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Best Addiction and Substance Abuse Grants
Find grants for addiction treatment, prevention, and recovery. Get funding for rehab centers, education, opioid response, and substance abuse programs
200+
Available grants
$76.7M
Total funding
$123.5K
Median grant
200+
grants
$76.7M
total
$123.5K
median
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Last updated: July 6, 2026. Next update: August 2, 2026.
Unspecified amount
Creag Foundation Grant
Rolling deadline
The Creag Foundation, established in 2009 in Woodinville, Washington, provides funding to innovative 501(c)(3) nonprofit organizations addressing social issues. Focused on smaller organizations, the foundation seeks to support those with unique approaches to improve the human condition. Eligible applicants must have held 501(c)(3) status for at least one year and present a new or previously unaddressed solution to societal challenges. Applications are by invitation only, encouraging creativity and passion in charitable work.
Creag Foundation
Up to US $15,000
DanPaul Foundation Grants
Rolling deadline
The DanPaul Foundation aims to enhance early childhood development by training teachers and parents, protecting children from abuse, and promoting social responsibility. They provide grants to non-profits for programs that focus on education, health, and welfare of youth. Key initiatives include scholarships, environmental education, and support for underprivileged children. Grant amounts range from a few hundred dollars to $15,000 annually, with a focus on impactful, community-driven projects.
The Dan Paul Foundation
Unspecified amount
Good Neighbor Citizenship Company Grants
Rolling deadline
State Farm's Good Neighbor Citizenship Company Grants aim to enhance community safety, development, and education. Focused on long-term impact, they support initiatives in auto and home safety, disaster preparedness, affordable housing, and educational programs. Eligible recipients include nonprofits, educational institutions, and government entities. However, funding is not available for individuals, religious programs, or organizations outside the U.S. By addressing critical community needs, these grants foster safer and more resilient neighborhoods.
State Farm Companies Foundation
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More than US $100,000
Hearst Foundation: Social Service Grant
Rolling deadline
The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.
William Randolph Hearst Foundation
Unspecified amount
LabCorp Charitable Foundation Grants
Rolling deadline
The Labcorp Charitable Foundation, a private 501(c)(3) entity, aims to enhance healthcare access and education for all. With grant opportunities focusing on food programs, healthcare services for underserved populations, and STEM initiatives, it seeks to support community health and well-being. Organizations eligible for funding must be U.S.-based and hold tax-exempt status. Requests are reviewed biannually, in March and September, to foster impactful community projects.
Labcorp Charitable Foundation
More than US $50,000
Michael & Susan Dell Foundation Grants
Rolling deadline
The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.
Michael & Susan Dell Foundation
Unspecified amount
Roche Corporate Donations and Philanthropy (CDP)
Rolling deadline
Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.
La Roche, Inc.
Unspecified amount
Semnani Family Foundation Grants
Rolling deadline
The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.
Semnani Family Foundation
Unspecified amount
The Bank of America Foundation Sponsorship Program
Rolling deadline
The Bank of America Foundation Sponsorship Program aims to enhance economic mobility and social progress in low- and moderate-income communities through partnerships with nonprofit organizations. This initiative focuses on critical areas such as workforce education, basic needs like food and housing, and community development. The Foundation invested $350 million last year and encourages employee volunteerism and giving, supporting nonprofits in various sectors, including arts, culture, and diversity initiatives.
Bank Of America Charitable Foundation Inc
Up to US $750,000
HEAL: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)
Applications due Jul 10, 2026
The HEAL initiative aims to translate addiction research into practice to combat the opioid crisis and overdose events. It focuses on identifying barriers to reducing substance use and developing scalable, evidence-based interventions. Emphasizing recovery, prevention, and the integration of mental health, the initiative encourages collaboration among experts in various fields. Although applications are not currently solicited, potential applicants are urged to prepare for future opportunities to apply innovative solutions to enhance addiction treatment and prevention efforts.
