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Best Operating Grants for Nonprofits

Get operating grants for nonprofits covering essential expenses, staffing, program delivery, and organizational sustainability.

32,000+

Available grants

$8.25B

Total funding

$6K

Median grant

32,000+ grants
$8.25B total
$6K median

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32,241 Results based on applied filters

Cancer Prevention in Maine

Maine Cancer Foundation
Private
Maine
Up to US $80,000

Cancer Prevention in Maine

Cancer remains a leading cause of death in Maine, impacting thousands of Mainers each year. Fortunately, there are many ways to reduce cancer risk and prevention certain types of cancer, ultimately reducing the burden of the disease in our state.

To support cancer prevention efforts, Maine Cancer Foundation is now accepting applications for evidence-based interventions to reduce the risk of cancer in Maine.

Cancer Prevention Focus Areas that will be considered include:

  • Alcohol Use
  • Environmental Factors that Impact Cancer (Arsenic, PFAs, Radon)
  • HPV Vaccinations
  • Obesity Prevention
  • Sun Safety
  • Tobacco Use and Prevention and/or Treatment

Proposals should utilize evidence-based practices in preventing cancer. Please be prepared to provide quantitative and/or qualitative data to support your proposed strategies throughout an application.

Grant Term & Request Amount

Applicants may request a 1- or 2-year grant. Request amounts up to $40,000 per year will be accepted. The maximum request over two years is $80,000. Please note, requests do not have to meet the maximum amount. Smaller, pilot projects are also encouraged.

Cancer / Oncology Smoking Obesity

Hope For Our Future Scholarships: Soon Phil Choice Scholarship Endowment

Adena Health System
Private
Fayette County, Ohio, Highland County, Ohio +7 more
Unspecified amount
The Hope For Our Future Scholarships, funded by Adena Health System, support high school students in their pursuit of careers in healthcare fields such as nursing and radiology. Eligible applicants must reside in the service area and maintain a minimum GPA of 3.0. These scholarships aim to enhance educational opportunities for students while addressing workforce needs in the healthcare sector across southern Ohio.
Education - Higher Education Biomedical Imaging Academic Scholarship Programs +2 more

NAC: Arts Projects for the General Public Grant

Nebraska Arts Council
State/Local Government
Nebraska
US $2,000 - US $7,500
The NAC: Arts Projects for the General Public Grant provides funding for various arts and arts education projects, both online and in-person, adhering to health guidelines. With a focus on public accessibility, it supports exhibitions, performances, and new artwork development. Eligible applicants include tax-exempt nonprofits and government entities in Nebraska, requiring a dollar-for-dollar match for funds. Projects should enhance arts opportunities for underserved communities and must be completed within the fiscal year.
Arts / Culture Access & Participation Public / Community Art Poetry +4 more

The Excellence in Diversity, Equity, & Inclusion Award

Midwest Nursing Research Society (MNRS)
Association/Society
Illinois, Indiana +11 more
Unspecified amount

Midwest Nursing Research Society (MNRS)

The MNRS originally began to provide a place for nurses to collaborate, and collaborate they did! Over time, the founding members began to realize the benefits of having an organization dedicated specifically to nursing research. With some careful attention and a lot of hard work, we have grown into the organization it is today. We're a society where scientists, innovators, and drivers of clinical practice across the career trajectory, come together to share ideas and grow our field through innovative research.

The mission of the MNRS is to generate knowledge, translate evidence into practice, and enhance careers through collaborative engagement, implementation, and dissemination among diverse scholars. Our Vision to be the premier society that advances science, fosters leadership, and drives dissemination to improve health equity for all people.

It is an honor to recognize the important contributions of our nursing colleagues. MNRS accepts nominations for our five very prestigious awards to selected members of the Society who have made significant and notable contributions to the field of nursing through research.

