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Best Kentucky Grants for Nonprofits

Find nonprofit grants in Kentucky, including opportunities in Louisville, Lexington, and Bowling Green. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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Filters

9,433 Results based on applied filters

Igor Gorin Memorial Award

Community Foundation for Southern Arizona
Private
United States
Up to US $12,000
The Igor Gorin Memorial Award, established in 1993 by the Community Foundation for Southern Arizona, honors the legacy of Igor Gorin by supporting aspiring vocalists. With $382,000 awarded to 49 young talents, this fund provides unrestricted financial assistance for coaching, travel, and auditions. The 2026 award offers up to $12,000, aimed at those overcoming financial barriers to pursue operatic careers, ensuring that exceptional vocalists can thrive in their artistic journeys.
Opera

Community Collaboration Challenge

National Partnership for Student Success
Association/Society
United States
US $5,000 - US $10,000

Community Collaboration Challenge

Applications for the 2026 Community Collaboration Challenge are now open! With support from the Leon Lowenstein Foundation, the Challenge provides $5,000 – $10,000 awards to communities and is designed to support collaboration that expands and pilots evidence-based K-12 student supports in the form of high-impact tutoring, mentoring, student success coaching, postsecondary transition coaching, and/or wraparound/integrated student supports.

Tutoring & Mentoring College Success / Persistence

Smart Family Fund

Smart Family Fund
Private
United States
US $25,000 - US $100,000
The Smart Family Fund is a private foundation dedicated to supporting early-stage non-profits that demonstrate the potential for scalable, positive impact. With grants ranging from $25,000 to $100,000, they aim to assist organizations in refining their models and preparing for larger investments. The foundation, guided by three brothers, focuses on mentoring and backing social entrepreneurs facing challenges in securing funding for innovative yet untested ideas, fostering a brighter future for communities.
All fields of work Nonprofit Growth & Development

Impact100 Owensboro: Regular Grant

Impact 100 Owensboro Inc
Private
Daviess County, Kentucky, Hancock County, Kentucky +1 more
US $100,000
Impact100 Owensboro offers transformational grants of at least $100,000 to empower women in philanthropy and support local nonprofits. The grant focuses on five key areas: Arts & Culture, Education, Family, Health & Wellness, and Environment & Recreation. Organizations must document their 501(c)(3) status and demonstrate community support. Grants cannot fund operating expenses unrelated to new programs or projects already completed. This initiative aims to uplift the Greater Owensboro community through strategic philanthropic endeavors.
Art & Culture Education Recreation +9 more

Impact100 Owensboro: Residual Grant

Impact 100 Owensboro Inc
Private
Daviess County, Kentucky, Hancock County, Kentucky +1 more
Approximately US $34,000
The Impact100 Owensboro Residual Grant empowers women philanthropists by providing significant funding for transformative projects in the Greater Owensboro area. With a minimum grant size of $100,000, this grant supports initiatives in arts, education, family services, health, and environmental restoration. Organizations must demonstrate sustainability and community support while adhering to eligibility criteria, ensuring that funds are used effectively for community benefit. The residual grant amount varies yearly, allowing for flexible funding opportunities.
Art & Culture Education Recreation +9 more

The Rona Jaffe Foundation Fellowship

Fine Arts Work Center in Provincetown
Private
United States
More than US $2,500
The Rona Jaffe Foundation Fellowship supports emerging women writers with a fully funded 7-month residency at the Fine Arts Work Center. Established by the Rona Jaffe Foundation, it includes a $2,500 prize to assist with travel and living expenses. Eligible candidates must be U.S. residents, at least 18 years old, and not enrolled in a degree program during the fellowship year. This prestigious fellowship aims to nurture exceptional literary talent.
Writing & Literature

Limited Competition: Renewal of Existing NINDS-Supported Clinical Trial Cooperative Agreement Awards (U01 - Clinical Trials Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This funding opportunity invites renewal applications for existing NINDS-supported clinical trial cooperative agreements (U01) that require additional time and resources. The National Institute of Neurological Disorders and Stroke (NINDS) expects applicants to request only what is necessary for trial completion, without introducing new aims. Discussions with NINDS prior to submission are encouraged. Eligible applications must be renewals of previously approved cooperative agreements under specified NIH funding announcements.
Neuroscience Neurological Diseases & Disorders Stroke

