Best Large Grants for Nonprofit Organizations

The North Carolina Land and Water Fund provides grants to support local governments, state agencies, and conservation non-profits in addressing water pollution issues. This initiative aims to enhance and restore degraded waters, protect unpolluted waters, and contribute to ecological diversity. Projects may include land acquisition, stream restoration, and innovative stormwater management practices. By fostering community involvement, the fund seeks to develop effective solutions that safeguard North Carolina's natural resources for future generations.

The Wildfire Prevention Grant Program, managed by the California San Gabriel and Lower Los Angeles Rivers and Mountains Conservancy, focuses on enhancing wildfire resilience and environmental protection. Key priorities include safeguarding native forests, supporting community fire safety, and promoting sustainable land use. Funding categories cover fire prevention planning in urban and wildland areas, alongside forest health initiatives. Applicants must submit a Concept Proposal for review before a Full Application, ensuring alignment with program goals.

The Dermody Properties Foundation Grant focuses on enhancing community well-being through support for the arts, education, and families, particularly children and the elderly. Established in 1988, the foundation has provided over $3.65 million in donations to various nonprofits, including grants and scholarships. Eligible organizations must have IRS 501(c)(3) status and be located within 30 miles of Dermody's projects. Grants typically range from $500 to $3,000, reflecting a commitment to corporate philanthropy.

The Gloria Barron Wilderness Society Scholarship encourages graduate students to contribute to wilderness protection, honoring Gloria Barron's legacy. The Wilderness Society prioritizes projects addressing climate change and equitable access to public lands. Applicants must be enrolled in a U.S. graduate program, possess strong academic qualifications, and focus on long-term wilderness conservation. Research proposals on biodiversity, climate adaptation, and social-ecological contexts are particularly welcome, aiming for inclusive and impactful conservation efforts.

The Maine Sea Grant Biennial Request for Proposals aims to fund diverse research projects that connect Maine's scientific expertise with the needs of coastal communities. Approximately $600,000 is available over two years, with a maximum of $200,000 per project. Proposals supporting the 2024-2027 strategic plan, engaging diverse partners, and addressing climate action strategies are encouraged. This initiative is open to various institutions and aims to enhance the state's support for underserved coastal communities.

The NJ Water Bank Technical Assistance Planning and Design Grant provides crucial funding for disadvantaged communities to cover planning and design costs for clean water and drinking water infrastructure projects. This initiative supports various environmental infrastructure projects, including wastewater treatment and stormwater management facilities. Eligible applicants must meet the affordability criteria set forth by the Clean Water and Drinking Water State Revolving Fund and have a pending project application. This grant aims to enhance water quality and accessibility.

The Klamath Basin Forests and Watersheds Restoration RFP aims to enhance critical fish habitats in the Klamath River Basin following the historic removal of four dams. With up to $11,553,000 in funding from the National Fish and Wildlife Foundation, this initiative seeks to restore populations of native fish species and improve habitat conditions. The program will support various conservation projects, ensuring the ecological integrity of this vital ecosystem is preserved for future generations.

The Babson Foundation's Competitive Grants Program supports entrepreneurship, youth development, and urban environmental improvements in Greater Boston. Focusing on three key areas—entrepreneurship education, community building through urban gardens, and violence reduction—this initiative aims to enhance the quality of life in the region. Eligible organizations must be located within Greater Boston, while specific individuals and certain types of requests, such as summer camps and scholarships, are not funded.

Women, Infants and Children (WIC) Administration Continuation Solicitation

Up to 74 grants may be awarded for a total amount of $58,129,373. The maximum funding that will be awarded to each designated service area listed in the FY2027 Local Project Funding and Caseload Plan, Appendix B, in the FY27 Total NOA column. Federal WIC funding may not cover all costs incurred by a Local Agency to administer or operate the WIC Program.

No grant award will be issued for less than $30,000. The minimum amount is exclusive of any required matching amounts and represents only ODH funds granted. Applications submitted for less than the minimum amount will not be considered for review.

Foundation for Cincinnati Jewish Seniors

Goal

By year-end 2028, we will have funded successful programs and services with measurable impact on the lives of Greater Cincinnati's Jewish seniors.

Mission

To improve the quality of life of Greater Cincinnati Jewish seniors by investing in impactful services and programs.