The Excellence in Diversity, Equity, & Inclusion Award

The purpose of the Excellence in Diversity, Equity, and Inclusion Award is to recognize the contribution of a member who has demonstrated outstanding commitment and made significant contributions to advance equitable health outcomes and reduce health disparities through research, which has enhanced the science and practice of nursing in the MNRS region.  

Nursing Hospital Care Primary Health Care

MT Urban and Community Forestry: Program Development Grants

Montana Department of Natural Resources & Conservation
State/Local Government
Montana
Unspecified amount
The Montana Urban and Community Forestry program offers grants aimed at enhancing community forests' health. These grants support local governments in developing urban forestry programs through various projects such as tree inventory, urban forest management plans, and strategic tree planting. Eligible applicants include cities, counties, non-profits, and tribal governments in Montana. The program encourages innovative projects that promote biodiversity, climate change education, and workforce development, ensuring sustainable urban forestry practices.
Forestry

Hoke County Community Foundation Grant Program

North Carolina Community Foundation Inc
Private
Hoke County, North Carolina
US $500 - US $2,000
The Hoke County Community Foundation Grant Program, part of the North Carolina Community Foundation, supports charitable organizations across 67 counties. It offers funding for diverse purposes, including education, health, and arts. Eligible applicants must be tax-exempt public charities or local government units, ensuring programs are accessible without discrimination. The program also includes the Mary Archie McNeill Endowment, specifically for music and cultural arts in Hoke County, with $12,650 available for grants.
Education Environment Basic Human Needs +7 more

Thriving Community Impact Fund: Event Sponsorship, Local Membership, and Community Engagement Requests

GUNDERSEN LUTHERAN MEDICAL FOUNDATION INC
Private
Adams County, Wisconsin, Allamakee County, Iowa +19 more
Unspecified amount
The Thriving Community Impact Fund supports local events and initiatives that promote health and well-being in the community. Applications should be submitted at least 12 weeks prior to the event date. The fund prioritizes non-profit organizations, schools, and government agencies that align with the Health System’s Community Health Improvement Plan. Event sponsorships, local memberships, and partnerships are encouraged to enhance community engagement and address social needs, ultimately fostering a healthier community.
Wellness & Healthy Living Community Health Education Epidemiology & Public Health +4 more

Ryan White HIV/AIDS Program Part B States/Territories Supplemental Grant Program (363163)

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Up to US $9,000,000
The Ryan White HIV/AIDS Program Part B Supplemental Grant aims to provide essential funding to support HIV care and treatment services across states and territories. This program supplements existing formula-based funding from the RWHAP Part B and ADAP, improving access to necessary resources for those affected by HIV/AIDS. By enhancing support structures, it addresses critical healthcare needs, ensuring better health outcomes for vulnerable populations.
HIV / AIDS

Glass Foundation Grant

Glass Foundation, Inc.
Private
Avery County, North Carolina, Buncombe County, North Carolina +17 more
Up to US $200,000
The Glass Foundation Grant supports initiatives that enhance the quality of life in Western North Carolina. Established in 2000, the foundation provides funding for capital campaigns, construction, and program supplies, focusing on environmental education and youth development. Eligible applicants include 501(c)(3) organizations operating in specified WNC counties. The foundation prioritizes projects that foster educational and cultural opportunities while preserving natural resources, aiming to create a thriving community.
Environmental Education Environmental Conservation Education - K through 12 +3 more

HIV Care Grant Program - Part B States/Territories Formula and AIDS Drug Assistance Program Formula and AIDS Drug Assistance Program Supplemental Awards

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +7 more
Unspecified amount
The HIV Care Grant Program, funded by the US HHS: Health Resources & Services Administration (HRSA), aims to enhance access to high-quality HIV care and treatment for low-income individuals. This initiative supports states and territories in developing comprehensive systems to address the needs of those living with HIV. By providing essential resources, the program seeks to improve health outcomes and ensure that vulnerable populations receive the necessary support and services.
HIV / AIDS

