Best Large Grants for Nonprofit Organizations

The Aaron Thomas Gelineau Fund for Educational Opportunity, managed by the Boreal Waters Community Foundation, focuses on supporting Duluth nonprofits that assist underserved youth and families. It aims to promote cradle-to-career success through education, including high school completion and GED support. The fund prioritizes programs that address the opportunity gap and demonstrate a positive impact on youth and families. Funding may cover essential expenses such as transportation and supplies to enhance educational access.

The Norris Area Community Foundation Grant, an affiliate of the East Tennessee Foundation, aims to address charitable needs in the Norris area. This grant prioritizes projects benefiting youth, military recognition, humane animal care, arts, community pathways, and senior support. Eligible applicants must have a local presence and demonstrate a significant community impact with a minimum funding match of 10%. Certain requests, such as individual grants and capital campaigns, are not funded.

The Jacquelyn Bogue Foundation is dedicated to combating the stigma surrounding suicide in Orange County. By fostering awareness and understanding of suicide as a public health issue, the foundation aims to reduce suicide rates through education and community programs. It invites partnerships with organizations that share its mission, and it emphasizes the importance of supporting families affected by suicide. This initiative aligns with California's Strategy for Suicide Prevention, focusing on community stewardship and collaborative efforts.

The SAF National Awards Program recognizes outstanding contributions to forestry through various awards, including the Employer Leadership Award. This award honors employers who significantly support SAF members' professional engagement. Recipients receive a $500 honorarium, complimentary convention registration, and travel expense support. The program aims to celebrate the achievements of individuals and organizations in promoting sustainable forestry practices and enhancing professional development, ultimately driving excellence in natural resource management.

Cancer Prevention in Maine

Cancer remains a leading cause of death in Maine, impacting thousands of Mainers each year. Fortunately, there are many ways to reduce cancer risk and prevention certain types of cancer, ultimately reducing the burden of the disease in our state.

To support cancer prevention efforts, Maine Cancer Foundation is now accepting applications for evidence-based interventions to reduce the risk of cancer in Maine.

Cancer Prevention Focus Areas that will be considered include:

• Alcohol Use
• Environmental Factors that Impact Cancer (Arsenic, PFAs, Radon)
• HPV Vaccinations
• Obesity Prevention
• Sun Safety
• Tobacco Use and Prevention and/or Treatment

Proposals should utilize evidence-based practices in preventing cancer. Please be prepared to provide quantitative and/or qualitative data to support your proposed strategies throughout an application.

Grant Term & Request Amount

Applicants may request a 1- or 2-year grant. Request amounts up to $40,000 per year will be accepted. The maximum request over two years is $80,000. Please note, requests do not have to meet the maximum amount. Smaller, pilot projects are also encouraged.

The National Institutes of Health is launching a funding opportunity to explore the mechanisms of skin injuries caused by toxic chemicals. This initiative aims to understand the common pathways of injury from various harmful substances, facilitating the discovery of therapeutic targets. Researchers are encouraged to collaborate and apply their expertise in cutaneous wound healing. The goal is to develop broad-spectrum medical countermeasures for mass casualty events involving toxic exposures, enhancing public health safety.

The BETA: Roadmaps initiative by MassCEC aims to accelerate building electrification and decarbonization for non-profit and public entities in Massachusetts. This program provides actionable roadmaps to achieve zero-emissions building portfolios by 2050, supporting the state’s climate goals. Participants receive tailored decarbonization strategies, addressing their unique needs while fostering sustainable practices across diverse building types. With a focus on efficient procurement and implementation, the initiative aligns with the Commonwealth's broader clean energy objectives.

The Holloway Family Foundation, established in North Central Texas, aims to enhance community quality of life regardless of race, gender, or religion. Their mission focuses on financial security, creative expression for under-resourced youth, and mentorship for personal development. The foundation supports organizations that provide workforce training, artistic opportunities for children, and guidance for youth in need. By fostering individual growth and economic stability, they empower families and strengthen communities, staying true to the founders' core values and personal experiences.

Reader’s Digest Partners for Sight Foundation

The Reader’s Digest Partners for Sight Foundation is a philanthropic organization dedicated to improving the lives of individuals who are blind or visually impaired by fostering independence and self-sufficiency. Its mission is to support programs that help people with vision loss lead independent, productive lives, while its vision is an accessible and inclusive world where individuals have the tools, resources, and opportunities to fully participate in society.

