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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

32,000+

Available grants

$8.25B

Total funding

$6K

Median grant

32,000+ grants
$8.25B total
$6K median

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32,499 Results based on applied filters

Arthur N. Rupe Foundation Grant

Arthur N Rupe Foundation
Private
United States
Unspecified amount
The Arthur N. Rupe Foundation Grant focuses on promoting positive social change through scholarly studies, education, and public debate. It supports projects related to caregiving, civil debate, and public policy, aiming to enhance the quality of life in America. The foundation prioritizes specific project funding over general operations and does not support individuals or capital campaigns. Grant inquiries are invited through a letter of inquiry process, ensuring alignment with its mission.
Home Health Care Public Policy Nursing +3 more

Clean Water Revolving Fund (MN)

Minnesota Public Facilities Authority
State/Local Government
Minnesota
Unspecified amount
The Clean Water Revolving Fund in Minnesota provides below-market-rate loans to support communities in upgrading wastewater treatment facilities to meet federal standards. Managed by the Minnesota Public Facilities Authority and the Minnesota Pollution Control Agency, the fund aims to enhance water quality and public health. Eligible applicants include cities and counties, with specific project requirements and loan terms based on population size. The program promotes financial responsibility and environmental compliance, ensuring sustainable water management.
Water Resource Management Waste Management

Keep Communities Flowing Grant Program

American Water Works Company, Inc.
Corporate
California, Hawaii +11 more
Unspecified amount
The AW Environmental Grant Program, backed by American Water Works Company, Inc., aims to support community-driven projects focused on water conservation and the protection of vital water resources. Since 2012, the foundation has invested over $15 million in innovative initiatives that enhance access to clean water and promote responsible water usage in underserved communities. Eligible applicants include 501(c)(3) charities and educational institutions committed to environmental stewardship.
Freshwater Conservation Water Resource Management Sanitation & Clean Drinking Water

Texas Longleaf Conservation Assistance Program

Texas A&M Forest Service
State/Local Government
Hardin County, Texas, Jasper County, Texas +3 more
Unspecified amount
The Texas Longleaf Conservation Assistance Program offers financial and technical support to landowners in East Texas for establishing and managing Longleaf Pine. This initiative aims to restore the historical range of Longleaf Pine, which has diminished over time. Participants can receive assistance for practices like prescribed burning and reforestation, enhancing both ecological health and economic viability. The program fosters collaboration among federal, state, and local partners to promote sustainable forestry in the region.
Forestry Habitat & Ecosystem Restoration

Dr. Richard W. Adams Charitable Foundation Grant

Adams Dr Richard Char Fdn Trust
Private
Alamance County, North Carolina, Alexander County, North Carolina +5 more
Unspecified amount
The Dr. Richard W. Adams Charitable Foundation Grant supports nonprofit organizations and governmental units in the Piedmont region of North Carolina. It particularly emphasizes education in medical science, scholarships for employees of Davis Regional Medical Center, agriculture, conservation, and wildlife preservation. Grants are administered by Wells Fargo Bank and are available through a year-round application process, focusing on enhancing local medical practice and community well-being.
Medical Education & Professional Training Environmental Conservation Wildlife Management +3 more

Susquehanna Riverlands Conservation Landscape Mini-Grant Program

WeConservePA
Private
Lancaster County, Pennsylvania, York County, Pennsylvania
US $2,500 - US $25,000
The Susquehanna Riverlands Conservation Landscape Mini-Grant Program offers competitive grants ranging from $2,000 to $20,000 for projects enhancing habitat connectivity, sustainable river access, and community collaboration. This initiative is part of a collaborative effort to protect natural resources and improve quality of life along the Susquehanna River in Pennsylvania. Applications are accepted until July 1, 2025, encouraging local nonprofits and municipalities to apply for funding that aligns with the program's goals.
Habitat & Ecosystem Restoration Freshwater Conservation Land / Habitat Conservation +2 more

