Best Operating Grants for Nonprofits

The National Institute of Allergy and Infectious Diseases (NIAID) is launching a funding opportunity for up to four Clinical Trials Network Laboratory Centers (LCs). These LCs will support HIV prevention and treatment strategies by providing necessary laboratory infrastructure and technologies for clinical trials. They will ensure rigorous laboratory testing and oversight, enhance sample integrity, and utilize advanced data management systems to meet evolving demands in HIV research and testing.

Gilead Sciences

At Gilead, we are relentlessly committed to advancing transformative therapies for the most serious diseases, delivering an exponentially positive impact on health.

For more than three decades, we have combined scientific rigor with a deep sense of purpose to improve health outcomes and reimagine care. Our work spans more than 35 countries with a focus on three therapeutic areas: virology, oncology, and inflammation, where unmet medical needs remain greatest.

From individual patients to whole populations, we’re committed to delivering healthier futures for people and communities worldwide.

Our Mission: To discover, develop and deliver innovative therapeutics for people with life-threatening diseases.

HIV Prevention NOVA 2026

Program Description

Gilead Sciences invites research proposals that advance the evidence base for innovative and scalable models of delivery for long-acting (LA) HIV pre-exposure prophylaxis (PrEP) in the United States.

This Topic of Interest (TOI) is focused on care delivery models implemented in non-traditional settings, defined as clinical and non-clinical environments where PrEP services are not routinely provided. Emphasis is placed on approaches that reflect real-life practice and address gaps in current PrEP delivery infrastructure.

Persistent inequities in PrEP uptake in the U.S. suggest that expanding availability within traditional clinical settings alone is unlikely to reach all populations with unmet PrEP need.1,2 Rigorous implementation studies in non-traditional settings where PrEP services are not routinely provided are needed to evaluate whether these models can reduce access barriers and improve equitable reach among individuals who may benefit from PrEP.2,3,4

The goal of this TOI is to generate practical, decision-relevant evidence that informs how LA PrEP can be implemented, scaled, and sustained in real-life U.S. settings.

The Bernick's Beverages and Vending Fund Grants aim to support organizations that align with the Bernick family's values, offering up to $150,000 in funding for 8-10 eligible groups. Focus areas include youth education and fitness initiatives, with grants ranging from $5,000 to $40,000. Eligible applicants include 501(c)(3) nonprofits, schools, and government entities within Bernick's operational regions. The foundation seeks innovative programs that foster community engagement and promote healthy lifestyles.

Napa Valley Community Foundation

There are more than 800 Community Foundations in the US, each devoted to a specific region. We operate independently, with a common goal in mind: to be a platform for local people who want to pay it forward. To deliver resources to effective charitable programs. And to make our communities stronger and more successful by doing these two things.

Among our peers, Napa Valley Community Foundation ranks first on several key measures of donor satisfaction and impact, according to a recent donor survey conducted by the Center for Effective Philanthropy. Our donors say that we deeply understand their interests, and deeply understand the needs of Napa Valley. That, in a nutshell, is our job.

Fruit of the Vine Scholarship

The Fruit of the Vine Scholarship Fund benefits graduating Napa County high school seniors and Napa Valley College transfer students who will find the cost of higher education a financial hardship. Consideration is given to applicants who are the first in their family to attend college or are employed (or have a parent or guardian who is employed) in the Napa County wine or grape industry. Recipients of the scholarship will receive funding for up to four years of undergraduate study.

The Lead-Safe Homes Program (LSHP) is offering grant opportunities from October 1, 2025, to September 30, 2026, aimed at reducing childhood lead poisoning in Wisconsin. The program seeks local partner organizations for lead laboratory analysis and services, funded through the Children's Health Insurance Program (CHIP). Selected organizations will coordinate environmental investigations and remediation efforts in eligible homes statewide, prioritizing projects based on children's blood lead levels.