The Foundation’s funding priorities focus on supporting nonprofit organizations and initiatives that provide education, training, and rehabilitation services, assistive technology innovations, vision care and access to aids, and capacity building for professionals serving the visually impaired community. It also invests in programs that enhance employment opportunities, promote independence, and improve service delivery systems for people with vision loss, emphasizing practical, community-based solutions and long-term impact.

Small Discretionary Grants

The Reader’s Digest Partners for Sight Foundation (RDPFS) Track #3 Small Discretionary Grants provide flexible, year-round funding for smaller-scale initiatives that support individuals who are blind or visually impaired. Grant requests are accepted on a rolling basis and awarded at the discretion of the Executive Director. Awards are made until available funds are exhausted, allowing the Foundation to respond to timely or emerging needs.

The Jurgens, Virgil Scholarship, funded by the Beatrice Educational Foundation, offers a $375 award to a Beatrice High School senior who excels in baseball and ranks in the top 25% of their class. The Foundation, established in 1987, provides financial support for educational opportunities. This scholarship aims to assist deserving students in pursuing higher education, emphasizing the importance of academic achievement and community involvement.

Carl Hill Memorial Scholarship

Awards:

• One time award of $500.

The Fund for Williamstown Grant, offered by the Berkshire Taconic Community Foundation, provides vital support for nonprofits aiding residents in Williamstown, Massachusetts. Aiming to enhance community life through innovative programs, the grant targets social, emotional, and physical development. Eligible applicants include 501(c)(3) organizations and fiscally sponsored groups that demonstrate financial resiliency and commitment to future planning. This initiative focuses on fostering inclusivity and sustainable community growth, ensuring access to essential services and opportunities for all.

The Fund for Women Grant, administered by the Delaware Community Foundation, supports nonprofit organizations dedicated to empowering women and girls in Delaware. This one-year grant provides financial assistance for innovative programs that enhance the potential of women and girls. Eligible applicants must demonstrate 501(c)(3) status and address the specific needs of this demographic. The grant aims to foster self-sufficiency and productive lives, ensuring that women and girls can achieve their full potential.

The AOS-Sponsored Student Memberships provide one year of free membership to students globally interested in ornithology. Awardees gain full access to AOS membership benefits and are encouraged to participate in various opportunities, including the annual meeting and travel grants. This initiative aims to foster the next generation of ornithologists by supporting their academic and professional growth while upholding high ethical standards aligned with the AOS Code of Conduct.

The Harbor Point Charitable Foundation Grant aims to enhance the quality of life for underserved adults and children in the Bay Area. With a focus on innovative organizations addressing health crises and supporting educational, arts, and nutritional programs, the Foundation has distributed over $4.6 million in grants. Their mission emphasizes community engagement and advocacy, ensuring that funds support nonprofit organizations exempt under section 501(c)(3) of the Internal Revenue Code, particularly those benefiting Marin County residents.

South Dakota Community Foundation

As a statewide community foundation, we work with donors, nonprofits and community leaders to strengthen philanthropy in South Dakota every day.

Scholarships

At South Dakota Community Foundation (SDCF), we proudly manage more than 350 scholarship funds in partnership with generous donors who are committed to supporting students. These scholarships offer countless opportunities to help ease the financial burden of continuing their education.

Spearfish Volunteer Firefighters' Association Scholarship

To provide financial support to individuals pursuing an education and training in the public safety industry.

The Spearfish Fire Department, established in the late 1880s as a volunteer organization, serves the northern Black Hills in western South Dakota. Its mission is to protect lives and property within the fire protection district and mutual aid area. Additionally, the department advocates for fire safety and provides fire safety education in local schools and the wider community.

N.C. Forest Service - Urban and Community Forestry Financial Assistance Program

The goal of the North Carolina Urban and Community Forestry (U&CF) Program is to help municipalities reach a level of sustainable U&CF management that matches their goals and capacity. We define urban and community forestry as follows:

Urban forestry is defined as the management of the planting, maintenance and protection of tree populations in urban settings to enhance the economic and ecosystem services trees provide to the community.

Community forestry is a branch of forestry that engages the community in the completion of urban forestry practices in support of local government, serves broader community needs and works for positive change.

When municipalities and partners accomplish urban and community forestry practices and activities in an ordered manner, they enhance the level of management in the community, leading to sustainable program success. 

