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Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.
33,000+
Available grants
$9.00B
Total funding
$6K
Median grant
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About Us
Community Foundation of White County
Your community foundation is a philanthropic, nonprofit 501c3 organization that partners with visionary donors who believe that philanthropy has power to positively transform our White County community … forever.
To strengthen and transform our White County community by fostering charitable giving, philanthropic aspirations, and leadership.
Grants Available
Women Giving Together Grants
Grant are available to non-profit organizations serving White County women and children. This year's cycle will have an added focus on early childcare initiatives.
St. Ignace Area Community Foundation: CTE Technical Scholarship
The St. Ignace Community Fund annually awards scholarships assisting students with higher education, technical training, vocational training or retraining based largely on acknowledgement of student responsibility, community service, and civic involvement. These Scholarships are made possible through the generosity of donors to the various accounts within the St. Ignace Area Community Fund. Some accounts specifically are awarded to recognize higher education in the areas of special education, vocational/technical careers, teaching, law enforcement, and health care.
Hutsell, Alan Scholarship Fund
For a high school senior from Central Noble, East Noble, Wawasee, West Noble or homeschool (homeschooled student must live in Noble County) who will be pursuing advanced education in emergency services involving fire, police, criminal justice and/or EMS.
Awards Per Year:
Applicant High School:
Colleges:
Areas of Study:
The mission of The Modesto Rotary Club Foundation (MRCF) is to support local organizations and projects through charitable contributions.
Grants
The Modesto Rotary Club Foundation’s aim is to help organizations stretch and have bigger impact in Modesto.
The Modesto Rotary Club Foundation will support game-changing work across all program areas, and we especially encourage initiatives that support:
Successful applications will demonstrate community need, and yield tangible and measurable results. Funds are available for program development/expansion, innovation, technology and equipment.
Award amounts will be based on:
Cures Within Reach
Cures Within Reach is the philanthropic leader in drug, device and nutraceutical repurposing research, which has the potential to transform the lives of patients with unsolved diseases by delivering treatments that can be used in the near-term. Our focus: we find and fund proof-of-concept clinical trials that, once successful, de-risk and catalyze follow-on funding, building the clinical evidence required for regulatory approval or to support off-label use by patients everywhere.
Clinical Repurposing Research to Impact US Veterans/Military
This Request for Proposals (RFP) from Cures Within Reach (CWR) is seeking clinical repurposing trials from US-based research institutions using already approved treatments to address unmet and high-priority medical needs of US veterans and/or active US military, such as mental health, post-traumatic stress disorder (PTSD) and brain injuries. Our strongest preference is for proof of concept, pivotal, Phase I or Phase IIA clinical repurposing trials. Eligible trials may be conducted at accredited US-based academic, nonprofit and governmental research institutions and/or health systems involved with medical research, including Veterans Administration (VA) health systems and hospitals.
Repurposed therapies must be approved and/or generally recognized as safe for human use by some regulatory agency, such as the US Food and Drug Administration, European Medicines Agency, Health Canada or Japan’s Pharmaceuticals and Medical Devices Agency, and may include drugs, devices, nutraceuticals or diagnostics, as well as combination therapies. These repurposed therapies must be tested in a new indication for which they are not already approved or used widely in clinical practice as standard of care. Repurposed therapies also may be added to current standard of care to improve patient outcomes and/or quality of life.
Each PLTW Engineering course engages students in interdisciplinary activities like working with a client to design a home, programming electronic devices or robotic arms, or exploring algae as a biofuel source. These activities not only build knowledge and skills in engineering, but also empower students to develop essential skills such as problem solving, critical and creative thinking, communication, collaboration, and perseverance.
Through this partnership, Intel Foundation has committed funds to support PLTW grants to schools interested in starting or expanding PLTW programs beginning in the 2027-2028 academic year.