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) (356879)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $100,000
This funding opportunity invites applications for pilot projects focused on understudied proteins linked to rare diseases. The goal is to generate preliminary data and tools related to these proteins, which belong to druggable families with known rare disease associations. By supporting innovative research, this initiative aims to facilitate the characterization of these proteins, ultimately contributing to advancements in understanding and treating rare diseases.
Human Genome & Genetics Rare Diseases

Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This Funding Opportunity Announcement (FOA) aims to advance the identification and evaluation of candidate biomarkers for neurological and neuromuscular disorders. By facilitating the clinical development of neurotherapeutics, the FOA encourages research that includes both animal studies and preliminary human evaluations. The ultimate goal is to produce biomarkers ready for rigorous analytical and clinical validation, enhancing the effectiveness of treatments in clinical practice.
Biomedical informatics Neurological Diseases & Disorders Musculoskeletal Diseases

Limited Competition: Basic Instrumentation Grant (BIG) Program (S10 Clinical Trial Not Allowed) (356887)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $5,000,000
The Limited Competition: Basic Instrumentation Grant (BIG) Program, supported by the NIH, invites applications from institutions that have not received significant S10 funding in recent years. This program provides a minimum award of $25,000 and allows for a maximum of $350,000 to purchase specialized instruments essential for NIH-supported research. Eligible instruments include cell sorters, confocal microscopes, and more, promoting advancements in biomedical research.
Biology Health & Medicine Medical Technology, Devices, and Equipment

Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed) (356886)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $5,000,000
The Shared Instrumentation Grant (SIG) Program supports NIH investigators in acquiring high-cost, specialized instruments essential for research. With a minimum award of $50,000 and a maximum of $750,000, this program facilitates the purchase or upgrade of equipment like mass spectrometers and light microscopes. It encourages collaborative efforts among researchers to enhance capabilities and foster innovation in biomedical research.
Biology Health & Medicine Medical Technology, Devices, and Equipment

High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed) (356883)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $5,000,000
The High-End Instrumentation (HEI) Grant Program, funded by the NIH, supports NIH-supported investigators in acquiring high-end, specialized instruments. With a minimum award of $750,001 and a maximum of $2,000,000, this program aims to enhance research capabilities. Eligible instruments include nuclear magnetic resonance spectrometers, mass spectrometers, and advanced imaging systems, among others. Applications are due by 5:00 pm local time of the applicant organization.
Medical Technology, Devices, and Equipment Health & Medicine Biotechnology +1 more

Computational Approaches to Curation at Scale for Biomedical Research Assets (R01 Clinical Trial Not Allowed) (356888)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.
Biomedical informatics Epidemiology & Public Health Health Information Technology

Reboot Representation Grant

Reboot Representation Tech Coalition
Association/Society
United States
Unspecified amount
The Reboot Representation Tech Coalition aims to significantly increase the number of Black, Latina, and Native American women earning computing bachelor’s degrees. They invite qualified organizations to submit grant inquiries focused on recruiting and retaining these women in tech. Programs that leverage existing resources and operate across multiple regions will be prioritized, and the Coalition seeks initiatives backed by substantial research and community trust.
Computer Science & Engineering Diversity, Equity & Inclusion Women's Rights & Equality +4 more

Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
The Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program, funded by the NIH, aims to enhance the biomedical research landscape by supporting resource-limited organizations. It targets domestic institutions with limited research resources and few doctoral students in biomedical fields, promoting broader participation in research and boosting administrative capacities for sponsored programs. Applications are due by 5:00 PM local time of the applicant organization, ensuring timely submissions.
Biology Health & Medicine

Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) (356925)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
This grant opportunity from the NIH aims to enhance mechanistic research on precision probiotic therapies through a biphasic R61/R33 award mechanism. It encourages innovative studies to identify specific biological factors influencing probiotic responses, thereby improving clinical outcomes. The program supports up to five years of research, with the initial phase focused on discovering unique host characteristics and the second phase assessing improvements in probiotic efficacy through rigorous studies.
Integrative & Alternative Health Microbiomes

NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional) (357073)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $15,000,000
The NeuroNEXT program invites small businesses to submit applications for exploratory clinical trials of investigational agents, including drugs and devices. This initiative aims to generate critical data that supports the design of clinical studies, focusing on diseases aligned with the NINDS strategic plan. Applications must be submitted by 5:00 PM local time of the applicant organization. This is a unique opportunity for small businesses to contribute to significant advancements in clinical research.
Pharmacology Neurological Diseases & Disorders Biotechnology +1 more

NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Clinical Trial Not Allowed) (357072)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIDCR Dentist Scientist Career Transition Award (K22) supports dentists transitioning from NIH postdoctoral roles to tenure-track faculty positions. It provides two years of mentored research training in the NIH Intramural Research Program, followed by three years of independent research funding at an extramural institution. Key deadlines for grant applications include February 12, 2025, and subsequent dates in June and October 2025, with additional deadlines for renewal and AIDS-related applications.
Dental Health Medical Education & Professional Training

PLTW Gateway - Program Expansion (L3Harris Technologies)

Project Lead The Way Inc
Private
Alexandria City, Virginia, Amherst County, Virginia +64 more
Up to US $10,000
L3Harris Technologies is collaborating with PLTW to enhance STEM education for PreK-12 students. This initiative supports schools in expanding PLTW Gateway programs starting in the 2025-2026 academic year, with a total grant award of $10,000. Eligible schools are located in specific counties across several states, focusing on diverse and economically challenged communities. The program aims to inspire students and develop essential skills in technology and engineering, aligning with L3Harris's commitment to community engagement.
STEM / STEAM Education

PLTW Computer Science - New Program

Project Lead The Way Inc
Private
American Samoa, District of Columbia +5 more
US $14,000
Project Lead The Way Inc is offering a grant of $14,000 to schools looking to implement the PLTW Computer Science program for the first time. Schools must commit to offering PLTW Computer Science courses over the next three years, ensuring that at least one course is available in the first year. This funding will support program implementation costs, with awards distributed directly to PLTW accounts for eligible schools.
Computer Science & Engineering

PLTW Launch - New Program ( L3Harris Technologies )

Project Lead The Way Inc
Private
Alexandria City, Virginia, Amherst County, Virginia +64 more
Up to US $20,000
L3Harris Technologies has partnered with Project Lead The Way (PLTW) to inspire PreK-12 students in STEM fields, providing $20,000 in grants for schools to launch and expand PLTW programs starting in the 2025-2026 academic year. The initiative focuses on public and charter schools in specific counties, aiming to enhance educational opportunities and support diverse, economically challenged communities through STEM education.
STEM / STEAM Education

PLTW Launch - Program Expansion ( L3Harris Technologies

Project Lead The Way Inc
Private
Alexandria City, Virginia, Amherst County, Virginia +64 more
Up to US $5,000
L3Harris Technologies is collaborating with Project Lead The Way (PLTW) to expand STEM education for PreK-12 students. This initiative aims to inspire young learners through enhanced PLTW programs starting in the 2025-2026 academic year. Eligible schools, including public and charter institutions in specified counties, can receive grants of $5,000 to support program expansion. The focus is on providing resources for new modules, teacher training, and ensuring access for diverse and economically challenged communities.
STEM / STEAM Education

Tobacco, Alcohol, and Cannabis Policy Research for Health Equity (R21 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
The Tobacco, Alcohol, and Cannabis Policy Research for Health Equity grant aims to support innovative research examining policies around tobacco, alcohol, and cannabis in the U.S. This initiative focuses on understanding their impact on health disparities related to usage and secondhand exposure. Funded projects will engage with community organizations to promote equity in cancer prevention, ultimately striving to enhance health equity and reduce cancer risks through informed policy research.
Alcoholism Smoking Health Disparities & Social Determinants of Health +2 more

Tobacco, Alcohol, and Cannabis Policy Research for Health Equity (R01 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
The Tobacco, Alcohol, and Cannabis Policy Research for Health Equity program aims to fund research projects that investigate the impact of policies on tobacco, alcohol, and cannabis use, particularly among communities facing health disparities. This initiative encourages collaboration with community organizations to enhance equity in cancer prevention efforts. Key deadlines for applications span from February 2025 to October 2027, with opportunities for both standard and renewal submissions.
Alcoholism Smoking Health Disparities & Social Determinants of Health +2 more