We use the accomplishment of six specific standards to measure and classify the development status of a community’s U&CF program into one of four management classifications. This helps a community measure its progress, celebrate accomplishments, and allows us to best serve each community’s individual needs.

The Urban and Community Forestry Project Financial Assistance Program is designed to help communities climb this sustainable management hierarchy. The program accomplishes this by providing financial assistance and guidance in the development and completion of U&CF projects comprised of urban and community forestry practices and activities. A Request for Applications (RFA) process is offered several times a year to help you plan and apply for these assistance opportunities. Definitions of the practices, activities and project deliverables can be found in the following document: NCFS U&CF FAP Glossary of Deliverables and Requirements

Financial Assistance Program Packages

We offer the following packages of specific practices and activities, each designed to help move a community up the management hierarchy or address a specific need.

• Climb to Tree City USA Package (Consolidated Program Grant (CPG); Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA))
• Climb to Managing Community Package (Consolidated Program Grant (CPG); Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA))
• Tree Maintenance and Planting Packages: i) Tree maintenance and planting project (Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA)) and ii) Bad tree bounty project);
• Professional Staff Development Assistance
• N.C. Arbor Day Celebration Assistance
• Special Projects: Climb to Tree City USA Services (Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA))

Climb to Tree City USA Package

This assistance package is designed to help municipalities that have not met all the Tree City USA standards complete select urban forestry practices and community forestry activities that are foundational in the management of public trees and to achieve Tree City USA designation. The RFA opens in January each year.

Funding Program Options

A grant will be funded by one of the three funding programs. You will need to select one. (Contact NCFS U&CF program staff for guidance, if needed):

• Consolidated Program Grant (CPG)
• Hurricane Helene Recovery (HHR)
• Inflation Reduction Act (IRA)

Hurricane Helene Recovery (HHR)

• Tribal government or a municipality located in Alleghany, Ashe, Avery, Buncombe, Caldwell, Henderson, Madison, Mitchell, Polk, Rutherford, Transylvania or Yancey counties.
• Cost share %: Reimbursement of 100% of eligible purchased goods and services.
• Indirect administration – 15% de minimis/total purchased goods and services.
• $2.2 million in assistance is available for award of all HHR funded RFAs.

The Patient-Centered Outcomes Research Institute (PCORI) will announce the Phased Large Awards for Comparative Effectiveness Research on December 2, 2025. This funding aims to support high-quality, patient-centered comparative clinical effectiveness research projects. The initiative encourages applicants to engage with patients and stakeholders to address critical healthcare dilemmas and improve decision-making. Projects should compare established clinical alternatives with evidence of efficacy, targeting vital health issues across diverse populations.

The Jean Longwith Scholarship for Radio-Television-Film, offered by the San Antonio Area Foundation, supports students pursuing degrees in broadcasting, radio, television, and film. This scholarship is available to full-time students in Texas, including high school seniors and current college students. It is renewable for up to three years, provided recipients maintain a minimum GPA of 3.0. Funding covers tuition, fees, books, and supplies, making it a valuable opportunity for aspiring media professionals.

The Water System Sustainability Grant Program provides funding to assist community water systems in developing sustainable operations and improving their technical, managerial, and financial capacities. The Strategic Planning Grant specifically supports the creation of engineering and hydrogeological reports, helping decision-makers implement necessary infrastructure improvements. Eligible projects include alternative analysis studies, pilot studies, and source exploration investigations. This initiative aims to secure necessary funding through informed outreach and detailed planning.

The Water System Sustainability Grant Program provides essential funding for community water systems to enhance their operational efficiency through effective asset management practices. This initiative supports both new programs and improvements to existing asset management efforts, encouraging proactive management strategies that ensure sustainability and financial viability. With a focus on technical and managerial capacity, the program aims to empower communities to make informed decisions about their water infrastructure and resources.

The SACF: Healthy Youth & Healthy Seniors Fund Grant, managed by the Sturgis Area Community Foundation, aims to enhance health and wellness for youth and seniors in St. Joseph County. This grant supports programs that promote healthy lifestyles, including nutrition, mental health, and preventive care. Eligible applicants include 501(c)(3) organizations and government entities serving the Sturgis community. With a focus on impactful initiatives, this grant fosters a healthier future for both youth and seniors.

