Best Large Grants for Nonprofit Organizations

The Lincoln and Therese Filene Foundation supports tax-exempt organizations in the Greater Boston area, focusing on civic education, human development, music education, and public broadcasting. Their mission aims to empower disadvantaged individuals, promote civic engagement, and enhance access to the performing arts. Grants typically range from $10,000 to $20,000 and are awarded to organizations with specific, achievable proposals. The foundation prioritizes initiatives that foster community growth and self-sufficiency.

The Sauer Family Foundation Grant focuses on enhancing the lives of at-risk children in Minnesota, particularly in the seven-county metro area. The foundation prioritizes funding for initiatives that promote family stability, emotional safety in schools, and educational success for children facing learning disabilities. With a commitment to community-based support, the foundation also emphasizes the importance of diverse workforce pathways, ensuring that programs are inclusive and equitable. Applications for new funding opportunities will be limited as the foundation approaches its planned sunset in 2027.

The Wildfire Prevention Grant Program by the California San Gabriel and Lower Los Angeles Rivers and Mountains Conservancy aims to mitigate the impact of wildfires exacerbated by climate change. This program supports projects that enhance forest health, promote sustainable land use, and develop community resilience. Funding ranges from $300,000 to $2,000,000, focusing on strategic fire prevention planning and management in vulnerable areas, particularly the San Gabriel Mountains and urban wildlife corridors.

The Gloucester Community Foundation (GCF) offers Community Impact Grants to nonprofit organizations in Gloucester County, aiming to foster a vibrant community through innovative, collaborative, and sustainable initiatives. This annual competitive grants program focuses on areas like cultural vibrancy, economic prosperity, educational success, and health & wellness, ensuring positive and lasting change. GCF encourages proposals that directly address community needs and challenges, making a significant impact in the region.

The Hugh and Jane Ferguson Foundation offers grants to nonprofit organizations in the Pacific Northwest and Alaska, focusing on habitat restoration and wildlife preservation. Established in 1987, it aims to support community-based projects and collaborative initiatives that emphasize cultural and natural history. Eligible applicants include 501(c)(3) organizations, with a preference for marginalized communities. The foundation does not fund research projects or media production and is particularly interested in those with limited access to traditional funding sources.

About the ASHFoundation

ASHFoundation supports innovators and sparks innovation in communication sciences. We give early support to promising students, researchers, and clinicians exploring bold ideas to transform the field and improve people's lives.

Artificial Intelligence in Communication Sciences and Disorders Research Grant

About

The American Speech-Language-Hearing Foundation (ASHFoundation) invites investigators to submit proposals for up to four research grants ranging from $25,000 to $50,000. The Artificial Intelligence in Communication Sciences and Disorders Research Grant (AI in CSD Research Grant) supports interdisciplinary studies that advance the ethical, clinically and scientifically grounded application and integration of artificial intelligence (AI) into communication sciences and disorders (CSD) practice and service delivery. Funding may be applied to one- or two-year studies.

Specific Objectives of the Funding Opportunity

As part of this initiative, the ASHFoundation invites proposals that implement AI technologies to transform clinical practice, education, and research in CSD. Proposals that are submitted under this funding opportunity must meet the following:

• Include interdisciplinary research teams that integrate clinicians and AI researchers,
• Address clinically relevant questions or have a clear translational potential, and
• Cover one or more of the following priority areas: AI-driven assessment and diagnosis; personalized and adaptive interventions; equitable access to care; data infrastructure for predictive analytics; technology innovation; prevention for public health; and ethical standards for AI integration.

The Equity in Arts Learning for Colorado Youth (EAL) Grant Program aims to enhance access to arts education for historically marginalized youth in Colorado. Grants ranging from $10,000 to $25,000 will support projects that engage professional artists in educational settings for youth aged 4-21. This initiative, backed by significant foundations, seeks to dismantle barriers to arts education, fostering creativity and community engagement while promoting equity, diversity, and inclusion.

The Columbus Foundation offers the Focused Funds Grants to enhance community well-being through strategic support for 501(c)(3) nonprofits in diverse areas, including environment, health, special populations, and social services. Grants typically range from $1,000 to $10,000, with a maximum of $25,000 available. Applications are accepted biannually in May and October, fostering impactful projects that promote sustainability and improve quality of life in central Ohio.