The National Institute of Allergy and Infectious Diseases (NIAID) is launching a funding opportunity for Clinical Trials Units (CTUs) as part of its effort to combat HIV/AIDS. This initiative aims to support innovative clinical trials and implementation research to improve prevention and treatment strategies. With a focus on both domestic and international research sites, CTUs will play a crucial role in addressing the HIV epidemic and enhancing participant recruitment and retention. This funding opportunity is authorized under the Public Health Service Act.

The Eckblad Williams Community Fund Grant supports enriching projects for ISD 742 orchestra students. With funding ranging from $100 to $900, applications are encouraged for travel scholarships, professional development for teachers, and additional resources for instrument repair and music purchases. The grant aims to enhance existing programs and provide unique learning opportunities for students who may lack access to such experiences.

STI and HIV Prevention Grant Program

The Minnesota Department of Health aims to identify organizations across the state to implement HIV prevention initiatives centered on HIV testing and PrEP. These programs are designed to reduce HIV transmission by prioritizing populations most affected by the epidemic, ensuring that available state funding achieves the greatest possible impact.

MDH is seeking applications through this RFP to support the development and implementation of innovative program activities that increase people’s knowledge of their HIV status, reduce HIV transmission, prevent new HIV infections, strengthen linkage to care, and improve viral suppression. 

Program Goals

MDH is seeking applications through this request for proposals (RFP) to support the development and implementation of innovative program activities that increase people’s knowledge of their HIV status, reduce HIV transmission, prevent new HIV infections, strengthen linkage to care and improve viral suppression. Collectively, these activities advance the goals of the National HIV/AIDS strategy for the United States (NHAS), Ending the HIV Epidemic (EHE) initiative – (diagnose, treat, prevent and respond), the Centers for Disease Control and Prevention (CDC)’s high impact HIV prevention (HIP) approach, which emphasizes a comprehensive whole-person approach, and the legislatively mandated END HIV Minnesota (MN) initiative. The End HIV MN initiative aims to eliminate new HIV infections and improve health outcomes for people living with HIV in Minnesota, with a goal to reduce new HIV infections in Minnesota by at least 75% in 2035 by prioritizing communities most affected by HIV. 

The TX State Wildlife Grants program, initiated by Congress in 2000, offers essential funding to U.S. states and territories for proactive conservation efforts, aiming to prevent fish and wildlife from becoming endangered. This core initiative, supported by a diverse coalition of stakeholders, including conservationists and land developers, plays a vital role in maintaining species health and reducing listings on federal endangered species lists. The Nongame and Rare Species Program will not accept proposals for FY 2024.

The Henry and Ruth Blaustein Rosenberg Foundation, established in 1959, focuses on enhancing educational opportunities and community vitality in Baltimore. It supports nonprofit organizations in two areas: Youth Development, promoting trauma-informed enrichment programs for high school youth, and Environmental Stewardship, aiming to foster community engagement in small-scale environmental initiatives. The foundation accepts proposals on a rolling basis and prioritizes organizations with proven success in improving educational outcomes and community well-being.

Jack Kent Cooke Foundation

The Jack Kent Cooke Foundation is dedicated to advancing the education of exceptionally promising students who have financial need. Since 2000, the Foundation has awarded $304 million in scholarships to more than 3,400 students from 8th grade through graduate school, along with comprehensive academic advising, career pathway counseling and other support services. The Foundation has also provided $136 million in grants to organizations that serve such students.

The Jack Kent Cooke Foundation’s scholarship programs are designed to encourage and support outstanding students who work hard and have financial need. Our scholarships provide financial assistance and academic support to high school, undergraduate, and graduate students. In addition to the monetary award, students join a thriving network of more than 3,400 Cooke Scholars.

Young Scholars Program

The Cooke Young Scholars Program is a selective five-year, pre-college scholarship for exceptionally promising 7th grade students with financial need. It provides comprehensive academic and college advising, as well as financial support for school, Cooke-sponsored summer programs, internships, and other learning enrichment opportunities.