Program Requirements:
Grant Award and Distribution Schedule:
About PLTW Biomedical Science
PLTW Biomedical Science students have experience with state-of-the-art tools and techniques that are used by professionals in hospitals and labs every day. By immersing students in activities like practicing suturing and constructing body structures from clay, PLTW Biomedical Science empowers students to build knowledge and skills in biomedical science, as well as in-demand, transportable skills like problem solving, critical and creative thinking, communication, and collaboration.Public schools, including charter schools, that meet the 10-county geographic requirement that do not yet offer PLTW Biomedical Science are eligible for consideration to support program implementation. PLTW will disburse grant funds over two years and require two years of reporting from awarded schools. Program Requirements
Grant Award and Distribution Schedule:
Parkview Legacy Foundation
The Parkview Legacy Foundation was created in July of 2019 by the sale of Parkview Community Hospital Medical Center (a non-profit hospital) to AHMC (a for-profit hospital group). With the sale, the State of California required that the proceeds of the non-profit hospital be put to use for the benefit of the community through the creation of non-profit public charity or private foundation. The Parkview Legacy Foundation is the result of that transaction, and Parkview Legacy Foundation now exists as an independent Public Charity serving the Riverside region. With the funds endowed to the foundation, we are honored to invest back into the local community with a broader scope of ensuring the equitable probability of wellness through social determinants of health.
Parkview Legacy Foundation is committed to support organizations, collaborations, and initiatives that directly address the root causes which negatively affect the four focus areas of housing stability, social mobility, whole health accessibility, and integrated solutions, and therefore, prevent residents of the Inland Region from achieving wellness and stability.
Collective Impact Grant
Parkview Legacy Foundation’s Impact Grants Program is driven by our core values and intended to support organizations seeking to make transformational progress in addressing needs and seizing opportunities in our four focus areas throughout the Riverside region.
Collective Impact funding is intended to support the advancement of efforts toward specific and stated objectives (goals, outcomes, and/or impacts) being carried forth by strategically coordinated and operated multi-sector collaborations and initiatives involving multiple organizations and/or institutions. Examples of ways the Collective Impact Grant may be used include:
Department of Labor and Workforce Development
The New Jersey Department of Labor and Workforce Development is dedicated to protecting our workforce, strengthening our businesses, and promoting the dignity of work.
The Division of Workforce Development is responsible for New Jersey’s workforce services, including vocational rehabilitation services, veteran’s services, and more. The division oversees the One-Stop Career Centers throughout the state, which offer a variety of programs and services to help employers meet their need to secure talented workers.
New Jersey Competitive Integrated Employment (CIE): Implementation & System Advancement (Phase II)
Grant Overview
Grant funds will be awarded to successful applicants who were previously awarded NJCIE Pilot Program grant funds from the NJCIE Pilot Program launched in 2024. Building on the success of the initial NJCIE Pilot launched in 2024, this next phase focuses on advancing participant outcomes and strengthening employer partnerships through more structured, outcome-driven service delivery models. This Phase II opportunity supports community rehabilitation providers in refining and scaling strategies that connect career pathway development, industry-recognized credential attainment, and competitive integrated employment. The program places an increased emphasis on measurable outcomes, including retention, wage progression, and long-term employment stability, while continuing to support the transition toward fully integrated employment opportunities statewide.
The purpose of the NJCIE program is to provide an opportunity for community rehabilitation providers to strengthen organizational capacity and pilot innovative employment and training services for people with disabilities that are intended to lead to competitive integrated employment.
Minnesota Department of Health
Mission: Protecting, maintaining and improving the health of all Minnesotans.
Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.
Rural Health Transformation Program: Healthcare Workforce Retention Program
Program Description
Minnesota’s RHTP covers a broad range of initiatives designed to transform the state of the rural health system by improving health outcomes and access to care for rural Minnesotans, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments.
This RFP seeks proposals to understand systemic factors leading to provider/clinician burnout; develop, pilot and scale responsive solutions to decrease burnout; and link the solutions to improved working conditions to improvements in provider retention and patient experience and/or outcomes.