US Dept. of Health & Human Services: National Institutes of Health (NIH)
Unspecified amount
Scaife Family Foundation Grant
Applications due Aug 1, 2026
The Scaife Family Foundation Grant has been supporting vulnerable community members for nearly 40 years, providing over $180 million in donations to non-profits. The Foundation aims to match organizations with aligned goals, focusing on women and children, addiction prevention, and animal welfare. It offers grants for general operating and program support, prioritizing impactful programs that address societal issues. Notably, the Foundation considers proposals that foster healthy relationships and promote treatment for addiction, enhancing the welfare of both humans and animals.
Scaife Family Foundation
Up to US $275,000
Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional) (357941)
Applications due Aug 6, 2026
The Cutting-Edge Basic Research Awards (CEBRA) from the National Institute on Drug Abuse (NIDA) aim to support innovative research in substance use disorders (SUDs). This program encourages high-risk, high-impact projects that may not be represented in current research portfolios. Applicants are invited to develop revolutionary techniques or test significant hypotheses that could transform addiction research. Letters of Intent are encouraged and due 30 days prior to the proposal deadline.
US Dept. of Health & Human Services: National Institutes of Health (NIH)
US $5,000 - US $250,000
Gupta Family Foundation Grant
Applications due Aug 31, 2026
The Gupta Family Foundation Grant aims to empower disadvantaged individuals by providing financial support to organizations that foster self-reliance. Headquartered in Herndon, Virginia, the foundation offers grants ranging from $5,000 to over $250,000, prioritizing smaller organizations with a strong commitment to their missions. Eligibility typically includes US-based IRS 501(c)(3) entities, with operations extending to countries like India and Kenya. The foundation emphasizes mission alignment and effective resource allocation to ensure maximum impact.
Gupta Family Foundation
Up to US $275,000
Mechanism for Time-Sensitive Substance Use Research (R21 Clinical Trial Optional)
Applications due Sep 9, 2026
The Mechanism for Time-Sensitive Substance Use Research (R21 Clinical Trial Optional) invites applications that address urgent research needs in substance use epidemiology and health services. This funding opportunity encourages pilot studies focusing on emerging drug issues, unexpected prescription drug abuse trends, and timely medical system challenges. Letters of Intent are recommended 30 days before the proposal deadline, emphasizing the necessity for rapid review and funding to address pressing scientific questions.
US Dept. of Health & Human Services: National Institutes of Health (NIH)
US $1,000 - US $10,000
Hansen Family Foundation Grant
Applications due Sep 11, 2026
The Hansen Family Foundation Grant seeks to empower organizations that uphold the American values of life, liberty, and the pursuit of happiness. Focused on diverse causes like children, education, animals, environmental conservation, humanitarian efforts, and arts, the foundation is committed to supporting initiatives that create positive change. Eligible applicants must be 501(c)(3) nonprofits, while political campaigns and organizations with high budgets or overheads are ineligible. This grant fosters impactful contributions to society.
Hansen Family Foundation
Unspecified amount
Establishing a Center for the Advancement of Substance Use Disorder (SUD) Pharmacotherapeutics through Training and Preclinical Support
Applications due Sep 30, 2026
The National Institute on Drug Abuse (NIDA) aims to establish a Center for the Advancement of Substance Use Disorder (SUD) Pharmacotherapeutics. This Center will educate researchers on product development for SUD therapies and provide technical and financial support for initial experiments. It encourages collaboration and outreach to enhance research efforts in drug addiction. Investigators with relevant expertise are invited to consider applying for future opportunities to develop impactful solutions in SUD pharmacotherapeutics.
US Dept. of Health & Human Services: National Institutes of Health (NIH)
Up to US $350,000
Growing Great Ideas: Research Education Course in Product Development and Entrepreneurship for Life Science Researchers
Applications due Oct 1, 2026
The National Institute on Drug Abuse (NIDA) is launching a specialized entrepreneurship program aimed at life science researchers in the field of substance use disorders (SUD). This initiative will equip researchers with essential skills to transform their innovative ideas into viable products, focusing on aspects such as market evaluation, customer discovery, and intellectual property. The course will be delivered in a hybrid format to engage US-based SUD researchers effectively, fostering collaboration and advancing the field.