Vilcek Foundation Grants

The Vilcek Foundation Inc
Private
American Samoa, Guam +4 more
US $5,000 - US $20,000
The 2025 Vilcek Foundation Grants aim to support nonprofit organizations that celebrate immigrant contributions to the arts and sciences. The foundation invites applications from organizations operating under U.S. IRS Section 501(c)(3) that promote diversity and inclusivity. Grants will be prioritized for new partners and those in states without prior funding. This initiative underscores the foundation's commitment to fostering appreciation for immigrant communities and their impact on society.
Immigrant Services Art & Culture Education - Higher Education +1 more

Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed) (357113)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
This funding opportunity supports innovative research aimed at establishing proof of concept for new technologies aligned with the NIGMS mission. Applicants are encouraged to submit Letters of Intent ahead of the deadlines, which span from February 2025 to October 2027 for standard applications. Research proposals should demonstrate a high degree of novelty and risk, while promising significant potential impacts on biomedical research, particularly in the context of emerging technologies.
Biotechnology Emerging Technology Development Medical Technology, Devices, and Equipment +1 more

Focused Technology Research and Development (R01 Clinical Trial Not Allowed) (357112)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Focused Technology Research and Development (R01) grant supports innovative projects aimed at developing technologies to enhance biomedical research. This funding opportunity emphasizes the creation of laboratory instruments, algorithms, and biological systems that can significantly improve research capabilities. Key deadlines for applications are set for February, June, and October of 2025 through 2027, ensuring ample time for proposal submissions. The initiative is funded by the National Institutes of Health (NIH), part of the US Department of Health and Human Services.
Biotechnology Biomedical Imaging Medical Technology, Devices, and Equipment +1 more

Kentucky Grants for Nonprofits Highlights

Kentucky grants for nonprofits provide funding to support public health, education, and rural development projects. The following grants help organizations address state-specific challenges, promote equity, and improve the quality of life across Kentucky.


Search Instrumentl's Kentucky Grants Database


Explore 136 funding opportunities for nonprofits in Kentucky, with $57.7M in resources. Instrumentl streamlines the funding search with deadline notifications, customized filtering, and key insights to support impactful initiatives throughout Kentucky.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Kentucky Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Kentucky grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 Kentucky grants for nonprofits over $25K in average grant size

21 Kentucky grants for nonprofits over $50K in average grant size

22 Kentucky grants for nonprofits supporting general operating expenses

100+ Kentucky grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Kentucky grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.9%
Q2
21.2%
Q3
23.7%
Q4
21.2%

Typical Funding Amounts

What's the typical grant amount funded for Kentucky Grants for Nonprofits?

Grants are most commonly $8,000.

$500 $500 Min.
$8,000 $8 K Median
$711,767 $711.8 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in Kentucky. Over 100+ individual grants, totaling $57,653,111, are available. If you’re interested in applying for grant funding in Kentucky, know that the median grant size is $8,000. Grants for nonprofits in Kentucky provide funding to support areas like public health, education, and rural development initiatives.

In Kentucky, grants come from all different types of funders, including private foundations, federal government agencies, and corporations. Here’s a breakdown of where you’ll find available grants in Kentucky:

  • Private Foundations: Private foundations in Kentucky fund 81 grant opportunities. When filtering for these grants, you'll see that many focus on education, arts and culture, and more.
  • Federal Government Agencies: There are 14 grants available in Kentucky through federal government agencies. Many of these funding opportunities focus on initiatives like agriculture, rural development, and health care.
  • Corporations: There is a moderate amount of grants from corporations available in Kentucky. The 16 grants available focus on food access and hunger, community services, and more.

Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in Kentucky is in Q1, which is when 33.9% of grant deadlines fall. Of the available grants, 23.7% of deadlines fall in Q3 and 21.2% fall in Q2. Comparatively, Q4 is the grant period with the least activity, as only 21.2% of deadlines fall within this timeframe. To maximize your odds of receiving funding, be aware of the peak fundraising periods.

The nonprofit funding landscape throughout Kentucky has shown large activity across the past several years. Based on the funding reports sent to the IRS, overall grant funding reached up to ~$1.7 billion in 2021 and increased to ~$1.8 billion in 2022, a growth of nearly 6%. Among all of the grants awarded in Kentucky during this time, the most popular focus areas for funding were single-organization support from professional societies and associations and alliance/advocacy organizations. Likewise, the top counties receiving the most funding were Jefferson County, Kenton County, and Fayette County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within Kentucky for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in Kentucky. Learn more about Instrumentl's platform.

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