Syndax Pharmaceuticals, Inc.
At Syndax, we are determined to realize a future in which people with cancer live longer and better than ever before. We believe that it takes a community to build a great medicine, and that is why we are working to set the new standard for developing medicines in the field of oncology – one that revolves around collaboration, shared learning, and excellence.
Syndax’s mission is to obtain regulatory approval and commercialize drugs that extend and improve the lives of cancer patients by drawing on the newest scientific research and advances, collaborating with determined problem solvers, and identifying value in overlooked aspects of science.
Educational Funding
At Syndax, we are committed to the goal of supporting objective, balanced and scientifically rigorous education that furthers improvements in science, medicine, and patient care. We accomplish this goal, in part, by providing grants for independent medical education (IME) programs. These can include live, online, and/or enduring programs that educate healthcare providers (HCPs), patients, or caregivers. Programs that are funded via Syndax medical education grants must be primarily dedicated, in both effort and time, to medical, health or scientific topics that are objective, balanced, unbiased, and scientifically rigorous. Medical education grants must never be made with the intent to directly or indirectly reward, influence or encourage the recipient to prescribe, purchase, sell or arrange for any Syndax product.
About the Hartford Foundation for Public Giving
Greater Hartford Gives Foundation, formerly known as the Hartford Foundation for Public Giving, is the largest community foundation in Connecticut. We serve 800,000 residents across 29 towns that make up Greater Hartford. Community is at the heart of what we do. We want to make this region a more inclusive and equitable place to live, work, and start a family.
OAHSTRIDES Fund
The Greater Hartford Gives Foundation is pleased to announce that it is accepting applications for grants through the OAHSTRIDES Fund. OAHSTRIDES is the philanthropic arm of Orthopedic Associates of Hartford, PC. They work with under-resourced populations in the Greater Hartford Community to provide the support needed to build essential life skills and live healthier lifestyles. Their Mission is to improve physical, emotional, and mental health with an emphasis on movement and mobility.
For the 2026 grant cycle, OAHSTRIDES is focused on supporting veterans in the Greater Hartford community through adaptive physical activity, mental wellness initiatives, and opportunities for meaningful community connection and reintegration. We recognize that many veterans carry visible and invisible impacts of service, including physical injuries, chronic pain, mobility challenges, post-service transition difficulties, and social isolation.
Through this funding opportunity, OAHSTRIDES seeks to partner with organizations that honor veterans’ experiences and are committed to empowering them through movement-based and wellness-centered programs. We aim to support initiatives that foster resilience, restore confidence and connection, and promote lifelong health and well-being for those who have served.
Programmatic and project-specific requests are strongly encouraged.
Utah Outdoor Recreation Grant
The Utah Outdoor Recreation Grant (UORG) is for new outdoor recreation infrastructure projects and helps communities build recreation amenities that support local economic development, tourism, and quality of life improvements for Utah’s residents.
Introduction
The Utah Division of Outdoor Recreation (DOR) is committed to ensuring every Utahn can live a healthy and active lifestyle through outdoor recreation and access to natural space. The DOR focuses on four key areas: expanding recreational access, promoting safety and education, ensuring responsible stewardship and sustainable visitation, and driving economic growth through outdoor recreation.
With our grant programs, we support local communities in achieving these goals and are thrilled to offer five grants under the Utah Outdoor Recreation Grant (UORG) Program in 2026.
Mini Grant
Ideal for smaller projects
Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.
Discover 8,000+ funding opportunities for nonprofits, with $3.34B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.
How common are grants in this category?
Quite common — grants in this category are more prevalent than in others.
Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?
Most grants are due in the first quarter.
What's the typical grant amount funded for Large Grants for Nonprofit Organizations?
Grants are most commonly $32,500.
Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.
Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.7% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.
Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.
Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $32,500, while the average grant awarded is $633,837. Understanding these funding trends can help nonprofits set realistic expectations when applying.
Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.
To improve the chances of receiving large grants, nonprofits should:
Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.
Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.