Best Large Grants for Nonprofit Organizations

The Forward Turn Youth Grantmakers is a youth-led program aimed at supporting positive community initiatives in Fauquier and Loudoun Counties. Funded by the Community Foundation for Loudoun and Northern Fauquier Counties, it encourages youth involvement in grant applications that address issues like substance abuse, internet safety, and mental health. The program prioritizes projects led by teens, fostering collaboration and innovative solutions to enhance community engagement and support for youth.

About Regions

Regions Financial Corporation is a member of the S&P 500 Index and is one of the nation's largest full-service providers of consumer and commercial banking, wealth management and mortgage products and services. Regions serves customers across the South, Midwest and Texas.

Regions Foundation

Regions Foundation supports community investments that positively impact the communities served by Regions Bank. The Foundation engages in a grantmaking program focused on priorities including economic and community development; education and workforce readiness; and financial wellness. The Foundation is a nonprofit 501(c)(3) corporation funded primarily through contributions from Regions Bank.

Matching Gifts Program

Full-time associates and recent retirees (up to 5 years after retirement) of Regions and its affiliated companies can request a Regions Matching Gift to eligible organizations. The recipient organization must be a 501(c) or 170(c) organization located in the Regions footprint (except for accredited educational institutions, which may be located anywhere in the United States) and has a primary mission that clearly fits one of these categories:

• Economic and community development: Supporting economic prosperity through affordable housing, job creation, small-business development, homebuyer education and retention, neighborhood revitalization and stabilization, food security/hunger relief.
• Education and workforce readiness: Supporting career prosperity through student competency and skill building, college and career readiness, educational access and success, credential building and employment and educator training and resources.
• Financial wellness: Supporting financial prosperity through K-12 and college financial education, adult and workforce financial empowerment.
• Arts and culture: Organizations that promote visual or performing arts, historic or science museums, zoos, botanical gardens, libraries, parks or public radio and television.
• Service members and Veterans: Organizations that have a primary mission of supporting U.S. military service members and veterans.
• Individuals with disabilities: Organizations that have a primary mission of supporting individuals with disabilities.

Regions Matching Gifts for Recent Retirees

Retirees of Regions and its affiliated companies are eligible for the Matching Gift Program for up to 5 years after retirement (the gift date must be within the first 5 years of retirement). Regions will match donations of $25 or more, up to a total of $1,000 per year per retiree.

The Regions Community Affairs team will contact the organization on your behalf to verify the gift and review eligibility.

The Henry Mayo Newhall Foundation, established in 1963, is dedicated to enhancing life quality in communities linked to California pioneer Henry Mayo Newhall. It funds initiatives in academic enrichment, animal welfare, scholarships, historical preservation, and outreach for the disadvantaged. Grants typically range from $5,000 to $20,000 for one year, with potential renewals based on effectiveness. The Foundation prioritizes proposals from nonprofit organizations in specific California regions, emphasizing matching or challenge grants.

The WA Agricultural Conservation Easement Program (WRE) supports landowners in protecting and restoring wetlands degraded by agricultural activities. This program enhances wildlife habitats, improves water quality, and offers various easement options, including permanent and 30-year easements, with funding for restoration costs. With a focus on climate resilience and biodiversity, WRE encourages participation from eligible private landowners and Indian tribes, promoting sustainable land management practices.

The Melrose Cooperative Bank Foundation Grant supports community service organizations in Melrose and surrounding areas. It focuses on education, health, human services, affordable housing, and general community support. Grants range from $250 to $10,000 and are available to 501(c)3 organizations. Applications are reviewed on a rolling basis, and applicants may reapply if previous submissions were denied due to missing information or relevance. The Foundation does not fund political activities or individual scholarships.

Background

The Community Services Block Grant (CSBG) is a federally funded program that provides formulaic grants to alleviate the conditions of poverty in communities. The objective of CSBG is to address the causes of poverty by implementing programs and services that empower low-income families and individuals, revitalize low-income communities, and improve the economic self-sufficiency of low income customers.

