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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

33,000+

Available grants

$9.00B

Total funding

$6K

Median grant

33,000+ grants
$9.00B total
$6K median

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32,618 Results based on applied filters

Tuscora Park Health & Wellness Foundation Grants

Barberton Community Foundation
Private
Summit County, Ohio
US $2,000 - US $15,000
The Health and Wellness Grant, offered by the Barberton Community Foundation, supports tax-exempt nonprofits that benefit Barberton residents. This grant emphasizes projects focused on health and wellness, education, and economic development. Organizations are encouraged to submit a Letter of Inquiry prior to applying. The foundation aims to foster collaboration and strengthen the Barberton community through transformational partnerships, ultimately creating a lasting legacy of giving.
Wellness & Healthy Living Health & Medicine

U.S. Venture Program Grants

Us Venture Schmidt Family Foundation Inc
Private
United States
Unspecified amount
The U.S. Venture/Schmidt Family Foundation supports initiatives that drive self-sufficiency and community enrichment for vulnerable populations. With over $4.31 million awarded last year, the foundation prioritizes projects that demonstrate measurable impact and foster stronger communities. Eligible organizations include those designated as public charities by the IRS. The foundation emphasizes collaboration with other funders, avoiding sole financial support to ensure comprehensive community development.
Community Development & Revitalization Nonprofit Growth & Development Basic Human Needs

Next Wave Grant

City of Tempe
State/Local Government
Maricopa County, Arizona
Up to US $2,500
The Next Wave Grant, offered by the City of Tempe, supports innovative arts projects with funding up to $2,500 for newer nonprofits and small creative businesses. This initiative aims to foster growth in the local arts community by empowering first-time applicants to explore fresh ideas and approaches. By prioritizing grassroots efforts, it enhances cultural vibrancy and accessibility in Tempe, ensuring a dynamic artistic future that resonates with the community.
Art & Culture Public / Community Art

ACS Catalyst Scholarship

American Chemical Society
Association/Society
United States
US $10,000

American Chemical Society

Science moves forward when people come together. For over 150 years, ACS, a nonprofit organization, has united the global scientific community to foster research excellence, advance scientific education, and champion innovation. Discover how, together, we advance scientific knowledge, champion integrity, and build a community where science is for everyone.

Our Vision: A world built on science

Our Mission: 

  • Advance scientific knowledge
  • Empower a global community
  • Champion scientific integrity

Core Values: 

  • Passion for Science
  • Lifelong Learning
  • Inclusion and Belonging
  • Sustainability

ACS Catalyst Scholarship

Description

The Catalyst Scholarship is a need-based award that supports undergraduate students pursuing chemistry or chemistry-related fields. Providing $10,000 in funding, with the potential for renewal, the scholarship helps students overcome financial barriers, persist in their studies, and advance toward their academic and career aspirations.

Education - Higher Education Chemistry

Ai2 Young Investigators Program

The Allen Institute For Artificial Intelligence
Private
King County, Washington
Unspecified amount
The Ai2 Young Investigators Program offers postdoctoral researchers the chance to engage in impactful AI research while balancing collaborative projects at Ai2. Founded by Paul Allen, Ai2 is a Seattle-based non-profit committed to advancing AI for real-world applications. With flexible start dates, dedicated mentorship, and access to extensive resources, this program is designed for candidates nearing completion of their PhD or who already possess one, welcoming international applicants and providing support with visas.
Computer Science & Engineering Artificial Intelligence (AI)

Michael Scott Kramer Memorial Scholarship

San Juan Island Community Foundation
Private
United States
US $2,000
The Michael Scott Kramer Memorial Scholarship, offered by the San Juan Island Community Foundation, is designed for post-secondary students pursuing education in fields like recreation, adventure tourism, and marine trades. This scholarship honors Mike Kramer, a beloved outdoorsman, by encouraging students to embrace life and adventure. Candidates should demonstrate community service, a strong work ethic, and a passion for their studies. It aims to inspire the next generation to live authentically and pursue their dreams.
Academic Scholarship Programs Recreation

JDF: FIRST Tech Challenge

John Deere Foundation
Private
Barnes County, North Dakota, Black Hawk County, Iowa +17 more
Unspecified amount in in-kind support
The John Deere FIRST Tech Challenge grant supports teams engaging in STEM through robotics. It serves schools and non-profits, prioritizing those in John Deere's Inspire communities and with volunteer mentors. Grants cover registration and equipment costs, fostering innovation and inclusion among underserved students. Teams are encouraged to apply regardless of financial need, furthering John Deere's commitment to empowering youth in engineering and technology through hands-on learning experiences.
STEM / STEAM Education Robotics