MT 319 Nonpoint Source Pollution Reduction Grants

Montana Department of Environmental Quality (DEQ)
State/Local Government
Montana
US $10,000 - US $300,000
The MT 319 Nonpoint Source Pollution Project Grants, administered by the Montana Department of Environmental Quality, aim to reduce nonpoint source pollution through competitive funding for eligible projects. This program supports various initiatives, including technical assistance and restoration efforts, to protect Montana's water quality. By implementing Best Management Practices and fostering community engagement, the program seeks to address diffuse pollution sources effectively. The 2012 Montana Nonpoint Source Management Plan outlines strategic goals to enhance these efforts.
Water Resource Management Freshwater Conservation Environmental Contamination & Pollution

Houston Astros Group Charity Ticket Program

The Astros Foundation
Private
Harris County, Texas
Unspecified amount in in-kind support
The Houston Astros Group Charity Ticket Program aims to support local 501(c)(3) nonprofits by providing complimentary home game tickets. This initiative allows qualifying organizations to apply for up to two games per year, with a maximum of 50 tickets per game. The program emphasizes responsible ticket usage, ensuring that awarded tickets are fully utilized to foster community engagement. This effort not only honors the Astros' commitment to local charities but also enhances the overall experience of attending a game.
Baseball & Softball Homelessness Services Domestic Violence +3 more

Elea Institute: Midwest Grants Program

Elea Institute
Private
Boone County, Illinois, Cook County, Illinois +11 more
Up to US $300,000
The Elea Institute's Education Grants Program aims to enhance hospice and palliative care education for healthcare providers, patients, and families in Illinois. With grant sizes ranging from $50,000 to $100,000, this initiative supports 1-3 projects over a period of up to two years. Eligible organizations must be 501(c)(3) tax-exempt and focus on the specified Illinois counties, fostering community outreach and educational efforts to improve patient care.
Community Health Education Hospice / End of Life Care Palliative Care +2 more

Merger/Regionalization Feasibility Grants

North Carolina Department of Environmental Quality
State/Local Government
North Carolina
US $50,000
The Merger/Regionalization Feasibility Grants, established by Session Law 2015-241, aim to support local government units and nonprofit water corporations in evaluating the consolidation of water and wastewater systems. Grants, capped at $50,000 over three years, encourage proactive management and financing of utilities. Eligible projects include studies on potential system interconnections for regional water supply and wastewater treatment. Training is recommended for applicants to maximize grant benefits.
Waste Management Water Resource Management

Asset Inventory and Assessment Grants

North Carolina Department of Environmental Quality
State/Local Government
North Carolina
US $225,000
The Asset Inventory and Assessment Grants, established by Session Law 2015-241, aim to enhance the viability and proactive management of water and wastewater utilities. Grants can reach up to $150,000 over three years, available to local government units and nonprofit water corporations for projects such as asset inventory and critical asset condition assessments. Eligible applicants are encouraged to participate in training sessions, which are free of charge, to better navigate the grant application process.
Waste Management Water Resource Management

Florida Department of Environmental Protection: Resilient Florida – Implementation Grants

Florida Department of Environmental Protection
State/Local Government
Florida
Unspecified amount
The Florida Department of Environmental Protection offers Resilient Florida Implementation Grants to support local governments and special districts in infrastructure projects addressing risks from vulnerability assessments. This funding aims to enhance the protection and restoration of Florida's water resources, especially against flooding and storm surge. Eligible entities include counties, municipalities, and water management authorities. Proposals submitted will be public records, with no guarantee of funding upon submission.
Habitat & Ecosystem Restoration Water Resource Management

Beverage Container Redemption Innovation Grant Program- Cycle 9 – Reverse Vending Machine

California Department of Resources, Recycling, and Recovery (CalRecycle)
State/Local Government
California
US $500,000 - US $5,000,000
The Beverage Container Redemption Innovation Grant Program, administered by CalRecycle, supports innovative recycling initiatives in California. This program aims to provide funding for start-up costs associated with recycling centers, mobile recycling, reverse vending machines, and bag drop programs. It encourages applicants to adopt Environmentally Preferable Purchasing and Practices (EPPP) Policies to enhance recycling outreach and improve California Refund Value (CRV) redemption opportunities.
Recycling Waste Management