CSBG funding supports projects that:

• Lessen poverty in communities
• Address the needs of low-income individuals including the homeless, migrants and the elderly
• Provide services and activities addressing employment, education, better use of available income, housing, nutrition, emergency services and/or health

CSBG Service Categories & Eligible Activities

• Education
  • vocational skills training, cultural opportunities for disadvantaged children, GED assistance for high school dropout, adult and youth literacy training.
• Employment
  • job creating economic development programs which result in the employment and self-sufficiency of low-income persons.
• Health & Social Development
  • health related activities including transportation to medical services, medical and dental screening, immunizations, prevention and treatment assistance and medication prescriptions and other related services.
• Housing
  • includes aid to renters seeking a residence, landlord/tenant rights education and arbitration
• Income Management
  • programs to encourage better use of available income that includes family budget counseling, financial management, credit, income taxes and social security.
• Self-Sufficiency/Multiple Domain
  • comprehensive family case management programs that promote, empower and nurture family members toward self-sufficiency.

The California State Loan Repayment Program (SLRP) aims to bolster the number of healthcare providers in underserved areas, including primary care physicians, dentists, and mental health professionals. By offering financial incentives, SLRP encourages qualified applicants to serve in California Health Professional Shortage Areas (HPSAs). Funding priorities include previous recipients who have fulfilled their obligations, new applicants, and equitable distribution of awards across various regions and disciplines.

About Regions

Regions Financial Corporation is a member of the S&P 500 Index and is one of the nation's largest full-service providers of consumer and commercial banking, wealth management and mortgage products and services. Regions serves customers across the South, Midwest and Texas.

Regions Foundation

Regions Foundation supports community investments that positively impact the communities served by Regions Bank. The Foundation engages in a grantmaking program focused on priorities including economic and community development; education and workforce readiness; and financial wellness. The Foundation is a nonprofit 501(c)(3) corporation funded primarily through contributions from Regions Bank.

Matching Gifts Program

Full-time associates and recent retirees (up to 5 years after retirement) of Regions and its affiliated companies can request a Regions Matching Gift to eligible organizations. The recipient organization must be a 501(c) or 170(c) organization located in the Regions footprint (except for accredited educational institutions, which may be located anywhere in the United States) and has a primary mission that clearly fits one of these categories:

• Economic and community development: Supporting economic prosperity through affordable housing, job creation, small-business development, homebuyer education and retention, neighborhood revitalization and stabilization, food security/hunger relief.
• Education and workforce readiness: Supporting career prosperity through student competency and skill building, college and career readiness, educational access and success, credential building and employment and educator training and resources.
• Financial wellness: Supporting financial prosperity through K-12 and college financial education, adult and workforce financial empowerment.
• Arts and culture: Organizations that promote visual or performing arts, historic or science museums, zoos, botanical gardens, libraries, parks or public radio and television.
• Service members and Veterans: Organizations that have a primary mission of supporting U.S. military service members and veterans.
• Individuals with disabilities: Organizations that have a primary mission of supporting individuals with disabilities.

Regions Matching Gifts for Full-Time Associates

Regions supports organizations important to our associates through the Regions Matching Gifts Program. This program, which is open for use for all full-time Regions associates, affiliate associates and recent retirees, allows you to make an even greater difference to your favorite charities by doubling your tax-deductible contributions to these organizations. 

The Pinetop Assistance League (PAL) Grant provides crucial financial support to elderly blues musicians, ensuring their well-being during emergencies. This grant, part of the Pinetop Perkins Foundation's mission, offers assistance for medical expenses, home care, and essential living costs. Eligible applicants must be professional artists aged 50 or older with a household income below $35,000. By addressing these needs, PAL plays a vital role in preserving the legacy and care of blues musicians.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CRRP 

Through the competitive Collaborative Regional Research Programme (CRRP), we promote regional research that has potential to improve our understanding of global change and its implications while contributing to a sound scientific basis for policymaking in areas affected by global change. Under this pillar, APN supports collaborative research that contributes to the evolving science-policy arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction and the UN Decade of Ocean Science as well as ongoing and new global change and sustainability research programmes.

