR initiative, this funding opportunity seeks to develop integrated care strategies that enhance treatment delivery at health systems levels. By identifying effective interventions and collaborative care models, the initiative strives to improve patient outcomes in managing both chronic pain and OUD, while emphasizing the roles of various healthcare professionals in this integrated approach.
Epidemiology & Public Health Addiction & Substance Use Disorders Health Care Access & Delivery +3 more

Guy Harvey Fellowship

Florida Sea Grant
State/Local Government
Florida
Up to US $5,000
The Guy Harvey Fellowship, established in 2024 by Florida Sea Grant, supports graduate students conducting vital research on sustainable marine fisheries at Florida's higher education institutions. Each fellow can receive up to $5,000 as a research stipend, with additional funding available for travel and professional development. This initiative enhances coastal resilience and promotes effective management of marine resources while fostering communication and collaboration within the Sea Grant network.
Marine Biology Oceanography Marine / Ocean Conservation +1 more

Technical Assistance Grants in New York City

The New York Community Trust
Private
Bronx County, New York, Kings County, New York +3 more
US $5,000 - US $200,000
The New York Community Trust offers Technical Assistance Grants aimed at enhancing the management capacity of nonprofits in New York City. This program supports public charities and organizations with a focus on skill development and technical assistance. Eligible applicants include nonprofits that promote policy change and build organizational capacity. Grants are typically awarded for one year, with an emphasis on fostering collaboration and service improvements within the nonprofit sector.
Equitable & Affordable Housing Arts / Culture Access & Participation Civic Engagement & Education +1 more

RRCU Gives Foundation Grant

RRCU Gives Foundation
Association/Society
United States
Unspecified amount

RRCU Gives Foundation Grant

Mission Statement:

RRCU Gives strengthens our region by providing meaningful financial support to nonprofits addressing hunger, housing, and financial education. Through our annual grant awards and major funding initiatives, we help local organizations grow, thrive, and create lasting change.

 We award grants annually, with applications in June and awards in August.

Focus Areas

  • Hunger
  • Housing
  • Financial Education
Food Access & Hunger Financial Literacy Equitable & Affordable Housing

1954 Project - Luminary Award

Cleveland Avenue Foundation for Education Group
Corporate
United States
US $1,000,000
The 1954 Project - Luminary Award seeks visionary nonprofit leaders dedicated to advancing educational equity for Black students. Awardees receive $1 million in funding, leadership development, and networking opportunities. The selection prioritizes leaders demonstrating strategic vision, community commitment, adaptability, and collaborative spirit. Applicants must align with one of three impact areas: Innovation in Teaching and Learning, Diversity in Education, or Pathways to Economic Mobility, ensuring their initiatives foster systemic change and uplift marginalized communities.
Educational Access & Equity Education System Policy & Reform Teacher Development & Training +3 more

Aylesworth Scholarship Award

Florida Sea Grant
State/Local Government
Florida
Unspecified amount
The Aylesworth Scholarship Award, offered by the Florida Sea Grant, supports full-time students at Florida universities conducting marine science research. This career award provides approximately $2,500 each semester to eligible students, ensuring they receive financial assistance until they achieve their educational goals. Established in 1984 by Ralph and Kitty Aylesworth, the scholarship aims to foster scientific knowledge and sustainable management of marine resources, benefiting both the economy and the environment.
Marine Biology Oceanography Fisheries +2 more

NourishMD Grant Program

Maryland Department of Housing and Community Development
State/Local Government
Maryland
US $25,000 - US $150,000

Maryland Department of Housing and Community Development 

The Maryland Department of Housing and Community Development transforms communities into places people want to call home. Through investments in community-led placemaking, housing and small business development, infrastructure and broadband deployment, we partner with local government, nonprofits, and private sector stakeholders to make great places.

NourishMD Grant Program

The Nouri​shMD Grant Program is a targeted investment designed to expand access to healthy and fresh foods in Maryland communities experiencing food insecurity by providing direct grants to eligible retailers. 

Food Security Rural Development Food Access & Hunger

Mitsuo Shito Public Housing Scholarship

Hawai'i Community Foundation
Private
Hawaii
Unspecified amount
The Mitsuo Shito Public Housing Scholarship, established in 1997 by The Friends of Hawai'i's Public Housing, supports eligible students from Hawaii who maintain good academic standing and demonstrate financial need. This scholarship prioritizes applicants living in public housing and those who were awarded in the previous year, ensuring continued support for those who meet the criteria. It's a vital resource for encouraging educational advancement among public housing residents.
Equitable & Affordable Housing Supportive Housing & Shelters

Ochylski Family Foundation Grants

Ochylski Family Foundation
Private
United States
US $50,000 - US $75,000
The Ochylski Family Foundation supports registered 501(c)(3) nonprofit organizations through grants aimed at enhancing their operational capacity. With an application deadline of October 1, organizations must submit a detailed request outlining their initiatives. The foundation's mission aligns with its commitment to foster community development and nonprofit effectiveness in Iowa, ensuring that resources are allocated to impactful projects that serve the public good.
Youth Services Family Services Human & Social Services +3 more