John W. Alden Trust Grant

John W. Alden Trust
Corporate
Barnstable County, Massachusetts, Bristol County, Massachusetts +8 more
US $7,500 - US $50,000
The John W. Alden Trust Grant supports organizations in Eastern Massachusetts that provide care and services to children and youth (ages 0-24) with disabilities or those at risk due to social factors. Grants can fund capacity building, program support, and more, but applicants must demonstrate a focus on high-risk youth and meet specific criteria. The Trust emphasizes sustainability and may require matching funds for grant approval.
Children’s Mental Health Teen Parenthood Children’s Health & Pediatrics +3 more

Community Responsive Grants

Southern Minnesota Initiative Foundation
Private
Blue Earth County, Minnesota, Brown County, Minnesota +18 more
Up to US $75,000
The Community Responsive Grants, offered by the Southern Minnesota Initiative Foundation (SMIF) in partnership with the Otto Bremer Trust, aim to support organizations addressing critical community needs in south central and southeastern Minnesota. Grants of up to $75,000 will be awarded to eligible nonprofits focusing on areas such as literacy, children's health, and mental health. Applicants must have a 501(c)(3) designation and a proven operational history of at least five years.
Disability Care & Services Basic Human Needs Community Health Education +5 more

Govenor's Industry Vocations Scholarship (NJ)

New Jersey Higher Education Student Assistance Authority
State/Local Government
New Jersey
Up to US $2,000
The Governor's Industry Vocations Scholarship (NJ-GIVS) supports women and minority students pursuing certificates or degrees in construction-related fields. Funded by the Schools Development Authority and administered by HESAA, this scholarship can cover up to $2,000 per year or the full cost of tuition, minus any other financial aid. It is renewable for one year, contingent on future funding availability, and awards are distributed on a first-come, first-served basis.
Black American Services Native American Services Hispanic and Latino Services +5 more

Spartanburg Regional Foundation Grant

The Spartanburg Regional Healthcare System Foundation
Private
Cherokee County, South Carolina, Greenville County, South Carolina +2 more
Unspecified amount
The Spartanburg Regional Foundation, established in 1991, plays a crucial role in enhancing community health in the Upstate of South Carolina. By supporting projects and initiatives, the Foundation has contributed over $100 million to healthcare efforts. It allocates funds to priority areas such as maternal health, behavioral health, and workforce development. The Foundation aims to empower change through innovative grantmaking, benefiting both Spartanburg Regional Healthcare System and community partners dedicated to improving health outcomes.
Maternal And Perinatal Health Workforce Preparation & Job Readiness Health Disparities & Social Determinants of Health +1 more

Aiken Audubon Mini-Grants

Aiken Audubon Society
Private
Colorado
US $100 - US $500
The Aiken Audubon Mini-Grants program, initiated by the Aiken Audubon Society, aims to promote bird conservation in the Pikes Peak region. Grants ranging from $100 to $500 are available for individuals and community organizations that align with the society's mission. The program continues the legacy of ornithological study established by pioneers like Charles Aiken. With the goal of supporting at least four mini-grants per year, it fosters local engagement in wildlife conservation efforts.
Environmental Education Environment Ornithology +1 more

Butler Foundation Charity Grant

Butler Foundation
Private
Boone County, Kentucky, Bracken County, Kentucky +5 more
Unspecified amount
The Butler Foundation Charity Grant aims to alleviate poverty in Northern Kentucky by funding programs that emphasize individual dignity, employment, self-sufficiency, and education. With over $1.9 million invested in 2024 alone, the Foundation seeks to create long-term, positive outcomes through catalytic and impactful grants. Priorities include support for local charities addressing basic needs such as shelter, food, and education. The Foundation encourages collaborative efforts and challenge grants to maximize community resources.
Poverty Alleviation & Services Entrepreneurship Educational Access & Equity +5 more