Activities of interest under the CRRP Programme

APN promotes regional collaborative research that improves understanding of the physical, biological and human dimensions of change in the Earth system and advances actionable science that informs decision-making. APN accepts proposals that engage at least 3 member/approved countries in the region, and prioritise collaboratively designed, actionable research with non-academic stakeholders. Proposals must address one or more of the following activities:

• Collaborative research on global change and sustainability that particularly addresses GAPS, ANALYSIS, SYNTHESIS and ASSESSMENT work.
• Collaborative research that develops PATHWAYS and MECHANISMS to achieve sustainable development, and develop adaptation strategies.
• Collaborative PLACE-BASED INTEGRATIVE RESEARCH, particularly from developing countries.
• Collaborative research that is CO-DESIGNED to contribute to the Paris Agreeemnt, Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, Post-2020 Global Biodiversity Framework, UN Decade of Ocean Science (2021-2030), and the accumulation of scientific knowledge at IPCC, IPBES, etc.

The Agricultural Conservation Easement Program in Mississippi, managed by the USDA's Natural Resources Conservation Service, promotes environmental sustainability through Wetland Reserve Easements. This program supports migratory waterfowl and other wildlife, enhances water quality, and combats climate change. Eligible landowners can receive 100% funding for permanent easements and partial funding for restoration. These efforts not only protect biodiversity but also offer opportunities for scientific and recreational activities, ensuring the preservation of valuable wetland ecosystems.

The NewAlliance Foundation Grant offers support to not-for-profit organizations in four key areas: arts, community development, health and human services, and youth education. It prioritizes programs that engage diverse and underserved populations, promote economic self-sufficiency, and provide essential services to vulnerable communities. Eligible applicants must be 501(c)3 non-profits located within specific towns. The foundation does not fund start-ups or organizations outside its service area, ensuring targeted support for impactful initiatives.

The National Institutes of Health (NIH) is inviting applications for the Screening, Brief Intervention, and Referral to Treatment or Prevention (SBIRT/P) program. This funding opportunity aims to explore innovative methods for addressing alcohol, tobacco, and other drug use among adults facing health disparities. The initiative seeks research proposals that will implement and evaluate SBIRT/P strategies in collaboration with healthcare and community partners. This approach is crucial for enhancing public health and ensuring effective interventions.

About

Being deeply connected to the community means more than providing access to excellent healthcare. It means understanding, and investing in, the health needs of our community.

Through our Community Investment Fund (CIF), Endeavor Health has awarded more than $38.5 million to 59 local partnerships dedicated to enhancing community health and wellbeing, advancing health equity and supporting local economic growth. Together, we’re committed to helping everyone in our communities be their best.

Award categories

Through the CIF, we will make meaningful and intentional investments through impact awards and capacity builder awards. These awards are intended to meaningfully advance the health of our community over time towards three bold aspirations through investments in five areas of focus.

We aspire to a future where:

• A person’s zip code does not determine how long they will live
• Hunger and homelessness in our communities are history
• The healthcare workforce is thriving and representative of the communities we serve

To help advance these aspirations, the CIF will invest in the following areas:

• Access to healthcare
• Behavioral health
• Food insecurity
• Housing insecurity
• Workforce development for careers in healthcare

Impact awards

• Designed for 5-year initiatives where organizations come together to drive measurable impact and longer-term change in the communities we serve by improving existing systems and innovation
• Emphasize strategic cross-sector and/or intra-sector partnerships between community-based organizations
• Uplift community members of greatest need
• Directly align with CIF areas of focus and meaningfully contribute to CIF goals
• Award amount: $1 million per year, up to 5 years

The Urban Farm Conservation Mini-Grant provides up to $5,000 to support commercial urban farmers in Minnesota in implementing vital conservation practices. Funded by the USDA's NRCS, this grant helps farmers acquire equipment and materials necessary for sustainable management of soil, water, and biodiversity. Eligible projects may include soil improvement, water management systems, and enhancing plant and animal health. This initiative aims to promote environmentally friendly farming techniques and bolster urban agriculture.