Youth 90-Day Emergency Shelter and Case Management Services Provider Community Grant

District of Columbia Department of Human Services
State/Local Government
District of Columbia
Up to US $2,200,003
The Youth 90-Day Emergency Shelter and Case Management Services grant aims to enhance year-round shelter options for youth aged 18-24 facing housing crises in the District. This initiative will provide a comprehensive array of services, including meals, case management, health and wellness support, and workforce development, to empower young individuals towards stability and independent living. The project seeks to connect youth with essential resources and create a supportive environment for their growth and well-being.
Homelessness Services Youth Services Poverty Alleviation & Services +1 more

Environment Initiatives Grant Program

Catherine Donnelly Foundation
Private
Canada
Unspecified amount
The Catherine Donnelly Foundation's Environment Initiatives Grant Program aims to foster a diverse and inclusive climate justice movement. It supports initiatives that empower underserved communities to lead in creating a climate-safe future. By promoting social, economic, and environmental justice, the program seeks to address inequities and encourage collaboration across various sectors. The foundation prioritizes Indigenous-led projects and those that engage marginalized voices, advancing sustainability and resilience in the face of climate change.
Environmental Justice & Advocacy Climate Change Resilience & Equity

Lawson Family Foundation Justice & Economic Mobility Grant

Lawson Family Foundation
Private
Knox County, Tennessee
US $2,500 - US $25,000

Lawson Family Foundation

The Lawson Family Foundation was established by Phil Lawson in 2020 to serve as a catalyst for the development of a more healthy, prosperous, and inclusive Knoxville community. As a private grantmaking foundation, the Lawson Family Foundation focuses support on organizations involved in the areas of Justice & Economic Mobility, Education & Youth Development, Prevention of Exploitation & Violence, and Community Health & Food Security. 

Driven by the belief that every life has equal value, the Lawson Family Foundation exists to support efforts that promote justice and opportunity in all aspects of society, primarily in Knoxville, Tennessee. In doing so, it seeks to achieve a positive impact in marginalized communities that will last for generations.

Lawson Family Foundation Justice & Economic Mobility Grant

Persistent poverty in Knoxville, especially in East Knoxville, reflects the lasting impact of historic injustices such as redlining and Urban Renewal. These forces have contributed to declining homeownership, loss of generational wealth, and increased risk of displacement—disproportionately affecting historically underserved communities and communities of color. Individuals with prior incarceration often face additional barriers to stable employment and economic advancement.

The Foundation supports initiatives that expand access to financial literacy, capital, and quality employment. 

Economic Services & Development Financial Literacy Employment Services +2 more

REALTORS Housing Opportunities Fund Grant

Coastal Community Foundation of South Carolina
Private
Berkeley County, South Carolina, Charleston County, South Carolina +1 more
Up to US $5,000
The REALTORS Housing Opportunities Fund Grant, initiated by the Charleston Trident Association of Realtors in 2003, aims to support affordable housing projects in Berkeley, Charleston, and Dorchester counties. With over $1 million invested, the grant prioritizes nonprofits focused on education, development, or repair of affordable housing. Interested organizations must register to apply, allowing two business days for processing. This competitive funding opportunity promotes community development and addresses housing needs.
Homeownership Equitable & Affordable Housing

NJ Statewide Family Centered Care Network (Ryan White Part D)

State of New Jersey Department of Health
State/Local Government
New Jersey
Up to US $2,969,085

New Jersey Department of Health (NJDOH)

The New Jersey Department of Health leads the state’s response to public health challenges and works to improve health outcomes for all New Jersey residents. Through its three primary branches—Public Health Services, Health Systems, and Integrated Health—the Department collaborates across programs and partners to strengthen New Jersey’s health system. Guided by its mission to protect public health, promote healthy communities, and improve the quality of health care, the Department supports initiatives that advance prevention, system integration, and equitable access to health services statewide.

NJ Statewide Family Centered Care Network (Ryan White Part D)

To provide comprehensive, culturally competent, coordinated medical care for infants, children, youth, women, and families who are infected or affected with HIV/AIDS. Referrals to appropriate ancillary medical & social services. 

HIV / AIDS

New England Food Vision Prize

Henry P. Kendall Foundation
Private
Connecticut, Maine +4 more
US $25,000 - US $100,000
The New England Food Vision Prize aims to enhance local food supply chains in New England's educational institutions by awarding up to $1.5 million. The program supports innovative projects that increase the amount of regionally produced food served to K-12 and college students. By fostering collaboration among schools, farmers, and community organizations, the Prize strengthens food systems while prioritizing access for students and communities with limited fresh food options.
Food Access & Hunger Farms & Farming Food Delivery & Distribution Services

Native American Preparatory Scholars Fund

New Mexico Community Foundation
Private
New Mexico
Unspecified amount

New Mexico Community Foundation

For over 40 years, New Mexico Foundation (NMF) has worked to improve the quality of life for all residents of New Mexico. The only statewide foundation, NMF was started in 1983 by a small group of dedicated and visionary volunteers who believed in the power of Philanthropy as a tool for inspiring creative, community-based change and prosperity.