MWDSC: Innovative Conservation Program Funding

The Metropolitan Water District of Southern California
State/Local Government
United States
Up to US $50,000
The Metropolitan Water District of Southern California's Innovative Conservation Program (ICP) has funded innovative water savings projects since 2001, with $250,000 available biannually. The program aims to evaluate and demonstrate the reliability of new water-saving technologies. Nearly 400 proposals have sought $36 million in funding. The ICP, supported by multiple agencies, encourages projects that can benefit Southern California's water efficiency, inviting proposals from outside its service area to enhance regional water management.
Water Resource Management

NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required) (352061)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $3,600,000
The NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) invites small businesses to submit applications for investigator-initiated clinical trials. This program particularly supports high-risk, hypothesis-driven studies that may involve non-routine interventions or unlicensed products. Letters of Intent are encouraged and due 30 days prior to the full proposal deadline. All applications must be submitted by 5:00 PM local time of the applicant organization.
Allergies & Allergic Diseases Infectious & Parasitic Diseases Immune System Diseases

Ryan White HIV/AIDS Program Part C Capacity Development Program (363166)

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Up to US $150,000
The Ryan White HIV/AIDS Program Part C Capacity Development Program aims to enhance the capabilities of community-based organizations, focusing on improving health outcomes and decreasing HIV transmission. This initiative supports individuals who have not yet accessed regular HIV care, emphasizing innovative care solutions and infrastructure development to address these critical needs.
HIV / AIDS

The Bews Foundation Grants

The Bews Foundation
Private
Ada County, Idaho
More than US $10,000
The Bews Foundation Grants support charitable organizations in Idaho's Treasure Valley, focusing on various sectors including education, health, community enhancement, and the arts. Grants up to $10,000 require a simple letter, while larger requests must follow a formal application process. The foundation prioritizes local initiatives and will not accept applications for services outside the Treasure Valley, ensuring that funds directly benefit the community.
Health Care Access & Delivery Educational Access & Equity Basic Human Needs +4 more

T. Rowe Price Foundation Grants

T. Rowe Price Foundation
Corporate
Baltimore County, Maryland, Bronx County, New York +6 more
Unspecified amount
The T. Rowe Price Foundation, established in 1981, primarily supports nonprofit organizations in Baltimore, Colorado Springs, San Francisco, and New York. While most grants are by invitation, unsolicited proposals are also considered. The foundation emphasizes community engagement, collaboration, and unrestricted funding to enhance the operational capacity of nonprofits, enabling them to address critical social issues effectively. With over $194 million in grants awarded, it focuses on fostering strong leaders and equitable solutions in the communities it serves.
Art & Culture Basic Human Needs Academic Success & Enrichment +4 more

Smart & Final Charitable Foundation Donations

Smart & Final Charitable Foundation
Private
Clark County, Nevada, El Dorado County, California +30 more
Unspecified amount
The Smart & Final Charitable Foundation focuses on enhancing community well-being through strategic donations. Committed to Health & Wellness, Education, Hunger Relief, Team Sports & Youth Development, and Disaster Relief, the foundation supports local non-profits in California, Arizona, and Nevada. Eligible organizations must be 501(c)3 registered and aligned with the foundation's focus areas. While the foundation aims to assist various groups, it has specific exclusions, such as for-profit entities and political activities.
Health & Medicine Education Food Access & Hunger +4 more

Distinguished Contribution Award

Midwest Nursing Research Society (MNRS)
Association/Society
Illinois, Indiana +11 more
Unspecified amount

Midwest Nursing Research Society (MNRS)

The MNRS originally began to provide a place for nurses to collaborate, and collaborate they did! Over time, the founding members began to realize the benefits of having an organization dedicated specifically to nursing research. With some careful attention and a lot of hard work, we have grown into the organization it is today. We're a society where scientists, innovators, and drivers of clinical practice across the career trajectory, come together to share ideas and grow our field through innovative research.