The John A. Hartford Foundation offers scholarships for the Age-Friendly Health Systems Cohort as part of the AHA Next Generation Leaders Fellowship. This initiative targets healthcare leaders aiming to implement the 4Ms Framework, enhancing care for older adults. Selected fellows will receive a program fee scholarship of $13,995, enabling them to focus on transformation efforts in health systems. This fellowship seeks diverse leaders to address critical healthcare challenges and improve quality, safety, and affordability.

Illinois Department of Commerce and Economic Opportunity

The mission of the Illinois Department of Commerce and Economic Opportunity (DCEO) is to create equitable economic opportunities across the State of Illinois. By attracting and supporting major job creators, investing in communities, strengthening Illinois’ world-class workforce, fostering innovation, and ushering in the new clean energy economy, DCEO works to fortify Illinois’ reputation as a global economic powerhouse while ensuring Illinois is the best state to live, work and do business.

Community Development Block Grant Public Infrastructure Program

Notice of Funding Opportunity Intent

The Illinois Department of Commerce and Economic Opportunity (the “Department” or “DCEO”) is issuing this Notice of Funding Opportunity (“NOFO”) to solicit applications for the Public Infrastructure Grant opportunity funded by the Community Development Block Grant (CDBG) through the U.S. Department of Housing and Urban Development.

Program Description

The purpose of grants relative to the Public Infrastructure (PI) Notice of Funding Opportunity is to fund water and sanitary systems and storm sewer construction projects that alleviate public health, safety, and public welfare and help communities with substantial low to moderate-income populations. Project areas must be primarily residential1 in character. Projects that are designed to benefit a commercial/business area are not eligible.

All grant funded projects must meet the following requirements:

• Low-to-Moderate Income (LMI) Benefit Requirements: Projects must benefit at least 51.0 percent low-to-moderate income persons. Those projects benefiting less than 51.0 percent LMI persons will not be considered for funding. 
• Documentation of Threat to Health and Safety: Projects must address present conditions that affect public health and safety.
• Water and Sewer Rates: Water or sewer rates must currently meet or exceed 1 percent of the Median Household Income (MHI) per 5,000 gallons. This requirement does not apply to storm sewer or drainage projects. 

The SSUS Housing Opportunities for Persons With AIDS (HOPWA) program, administered by the New Jersey Department of Health, aims to enhance housing stability for low-income individuals living with HIV. This initiative provides tenant-based rental assistance and security deposit support, promoting access to essential services. By focusing on long-term strategies for housing and care, HOPWA seeks to improve health outcomes and quality of life for affected individuals throughout New Jersey.

The Public Health Laboratory Fellowship Program, supported by the Association of Public Health Laboratories, develops future public health scientists through experiential learning in laboratory science. Participants receive training aligned with core competencies and work on impactful projects in various focus areas such as bioinformatics, food safety, and infectious disease. With flexible terms and potential for extension, this fellowship ensures a robust foundation for a career in public health laboratory science.

The ACFM General Support Program provides funding ranging from $2,000 to $20,000 for organizations committed to contemporary American concert music and jazz. It supports performing ensembles, presenters, and music service organizations that enhance public appreciation of these genres. Eligible applicants must have a minimum of two years of programming history and a professional operational level. Activities must occur within the specified support year of September 1, 2026, to August 31, 2027.

Delaware Community Foundation

The Delaware Community Foundation (DCF) is a nonprofit organization focused on partnering with donors to build opportunity and advance equity in Delaware.

Our mission is to strengthen Delaware by maximizing community-based philanthropy.

Healthy Communities Delaware

Healthy Communities Delaware (HCD) is pleased to announce this Request for Proposals for work that advances community level-change and improves the Vital Conditions that all people and communities need to thrive—humane housing, lifelong learning, a thriving natural environment, meaningful work and wealth, basic needs for health and safety, reliable transportation, a sense of belonging and civic muscle. This funding aims to support projects that align with their mission of working with communities, investors and systems to create thriving places for thriving people.

The Water Quality Protection and Restoration Program (WQPRP) provides funding for projects aimed at safeguarding Suffolk County's water resources. This program allocates 11.75% of the revenues from the ¼% Drinking Water Protection Program to support municipalities and non-profits in initiatives like pollution prevention, habitat restoration, and education. Grants range from $50,000 to $250,000, ensuring impactful projects enhance the community's environmental health and sustainability.

Department of Energy and Environment

The Department of Energy and Environment (DOEE) is the leading authority on energy and environmental issues affecting the District of Columbia. Using a combination of regulations, outreach, education, and incentives, our agency administers programs and services to fulfill our mission. We work collaboratively with other government agencies, residents, businesses, and institutions to promote environmentally responsible behavior that will lead to a more sustainable urban environment.

