Best Large Grants for Nonprofit Organizations

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

The Coastal Conservancy offers grants to restore and protect California's coast, enhance public access, and improve climate resiliency. With millions in funding available, projects that serve disadvantaged communities or utilize nature-based solutions are prioritized. Applicants must engage with a Regional Manager for eligibility guidance and can expect grants typically between $200,000 and $5 million. This ongoing funding supports various stages of project development, including planning, construction, and monitoring.

The Green Bay Packers Foundation, established in 1986, supports Wisconsin charities that promote family values, athletics, and welfare. Eligible organizations can apply for grants addressing specific focus areas, including animal welfare and education, during the 2026-2029 cycle. Applicants must be 501(c)(3) entities with a valid IRS Tax ID, ensuring they meet community needs effectively. The Foundation prioritizes impactful projects that align with its mission of enhancing community well-being and preventing cruelty to animals.

The Joseph Robert Foundation Grant provides essential funding for non-profit organizations focused on the arts, animal welfare, and environmental protection. Based in Pennsylvania, the foundation prioritizes smaller local organizations in the mid-Atlantic region, offering grants typically under $10,000. It encourages innovative projects and supports first-time grant seekers, prioritizing those with limited resources. Organizations can apply for general operating support or specific project funding to further their missions and impact their communities.

The Karen Colina Wilson Foundation Grant supports programs for children, youth, and women, enhancing their health and well-being through education, art, literature, and music. Established in 2006, the foundation aims to make a positive difference in their lives, particularly in Southern and Western Wayne County, Michigan. Grants typically range from $500 to $10,000, often as matching funds, fostering broader fundraising efforts by local nonprofit organizations.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

NorthWestern Energy Community Works Grants aim to enhance community well-being in Montana, Nebraska, and South Dakota. The program supports qualified nonprofit organizations with monetary donations focused on education, health services, civic improvement, culture, and resource conservation. Since 2019, over $2.1 million has been contributed towards community projects. Eligible applicants must demonstrate tax-exempt status and proposals should favor funding for programs and physical improvements. National organizations and political activities are generally excluded.

The Larimer County Community Foundation offers Intersections Grants, focusing on impactful funding for organizations addressing community needs in Berthoud, Estes, Fort Collins, and Loveland. Aimed at 501c(3) entities and educational institutions, these grants prioritize general support for initiatives related to Sheltering & Caring and Connecting Intersections. This approach ensures that donor contributions effectively enhance community legacy and engagement.

TOT Grant Program

The Transient Occupancy Tax (TOT) Grant was established in 2017. It is a project/program based award providing support to non-profit organizations located in Sacramento County that carry out community-based programs and/or services in the areas of arts and culture, community development and services, economic or workforce development​ and health and human services. Once awarded, grant funds are administered on a reimbursement basis upon review and approval of an invoice submission with supporting documentation.

The TOT Grant funding support is designed for, but not limited to:

• Training, development, and education; 
• Programs, projects and events that support tourism;  
• Projects that address a community issue or problem; and/or
• Projects that extend the reach of services to underserved populations.

Annually the Sacramento County Board of Supervisors dedicates $1,000,000 of the County's Transient Occupancy Tax (TOT) revenue to be allocated to the TOT Grant Program through a competitive application process. Fiscal Year (FY) 2026-27 is the tenth TOT Grant funding cycle which will be approved during the June Recommended Budget hearings on June 2026.  

The Wilson Foundation's Empower Grant supports transformative projects in North Baton Rouge, particularly in ZIP codes 70802, 70805, 70806, 70807, 70811, and 70812. With a focus on housing, education, community wellness, and economic vitality, the foundation seeks to empower local residents through collaborative efforts. By prioritizing community engagement and sustainable change, the grant aims to address the underlying social and economic challenges faced by over 124,000 residents in the region.

The Beasley Foundation Grant supports nonprofit organizations in Dallas that focus on critical areas such as education, healthcare, substance abuse prevention, and mental health. To apply, organizations must have 501c3 status and align with the foundation's mission. The application process includes creating a login, submitting a Letter of Inquiry, and, if accepted, completing a full proposal. The foundation reviews applications quarterly, ensuring support for initiatives that make a positive impact in the community.

The Susan Terry Foundation Grant Program

Empowering Communities, One Grant at a Time

The Susan Terry Foundation Proudly supports local opportunities and initiatives through community-focused grants in Tampa Bay and Sarasota.