The mission of the MNRS is to generate knowledge, translate evidence into practice, and enhance careers through collaborative engagement, implementation, and dissemination among diverse scholars. Our Vision to be the premier society that advances science, fosters leadership, and drives dissemination to improve health equity for all people.

It is an honor to recognize the important contributions of our nursing colleagues. MNRS accepts nominations for our five very prestigious awards to selected members of the Society who have made significant and notable contributions to the field of nursing through research. 

Distinguished Contribution Award

The purpose of the Distinguished Contribution Award is to recognize the scientific contribution of a member who has conducted or promoted research, which has enhanced the science and practice of nursing in the MNRS region.

Nursing Hospital Care Primary Health Care

Amy Ellen Polk Memorial Scholarship

American Association of Birth Centers Foundation (AABC)
Private
Multnomah County, Oregon
US $500
The Amy Ellen Polk Memorial Scholarship, offered by the American Association of Birth Centers Foundation, supports individuals developing freestanding birth centers. This scholarship honors Amy Ellen Polk, a passionate advocate for birthing centers. Recipients receive tuition for the 'How to Start a Birth Center Workshop' and an additional $500 for travel if attending in person. Eligible applicants must demonstrate financial need and cannot have attended the workshop in the last three years.
Obstetrics & Neonatal Care

INTESOL Wendy Wildman Long Scholarship

Central Indiana Community Foundation
Private
Indiana
Unspecified amount
The INTESOL Wendy Wildman Long Scholarship, established by Indiana Teachers of English to Speakers of Other Languages, supports current or former English learners from Indiana. It aims to provide educational funding for college or vocational training, with preference given to students of color. Eligible applicants must have a minimum GPA of 3.0 and demonstrate financial need, ensuring access to opportunities for historically marginalized communities in Central Indiana.
Education - Higher Education Vocational & Trade Education Education - High School +3 more

Nature Conservation Grants: Agriculture

The Turing Foundation
Private
Burkina Faso, Cameroon +6 more
Unspecified amount
The Turing Foundation focuses on enhancing sustainable practices in agriculture and nature conservation, specifically targeting the protection and sustainable management of marine ecosystems in developing countries. It emphasizes the importance of coral reefs and mangroves while working to combat climate change. Organizations directly invited by the Foundation can contribute to these crucial efforts, ensuring that current needs are met without compromising future generations' ability to thrive.
Climate Change Resilience & Equity Coastal Conservation

Joseph O. & Geraldine C. Waymire Nursing Scholarship

Central Indiana Community Foundation
Private
United States
Unspecified amount
The Joseph O. & Geraldine C. Waymire Nursing Scholarship, established by the Waymire family, supports students pursuing nursing careers. It is open to high school seniors from accredited Marion County institutions and those enrolled in nursing programs at various educational levels. Funds can be used for tuition, fees, and other educational expenses. The scholarship aims to foster a diverse nursing workforce, reflecting the mission of the Central Indiana Community Foundation to enhance community opportunities.
Education - High School Academic Scholarship Programs College Success / Persistence +2 more

Harriet H. Werley New Investigator Award

Midwest Nursing Research Society (MNRS)
Association/Society
Illinois, Indiana +11 more
Unspecified amount

Midwest Nursing Research Society (MNRS)

The MNRS originally began to provide a place for nurses to collaborate, and collaborate they did! Over time, the founding members began to realize the benefits of having an organization dedicated specifically to nursing research. With some careful attention and a lot of hard work, we have grown into the organization it is today. We're a society where scientists, innovators, and drivers of clinical practice across the career trajectory, come together to share ideas and grow our field through innovative research.

The mission of the MNRS is to generate knowledge, translate evidence into practice, and enhance careers through collaborative engagement, implementation, and dissemination among diverse scholars. Our Vision to be the premier society that advances science, fosters leadership, and drives dissemination to improve health equity for all people.