Clean Water Construction Grant Program

The mission of the District of Columbia’s Clean Water Construction (CWC) program is to fund the design and construction of voluntary projects that provide clean water to District streams and rivers.

Clean Water Construction Treatment Works Projects - Notice Of Funding Availability and Request For Partners (RFP)

DOEE seeks to identify collaborative partners for its fiscal year (FY) 2027 Clean Water Construction (CWC) grant application to the Environmental Protection Agency (EPA). Applications are requested for project partners in three categories of work: (1) Sewage Infrastructure Projects, (2) Stormwater Grey Infrastructure Projects, and (3) Stormwater Green Infrastructure Projects. This RFP is competitive.

Clean Water Construction Grant Program - Sewage Infrastructure Projects

Sewage Infrastructure Projects include work on devices or systems that collect liquid municipal waste, including sanitary sewage and combined stormwater and sanitary sewage, convey these waste waters to a central location, process them to reduce their pollutant potential, and provide for proper disposal of residues and byproducts resulting from wastewater treatment.

Project examples

• New, expanded, or rehabilitated wastewater treatment works, including Biological Nutrient Removal;
• Infiltration/inflow correction;
• Replacement/rehabilitation of sanitary and/or storm sewers;
• Replacement/rehabilitation of collector, trunk, and interceptor sewers and of pumping stations;
• Combined sewer overflow abatement;
• Repair or replacement of damaged sanitary or combined sewer infrastructure that leaks untreated sewage into District waters;
• New, expanded, or rehabilitated sludge handling and disposal facilities;
• Water treatment plant filter backwash and sludge treatment; and
• Measures to reduce energy consumption for publicly-owned treatment works.

The Richard M. Fairbanks Foundation Grant Program focuses on enhancing the vitality of Indianapolis through targeted grantmaking in education, health, and economic development. The program prioritizes support for tax-exempt organizations that align with its goals, addressing critical issues such as public health, academic outcomes, and workforce development. By fostering collaboration and sharing data-driven insights, the Foundation aims to create a more vibrant, equitable city where all residents can thrive.

The Yale Appliance Foundation Grant supports 501c3 nonprofits focused on aiding veterans, the elderly, minors, and the homeless in the Boston area. Grants of up to $10,000 are available for capital projects and program purchases that directly benefit these vulnerable groups. Organizations receiving $2,000 or more must submit a detailed report on fund usage. Applications are reviewed quarterly, emphasizing local charities making a significant impact.

The F26AS00083 Aquatic Invasive Species Grants are part of the Great Lakes Restoration Initiative for Fiscal Year 2026. These grants, administered by the U.S. Fish and Wildlife Service, aim to support state-level management plans to combat aquatic invasive species in the Great Lakes region. Eligible applicants include Great Lakes states and their designees, with funding awarded through a competitive selection process.

Housing Opportunities for People Living with HIV/AIDS

Funding Opportunity Description:

This funding opportunity is to support rental assistance and housing-related supportive services for eligible District and Maryland residents living with HIV through the Housing Opportunities for Persons with AIDS program.

Overview

The mission of DC Health is to promote and protect the health, safety, and quality of life of residents, visitors, and those doing business in the District of Columbia. The agency is responsible for identifying health risks; educating the public; preventing and controlling diseases, injuries, and exposure to environmental hazards; promoting effective community collaborations; and optimizing equitable access to community resources.

The mission of HAHSTA is to protect and improve the health of District residents by preventing, diagnosing, treating, and reducing the transmission of HIV, viral hepatitis, sexually transmitted diseases, and tuberculosis, while ensuring access to high-quality, coordinated, and culturally responsive care and support services for individuals and communities most impacted by these conditions.

The mission of the Capacity Building, Housing and Community Partnership Division (CBHCP) is to strengthen the HIV service delivery system by expanding access to stable housing, enhancing organizational and workforce capacity, and fostering strategic community partnerships that improve health outcomes, promote service coordination, and address structural barriers impacting people living with HIV in the District of Columbia.

The mission of the Housing Opportunities for Persons with AIDS (HOPWA) program is to provide stable, affordable housing and housing-related supportive services for low-income individuals living with HIV and their households, recognizing housing stability as essential to improved health outcomes, sustained engagement in care, and overall well-being.