NMF has distinguished itself as a leader in philanthropy. Our progressive, grassroots approach to building stronger communities empowers community members to collaborate on critical issues by tapping into local resources and discovering the strength in themselves.

In 2019 we changed our name to better define our purpose and identity as the only community foundation serving the state of New Mexico.

Native American Preparatory Scholars Fund

The Native American Preparatory Scholars (NAPS) Fund was established in 2012 from the remaining assets of the former Native American Preparatory School located in Rowe, NM. The purpose of the fund is to support programs that increase the number of New Mexico Native American students who shall aspire to, be prepared for, and graduate from colleges and universities.

To accomplish this mission, New Mexico Community Foundation is pleased to announce a funding opportunity through our NAPS Fund.

Grant Focus Areas

  • Programs that assist Native students with college acceptance.
  • Programs whose goal is to increase college matriculation of Native students.
  • Programs that support Native students for career readiness.

Native American Services Educational Access & Equity Career / College Preparation +1 more

Communication Access Service Centers: Language Acquisition

State of Nevada Aging and Disability Services Division
State/Local Government
Nevada
Unspecified amount
The Communication Access Service Centers provide essential support for individuals who are deaf, hard of hearing, or have speech disabilities. Focused on ages 0-21, the program offers American Sign Language (ASL) classes and Deaf Mentoring to enhance language acquisition. With services available statewide through Nevada Hands and Voices and Communication Services for the Deaf, families can access resources and training in various formats, including online and in-person classes.
Hearing Disorders & Audiology Hearing Impairment Care & Services Communication Disorders

Music Therapy Grants

Music Movement
Association/Society
United States
US $1,500 - US $2,500
Music Movement offers grants for music therapy aimed at children and young adults with Autism Spectrum Disorder (ASD) and other developmental challenges. Grants typically range from $1,500 to $2,500, providing financial relief to families seeking therapeutic resources. Eligible applicants include legal guardians of children in the U.S. who select qualified therapists. The organization focuses on enhancing communication, social skills, and emotional well-being through music, benefiting diverse communities and promoting personal growth.
Autism Children With Disabilities Music Education

Peter J. Rappa Resilient and Sustainable Coasts Fellowship

Hawai‘i Sea Grant
Association/Society
Honolulu County, Hawaii
US $8,000
The Peter J. Rappa Resilient and Sustainable Coasts Fellowship, established by the University of Hawai‘i Sea Grant, honors coastal sustainability pioneer Peter Joseph Rappa. This 8-week summer program, based at the Mānoa campus, engages undergraduate and graduate students in research and training focused on coastal resilience. Participants will explore community planning, hazard mitigation, and traditional knowledge to enhance sustainability in Hawaiian coastal communities.
Coastal Conservation Climate Change Resilience & Equity

Instrument Donations Program

Music Movement
Association/Society
United States
US $500 - US $1,500 in in-kind support
The Instrument Donations Program by Music Movement supports children and young adults with Autism and learning differences by providing funding for musical instruments. This initiative fosters self-expression, personal growth, and emotional well-being through music. Grants typically range from $500 to $1,500 and are available to applicants within the United States. The program encourages artistic development and enhances social skills, making a significant impact on the lives of those facing developmental challenges.
Music Autism Children With Disabilities

Community Support for Marine Debris Removal RFP

Alaska Sea Grant
State/Local Government
Alaska
Up to US $200,000
The Community Support for Marine Debris Removal RFP aims to tackle the pressing issue of marine debris in Alaska's coastal and offshore waters. This initiative, funded by the NOAA Marine Debris Program, empowers local communities by providing small grants to support their efforts in cleaning up litter and debris. The program addresses essential food safety and security concerns while promoting environmental stewardship and community resilience in the face of ongoing challenges related to marine waste.
Marine Debris

Never Let Go Fund

Emporia Community Foundation
Private
United States
Up to US $2,000

About the Emporia Community Foundation

Our Mission

To connect caring people with causes that build stronger communities within the Emporia area which includes Chase, Coffey, Greenwood, Lyon, Morris, Osage and Wabaunsee counties.

Never Let Go Fund

The purpose of the Never Let Go Fund is to provide funds to qualified individuals to cover expenses related to the treatment of childhood cancer. Grant requests will be considered for children under the age of 18.

Health Care Access & Delivery Cancer / Oncology Children’s Health & Pediatrics +1 more

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.34B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.7%
Q2
24.7%
Q3
23.5%
Q4
22.1%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $32,500.

$0 $0 Min.
$32,500 $32.5 K Median
$633,837 $633.8 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.7% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $32,500, while the average grant awarded is $633,837. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.