Program Experience

Educational Advisers support Young Scholars to maximize high school experiences and to go on to thrive at the nation’s top-performing colleges. Our programming and support may include:

• Identifying an appropriately rigorous high school.
• Engaging in four-year planning and goal-setting.
• Funding for academic and extracurricular opportunities, such as music and art lessons, supplemental academic classes and technology.
• Annual summer programs, including two required Young Scholar programs.
• Year-round Young Scholars community programming.
• Networking opportunities with a high-achieving peer community.

The Oklahoma Department of Environmental Quality offers grants for Food Waste Management Projects aimed at reducing food waste through diversion efforts. Eligible applicants include governmental units, educational institutions, and non-profits that can demonstrate specific service provisions. Grants reimburse 80% of eligible equipment costs ranging from $5,000 to $50,000, with total funding amounts typically between $1,000 and $50,000. This initiative promotes sustainable practices while enhancing food recovery infrastructure in the community.

Lewes-Rehoboth Association of Congregations

The Lewes-Rehoboth Association of Congregations (LRAC) is a 501(c)3 charitable nonprofit corporation established in 1983 as a collaborative effort of local churches to come together to serve those in need in the community. LRAC runs the New Life Thrift Shop which funds grant support for the Community Resource Center and a host of other local ministry partners.

LRAC grants

Our mission is to help those in need, primarily feeding the hungry and housing the homeless. Please be sure your mission addresses food or housing insecurity.

The LBCF Community Impact Grant aims to support organizations addressing post-pandemic learning loss and mental health needs of youth in Long Beach. The Long Beach Community Foundation awards these grants to eligible 501(C)(3) organizations, educational institutions, and government entities that provide impactful programs. This initiative reflects the Foundation's commitment to enhancing community welfare and creating new opportunities for Long Beach's youth and young adults.

The Elizabeth Pastor Ashland University Music Education Scholarship supports music students at Ashland University, honoring the legacy of Elizabeth Pastor, a renowned pianist and educator. This scholarship aims to assist students pursuing a music-related career, reflecting Pastor's belief in the transformative power of art. Established through her estate plan, it embodies her commitment to fostering musical talent and enriching the community through education and the arts.

Expanding Access to Middle-Wage Occupations

Request for Proposals

The New York City Workforce Funders Collaborative invites proposals for system and pathway models and policy and advocacy efforts that expand access to middle-wage occupations and upskilling opportunities for low-income New Yorkers. Proposals may be submitted by a single organization or a coalition of organizations working together with one organization as the lead.

The collaborative will award grants of up to $200,000 for policy and advocacy efforts that:

• Increase the share of New York City’s middle-wage occupations;
• Expand access to middle-wage occupations for low-income New Yorkers, with a focus on reducing structural barriers to entry and advancement (including advocacy to increase public investments in pathways to middle-wage occupations);
• Develop and/or advance public policy solutions to support reskilling and upskilling for workers who have experienced labor market disruption; and/or 
• Implement concrete reforms to NYC’s workforce development systems that facilitate new or improved solutions to move more New Yorkers into middle-wage occupations.

The IPCF's Mirza/Arts & Culture Grants support programs focused on art, music, and theatre education, as well as performing and visual arts. Open to tax-exempt organizations, these grants encourage innovative projects benefiting residents of McLean, DeWitt, Livingston, and Logan counties. Applicants may request funding between $600 and $5,000, with a minimum request of $500. The grants emphasize ongoing self-sufficiency and measurable outcomes, fostering community enrichment through diverse artistic initiatives.

The Foundation

In 1946, The Alfred E. Smith Memorial Foundation was established by Francis Cardinal Spellman to honor the legacy of Alfred Emanuel Smith, New York’s most renowned Catholic governor and the first Roman Catholic to run for President of the United States on a major party ticket.

Our Grants

The Alfred E. Smith Memorial Foundation grants support family services, education, and healthcare.

We understand that although life can be unfair, an investment in those who are less fortunate can help to level the playing field.