It is an honor to recognize the important contributions of our nursing colleagues. MNRS accepts nominations for our five very prestigious awards to selected members of the Society who have made significant and notable contributions to the field of nursing through research. 

Harriet H. Werley New Investigator Award

The purpose of the Harriet H. Werley New Investigator Award is to recognize the scientific contribution of a new investigator who has conducted nursing research that has the potential to enhance the science and practice of nursing.

Nursing Hospital Care Primary Health Care

MNRS Distinguished Service Award

Midwest Nursing Research Society (MNRS)
Association/Society
Illinois, Indiana +11 more
Unspecified amount

Midwest Nursing Research Society (MNRS)

The MNRS originally began to provide a place for nurses to collaborate, and collaborate they did! Over time, the founding members began to realize the benefits of having an organization dedicated specifically to nursing research. With some careful attention and a lot of hard work, we have grown into the organization it is today. We're a society where scientists, innovators, and drivers of clinical practice across the career trajectory, come together to share ideas and grow our field through innovative research.

The mission of the MNRS is to generate knowledge, translate evidence into practice, and enhance careers through collaborative engagement, implementation, and dissemination among diverse scholars. Our Vision to be the premier society that advances science, fosters leadership, and drives dissemination to improve health equity for all people.

It is an honor to recognize the important contributions of our nursing colleagues. MNRS accepts nominations for our five very prestigious awards to selected members of the Society who have made significant and notable contributions to the field of nursing through research.

MNRS Distinguished Service Award

The Distinguished Service Award recognizes an MNRS member who has demonstrated sustained influential leadership and service to the organization, such as chairing committees, organizing annual conference activities, or serving on the Board of Directors. 

Nursing Hospital Care Primary Health Care

Limited Competition: Renewal of Existing NINDS-Supported Clinical Trial Cooperative Agreement Awards (U01 - Clinical Trials Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This funding opportunity invites renewal applications for existing NINDS-supported clinical trial cooperative agreements (U01) that require additional time and resources. The National Institute of Neurological Disorders and Stroke (NINDS) expects applicants to request only what is necessary for trial completion, without introducing new aims. Discussions with NINDS prior to submission are encouraged. Eligible applications must be renewals of previously approved cooperative agreements under specified NIH funding announcements.
Neuroscience Neurological Diseases & Disorders Stroke

Emma E. Hill Memorial Scholarship Fund

Chester County Community Foundation
Private
United States
Unspecified amount

Emma E. Hill Memorial Scholarship Fund

Mission Statement

The Emma E. Hill Memorial Scholarship Fund was established to memorialize Emma by helping female swimmers pursue their dreams of a college education. The scholarship awards will be granted on an annual basis to female graduating high school senior athletes in Southern Chester County.

About Emma

Emma was an excellent student as a sophomore at Unionville High School (UHS). She loved to swim and was a dedicated member of both the Kennett YMCA Sea Dragons and UHS swim teams. In her spare time, Emma was a lifeguard and also taught young children how to swim at the Y. As a younger child and teenager, Emma excelled on the ballfield in URA softball.

At the young age of 16, Emma passed away following complications caused by a rare type of gastric cancer, a form of the disease that was unheard of in a child and unfortunately found too late. Throughout Emma’s brief illness, she was strong and determined to get better, and did not let her health issues define her in any way.

Emma was beautiful in every sense of the word, and was loved throughout her community and beyond. She worked hard at whatever she was trying to accomplish, but always with a cheery, exuberant attitude and lovely smile. More than anything, her absolute kindness and warm heart are what made Emma our sweet girl.

Education - Higher Education Women & Girl Services Swimming +2 more

Montana Coal Endowment Program Infrastructure Grant

Montana Department of Commerce
State/Local Government
Montana
Up to US $750,000

Montana Department of Commerce

Mission

The Department of Commerce effectively and efficiently delivers programs and resources through technical assistance, funding/investments, training/consulting, promotion, research, reporting and outreach to provide affordable housing and create sustainable business and economic growth to enhance community vitality to benefit the citizens of Montana.