Vision

For every Jewish senior in our region to age with connection, dignity, and purpose.

Strategic Focus Areas for Priority Funding

• Reducing Social Isolation
• Supporting Caregivers
• Intergenerational Connections
• Food Insecurity and/or Access to Kosher Food
• Transportation
• Affordable Housing
• Health and Wellness/Healthy Living Longer
• Improving Awareness of Available Services for Seniors
• Engaging the Skills and Talents of Older Adults in the Community (including as volunteers)
• Jewish Engagement and Connection
• Innovation in programs, services or delivery

The Puffin Foundation's Environmental Artistic Activism Grant Program supports artists addressing environmental issues through diverse artistic genres such as film, music, and theater. Grants, typically around $1,750, fund projects that prioritize sustainability and innovative solutions to the climate crisis. Eligible applicants include U.S. citizens, permanent residents, and current DACA recipients. The foundation emphasizes projects that avoid contributing to environmental harm while fostering artistic expression and community engagement.

Foundation for Cincinnati Jewish Seniors

Goal

By year-end 2028, we will have funded successful programs and services with measurable impact on the lives of Greater Cincinnati's Jewish seniors.

Mission

To improve the quality of life of Greater Cincinnati Jewish seniors by investing in impactful services and programs.

Vision

For every Jewish senior in our region to age with connection, dignity, and purpose.

Strategic Focus Areas for Priority Funding

• Reducing Social Isolation
• Supporting Caregivers
• Intergenerational Connections
• Food Insecurity and/or Access to Kosher Food
• Transportation
• Affordable Housing
• Health and Wellness/Healthy Living Longer
• Improving Awareness of Available Services for Seniors
• Engaging the Skills and Talents of Older Adults in the Community (including as volunteers)
• Jewish Engagement and Connection
• Innovation in programs, services or delivery

The Specialty Care Access Grant Program, managed by the Patterson Family Foundation, aims to enhance access to specialty medical services in rural communities of Kansas and western Missouri. Organizations eligible for funding include nonprofits, school districts, and government entities serving these areas. The program emphasizes collaboration with local leaders to ensure quality healthcare access for communities, particularly in maternal care, oncology, and mental health, while encouraging early submission of proposals for timely review.

The ID AmeriCorps Formula Grant, funded by Serve Idaho, aims to support organizations targeting communities facing concentrated poverty, rural and tribal areas, and historically underserved individuals. This grant prioritizes initiatives focused on youth mental health, veteran support, environmental stewardship, and civic engagement. It encourages programs that enhance the quality of life for veterans and military families, while promoting resilience in underserved communities through sustainable practices.

Iowa Department of Health and Human Services

Iowa HHS provides high quality programs and services that protect and improve the health and resiliency of individuals, families, and communities.

Mobile Integrated Health

The Iowa Department of Health and Human Services (the Agency) is providing this notice of intent to release a request for proposal (RFP) on or around July 2026 for approximately seven Mobile Integrated Health (MIH) projects that will expand EMS‑led community care by delivering preventive, chronic disease, prenatal/postpartum, and acute care services directly to Iowans in their homes and communities. These projects will equip EMS agencies with the training, telehealth connectivity, and clinical tools needed to provide coordinated, in‑home care that reduces avoidable emergency department utilization and strengthens local access. A key objective of this initiative is to develop consistent and dependable care‑delivery patterns across rural regions, ensuring patients receive timely follow‑up, navigation support, and integrated care regardless of location. Please visit Healthy Hometowns - Iowa's Rural Health Transformation Plan | Health & Human Services for more information.

The Foundation for Pennsylvania Watersheds Grant Program supports local initiatives aimed at conserving and restoring Pennsylvania's vital water resources. Since 1995, the foundation has provided matching grants to nonprofit organizations, enhancing the health of local streams and ensuring clean water for future generations. Eligible applicants must be IRS 501(c)(3) nonprofits, focusing on areas from the Ohio border to the Susquehanna River, while individuals and government agencies are ineligible for funding.

The Career Development Bridge Funding Award: K Supplement, offered by the Rheumatology Research Foundation, supports junior investigators transitioning to independent research. Awarded up to $50,000 annually for a maximum of two years, it supplements NIH K series or VA CDA awards. Eligible applicants must hold a doctoral degree and be in the second, third, or fourth year of their existing award. This funding is crucial for developing new projects that contribute to the field of rheumatology.