The Susan Terry Foundation is committed to strengthening communities by supporting innovative, impactful projects that serve the public good. Through our grant program, we provide funding to individuals, organizations, and research teams working on non-event initiatives that align with our mission of community enrichment and positive change.

We invite applicants with clearly defined goals, thoughtful planning, and a strong commitment to making a difference. Whether you’re launching a new program, conducting meaningful research, or developing a long-term community initiative, we encourage you to apply. This program does not fund event sponsorships or promotional activities.

The Rome Prize Fellowship, offered by the American Academy in Rome, supports innovative artists and scholars in a vibrant community. With an extended application deadline of November 7, 2025, this prestigious award fosters cross-disciplinary work in various fields such as architecture, literature, and visual arts. Each recipient receives a stipend, housing, and workspace, enabling them to immerse in Rome's rich cultural heritage. This fellowship is ideal for U.S. citizens and long-term residents, emphasizing a commitment to excellence.

The Middle Tennessee Fund Grant, offered by the HCA Healthcare Foundation, supports nonprofits in addressing community needs related to basic necessities, healthcare, education, and the arts. Since its inception in 1997, it has prioritized organizations with established relationships with HCA Healthcare. Eligible applicants must be 501c3 organizations with a minimum budget of $250,000, serving the Middle Tennessee area, and demonstrating engagement with HCA Healthcare through board involvement or volunteerism.

BCBS of Texas provides sponsorships to organizations focused on improving community health and wellness. With awards ranging from $250 to $5,000, these sponsorships support various activities like health fairs, drives, and seminars. Organizations can apply for support but cannot receive both a grant and a sponsorship. Importantly, no 501(c)(3) status is required, making it accessible for diverse initiatives aimed at fostering healthier communities.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

About the Port of Oakland

The Port of Oakland generates vital economic activity, community benefits and environmental innovation, as the Port decarbonizes its operations for a cleaner and greener future. Along with its partners, the Port supports 98,345 jobs in the region and $174 billion in annual economic activity. The Port oversees the Oakland Airport (OAK), the Oakland Seaport and nearly 20 miles of waterfront including Jack London Square and a publicly owned utility. 

Community Investment Program

Approved by the Oakland Board of Port Commissioners on July 2015, the Port of Oakland Community Investment Program seeks to add value and best serve our diverse communities within the Port’s footprint. This program provides grants to benefit the communities in the Port’s Local Impact Area (LIA) in Oakland, Alameda, Emeryville, and San Leandro, as well as communities in the Port’s Local Business Area (LBA) in Alameda and Contra Costa counties.

The Port of Oakland provides quarterly grants up to $5,000 to non-profit organizations that align with the following funding priority areas:

• Economic Vitality:

The Port promotes community and economic viability by helping small businesses thrive and create and sustain jobs that support our local community. We proudly support programs that expand access to Port opportunities for small and local businesses, as well as organizations that provide technical assistance to businesses to expand their impact.

• Environmental Sustainability and Healthy Communities:

We are committed to sustaining healthy communities through leading-edge environmental stewardship via our air quality, clean water, and energy conservation programs. We proudly support organizations that promote our environmental programs.

• Workforce Development and Education:

We support programs that prepare individuals to participate successfully in an increasingly global society and to contribute back to the communities in which they live. Specifically, we focus on supporting programs that prepare individuals for careers in port-related industries. Examples include but are not limited to: training and education in construction; trade and logistics; science, technology, engineering and mathematics (STEM) education; aviation, and the building-construction trades.

The Anna B. Stearns Charitable Foundation provides grants to support projects enhancing education, independence, and well-being for women and children, particularly focusing on girls. With an emphasis on preventive measures, it funds programs in education, job training, and community services. The foundation seeks to empower organizations demonstrating significant impact through measurable outcomes. Grants typically range from $15,000 to $20,000 annually, aimed at fostering long-term self-sufficiency and addressing environmental and advocacy needs.

The Long Island Sound Study Research Grant Program, managed by Connecticut Sea Grant and New York Sea Grant, aims to fund research that supports effective management of Long Island Sound's resources. The program prioritizes actionable research addressing anthropogenic stressors while enhancing ecosystem health. A 50% non-federal match is required for funding, ensuring collaboration and sustainability. Applicants are encouraged to align their proposals with the themes outlined in the Comprehensive Conservation and Management Plan, facilitating informed decision-making for the region's environmental future.

