Best Large Grants for Nonprofit Organizations

About Us

Interact for Health works so that people in our region are healthy and thriving, regardless of who they are or where they live. We advance health justice by tackling the root causes of unfair systems, amplifying community power and partnering with trust.

Responsive Fund

The goal of the Responsive Fund RFP is to address immediate, emerging, or unanticipated needs within the community, recognizing that opportunities to build resilience require dedicated funding.

Grant Funding for Critical Services – Sustaining Civic Infrastructure: Total investment up to $1.5 million  

This funding supports the continuity of critical community infrastructure and services by addressing the time-sensitive operational and programmatic needs. Proposals for funding should focus on critical gaps or unmet needs with deep ties to community relationships. Organizations should demonstrate readiness to deploy resources quickly if funding is provided. This RFP will prioritize funding organizations essential to advancing health justice and youth well-being among our priority populations. Grants are available at three levels: $50,000, $75,000, or $100,000 for general operating or programmatic support.

About Us

Interact for Health works so that people in our region are healthy and thriving, regardless of who they are or where they live. We advance health justice by tackling the root causes of unfair systems, amplifying community power and partnering with trust.

Responsive Fund

The goal of the Responsive Fund RFP is to address immediate, emerging, or unanticipated needs within the community, recognizing that opportunities to build resilience require dedicated funding.

2) In-Kind Support for Sustainability Consultations and Capacity Building

Participants in this program will receive 1:1 consulting services tailored to an organization’s identified needs. Interact for Health will work with local consultants and community partners based on needs shared by grantee organizations.

Examples of needs include the following:

• Scenario planning  
• Legal support 
• Sustainability and development planning and implementation
• Diversified funding strategies and implementation
• Exploring collaboration, partnerships/alliances, shared services, and/or mergers
• Strategic planning and revisions 

Sustainability Consultations will include up to 30 hours of 1:1 support and will begin in late 2026. 

The 'What If...' Mini Grants program, funded by the Rosamond Gifford Charitable Corporation, aims to empower City of Syracuse residents aged 12 and older to enhance their neighborhoods. Grant applicants must attend an orientation and are encouraged to partner with an advisor if under 18. The initiative seeks projects that foster community participation and address local needs, ensuring that the voices of Syracuse residents are heard and valued.

The DeKalb County Community Foundation offers Community Needs Grants to support capital assets and equipment for various projects in DeKalb County, Illinois. This funding aims to enhance areas such as arts, community development, education, environmental welfare, and health services. Eligible organizations can request up to $20,000, with applications opening two months before deadlines. For those seeking facility construction or expansion, the Build the Future Grant is encouraged, providing a pathway for significant funding opportunities.

The Otter Tail Corporation Foundation Grant Program focuses on supporting 501(c)(3) organizations in communities across Arizona, Georgia, Illinois, Minnesota, North Dakota, and South Dakota. Priorities include early childhood education, health services for families in need, community development, and environmental sustainability. While the 2025 budget is fully allocated, they encourage applications for 2026, emphasizing collaborative projects that create measurable impacts.

The Custer County Foundation Grant aims to enhance community life in Custer County by supporting local nonprofit organizations. Eligible groups can apply for funding in various areas, including health care, education, and community services. The Foundation prioritizes requests demonstrating broad community support and prefers to partially fund projects. All grants expire 180 days post-approval, and recipients are encouraged to report on fund usage. This initiative fosters local engagement and development for a better future.

The Stray Dog Institute Grants aim to transform food systems by providing funding and support to nonprofits focused on animal welfare, environmental advocacy, and food justice. With grant amounts typically ranging from $2,500 to $10,000, the Institute prioritizes pragmatic solutions that foster dignity, justice, and sustainability. By addressing systemic issues in food production, they promote a compassionate approach that respects both people and animals. This initiative seeks to create a sustainable future for all stakeholders in the food system.

The REPI Challenge, initiated by the DOD's REPI Program, aims to protect critical testing and training capabilities through funded projects. Since 2012, over $193 million has been allocated to 69 initiatives, leveraging more than $512 million in partner contributions. The upcoming 2026 REPI Challenge will focus on strategic mission safeguarding, with up to $20 million available for preventing land use conflicts and enhancing military resilience, thus ensuring the longevity of vital defense capabilities.

The Park City Community Foundation offers grants to nonprofit organizations serving the greater Park City and Summit County area, focusing on community needs and effective programs. They encourage applications for general support, especially in light of COVID-19's impact. Eligible organizations must be 501(c)(3) nonprofits and operate within Summit County. The foundation prioritizes partnerships, professionalism, leadership, and innovation to enhance community wellbeing and address pressing issues.

