Best Addiction and Substance Abuse Grants

Nonprofit organizations providing addiction and substance use treatment or prevention programs in Mesa County, Colorado can apply for support from the Western Colorado Community Foundation’s Brownson Memorial Fund. Focused on substance abuse, alcoholism, and drug use disorders, this funding could help strengthen local prevention, treatment, and recovery services in the county.

Nonprofit and local government organizations providing education, health, public safety, or addiction-related services can seek funding for prevention, treatment, housing, arts, environmental, cultural, and other charitable programs. The Confederated Tribes of Siletz Indians provides grants to groups in eleven Oregon counties and Native American organizations across the U.S. addressing addiction and related community needs.

Wisconsin 501(c)(3) nonprofits addressing addiction, substance use disorders, domestic violence, or broader health and wellness can seek project funding of US $3,000 - US $8,000. Grants from Green Bay Packers Foundation help eligible organizations run programs that fit the current year’s focus areas within its 2026–2029 funding cycle.

U.S. research institutions and partners working on addiction and substance use disorders can access funding through the National Institutes of Health to test SBIRT/P approaches for alcohol, tobacco, and other drug use in adults facing health disparities. Projects must prospectively evaluate screening, brief intervention, and referral models in collaboration with healthcare and community settings.

Nonprofit 501(c)(3) organizations and fiscally sponsored projects serving Clark and Floyd counties in Indiana can seek capacity-building grants supporting governance, leadership, technology, evaluation, and strategic planning. Grants from Community Foundation of Southern Indiana, ranging from US $5,000 - US $25,000, may benefit organizations providing addiction and substance use disorder, mental health, and related community services.

Research institutions and other eligible organizations in the U.S. territories and states can apply for National Institutes of Health funding to test SBIRT/P approaches for alcohol, tobacco, and other drug use in adults experiencing health disparities. Projects must prospectively evaluate screening, brief intervention, and referral models in partnership with healthcare and community settings, supporting addiction and substance use disorder efforts.

Nonprofit organizations, community councils, and municipal agencies in Tompkins County addressing addiction, substance use disorders, and related mental health or basic needs may be eligible for this two-year community impact funding. Grants from United Way of Tompkins County support programs in areas like mental health, crisis intervention, and marginalized communities that strengthen local prevention, treatment, and recovery efforts.

Nonprofit and charitable organizations in Grays Harbor County can seek funding to start, expand, or sustain programs, equipment, or infrastructure. With a mission to improve quality of life, Grays Harbor Community Foundation provides US $5,000 - US $30,000 for efforts including substance abuse and alcoholism treatment, mental health services, crisis intervention, and related community wellness initiatives.

Nonprofits, schools, government units, and religious organizations serving Wicomico, Worcester, or Somerset Counties can seek funding for addiction, alcoholism, and drug use disorder programs, along with broader human services. Focused on community needs, Community Foundation of the Eastern Shore invites eligible organizations to submit a general Letter of Inquiry; requests submitted by the 15th receive decisions the following month.

Organizations in Grays Harbor County addressing addiction, substance use, or related community needs can apply for Grays Harbor Community Foundation’s Quarterly Impact Grants, with awards up to US $5,000 for small, near-term projects. Programs focused on alcoholism, drug use disorder, prevention, or recovery services may benefit, with priority for funds used within two months.

Nonprofit organizations, public schools, and governmental agencies in Lapeer, Macomb, Oakland, and St. Clair counties can seek funding for education, health, and community programs, including youth and adult initiatives. Four County Community Foundation supports projects such as smoking and vaping prevention, substance use education, and related health and counseling efforts that directly benefit local residents.

Nonprofit 501(c)(3) organizations and government equivalents providing addiction prevention, treatment, or recovery services in Colorado can access funding through the Daniels Fund, with typical awards around Approximately US $75,000. Eligible programs address drug and alcohol addiction within the Fund’s broader human services priorities, and requests may support programs, operations, or capital campaigns.

Nonprofits, faith-based organizations, and tax-exempt schools in Franklin County can apply for ADAMH Board of Franklin County’s mini-grants up to Up to US $5,000 to run community programs and events. Funding supports behavioral health awareness, prevention, stigma reduction, resilience, social connectedness, and diversity, equity, and inclusion, which may include addiction and substance use disorder initiatives.