The CIF Capacity Builder Awards by Endeavor Health focus on enhancing community health through strategic investments. With over $38.5 million allocated to local partnerships, these awards aim to address critical areas like healthcare access, food insecurity, and workforce development. Designed for nonprofit organizations, the awards range from $100,000 to $500,000 annually for 1-2 years, fostering long-term community impact and advancing health equity in the service areas.

The Community Impact Grants, offered by the Texas Capital Bank Foundation, are aimed at supporting Texas-based nonprofits that provide essential services to low- and moderate-income communities. These grants focus on key areas such as housing solutions, education, workforce development, and support for veterans and first responders. By investing in these initiatives, the foundation seeks to foster community development and enhance the quality of life for those in need across major Texas cities.

The Prenatal to Five (P-5) Innovation Fund aims to empower community-driven solutions for families in King County. With approximately $900,000 available, community leaders are invited to propose innovative, anti-racist approaches that prioritize Black, Indigenous, and families of color, as well as those facing systemic barriers. Proposals can request up to $30,000, or $50,000 for pilot activities, to implement impactful services and programs for underserved communities.

The Herndon Foundation, established in 1965, supports diverse local causes in the metro Richmond area, focusing on education, health, and cultural preservation. They prioritize programs that ensure educational advancement, meet basic human needs, and enhance access to arts and culture. Eligible organizations must be tax-exempt under IRS Section 501(c)(3). The Foundation particularly favors programmatic support that demonstrates a significant impact. Grant requests submitted through their website are given priority.

The Church of Jesus Christ of Latter-day Saints

Members of The Church of Jesus Christ of Latter-day Saints make up a diverse community of people around the world with a shared faith in God and His Son, Jesus Christ. Jesus Christ showed us that faith is more than a belief. When we put our faith into action and follow Christ’s example in all that we do, He can bring more joy and peace into our lives. This is the mission of The Church of Jesus Christ of Latter-day Saints.

Utah Area Humanitarian Operations

Relieve Suffering – Instill Hope – Build Self-Reliance

Humanitarian Strategy

Across the Utah Area, many individuals and families are facing significant and growing challenges. We are deeply grateful for the many compassionate community leaders and dedicated organizations working to relieve suffering, instill hope, and build stability and self-reliance.

Starting in 2026, we are elevating and focusing our humanitarian activities by prioritizing a set of targeted initiatives – population-specific initiatives and service gap initiatives. These initiatives are designed to strengthen community support and make the greatest possible difference for those who need it most.

We will:

• Focus on vulnerable populations
• Address critical gaps hindering holistic service delivery
• Strengthen coordination between service providers
• Prioritize ‘catalytic’ projects that improve self-reliance
• Promote long-term outcome tracking

We will also collaborate with community organizations on a limited number of non-initiative projects. Tracking of specific outcomes aligned with Utah Area priorities – especially Housing and Food – will be required.

