Best Grants for Heart Disease Research

The Hawai‘i Community Foundation (HCF) offers Medical Research Grants to support vital basic and clinical research conducted locally. Aimed at enhancing the medical research community in Hawai‘i, the program focuses on various health issues, including cancer, heart disease, and diabetes. Additionally, it fosters research infrastructure to bolster research capacity. Funded by multiple sources, including the Leahi Fund and the George F. Straub Trust, these grants are essential for advancing healthcare and scientific discovery in the region.

The Valley Baptist Legacy Foundation Grant supports initiatives that improve health and quality of life in the Rio Grande Valley. Grants range from $50,000 to over $500,000 for various projects, including responsive, collaborative, matching, and foundation initiatives. Eligible nonprofit organizations must serve specific counties and demonstrate positive health impacts. Prioritization is given to projects fostering collaboration and community support. Note: A Letter of Intent is required for requests exceeding $50,000.

The W. W. Smith Charitable Trust provides funding for basic medical research focusing on heart disease, cancer, and AIDS. Grants are available to 501(c)(3) nonprofit organizations located in the Greater Philadelphia area and Camden, NJ. Each grant typically ranges from $100,000 to $125,000 for a one-year term. The Trust aims to support unique and promising research projects that can lead to larger awards, ensuring a direct impact on health outcomes.

The Voelcker Fund Young Investigator Award supports promising young researchers in cancer, arthritis, heart disease, muscular dystrophy, and retinal diseases. With a funding capacity of up to $450,000 over three years, this award encourages innovation and aims to foster a pipeline of talented biomedical scientists from San Antonio institutions. Eligible candidates must hold a tenure-track position and demonstrate a commitment to research, enhancing the potential for further funding opportunities.

The A.P. Giannini Foundation offers a Postdoctoral Research Fellowship and Leadership Award to support innovative biomedical research. Since 1945, the Foundation has funded nearly $50 million in research aimed at translating scientific discoveries into effective treatments for various diseases. This fellowship program not only provides financial support but also includes leadership training and a collaborative learning community, preparing fellows for impactful careers in academia and industry.

The Fichtenbaum Charitable Trust, established in 2017, supports Texas charitable organizations in areas such as medical research for serious conditions, education for children with disabilities, and promoting fine arts. Grants typically range from $10,000 to $100,000, with an average of $35,000. The Trust prioritizes unique and necessary proposals that meet local community needs and do not duplicate existing services, particularly focusing on projects in Dallas County and surrounding areas.

The Expansion Award, offered by Additional Ventures, provides a one-time grant of $50,000 to support innovative research focused on single ventricle heart defects. This award is designed for both new and established investigators, enabling them to explore new directions in their work. Competitive applications must clearly demonstrate how the grant will enhance scientific impact and expedite research outcomes. The initiative also emphasizes diversity and inclusion within the research community.

The CFPBMC Year-Round Grant supports nonprofit organizations in Palm Beach and Martin Counties. It encourages projects aligned with four focus areas: Capacity Building, Economic Opportunity, Education and Youth, and Thriving Communities. Grants can reach up to $75,000 and are awarded based on a competitive process. Interested organizations must submit a Letter of Inquiry and may be invited to submit a full proposal based on their alignment with the foundation's mission and strategic goals.

The CFPBMC Summer Program Grant supports nonprofit organizations in Florida aiming to enhance community impact through strategic focus areas such as capacity building, economic opportunity, education and youth, and thriving communities. Grants of up to $75,000 are available for projects that align with these areas. Eligible organizations must be 501(c)(3) tax-exempt. The grant process encourages innovative solutions to community challenges, fostering collaboration and sustainable development.

Single Ventricle Research Fund (SVRF)

Our flagship funding program — the Single Ventricle Research Fund (SVRF) — is an annual research award program that supports foundational studies aimed at improving outcomes for individuals with single ventricle heart disease. By addressing the organ- and multi-organ-level complications and clinical sequelae that drive long-term morbidity and mortality, the SVRF seeks to close critical gaps in understanding and treatment, and accelerate progress toward better, more predictive, and preventative care.

In its sixth cycle, the SVRF welcomes foundational research that is directly relevant to improving outcomes for individuals with single ventricle heart disease.

What Fits

Through the SVRF, Additional Ventures aims to accelerate foundational research that will lead to improved care and new therapeutic opportunities grounded in a mechanistic understanding of single ventricle heart disease.