The NC Biotechnology Center Fund Event and Meeting Grant provides vital financial support for events and meetings that enhance networking and information sharing within North Carolina's life sciences community. The grants include up to $3,000 for Biotechnology Event Sponsorships and up to $10,000 for Biotechnology Meeting Grants, catering to both local and international gatherings. This initiative aims to foster innovation and collaboration among researchers and companies, ultimately driving growth in the biotechnology sector.

The ACA Research Grant, administered by the Alberta Conservation Association, supports high-quality research projects aimed at the effective management of wildlife, fish populations, and their habitats in Alberta. Since 1997, this funding initiative has encouraged conservation efforts by partnering with local stakeholders, including anglers and hunters, to enhance the province's biodiversity. By focusing on impactful research, the ACA promotes sustainable practices that benefit Alberta's natural resources and ecosystems.

The Narragansett Foundation Grant aims to support charitable, educational, and scientific endeavors, focusing on public charities in Buxton, Maine. It funds start-up expenses, new projects, and general operating support. Eligible applicants include nonprofit organizations with 501(c)(3) status and government entities using funds for public purposes. The foundation prioritizes local needs but may extend support throughout Maine and beyond as necessary.

The Ralph C. Wilson, Jr. Foundation, established in 2015, focuses on community transformation in Southeast Michigan and Western New York. With a spend-down structure by 2035, the foundation prioritizes collaborative investments in key areas like active lifestyles, success preparation, caregiver support, and economic development. Emphasizing urgency and innovation, it seeks to create lasting impacts by fostering partnerships and supporting visionary projects that address significant community needs.

The Rotary Charities of Traverse City offers Seed Grants to support early-stage projects that can create significant community impact. Eligible applicants include 501(c)(3) organizations and local governments within specific counties. Grants facilitate collaboration, planning, and capacity building, allowing organizations to develop and implement high-priority projects. Applications are accepted year-round, with a focus on initiatives that foster community engagement and address local needs. This funding aims to lay the groundwork for impactful community development.

Johnson County Community Development Office

The mission of the Johnson County Community Development Office is to secure federal, state and local funding for community development activities, to provide leadership in coordinating these activities, and to ensure continued funding through accountable, efficient and effective use of these funds in serving low- to moderate-income residents in Johnson County.

Community Development Block Grant

The Community Development Block Grant (CDBG) program provides annual grants on a formula basis to states, cities, and counties to develop viable urban communities by providing decent housing and a suitable living environment, and by expanding economic opportunities, principally for low- and moderate-income persons. The program is authorized under Title 1 of the Housing and Community Development Act of 1974.

Federal Objective

The primary objective of Title I of the Housing and Community Development Act of 1974, as amended, is to promote “development of viable urban communities, by providing decent housing and a suitable living environment and expanding economic opportunities, principally for persons of low and moderate income.” The Code of Federal Regulations, 24 CFR 570 Subparts A through O, govern how this objective is to be carried out.

Johnson County’s Priority Objectives

The primary goal of the program is to provide federal financial assistance to eligible applicants for the purpose of community development. In pursuit of this goal, the County has identified several strategies in the Plan that applicants should consider when applying. A unit of local government may also use local goals and/or objectives in support of a specific activity for which funds are requested. As stated in the 2025-2029 Consolidated Plan, the priority needs are: Non-Housing Community Development; Affordable Housing; and Homelessness.

The CDBG program includes funding for: 1) Housing Projects; 2) Public Facilities Projects 3) Public Services Projects; and 4) Economic Development Projects

Public Services Projects

Eligible Activities

Once the National Objective is determined then the activity must be a public service as defined at 24 CFR 570.201(e). Provision of public services, including but not limited to those concerned with employment, crime prevention, childcare, health, drug abuse, education, fair housing counseling, energy conservation, welfare, homebuyer downpayment assistance or recreational needs.

The Fall Field of Interest Grants from the Grand Traverse Regional Community Foundation aim to enhance the health of youth and seniors in Michigan. Established under the Tobacco Settlement Partnership, these grants support programs focusing on nutrition, counseling, and wellness for individuals aged 0-18 and 55 and older. Eligible applicants include nonprofits and governmental entities serving specified counties. With over $65.7 million awarded, the foundation continues its commitment to community health and well-being.

The Therapeutic Giving program by Johnson & Johnson focuses on funding initiatives that enhance patient access to treatment and advance health equity, particularly in immunology. Eligible nonprofit organizations can apply for support aimed at improving health outcomes through innovative programs. The initiative prioritizes measurable impacts over fundraising activities, emphasizing the importance of addressing healthcare disparities and promoting disease awareness efforts for diseases like rheumatoid arthritis and psoriasis.