US Dept. of Health & Human Services: National Institutes of Health (NIH)
Unspecified amount
Robinson Foundation Grant
Applications due Oct 15, 2026
The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.
Robinson Foundation
Unspecified amount
Dudley T. Dougherty Foundation Grant
Applications due Oct 31, 2026
The Dudley T. Dougherty Foundation Grant supports nonprofit charitable organizations recognized under section 501(c)(3) of the IRS Revenue Code. Established in 2002, the foundation aims to empower groups committed to positive change, fostering respect for life and the environment. Their vision emphasizes collaboration for a better future, encouraging applicants to embody these values in their initiatives. With a focus on impactful projects, this grant is an opportunity for organizations striving to make a critical difference in our world.
Dudley T Dougherty Foundation Inc
US $5,000 - US $20,000
Nordstrom Community Grant
Applications due Oct 31, 2026
The Nordstrom Community Grant focuses on supporting youth and families by providing over $1 million in grants annually. It aims to assist grassroots organizations that address essential community needs such as food, shelter, and clothing, as well as creating opportunities for economic mobility through mentorship and workforce development. Eligible organizations must be 501(c)(3) nonprofits located in areas where Nordstrom operates. Applications are encouraged for those meeting these criteria.
Nordstrom
Unspecified amount
TJX Foundation Grants
Letter of inquiry due Oct 31, 2026
The TJX Foundation Grants support nonprofit organizations located within 15 miles of a TJX store that align with their community mission. Eligible areas include basic needs, education for at-risk youth, workforce training, and safety from domestic violence. Organizations must be a registered 501(c)(3) for at least 12 months and have a nondiscrimination policy. Applications are invited through a Letter of Inquiry, with funding decisions based on community impact.
The Tjx Foundation Inc
US $5,000 - US $10,000
Lawrence Foundation Grant
Applications due Nov 1, 2026
The Lawrence Foundation is a private family foundation established in 2000, dedicated to granting funds for environmental and human services causes. Eligible organizations include 501(c)(3) nonprofits and public schools, with grants typically ranging from $5,000 to $10,000. The foundation supports unrestricted grants for various projects, including disaster relief and environmental programs, but does not fund individuals or for-profit entities. Applications are evaluated based on alignment with the foundation's priorities.
Lawrence Foundation
US $5,000 - US $25,000
Dr. Scholl Foundation Grants
Letter of inquiry due Jan 31, 2027
The Dr. Scholl Foundation offers grants annually to IRS 501(c)(3) organizations, primarily focusing on U.S. applicants. The foundation supports projects in education, social services, healthcare, civic and cultural initiatives, and environmental efforts. While the grant cycle runs from October 1 to March 1, it encourages innovative solutions to global challenges. Only one application per organization is accepted each year, and funding is limited to one year. Unqualified organizations, including political entities, are ineligible.
Dr Scholl Foundation
Approximately US $50,000
HABRI: Addressing Evidence-Based Health Benefits of Human-Animal Interaction Grant
Applications due Feb 27, 2027
The Human Animal Bond Research Institute (HABRI) invites research proposals exploring the health benefits of human-animal interactions. This grant aims to fund studies that examine the positive impacts of pet ownership and animal-assisted interventions on human and animal health. Key areas of interest include mental and physical health, social isolation, and the welfare of diverse populations. Successful proposals will adhere to high standards of animal care and demonstrate actionable outcomes for policy and practice.
Human Animal Bond Research Institute
Unspecified amount
O'Reilly Automotive Foundation Grant
Applications due Apr 15, 2027
The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.
O'Reilly Automotive Foundation Inc
US $30,000 - US $350,000
True Inspiration Awards
Applications due May 1, 2027
The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.
Chick Fil A Foundation Inc
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Sign up to see the full listAddiction and Substance Abuse Grants Highlights
Addiction and substance abuse grants provide critical funding for nonprofits addressing prevention, treatment, and recovery efforts. These grants support programs focused on education, mental health services, and community outreach, helping to combat the devastating effects of addiction and improve individual and public health outcomes.