Focused on community support and health services, Atkinson Foundation invites San Mateo County nonprofits to apply for grants up to Up to US $20,000. Eligible 501(c)(3) organizations under $10 million providing direct services, including alcoholism and drug use disorder treatment, mental/physical health care, and basic needs assistance, may benefit.

Substance Use Disorder Residential Bed Expansion

Many adult substance use residential treatment programs in Connecticut (CT) are funded by CT Medicaid, which covers the treatment and room and board costs for individuals enrolled in Medicaid, through the CT 1115 substance use disorder (SUD) demonstration that started in March 2022. The Department of Mental Health and Addiction Services (DMHAS) provides contract dollars to many of these Medicaid-funded programs to serve individuals who are uninsured. DMHAS is soliciting proposals to add additional beds to existing substance use residential treatment programs or add new substance use residential treatment programs. These beds/programs would be jointly funded by CT Medicaid and DMHAS as described above. The specific American Society of Addiction Medicine (ASAM) levels of care being expanded via this RFP are 3.5 and 3.1. There is particular interest in expanding services for women and those providing trauma and gender bestpractices.

RFP Purpose. To expand the number of beds in the Clinically Managed HighIntensity Residential Treatment services (ASAM Level 3.5) and Clinically Managed Low-Intensity Residential Treatment services (ASAM Level 3.1) levels of care in Connecticut.

RFP Focus: Risk Reduction Strategies to Prevent Overdose

Polk Bros. Foundation Goal:

• Closing the Life Expectancy Gap

Overview:

With this RFP, Polk Bros. Foundation is interested in supporting harm-mitigating programs, services, advocacy, and evidence-building for effective solutions that center the reduction of risk related to drug use and overdose.

Need/ Opportunity Statement

Despite overall reductions in overdose deaths since the peak in 2022, a deeper look at the data uncovers continued increases in overdose rates for some Chicago residents, with particular concentrations on the south and west sides of the city.

Reducing harm in drug use prioritizes safety and connection and promotes gradual reduction of risky behaviors by providing support that meets their basic needs without shame or fear of punishment. Harm mitigation approaches have a demonstrated track record of success.

In an effort to expand the demonstrated impact of risk reduction approaches in Chicago and build the evidence base for effective solutions, this RFP will support programs, services, and non-lobbying advocacy efforts that address overdose prevention, drug use, and related challenges including incarceration and housing instability. Grants will prioritize programs that are grounded in justice and human rights, focused on positive change, and work with people without judgment, coercion, or discrimination.

Goals

PBF seeks to support efforts that reduce harm related to drug use in Chicago through activities that:

• Increase the capacity of harm-reduction organizations to expand their reach and service areas and embed strategies in program delivery
• Build inclusive and diversified coalitions that include people with lived experience, advocates, policy-makers, community leaders, and service providers to align policy and advocacy agendas and to collaborate across neighborhoods
• Develop cross-sector partnerships that reduce trauma related to drug use, including trauma resulting from experience with incarceration, exposure to violence, and housing instability
• Support widespread education and outreach about substance use, overdose, and pathways to recovery that promote risk-reducing behaviors in schools, parks, at community events, and other public spaces that foster community connection
• Equip agencies working with people who use drugs to offer prevention and wellness services, including housing, mental health, and reentry supports
• Pursue non-lobbying policy and advocacy strategies centering and resourcing overdose prevention that is at low or no cost, and is broadly accessible.

Grant Amount

One-year (12-month) grants will support programs and operations and range from $50,000 to $150,000.

The Rapid Evaluation, Stabilization and Treatment (REST) Center, part of the Rural Health Transformation Federal Grant Program, aims to establish up to four 23-hour crisis stabilization centers in Connecticut. These centers will provide accessible mental health and substance use treatment, emphasizing a 'no wrong door' approach for individuals in crisis. The initiative seeks to enhance the continuum of care for adults, ensuring services are person-centered, community-based, and delivered in a trauma-informed manner.

The Healthcare Foundation of Wilson (HFW) offers responsive grants aimed at improving health and wellness in the Wilson, NC community. Established in 2014, HFW prioritizes tax-exempt organizations that address healthcare access, active living, and mental health. Funding is directed towards innovative programs, especially those targeting youth, while ensuring eligibility criteria, including three years of operational history, are met. This initiative reflects HFW's commitment to reinvesting resources back into the community.