The Madison Visionary Partners Community Impact Mini-Grant supports local nonprofits seeking to enhance quality of life in Madison, Alabama. Grants between $500 and $2500 are available for projects in areas such as animal welfare, arts, education, health, and housing. Eligible organizations must demonstrate a direct impact and be based in Madison County. Ineligible requests include administrative operations, fundraising events, and religious programs. This initiative aims to foster community development and support local needs.

The International Foundation Grant is aimed at U.S.-based non-profit organizations working in developing countries to enhance health, education, and income levels for impoverished communities. While currently not accepting new applications, the foundation reviews proposals from previously invited organizations. The focus lies on holistic, community-driven projects in sectors such as agriculture, education, environment, and health. Partnerships with local entities are encouraged to ensure sustainable and impactful outcomes.

The Community Foundation of Yavapai Grant, managed by the Arizona Community Foundation, supports nonprofit organizations in Yavapai County. Grants ranging from $1,000 to $20,000 are available to 501(c)(3) organizations, schools, and tribal entities that benefit the local community in various fields, including animal welfare, children’s services, environmental initiatives, and healthcare. Applicants must comply with non-discrimination policies and ensure their projects serve residents within the county.

The North East Community Foundation Grant aims to enhance the quality of life in North East, Pennsylvania, by supporting charitable organizations through funding. Focused on youth activities, the foundation encourages applications for tangible projects with a significant impact. Eligible organizations must typically be tax-exempt under Section 501(c)(3), but fiscal agents can assist those without this designation. Past funding has supported education, health, and community enrichment initiatives.

The Universal Leaf Foundation Grants support 501(c)(3) nonprofit organizations primarily in areas where Universal Leaf Tobacco Company operates. Focus areas include education for at-risk individuals, higher education, civic/community arts, and environmental initiatives. The Foundation emphasizes good corporate citizenship and community engagement through financial support and employee volunteerism. Organizations must operate within designated geographic areas and cannot be involved in political advocacy or restrict services based on demographics. Grants aim to enhance community well-being and educational opportunities.

The NOAA Digital Coast and Coastal Management Fellowship offers postgraduate students hands-on experience in coastal resource management. Established in 1996 and expanded in 2012, the program matches candidates with state coastal management programs and Digital Coast partners. Each year, up to six fellows are placed in coastal programs, while three fellows are placed in partner organizations. The fellowship provides a competitive salary, benefits, and reimbursement for professional development and travel, aiming to strengthen the next generation of coastal managers.

The Westly Prize, awarded by the Westly Foundation, supports young social innovators in California with innovative solutions to community challenges. Since 2012, the prize has provided up to $145,000 in unrestricted funding to finalists, encouraging creativity in categories such as AI, education, and health. The program seeks applicants under 28 years old who demonstrate strong leadership and impactful solutions, fostering a culture of growth and innovation.

The SMSNA Scholars in Sexuality Research Grants Program supports junior investigators in exploring human sexuality and sexual wellness. Funded by the Sexual Medicine Society of North America, this initiative provides $5,000 to undergraduate, medical, and graduate school students. Awards are disbursed in two payments, with specific reporting requirements. This program aims to enhance research in sexual medicine and foster diversity in the field, particularly focusing on historically underserved populations.

The SMSNA Scholars in Sexuality Research Grants Program supports junior investigators in the field of human sexuality and sexual wellness. With a funding of $7,500, the program aims to attract emerging researchers and clinicians to sexual medicine. Applications are accepted from graduate students, residents, and post-doctoral fellows, with an emphasis on diverse backgrounds. The program promotes ethical research practices and requires mid-term and final progress reports to ensure accountability.

The Hugh J. Andersen Foundation Grant supports community-focused initiatives aimed at enhancing inclusivity and self-sufficiency within the St. Croix Valley. The foundation prioritizes asset-based programs led by the communities they serve, particularly those benefiting children, seniors, and individuals with disabilities. Organizations must be tax-exempt under IRS 501(c)(3) and located in designated counties. The foundation does not fund individual scholarships or loans, lobbying, or fiscal agents, aiming for collaborative funding efforts.