Search Instrumentl's Addiction and Substance Abuse Grants Database
Find 200+ active grants with over $76.7M available for nonprofits tackling addiction challenges. Explore private, corporate, and government funding options tailored to your mission. Track deadlines, gain funder insights, and grow your impact with Instrumentl's comprehensive tools.
Last updated: July 6, 2026. Next update: August 2, 2026.
Top Searched Addiction and Substance Abuse Grants
Grant Insights : Addiction and Substance Abuse Grants
Grant Availability
How common are grants in this category?
Common — grants in this category appear regularly across funding sources.
200+ Addiction and Substance Abuse Grants grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.
100+ Addiction and Substance Abuse Grants over $25K in average grant size
100+ Addiction and Substance Abuse Grants over $50K in average grant size
29 Addiction and Substance Abuse Grants supporting general operating expenses
200+ Addiction and Substance Abuse Grants supporting programs / projects
600+ Grants on Instrumentl focused on Food Access & Hunger
1,000+ Grants on Instrumentl focused on Environment
Grant Deadline Distribution
Over the past year, when are grant deadlines typically due for Addiction and Substance Abuse grants?
Most grants are due in the second quarter.
Q1
26.6%
Q2
28.2%
Q3
25.8%
Q4
19.4%
Frequently asked questions
Nonprofits who want to win grants for addiction and substance abuse are usually organizations focused on prevention. They also likely provide treatment, harm reduction services, and recovery support. The funders offering these grants care about programs that serve at-risk populations. This includes low-income communities and individuals impacted by the opioid crisis. The grants you see will require your organization to have a 501(c)(3) charitable status.
Grants for addiction and substance abuse prevention typically have the highest concentration of deadlines in Q2, with 28.2% of grant deadlines falling in this period. If you're planning to apply, consider prioritizing your applications around this time to maximize opportunities. Conversely, the least active period for grants in this category is Q4.
Addiction and substance abuse grants are offered to nonprofit programs that focus on addiction prevention, harm reduction, and long-term recovery to oppose the detrimental effects of the disease on society. Over 200 grants are available, with more than $87.1 million in funding for nonprofit groups that address addiction challenges.
Funding for addiction and substance abuse grants varies widely, with award amounts ranging from a minimum of $500 to a maximum of $11,000,000. Based on Instrumentl’s data, the median grant amount for this category is $123,500, while the average grant awarded is $482,665. Understanding these funding trends can help nonprofits set realistic expectations when applying.
Of the $87.1 million available, most comes from private funders. In addition, there are many federal and state/local government funders. Some of the key funders who support addiction prevention services are the US Department of Justice, followed by a lot of state-level organizations like the Kentucky Opioid Abatement Advisory Commission and other community health foundations. On the private side of grant funding, grantors include Inasmuch Foundation, Humana Foundation, and more.
A carefully planned approach is needed in order to successfully win grants for substance abuse as well as addiction programs. Funders look for organizations that show a clear effect and align with the priorities of funders. These organizations also have strong community support. To greatly increase your chances of success, concentrate on all of these key areas.
- Forge completely meaningful partnerships – Collaborate closely with all healthcare providers, community organizations, and fellow nonprofits to strengthen your proposal and show a greatly united effort. Share your story using data by collecting statistics and success stories that depict the effectiveness of your programs. Some funders want to see effect that can be quantified.
- Offer an exhaustive financial plan – Show responsible financial management and present a budget detailing how each and every grant dollar will be allocated. Every funder favors organizations showing an undergoing vision. Organizations should show complete sustainability. Describe how your program will be supported once the first grant money is used up.
Visit our resource for a complete, step-by-step guide on how to find and apply for many grants. Find grants for nonprofits with a guide.
Instrumentl simplifies the grant application process by offering standards that helps nonprofits discover relevant funding opportunities and analyze funder-giving patterns. The platform's automated alerts ensure deadlines are never missed, while detailed funder insights help organizations modify their applications to align with grantor priorities. Discover how Oasis–A Haven for Women and Children cut their time spent on grant research by 83%.
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