Grant Procedure

Founded in 1946 to honor the memory of renowned New York Governor and champion of the “little people,” Alfred Emanuel Smith, The Alfred E. Smith Memorial Foundation awards annual grants to organizations that bring hope and support to the poor, sick, and underprivileged within the Archdiocese of New York, regardless of race, creed, or color. Selected organizations are well-managed, financially stable, and propose projects that are worthy, purposeful, and clearly targeted. Charitable efforts are directed primarily toward organizations that serve:

Individuals facing physical, developmental, or emotional challenges who can achieve improved health and well-being through specialized medical and therapeutic services. 

Children and youth affected by poverty or other barriers who can reach their full potential through innovative educational programs and learning opportunities. 

Families and children in need of social support or foster care, whose stability, safety, and long-term prospects can be strengthened through targeted, outcome-driven services. 

The Fennie Community Fund Grant, established by the Long Beach Community Foundation, supports charitable initiatives, particularly for children's organizations in Avalon and Long Beach. Since its inception in 1988, it has prioritized funding projects aligned with the Community Impact Fund. Eligible applicants are organizations addressing community needs in these areas. This grant represents a commitment to enhancing the welfare of local children and fostering community development.

Indigo Hope Foundation: At-Risk Youth Development Grant

Empowering programs that provide mentorship, education, life skills training, and opportunities for young people facing challenges.

Key Focus Areas:

• Mentorship Programs
• Educational Support
• Life Skills Training
• Career Development

Example Programs We Fund:

• After-school tutoring and mentorship
• Job readiness training
• Leadership development

The Claude Worthington Benedum Foundation promotes human development in West Virginia and Southwestern Pennsylvania by providing strategic charitable resources. The foundation focuses on education and economic development, prioritizing projects that enhance teacher quality, support early childhood education, and foster innovative economic initiatives. By investing in programs that bridge geographical boundaries and encourage collaboration among sectors, the foundation aims to cultivate leadership and sustainable growth in the region.

The Sociedad Amigos de Colombia de Indiana (SADCO) Scholarship, managed by the Central Indiana Community Foundation, supports Latinx and Hispanic students pursuing post-secondary education. Applicants must be Indiana residents with a GPA of 3.0 or higher, demonstrating financial need and community service. Preference is given to first, second, or third generation Latinx and/or Hispanic students. Scholarship funds assist with tuition, fees, and other educational expenses, reinforcing the foundation's mission to build inclusive opportunities.

The Jack Feldt Ambucs Memorial Scholarship, established in 1997, supports students in the Tri-Cities area pursuing a degree in Physical Therapy. Funded by the Grand Haven Area Community Foundation, this scholarship prioritizes applicants demonstrating financial need. It considers college juniors and graduating high schoolers, reflecting the spirit of community and collaboration championed by Ambucs. Eligible candidates need to provide transcripts and additional required documents to complete their application.

Impact100 Crawford County is a philanthropic organization focused on empowering local nonprofits through generous grants. With an emphasis on art, culture, education, health, and community betterment, they aim to enhance the lives of residents in Crawford County. Eligible organizations must meet specific criteria, such as being a recognized 501(c)(3) and having a minimum two-year operational history. This initiative fosters a spirit of giving and collaboration, ultimately strengthening the community.

The Limited Competition NOFO aims to provide ongoing support for specific pathogen-free (SPF) macaque colonies that facilitate vital HIV/AIDS research. Only recipients funded under previous ORIP-supported SPF colony announcements are eligible to apply. These breeding colonies are crucial for maintaining SPF macaques, which are free from certain viruses that could jeopardize research outcomes. The project emphasizes the genetic characterization of macaques to enhance understanding of immune responses related to HIV and SIV.

The GSCF: YW Legacy Fund, established in 2006, aims to enhance the lives of women and families in Salina, Kansas, through targeted grants. It supports initiatives promoting women's leadership, child development, health, and the elimination of racism. Eligible applicants include 501(c)(3) nonprofits and educational or governmental institutions, encouraging partnerships for broader community impact. Grants are focused on projects that benefit Saline County, ensuring a lasting legacy of support and empowerment for local women and families.