JDF: FIRST LEGO League Challenge

John Deere Foundation
Private
Barnes County, North Dakota, Black Hawk County, Iowa +19 more
Unspecified amount in in-kind support
The John Deere FIRST LEGO League Challenge aims to enhance equity, diversity, and inclusion in STEM by supporting teams from underserved communities. Eligible teams must have a John Deere mentor and meet specific criteria related to student demographics. Grants will be awarded to teams that demonstrate commitment to community engagement and volunteerism. This initiative aligns with John Deere’s goal to reach one million underserved youth by 2030, fostering innovation and creativity in future generations.
STEM / STEAM Education Robotics

California Advanced Services Fund: Broadband Infrastructure Grant Project

California Public Utilities Commission Foundation
Private
California
Up to US $15,000,000
The California Advanced Services Fund's Broadband Infrastructure Grant Project aims to provide free broadband service to residents of low-income communities through grants and loans. With a funding allocation of $15 million for the fiscal year, eligible applicants can request up to $150,000 to build broadband networks in public housing and mobile home parks. This initiative seeks to bridge the digital divide by ensuring access to high-speed internet for underserved populations.
Technology Access & Digital Literacy Cyberinfrastructure

Texas Criminal Justice Grant

Office of the Texas Governor
State/Local Government
Texas
More than US $10,000

Criminal Justice Grant Program, FY2027

Purpose:

The purpose of this announcement is to solicit applications for projects that promote public safety, reduce crime, and improve the criminal justice system.

Available Funding:

Federal Funds are authorized under 34 U.S.C. §10152 Edward Byrne Memorial Justice Assistance Grant Program (JAG). JAG funds are made available through a Congressional appropriation to the U.S. Department of Justice, Bureau of Justice Assistance. All awards are subject to the availability of appropriated federal funds and any modifications or additional requirements that may be imposed by law.

Crime & Justice Community / Public Safety

City of Covington: Neighborhood Grant Program

City of Covington
State/Local Government
Kenton County, Kentucky
Up to US $5,000
The City of Covington's Neighborhood Grant Program offers up to $5,000 to neighborhood groups for projects aimed at enhancing community appearance and social cohesion. This competitively awarded program emphasizes a simple application process for funding beautification initiatives, blight removal, and special events. By fostering local engagement, it aims to create vibrant, connected neighborhoods that reflect the community's identity and pride.
Community Development & Revitalization Greening & Beautification

Funds for Women Graduates: Theodora Bosanquet Bursary

Funds for Women Graduates (FfWG)
Private
Ireland, United Kingdom
Unspecified amount in in-kind support
The Theodora Bosanquet Bursary, established in memory of the notable writer and administrator, offers accommodation support for female postgraduate students pursuing research in History or English Literature. Eligible applicants, regardless of age, must require a short residence in London for up to four weeks during the summer. This annual bursary invites women from both Great Britain and overseas to apply, fostering academic excellence in these fields.
History Writing & Literature

ACS Graduate Student Success Grant

American Chemical Society
Association/Society
United States
US $25,000

American Chemical Society

The American Chemical Society (ACS) is a non-profit organization founded in 1876 and chartered by the U.S. Congress. ACS is committed to improving all lives through the transforming power of chemistry. Our mission is to advance scientific knowledge, empower a global community, and champion scientific integrity. Our vision is a world built on science.

What We Do

More than 145 years after our founding, we remain a champion for chemistry, its practitioners and our global community of members.

We’re recognized as a leading publisher of authoritative scientific information. Our 80+ peer-reviewed journals are ranked the “most-trusted, most-cited and most-read.”

We empower our members to advance chemistry, elevate their career potential, expand their networks, inspire future generations, collaborate globally and build communities that provide scientific solutions.

We provide broader networks that facilitate connections and open doors in a way no other professional organization can match!

ACS Graduate Student Success Grant

Purpose

To support graduate students (M.S. and Ph.D.), within one year of degree completion, whose education and training were disrupted due to termination or cancellation of research grants. Funding will be given to the Principal Investigator (PI) of the lab. This one-year award, the ACS Graduate Student Success Grant, will enable students to complete their degree programs. The grant seeks to lower the risk of a declining number of U.S.-trained chemists with advanced degrees, thereby preserving the strength and continuity of the scientific community.

Description

The ACS Graduate Student Success Grant provides $25,000 for one year to a faculty member who lost funding after October 1, 2024, that supports one or more graduate students. The award will also connect supported graduate students to ACS career development resources and programming to catalyze their transition into the workforce.