About Legacy Foundation

Legacy Foundation is the community foundation for Lake County, Indiana. We connect people, knowledge, and funding to build an equitable, accessible, and inclusive Lake County, now and for generations to come.

Legacy Foundation is supported by a broad base of individuals, families, and businesses connected by the desire to improve Lake County, Indiana. With a growing portfolio of over 300 funds and approximately $80 million in assets, Legacy Foundation is a trusted source for philanthropic giving in the region.

For over 30 years, Legacy Foundation has been empowering people, providing strategic leadership, and impactful philanthropic support to create an equitable Lake County where all people thrive.

Mission Statement

Transforming Lake County by providing strategic leadership and impactful philanthropic support to ensure equitable opportunity for all communities that we serve.

Vision Statement

Create an equitable Lake County where all people thrive.

Robert Rainsberger Scholarship - Purdue Northwest

Use the chart below to see which scholarships are the best fit for you! You must complete the Legacy Universal Application to apply.

Scholarship eligibility requires students to attend an accredited 2 or 4 year public or private institution of higher learning. All scholarships are for full-time students, unless otherwise noted. Renewable awards are for 4 years of undergraduate study and cannot be used for post graduate coursework; all awards are paid directly to the school or may be used for book reimbursement.

Texas Health and Human Services

Texas Health and Human Services, also known as the Texas Health and Human Services Commission (HHSC), helps more than 7.5 million Texans every month. The agency supports the needs of mothers, children and families through programs such as Medicaid, CHIP, SNAP, women’s health and behavioral health services.

HHSC provides long-term services and supports for seniors and people with disabilities, and operates state supported living centers for residents with intellectual and developmental disabilities and state psychiatric hospitals. HHSC also regulates health care providers, professions and facilities to protect the health and safety of Texans.

Fiscal Year 2026 Innovation Grant Program

Executive Summary

The Texas Health and Human Services Commission (HHSC), the System Agency, is accepting applications for the Fiscal Year 2026 Innovation Grant Program.

The purpose of this program is to support Rural Hospitals, Rural Hospital Authorities (RHA), and Rural Hospitals Districts (RHD) to provide access to health care, improve quality of care, strengthen financial stability, and ensure initiatives are sustainable.

The Les Mehrhoff Botanical Research Award, established by the New England Botanical Society, supports innovative botanical research that enhances our understanding of New England's flora. Open to applicants without membership, it prioritizes projects lacking traditional funding sources. Eligible expenses include fieldwork, lab supplies, and moderate stipends. This award encourages researchers to explore unconventional inquiries and fosters a deeper appreciation for the diverse plant life in northeastern North America.

Prevent Sleep-Related Infant Deaths in Minnesota’s American Indian and Black/African American Populations RFP

The Minnesota Department of Health (MDH) seeks proposals to fund one organization with the capacity and expertise to create, manage, and support Community Action Teams (CATs) to implement culturally appropriate, data driven solutions to reduce sudden unexpected infant deaths (SUIDs) in Minnesota’s American Indian and Black/African American populations. The organization selected for this grant must be uniquely positioned to support the CATs in implementing community prioritized solutions to improve infant sleep safety that align with the American Academy of Pediatrics safe sleep recommendations. The awarded applicant must also be immediately ready, upon being notified about the award, to begin forming the CATs and executing other duties as contractually agreed upon. This RFP aligns with both state and national goals to reduce infant mortality by addressing SUIDs in communities that are disproportionately affected by sleep-related tragedies during infancy.

The source of funding for this grant opportunity is the Centers for Disease Control and Prevention, Department of Health and Human Services, through NU58DP007698. Funding is currently available for $134,000 from July 15, 2026, to Sept. 29, 2027. However, the grant may be extended for an additional year contingent on the availability of funds and the awarded applicant’s performance during the initial project period. Funding will be allocated through a competitive process.

Estimated Amount to Grant

• $134,000

Estimated Number of Awards

• 1

The Reader’s Digest Partners for Sight Foundation offers Single Program Grants to support impactful programs for individuals who are blind or visually impaired. These grants, ranging from $25,000 to $50,000, prioritize initiatives that enhance independence and service delivery. Eligible organizations must be US 501(c)(3) non-profits, and unsolicited proposals are not accepted. The foundation emphasizes community-based solutions and invites qualified applicants to submit a Letter of Inquiry followed by a full proposal.