The Residential Substance Abuse Treatment (RSAT) Grant Program, funded by the California Board of State and Community Corrections, aims to enhance local governments' ability to provide substance use disorder treatment for incarcerated individuals. The program focuses on preparing justice-involved individuals for successful reintegration into their communities through comprehensive treatment and aftercare services, ultimately breaking the cycle of drugs and violence. Eligible counties may submit one proposal for funding to support these critical initiatives.

Federally recognized Tribal nations and Wisconsin county agencies in Wisconsin can receive funding to cover room and board for Medicaid members in residential substance use disorder treatment programs. The Wisconsin Department of Health Services supports treatment for people with opioid use disorder or at risk of overdose, helping expand access to addiction and substance abuse services.

South Dakota Statewide Opioid Settlement Funds

The South Dakota Department of Social Services, in coordination with the State Opioid Advisory Committee, has recently expanded the framework for organizations and communities to apply for funding through the Opioid Settlement Abatement funds. The new framework broadens the focus to include the full continuum of opioid remediation, expanding prevention efforts, strengthening treatment options, developing better recovery support, and investing in strategies that reduce relapse. The update also extends beyond individuals with opioid use disorder as a primary diagnosis to include strategies for those who have had limited opioid use, are at risk for opioid use, or have other conditions along with opioid use concerns.

Opioid Settlement Fund Community Grant Program

The South Dakota Opioid Advisory Committee seeks to empower local organizations working to prevent, treat, or reduce the impact of opioid use in South Dakota through investment of available statewide share opioid settlement funds.

Applications are accepted on an ongoing basis with awards made on a semi-annual basis or on an on-going basis depending on the funding request level.

Awards will be made in any one of three categories depending on the scope and size of the project:

• Resource Grants (up to $5,000)
• Organizational Grants (up to $50,000)
• Transformative Grants (more than $50,000) 

The National Institute on Drug Abuse is funding pilot and feasibility studies aimed at preparing for substance use and HIV prevention research trials. The program encourages innovative interventions for substance use disorders and HIV eradication, focusing on stakeholder collaboration and practical application. Projects may include assessment of service models, intervention development, and community engagement. This initiative is designed to fill critical research gaps and enhance partnerships, although applications are not currently being accepted.

The M&M Area Community Foundation (MMACF) provides essential financial support to enhance community initiatives in Marinette and Menominee Counties. With multiple grant cycles throughout the year, they cater to diverse needs of local nonprofits, schools, and organizations. MMACF emphasizes philanthropy and collaboration, aiming to foster positive change and tackle local challenges. Their funds include the Youth Field of Interest Fund, Alcohol & Drug Abuse Prevention Fund, and more, ensuring impactful investments in community development.

The Indiana Court Alcohol & Drug Grant Program, administered by the Indiana Office of Court Services, aims to enhance the effectiveness of Court-Administered Alcohol and Drug Programs throughout Indiana. With grants up to $2,500, this initiative focuses on activities such as curriculum development and technology upgrades. Applicants must contribute at least 20% of the project cost. This program reflects the Indiana Judicial Branch's commitment to improving justice and public safety through innovative and accessible solutions.

The NIH is offering access to biospecimens from the ABCD, HBCD, and PATH studies to promote research on health and disease across a lifetime. This initiative encourages projects that utilize these samples to deepen understanding of genetic and environmental influences, particularly substance exposure. Researchers can submit proposals to maximize the scientific utility of these resources, in alignment with the goals outlined under federal health regulations.

MN Community Justice Reinvestment Grant Program

In 2016, the Minnesota legislature established the Community Justice Reinvestment Account to provide supportive services to justice-impacted individuals to reduce further involvement in the criminal justice system. This Account is used to create the Community Justice Reinvestment Grant program, which most recently distributed $1,017,474.54 in 2024 to fund:

• Chemical dependency and mental health treatment programs,
• Programs that improve supervision,
• Pretrial and precharge supervision programs,
• Programs to reduce recidivism of controlled substances offenders on probation or supervised release or participating in drug courts,
• Support local participation in drug court initiatives approved by the Judicial Council.

Organizations providing research education experiences in addiction and substance use disorders in the U.S. and territories can apply for NIH R25 funding, with awards up to US $1,250,000. Grants from the National Institutes of Health help expand skills-development courses and hands-on research experiences to build a more diverse substance use and addiction scientific workforce.