The grant funds will be awarded to exclusively support graduate students (M.S. and Ph.D.) who are within one year of degree completion and in need of funds to ensure degree completion. This grant supports currently enrolled graduate students who conduct research related to the chemical sciences in a department at a U.S.-based institution of higher education. Each institution of higher education can receive a maximum of one ACS Graduate Student Success Grant.

Applicant must provide a signed letter on institutional letterhead from the Vice President of Research (or equivalent), confirming the institution’s support, including the following:

  • The PI’s loss of funding due to grant termination or cancellation after October 1, 2024.
  • The names, current academic status, and anticipated graduation time of the impacted graduate students.

Education - Higher Education Chemistry

NEA Arts and Artifacts Domestic Indemnity Program 2, FY2027 (12/26)

National Endowment for the Arts
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $100,000
The NEA Arts and Artifacts Domestic Indemnity Program provides museums and cultural institutions in the U.S. with financial protection against loss or damage to significant artworks during exhibitions. Established in 1975 and expanded in 2007, the program aims to enhance public access to art by minimizing insurance costs. Managed by the National Endowment for the Arts, it involves thorough evaluations by expert panels to ensure eligibility and compliance, facilitating the safe display of invaluable cultural treasures.
Art & Culture Arts / Culture Access & Participation

NLM Grants for Scholarly Works in Biomedicine and Health (G13 Clinical Trial Not Allowed) (363939)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $80,000
The NLM Grants for Scholarly Works in Biomedicine and Health (G13) program invites applications to support the creation of book-length manuscripts and scholarly works that are vital for U.S. health professionals and scientists. This initiative aims to foster critical reviews and analytical syntheses that enhance understanding of biomedical and public health challenges, ultimately contributing valuable resources for education, research, and clinical practice.
Health & Medicine Epidemiology & Public Health

Remote Biomarker Measurements in Microphysiological Systems Grant

Translational Research Institute for Space Health
Association/Society
United States
Unspecified amount
The Remote Biomarker Measurements in Microphysiological Systems Grant seeks innovative proposals to enhance remote biomarker analysis technologies for microphysiological systems, crucial for deep space missions. It prioritizes non-invasive, adaptable methods that allow for continuous monitoring of biomarkers without sample return. This initiative aims to advance personalized healthcare and biological research, addressing astronaut health in challenging environments. Eligible entities include U.S. institutions and collaborations with foreign entities under specific conditions.
Astrobiology Space Science

Greenwall Faculty Scholars Program

The Greenwall Foundation
Private
United States
More than US $5,000
The Greenwall Faculty Scholars Program supports junior faculty in bioethics research, offering 50% salary support for three years and project funding of $5,000 annually. Scholars engage in community-building through semi-annual meetings, mentoring, and philosophical seminars. Priority is given to applicants from underrepresented backgrounds and those not yet considered for tenure. This program aims to drive innovative research that addresses pressing ethical issues in clinical and public health settings, fostering future bioethics advancements.
Biology Medical Ethics

The Sherwood Foundation: Capital Grants

The Sherwood Foundation
Private
Nebraska
Unspecified amount
The Sherwood Foundation's Capital Grants program aims to enhance Nebraska's communities through strategic investments in public education, human services, and social justice. By providing funding for land purchases, construction, renovations, and significant equipment, the foundation supports projects that improve child and family welfare. Organizations seeking grants must provide their EIN/TAX ID, ensuring that funds are directed to eligible applicants committed to fostering community development and well-being.
Social Justice / Human Rights Education Human & Social Services

NEA Arts and Artifacts Domestic Indemnity Program 1, FY2027 (12/26)

National Endowment for the Arts
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $100,000
The NEA Arts and Artifacts Domestic Indemnity Program, administered by the National Endowment for the Arts, ensures that U.S. museums can exhibit significant art and artifacts without the burden of high insurance costs. Established in 1975, it provides indemnity against loss or damage, promoting access to cultural heritage. The program evaluates applications through expert advisory panels and typically meets three to six months after deadlines to decide on indemnity requests, thereby supporting the arts and enriching public engagement.
Art & Culture Arts / Culture Access & Participation