The St. Johns Cultural Council offers the State of the Arts Grants, providing six $1,500 awards to support individual artists and arts organizations in St. Johns County. Applications open annually on September 1st, aiming to fund innovative projects in various artistic disciplines. Priority is given to proposals that engage underserved communities or enhance arts education. This competitive grant process encourages creative proposals while ensuring minimal application burden on applicants.

What is a One Young World Scholarship?

One Young World scholarships open doors for extraordinary young changemakers to join the One Young World Summit and global Community, fully funded. These fully funded leadership scholarships cover travel, accommodation, and meals so your ability to make an impact is never limited by financial constraints.

From worldwide initiatives to regional programmes, we offer scholarships for young changemakers and scholarships for social impact leaders working on today’s most urgent challenges.

We partner with civil society organisations, governments, businesses, universities, and philanthropies to make these fully funded leadership scholarships possible — ensuring the brightest minds have the platform they deserve.

Our Scholars

Our scholars demonstrate proven leadership ability, creating change in their communities. Many of our scholars are changing the world at the grassroots level, some are top-performing industry professionals, while others are paving the way politically in their countries.

dsm-firmenich Progress Foundation Scholarship

About the scholarship

At dsm-firmenich, we believe that with capability comes responsibility. By focusing on societal impact and tackling challenges at their core, we bring progress to life, creating sustainable solutions for a better future.

This commitment to lasting impact is at the heart of our purpose. We're helping to realize progress for people everywhere - from our colleagues to our wider value chain and to the societies and people we reach through our solutions. And we don't want to stop there.

That's why we have established the dsm-firmenich Progress Foundation, to make a positive difference in the world. The independent dsm-firmenich Progress Foundation is focused on driving sustainable change, empowering communities and supporting the next generation of changemakers.

The foundation is proud to offer five impactful young leaders the opportunity to participate in the One Young World Summit 2026, which takes place in Cape Town, South Africa, from 3 - 6 November.

Join Us

The dsm-firmenich Progress Foundation Scholarship is looking to support young entrepreneurs making a local or global impact in communities around the globe in one of three focus areas:

• Fighting Malnutrition.
• Strengthening community resilience.
• Protecting and restoring ecosystems.  

Examples of relevant work include, but are not limited to:

• Initiatives which address micronutrient deficiencies and ensure food with the highest quality and nutritional value reach the most vulnerable.
• Initiatives which strengthen community resilience and address social inequality.
• Initiatives that restore and protect ecosystems, building nature's resilience by addressing climate action, biodiversity protection and safeguarding water systems. 

What will you receive?

Selected scholars will receive:

• Access to the One Young World Summit 2026 in Cape Town, South Africa.
• Hotel Accommodation in Cape Town, checking in on 31 October and checking out on 8 November.
• Travel to and from Cape Town (flights in economy).
• Catering which includes breakfast at the hotel accommodation and lunch and dinner during the core Summit days.
• Ground transport between the Summit accommodation and the Summit venue.
• Pre and post-programme in Cape Town and the opportunity to join the dsm-firmenich delegation during the Summit. 

The Lucy Downing Nisbet Charitable Fund, established in 2002, supports educational, health, human services, and arts programming for underserved populations in Vermont. It prioritizes organizations focused on healthcare, domestic violence awareness, and environmental conservation. Eligible applicants must have a Vermont office, while grants are not made for deficit financing or capital projects. Special consideration is given to local organizations serving Morrisville, VT, and those addressing critical health and community issues.

BMO Gives is committed to fostering positive societal impact through community support and charitable initiatives. It focuses on enhancing community and economic resilience, as well as environmental sustainability. Eligible applicants must be registered charities or non-profits operating in Canada or the U.S. and align with BMO's corporate values, which promote inclusivity and non-discrimination. The program aims to support projects that address significant societal needs and empower local communities.

The Kelley Foundation Grant Program provides funding to tax-exempt organizations in Barnstable County, Massachusetts, focusing on community enrichment through health services, housing, youth development, food security, arts, and environmental initiatives. Applications are accepted year-round, with a review process that may take up to six months. Note that grants are not awarded to the same organization within a three-year period, and private foundations are ineligible for funding.

The CREST program by the NSF aims to bolster research capabilities at minority-serving institutions (MSIs) through education and research integration. It specifically supports STEM doctoral programs and encourages proposals in high-priority areas such as AI and climate change. By enhancing the institutional capacity, the program seeks to increase the number of underrepresented doctoral graduates in STEM fields, thereby fostering diversity and innovation in scientific research.