Purpose

The purpose of this funding is to support the delivery of HOPWA-funded housing assistance and housing-related supportive services for eligible District and Maryland residents living with HIV and their households. Funding is intended to prevent homelessness, reduce housing instability, and promote long-term housing stability through time-limited and facility-based housing interventions, coordinated supportive services, and intensive case management.

Funds awarded under this opportunity will be used to implement HOPWA-allowable activities that support housing stability, improve continuity of care, and advance health outcomes, in alignment with federal HOPWA requirements and DC Health program priorities.

The Forest Conservation Program, initiated in 2006, aims to enhance California's native forests through conservation, restoration, and management. Funded by Proposition 84 and 68, it supports diverse projects such as meadow restoration and post-fire recovery. The program seeks to improve ecological integrity and economic stability while addressing water resource conservation and wildfire mitigation. This initiative aligns with the Board's strategic goals, ensuring long-term sustainability and protection of vital forest ecosystems.

The Park Foundation Grants: Sustainable Ithaca aims to support initiatives fostering a fully sustainable community in Ithaca and Tompkins County. The foundation prioritizes projects that integrate environmental, social, and economic systems, with a focus on accessibility for low-income and communities of color. Eligible organizations must be 501(c)(3) non-profits, and grants are limited to local sustainability projects. Proposals outside Tompkins County are generally not considered.

The Community Grants program, formerly known as PCAF, supports individuals and organizations in implementing community-based conservation projects. With an annual funding of approximately $150,000, the program emphasizes hands-on initiatives that enhance public awareness and conservation efforts. Eligible projects focus on the restoration and maintenance of native freshwater species and habitats, with a requirement for a volunteer component. Grants typically range from $2,500 to a maximum of $20,000 over the project's lifetime, fostering community engagement in environmental stewardship.

The South Carolina Biennial Sea Grant Program, managed by the S.C. Sea Grant Consortium, aims to enhance coastal conservation and sustainable development through research. With approximately $500,000 available annually for one- to two-year projects, grants typically range from $30,000 to $80,000. The program encourages collaboration among faculty from member institutions and supports initiatives that improve the social and economic well-being of coastal residents while conserving marine resources.

The 0-5 Maternal Behavioral Health Grant, funded by the California Behavioral Health Services Oversight and Accountability Commission, aims to enhance behavioral health services for children aged 0-5 and birthing individuals. With a budget of $1,601,000 over three years, the initiative focuses on providing technical assistance to six grantees, promoting integrated care systems, and ensuring access to essential resources. This collaborative approach seeks to improve outcomes, reduce school failures, and support families in navigating developmental and behavioral health challenges.

California Department of Health Care Access and Information

Mission: HCAI expands access to quality, equitable, affordable health care for all Californians by supporting high value delivery systems, resilient health facilities and workforces, and actionable health information and strategies.

HCAI is committed to expanding access to quality, equitable, affordable health care for all Californians by supporting high value delivery systems, resilient health facilities and workforces, and actionable health information and strategies.

California Rural Health Transformation (CalRHT) Program – California’s Implementation

The California Rural Health Transformation (CalRHT) program is California’s approach to the federal Rural Health Transformation Program (RHTP), led by the Department of Health Care Access and Information, with Centers for Medicare & Medicaid Services (CMS) oversight. CalRHT is designed to strengthen health care delivery in rural communities where access challenges, workforce shortages, and infrastructure gaps create unique barriers to care.

CalRHT Workforce Development Recruitment and Retention Program

Background and Mission

The Workforce Development Recruitment and Retention Program (WDRR), established under Initiative 2: Workforce Development of the California Rural Health Transformation (CalRHT) Program, aims to strengthen and sustain the rural healthcare workforce by improving recruitment, retention, and training for Health Professionals. WDRR funds eligible organizations to retain Health Professionals already practicing in rural communities and to recruit eligible Health Professionals to qualifying rural sites.

WDRR is an organizational grant program. HCAI awards grants to eligible rural-serving organizations who will provide bonuses to Health Professionals at their qualifying rural sites. Every bonus to Health Professionals carries a uniform five-year service obligation. 

The NJ Electric Vehicle Charging Grant Program aims to support the installation of electric vehicle charging stations across New Jersey. This initiative provides financial assistance to residents, businesses, and government entities, encouraging the adoption of electric vehicles. Grants are available on a first-come, first-served basis for Level 1 and Level 2 chargers, while DC Fast Charger applications are accepted during specific solicitation periods. This program is essential for expanding the state's electric vehicle infrastructure.