Broadband Equity, Access, and Deployment (BEAD) Program

Pennsylvania Department of Community and Economic Development
State/Local Government
Pennsylvania
Unspecified amount
The Broadband Equity, Access, and Deployment (BEAD) Program, administered by the Pennsylvania Broadband Development Authority, aims to enhance high-speed internet accessibility across the U.S. Funded by the Infrastructure Investment and Jobs Act of 2021, this initiative accepts applications year-round, with approvals occurring quarterly. To be eligible for the next funding round, applications must be submitted by the end of each calendar quarter, ensuring timely support for broadband development.
Technology Access & Digital Literacy Medical Technology, Devices, and Equipment

2025-2026 Charter School Program Technical Assistance Grant

Texas Education Agency
State/Local Government
Texas
US $360,000
The 2025-2026 Charter School Program Technical Assistance Grant, administered by the Texas Education Agency, aims to enhance the performance of Texas charter schools. This grant provides essential support and technical assistance to charter operators, ensuring they can successfully launch and sustain quality charter schools. By focusing on academic, financial, and organizational success, the program seeks to improve educational outcomes for students across Texas.
Education Academic Success & Enrichment

Samuel F. Atkins and Barbara H. Atkins Memorial Fund Grant

Boreal Waters Community Foundation
Private
Aitkin County, Minnesota, Ashland County, Wisconsin +8 more
US $1,000 - US $5,000
The Samuel F. Atkins and Barbara H. Atkins Memorial Fund Grant, managed by the Duluth Superior Area Community Foundation, supports projects that assist low-income individuals and address animal welfare. Eligible organizations include 501(c)(3) nonprofits, governmental entities, and tribal governments located in specific counties in Wisconsin and Minnesota. The fund prioritizes projects demonstrating financial need, including emergency services and training programs for the physically disabled. This grant exemplifies the foundation's commitment to enhancing community welfare.
Basic Human Needs Animal Welfare - General

LexArts General Operating Support (GOS) Grant Program

Lexarts Inc
Private
Fayette County, Kentucky
More than US $5,000
The LexArts General Operating Support Grant provides essential funding to arts organizations in Central Kentucky, supporting year-round cultural activities. With two tiers available, GOS I offers over $25,000 for established organizations, while GOS II provides $5,000 to $25,000 for mid-sized groups. This program aims to enhance community life through artistic and educational initiatives. Interested applicants must visit LexArts.gosmart.org and note that meeting eligibility does not guarantee funding.
Art & Culture Art Education

NEA Arts and Artifacts International Indemnity Program 2, FY2027 (3/27)

National Endowment for the Arts
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $100,000
The NEA Arts and Artifacts International Indemnity Program, established in 1975, supports the exhibition of significant art and artifacts by minimizing insurance costs for international exhibitions. Administered by the National Endowment for the Arts, it covers U.S. owned art during exhibitions in the country. The program evaluates applications through advisory panels and the Federal Council on the Arts and Humanities, ensuring that vital cultural works are accessible while providing necessary financial protections.
Art & Culture Arts / Culture Access & Participation

Alan and Grace Tenn Scholarship Fund

Hawai'i Community Foundation
Private
Hawaii
Unspecified amount
The Alan and Grace Tenn Scholarship Fund supports undergraduate seniors and graduate students majoring in education at Hawaiian institutions. Applicants must demonstrate financial need, maintain a minimum GPA of 2.7, and be residents of Hawaii. The fund prioritizes past recipients who continue to meet eligibility criteria and students planning to teach or counsel within the educational system. The scholarship fosters the development of future educators in Hawaii.
Education Education - Higher Education

CFMC Women Educators Endowed Fund

Community Foundation of Monroe County
Private
Michigan
Unspecified amount

About Us

Making a Difference, Together

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Women Educators Endowed Fund

The Women Educators Scholarship Fund supports applicants pursuing a degree in the field of education with a completion of at least 48 undergraduate credit hours at an accredited Michigan college of education or an institution with a reciprocal agreement.

Education Education - Higher Education

Portland Arts & Culture: General Operating Support

City of Portland Office of Arts & Culture
State/Local Government
Multnomah County, Oregon
US $25,000 - US $290,000
The Portland Arts & Culture General Operating Support program provides essential funding for local arts organizations that enhance the cultural ecosystem of the city. With a focus on accessibility, these grants support a wide range of activities including community events and arts education. Eligible organizations must be based in Portland, hold IRS 501(c)(3) status, and demonstrate a commitment to serving diverse communities. Over 1.5 million attendees benefit from these programs annually, bolstering the local economy.
Art & Culture Art Education

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.34B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.7%
Q2
24.7%
Q3
23.5%
Q4
22.1%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $32,500.

$0 $0 Min.
$32,500 $32.5 K Median
$633,837 $633.8 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.7% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $32,500, while the average grant awarded is $633,837. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.