The Fund for Santa Barbara's Emerging Need Grants provide crucial support to grassroots organizations combating systemic inequities. Offered year-round until funds are exhausted, these grants aim to empower groups addressing urgent social issues that were unforeseen. With a maximum request of $5,000 and funding for up to three months, the program prioritizes collaborative efforts to foster social change in areas such as racial, economic, and environmental justice.

The Fund for Santa Barbara Grants - Movement Building Grant aims to foster progressive change by empowering grassroots organizations in Santa Barbara County. By focusing on Economic, Environmental, Political, Racial, and Social Justice, the grant supports initiatives that dismantle systemic oppression. It prioritizes funding for groups that engage marginalized communities and promote self-determination. Eligible organizations must align with the FUND's mission and operational guidelines, ensuring impactful contributions to social change.

The NJ WorkClean Diesel Modernization Grant Program aims to improve air quality by funding diesel-to-diesel and diesel-to-electric projects. It targets older diesel vehicles and equipment that contribute to air pollution, particularly in overburdened communities. This reimbursement program supports replacing marine engines and non-road diesel vehicles while promoting the electrification of on-road diesel vehicles, such as school buses and garbage trucks, to enhance public health and environmental standards.

Georgia Department of Community Health

The Georgia Department of Community Health (DCH) is one of Georgia’s four health agencies serving the state’s growing population of over 10 million people.

DCH serves as the lead agency for Medicaid and PeachCare for Kids®, and also oversees the State Health Benefit Plan, Healthcare Facility Regulation Division and State Office of Rural Health, impacting one in four Georgians.

Through effective planning, purchasing and oversight, DCH provides access to affordable, quality health care to millions of Georgians, including some of the state’s most vulnerable and underserved populations.

GREAT Health Program

Description

Georgia’s Rural Enhancement And Transformation of Health (GREAT Health) program will bring about a transformation of health in rural Georgia. Achieving this vision means rural populations are healthier, live longer, have an improved quality of life, and can both live and work in the communities they love; rural places have healthcare that is high quality, more abundant, more accessible, and more effective; and rural progress creates systems-level change that leverages technology, drives innovation, and improves quality, while maintaining a patient focus.

The GREAT Health program will do this through five initiatives:

• Transforming for a Sustainable Health System
• Strengthening the Continuum of Care
• Connecting to Care to Improve Healthcare Access
• Growing a Highly Skilled Healthcare Workforce
• Leveraging Technology for Healthcare Innovation

Who Can Participate?

Georgia has 126 rural and partial rural counties designated as the program’s areas of focus, based on the Health Resources and Services Administration’s (HRSA) rural grants eligibility analyzer. Healthcare facilities and organizations serving these counties will be eligible to apply for funding through the program’s initiatives. Visit the list of eligible counties.

In addition to the 126 eligible rural and partial rural counties, 93 hospitals serving these rural areas and with Center for Medicare and Medicaid Service (CMS) designations of Critical Access Hospitals, Sole Community Hospitals, or Rural Referral Centers, were invited to participate in Initiative 1 and its associated value-based care model. Visit the Value-Based Care page to learn more.

The Community Opportunity Fund, managed by Boreal Waters Community Foundation, empowers local organizations in northeastern Minnesota and northwestern Wisconsin by providing essential funding for transformative projects. This initiative focuses on uniting community resources to foster innovative ideas, strengthen nonprofits, and drive impactful change. With a long-standing commitment to supporting civic engagement, the Fund directs support to where it's most needed, ensuring that communities can thrive even in challenging times.

The Community Opportunity Fund: Belonging Grant, offered by Boreal Waters Community Foundation, aims to foster inclusive spaces where all voices are valued. This grant supports community-driven projects that enhance collaboration and respect among diverse groups, particularly those from historically marginalized communities. It provides funding for program support, operating expenses, and capacity building to ensure lasting impact. By prioritizing equity and community ownership, this initiative seeks transformative change across northeastern Minnesota and northwestern Wisconsin.

The Community Opportunity Fund: Resilience Grant, offered by Boreal Waters Community Foundation, supports transformative projects in northeastern Minnesota and northwestern Wisconsin. It aims to enhance community resilience by funding initiatives that foster adaptation and recovery from challenges. Eligible applicants include established nonprofits and grassroots organizations focused on equity and sustainability. The grant emphasizes collaborative solutions that address pressing issues like housing stability and food security, ensuring a lasting impact for historically marginalized communities.