Population-Specific Initiatives

Workforce Development for Refugees & Immigrants

• Need: Growing risk of homelessness and negative family impacts due to high housing prices and a decline in government support
• Goal: Work with employers, refugee services, and education providers to offer credentialing, job placement, and wrap-around service support without destabilizing income
• Desired Outcome: Measurable increase in the number of refugees and immigrants earning sustainable living wages and retaining housing

Transitional Housing for Domestic Violence Victims and Homeless Youth

• Need: Severe shortage of service-rich housing that could prevent future homelessness and enable long-term recovery
• Goal: Support experienced organizations in quickly expanding transitional housing and wraparound services through affordable renovation projects
• Desired Outcome: Long-term retention of housing, income growth, and improvement in well-being and self-reliance indicators as assessed by case workers

Service Gap Initiatives

• Social Worker Workforce Expansion: We will collaborate with community organizations to provide scholarships, stipends, and employee retention support for current and prospective social workers to fill growing gaps in high-quality staff who provide wrap-around services and track outcomes.

• Pre- and Post-Homeless Community Support: We will collaborate with community organizations to establish ongoing follow-up support through case workers or volunteers after diversion or exit from shelter, with a focus on preventing a return to homelessness and long-term outcome tracking.

• Case Manager Support for Food Pantries: We will collaborate with community organizations to expand case management in high-volume food pantries to create a stronger funnel to needed wrap-around services and to better track progress towards self-reliance.

Humanitarian projects in the Utah Area follow a one-year cycle. Implementing organizations have up to 12 months to complete the project, beginning on the date the Church approves the project. Organizations receiving a humanitarian donation from the Utah Area are expected to help beneficiaries progress towards greater self-reliance. This includes connecting individuals with community resources and monitoring and reporting their progress. Organizations are expected to track and report outcomes and engage with collaborating organizations in an integrated systems/services model for project beneficiaries.

The Wabtec Direct Grant Program focuses on creating sustainable impacts in local communities by funding 501(c)(3) non-profit organizations. Emphasizing education and environmental stewardship, the program supports initiatives that improve literacy, academic outcomes, and workforce readiness. Grants range from $1,000 to $10,000, prioritizing organizations that engage local Wabtec employees in volunteerism. The program promotes equitable access and non-discrimination while ensuring measurable results in funded projects.

The Big Bets Fellowship: Economic Opportunity in the United States is a transformative 4-month program designed to empower emerging leaders to tackle economic challenges head-on. With a focus on innovative solutions for job creation, affordable housing, and equitable access to resources, the fellowship equips participants with essential skills and a supportive network. The initiative aims to drive systemic change and promote sustainable economic prosperity, addressing inequalities while fostering resilient communities across the nation.

The BlueCross BlueShield of South Carolina Foundation's Health Priority Grants support initiatives that enhance health access and outcomes for South Carolinians, especially the economically disadvantaged. Established in 2003, the Foundation aims to bridge health and healthcare gaps through innovative partnerships. Eligible applicants include nonprofits with 501(c)(3) status and government agencies. The Foundation prioritizes projects addressing oral health and mental health, among other systemic health issues, to create sustainable, data-driven solutions.

The University Technology Development Funding: Innovation Impact Grant from the North Carolina Biotechnology Center supports the acquisition of shared use research equipment for core facilities at academic and nonprofit institutions. This funding aims to enhance the life sciences ecosystem in North Carolina by facilitating significant scientific advancements. Proposals with a strong impact on both the institution and the broader research community will be prioritized. A cash match is required, with funding requests up to $150,000.

The Lloyd K. Johnson Foundation offers grants over $3,500 to nonprofits and public entities aiming to enhance community welfare, arts, education, economic development, and environmental stewardship. Operating since 1975, the foundation prioritizes projects that benefit residents in Cook, Lake, and Southern St. Louis Counties. Eligible applicants must have a 501(c)(3) designation or work with a fiscal sponsor. The foundation does not fund private foundations or projects for election campaigns or direct religious purposes.

The Lloyd K. Johnson Foundation, established in 1975, provides grants under $3,500 to nonprofit organizations and public entities in the North Shore region. Focused on areas like social welfare, arts and culture, education, community development, and environmental protection, the Foundation has awarded over $18 million in grants. It aims to enhance opportunities for local residents, particularly those in low-income situations, and supports initiatives that foster long-term positive impacts.

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.