Montana Coal Endowment Program Infrastructure (MCEP)

The Montana Coal Endowment Program was formally known as the Treasure State Endowment Program. Any references to the Treasure State Endowment Program or “TSEP” now refer to the Montana Coal Endowment Program or “MCEP” as authorized by the 67th Legislature in Senate Bill 258 (Chapter 330, Laws 2021). The Montana Coal Endowment Program (MCEP) is a state-funded program created in 1992 as a result of Legislative Referendum 110. It is designed to help solve serious health and safety problems and assist communities with the financing of public facilities projects. The program helps local governments with constructing or upgrading drinking water systems, wastewater treatment facilities, sanitary or storm sewer systems, solid waste disposal and separation systems, and bridges.

Applicants must have the management capacity to undertake and satisfactorily complete the project applied for and assure proper management of MCEP funds. Grant recipients must be in compliance with applicable auditing and financial reporting requirements and have the capability to specifically assure proper tracking and recording of funds.

Sanitation & Clean Drinking Water Waste Management Environmental Contamination & Pollution

Operating Grants for Nonprofits Highlights

Operating grants for nonprofits provide essential funding to support day-to-day operations, staff salaries, and infrastructure. The following grants help organizations build capacity, maintain sustainability, and focus on achieving their mission-driven goals.


Search Instrumentl's Operating Grants Database


Explore 8,000+ funding opportunities for operational support, with $3.43B in resources. Instrumentl helps nonprofits secure essential funding by offering grant discovery tools, deadline tracking, and strategic funder analysis to ensure long-term success.

Grant Insights : Operating Grants for Nonprofits

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Operating grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Operating grants for nonprofits over $25K in average grant size

3,000+ Operating grants for nonprofits over $50K in average grant size

1,000+ Operating grants for nonprofits supporting general operating expenses

7,000+ Operating grants for nonprofits supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits of all types can apply for operating grants, but they are especially useful for organizations needing flexible funding to support the core work of their mission. Operating grants are ideal for nonprofits involved in general population well-being. Specific sectors include healthcare, education, social services, and the arts. Unlike project-based grants that fund specific initiatives, operating grants help with essential costs like staff salaries, rent, and general admin costs. Funders often look for groups with a clear mission who serve a meaningful purpose and have potential for long-term impact.

Based on Instrumentl’s live grant database for operating, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Operating grants exist to help nonprofits function smoothly and grow effectively. The goal is to give organizations the financial means they need to focus on their mission, serve their communities, and support long-term stability. These grants allow nonprofits to improve everyday operations, invest in staff development, and expand programs. Funders want to see nonprofits thrive, not just survive, and providing operational support is a key element to making that happen.

Funding for operating grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Operating grants are often funded by private foundations like the popular Ford Foundation. Some government agencies offer grants to strengthen nonprofit infrastructure, especially in sectors like health, education, and social services. Corporate giving programs may also support nonprofits that align with their values and create lasting impact.

To improve the chances of getting operating grants, nonprofits should:

  • Showcase past impact – Use data and real-world examples to prove how your organization has already made a difference.
  • Prove how you align with funder priorities – Research what funders care about and explain how your nonprofit’s mission fits within their goals.
  • Prove financial stability – Funders want to support organizations that can manage funds responsibly and have a solid sustainability plan for the long-term.
  • Emphasize lasting growth – Describe how operating funds will help your nonprofit expand its reach, strengthen programs, and increase its overall impact.

For more advice on finding and winning operating grants, check out our step-by-step guide to general operating grants.

Instrumentl simplifies the process of applying for operating grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

Check out how Habitat for Humanity delivered over 200% ROI within just a few weeks.