The NIDCD invites R01 grant applications aimed at independent research projects related to the mission of the National Institute on Deafness and Other Communication Disorders. This opportunity promotes workforce development by supporting Early Stage and New Investigators, especially those from underrepresented backgrounds in health sciences. Letters of Intent are encouraged 30 days before the proposal deadline, allowing diverse researchers to collaborate and contribute to vital health-related studies.

Department of Business and Economic Affairs

The Department of Business and Economic Affairs (BEA) is the premier resource for businesses considering expansion in, or relocation to, New Hampshire, as well as people seeking a home in a place where they can balance their careers amid the natural beauty it offers.

Dedicated to enhancing the economic vitality of the state and promoting it as a destination for domestic and international visitors, BEA is comprised of the Division of Economic Development, Division of Planning & Community Development, and the Division of Travel and Tourism Development.

Within these divisions are programs that support BEA’s mission to keep the state’s economy strong and competitive, from international trade and government procurement to workforce development and municipal planning.

About NBRC

The Northern Border Regional Commission (NBRC) is a partnership between the federal government and the states of Maine, New Hampshire, New York, and Vermont. The NBRC targets resources to promote economic growth strategies and projects in designated counties within its member states. 

Mission Statement: The mission of the Northern Border Regional Commission is to catalyze community vitality and economic prosperity in the northern border region with flexible funding and strategic support.

Forest Economy Grant Program

The Forest Economy Program, administered by the Northern Border Regional Commission, makes awards in the form of Grant Agreements. The program stimulates economic growth in the forest-based industries, including new technologies and viable business models, across the NBRC four-state region in alignment with state economic development plans and forest economy initiatives. 

NBRC's Forest Economy Program (FEP) is designed to support state-identified development plans for the regional forest economy and to assist in the industry’s evolution to include new technologies and viable business models.

Forest Economy Program Priorities  

Successful projects support a broad range of initiatives such as, but not limited to:

• Public infrastructure projects that directly support the forest industry;  
• Community development projects that support the diversified use of forest for economic activity;  
• Workforce training and development projects for the purpose of building the skills and recruiting and retaining the workforce needed for forest businesses, and;
• Marketing, communication and education projects that are paired with a public infrastructure, community development or workforce training or development project.  
• Basic research projects will not be considered. Preference will be given to applied research and demonstration projects that demonstrate a strong connection to industry.

Community Foundations of the Hudson Valley 

Community Foundations of the Hudson Valley (CFHV) empowers individuals, families, businesses, and organizations to fulfill their philanthropic goals through the establishment of charitable funds that support the needs of Dutchess, Putnam and Ulster counties. With over $100 million in assets, CFHV manages nearly 600 charitable funds and has distributed more than $777 million in grants and scholarships since January 2000. We lead initiatives to address urgent community needs such as food insecurity and educational challenges, offering both immediate relief and long-term support.

Ulster County Community Grant

The Community Foundations Community Grant Program is an annual opportunity to provide nonprofits with unrestricted General Operating Support (GOS). GOS grants are flexible and allow funds to support an organization’s ongoing administrative and infrastructure costs and to provide support to maintain existing, effective programs, organizational development and capacity building in Dutchess, Putnam and Ulster Counties.

Funding Focus

Funding will support a broad variety of organizations and programming, including: effective and innovative programs in the areas of human services (food security, mental house, housing), arts and culture, education and youth, health, the environment and civic affairs. Funding will have a focus on benefiting people who are from historically marginalized and under-funded communities or populations based on their race, ethnicity, age, gender/gender identity, socioeconomic status, health status, abilities or geographic location.

General Operating Support grants will provide unrestricted support to the organization but can include specific support such as:

• Planning and/or the direct implementation of the program
• Technology, equipment, or material costs
• Strategic planning, staff/board development and/or succession planning
• Management systems (financial, HR)
• Marketing and communications
• Investments to increase organizational capacity

The Elizabeth Morse Genius Charitable Trust Grant focuses on grants that promote values-based initiatives addressing various community needs, particularly in Chicago and Cook County. It supports 501(c)(3) organizations that relieve human suffering, enhance self-esteem, and encourage athletic activities. The Trust emphasizes regional solutions to local challenges, ensuring that the quality of life improves for all citizens. Organizations outside the area may apply if they serve a significant number of Chicago residents.

The Whipple Foundation Fund Grant, established by Mildred Whipple in 2003, aims to enhance lifelong learning for Douglas County residents. It prioritizes support for reopening libraries, fostering civic engagement, and funding early childhood programs. The grant encourages sustainable community funding and collaboration among various educational initiatives. With a focus on local needs, it accepts applications annually, targeting projects that improve educational access and community involvement.