The 2027 SVRF welcomes research aligned with the focus areas and strategic topics described in the Additional Ventures’ 2026 Research Roadmap. We are particularly interested in proposals that seek to elucidate the mechanisms underlying, prevent, or reverse the interrelated organ- and multi-organ-level sequelae that contribute to long-term morbidity and mortality.

Eligible investigators include postdoctoral fellows or equivalents holding a mentored position. Collaborative proposals will not be accepted through this track.

Research institutions and teams conducting heart disease and cardiovascular research can apply for Additional Ventures Foundation’s Single Ventricle Research Fund, awarding up to US $600,000 for multi-year projects. Funding supports mechanistic, translational, or clinical studies on single ventricle heart defects, which may benefit heart disease researchers seeking substantial support for innovative projects.

The AHA Postdoctoral Fellowship supports early-career researchers in cardiovascular, cerebrovascular, and brain health research. This flexible award aims to enhance training through mentorship, allowing postdoctoral applicants to balance research and clinical commitments. Awardees can receive stipends based on years of experience, and additional project support for conference travel is provided. Eligibility includes holding a relevant doctoral degree, with restrictions on prior research experience. This initiative fosters academic growth while ensuring a commitment to research over administrative duties.

The Cytokinetics Communications Grant Program provides five grants of $20,000 each annually to patient advocacy organizations focused on hypertrophic cardiomyopathy (HCM) and heart failure. This initiative aims to enhance communication and outreach efforts, helping organizations expand their community engagement and awareness. By supporting crucial marketing initiatives, Cytokinetics fosters improved resources for advocacy groups, ensuring they can effectively address the needs of patients facing muscle performance challenges.

New Jersey Department of Health (NJDOH)

The New Jersey Department of Health leads the state’s response to public health challenges and works to improve health outcomes for all New Jersey residents. Through its three primary branches—Public Health Services, Health Systems, and Integrated Health—the Department collaborates across programs and partners to strengthen New Jersey’s health system. Guided by its mission to protect public health, promote healthy communities, and improve the quality of health care, the Department supports initiatives that advance prevention, system integration, and equitable access to health services statewide.

New Jersey Heart and Stroke Grant

The New Jersey Heart and Stroke Grant works with partners to implement activities aimed at improving the prevention and management of cardiovascular disease in New Jersey. 

Award amounts will be based on the availability of federal funds and may be subject to change.

Information for Grantseekers

The Legacy Foundation invests in and serves as a catalyst for ideas, partnerships, medical education, research and programs that improve the health and quality of life in the Rio Grande Valley. The Foundation defines health as a state of complete physical, mental, spiritual and social well-being.

Types of Grants

Collaborative Grants:

• $50,000 to $500,000
• Fosters partnerships for larger-scale projects.
• Letters of Support from collaborators strengthen applications.

Foundation Initiatives:

• $500,000 +
• For strategic projects aligning with our goals, such as capital grants or seed funding.

About

The Executive Office of the Mayor (EOM)’s mission is to improve the quality of life of District residents through advocacy, community outreach, education, and inter-agency coordination. The Mayor's Office of Community Affairs (MOCA) serves as a liaison to the city's diverse communities, ensuring residents' voices are heard and represented. Through MOCA, EOM serves as the liaison between the District Government and various District communities, including, but not limited to the returning citizens community, the Asian and Pacific Islander community, the Latino community, the African community, the African American community, the LGBTQ+ community, the Veterans community, the women’s community, the Caribbean community, and the faith community.1 EOM invites all CBOs that serve these communities and more within the District to apply for this grant to advance the below funding priorities

Healthy Heart Initiative for Men

The District of Columbia, Department of Health (DC Health) is requesting proposals from qualified applicants to provide services in the program and service areas described in this Notice of Funding Availability (NOFA). This announcement is to provide public notice of DC Health's intent to make funds available for the purpose described herein. The applicable Request for Applications (RFA) will be released under a separate announcement with guidelines for submitting the application, review criteria and DC Health terms and conditions for applying for and receiving funding.

Funding Opportunity Description:

This funding opportunity aims to identify a community-based organization to launch a community-based mobile outreach initiative that leverages trusted community influencers to engage Black men living in Wards 7 and 8, connecting them to primary care services and essential social supports.