Community Clean Air Grant Program

City of Boston
State/Local Government
Suffolk County, Massachusetts
Up to US $200,000
The Community Clean Air Grant Program, initiated by the City of Boston's Air Pollution Control Commission, seeks proposals from nonprofit organizations for projects that reduce urban air pollution. This initiative aims to enhance public health and tackle climate change impacts, particularly in marginalized communities disproportionately affected by air pollution. Eligible projects include efforts to mitigate pollution sources, improve community monitoring capabilities, and achieve measurable air quality improvements. The program emphasizes support for vulnerable populations facing health risks from environmental pollutants.
Environmental Contamination & Pollution Climatology Carbon / Greenhouse Gas Reduction

Notice of Intent to Publish a Funding Opportunity Announcement for HIV Pediatric, Adolescent and Maternal Clinical Trials

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $30,000,000
The US Dept. of Health & Human Services, through the Eunice Kennedy Shriver National Institute of Child Health and Human Development, is set to announce a funding opportunity focused on HIV research for pediatric and maternal populations. This initiative aims to foster innovative clinical trials addressing critical research areas in HIV, inviting collaborations from experts in various fields. Applications are not currently solicited, but potential applicants are encouraged to prepare for this opportunity.
Infectious & Parasitic Diseases HIV / AIDS Chronic Illnesses

Student & Resident Research Award

Rheumatology Research Foundation
Private
United States
US $2,000
The Student & Resident Research Award, part of the Choose Rheumatology campaign, recognizes outstanding students and residents for significant contributions in rheumatology. Eligible applicants must be authors of abstracts submitted to ACR Convergence 2025 and can receive up to $2,000 in funding for travel and registration. This award promotes engagement in rheumatology through innovative learning experiences at ACR Convergence, enhancing the understanding and care for patients with rheumatic diseases.
Musculoskeletal Diseases Immune System Diseases Arthritis +1 more

Rheumatology Scholarship – Workforce Expansion

Rheumatology Research Foundation
Private
United States
US $2,000
The Rheumatology Scholarship – Workforce Expansion aims to recruit future rheumatology professionals by supporting students and residents from underserved areas to attend ACR Convergence 2025. Awardees receive $2,000 for travel, registration, and a one-year ACR/ARP Membership. This initiative fosters networking opportunities and educational experiences crucial for enhancing patient care in rheumatology. It is part of a broader campaign to address the growing shortage of rheumatologists and improve patient access to care.
Musculoskeletal Diseases Immune System Diseases Arthritis +1 more

Community Waste Reduction and Recycling (CWRAR) Grant Program - Priority Projects

North Carolina Department of Environmental Quality
State/Local Government
North Carolina
Up to US $50,000
The Community Waste Reduction and Recycling (CWRAR) Grant Program is now accepting proposals for 2025, aiming to help local governments enhance waste reduction and recycling efforts in North Carolina. Grants of up to $40,000 are available for priority projects that implement or expand curbside recycling, hazardous waste programs, or electronics recycling initiatives. A 20% cash match is required, ensuring local investment in sustainability efforts. For more information, visit the N.C. Division of Environmental Quality website.
Waste Management Recycling

Ann W. Dooley Advancement Scholarship

Community Foundation of Northern Illinois
Private
United States
Unspecified amount
The Ann W. Dooley Advancement Scholarship supports individuals aged 18-25 with intellectual disabilities who reside in Boone, Ogle, Stephenson, or Winnebago County. This scholarship encourages empowerment through education, enabling recipients to enhance their life skills for employment and independence. Established in memory of Ann Dooley, a dedicated educator, this scholarship honors her legacy of service and commitment to helping others. Applicants must provide verification of their disability and enrollment in a post-secondary program.
Academic Scholarship Programs Education - Higher Education College Success / Persistence +5 more

Rheumatology Scholarship – Undergraduate Students and Post-Baccalaureate Training

Rheumatology Research Foundation
Private
United States
US $2,000
The Rheumatology Scholarship supports undergraduate and post-baccalaureate students in attending ACR Convergence 2025, a premier event for rheumatology. Awardees gain exposure to innovative research and networking opportunities, enhancing their understanding of rheumatic diseases. The scholarship includes $2,000 for travel expenses and complimentary registration, encouraging future professionals to explore careers in this essential field. This initiative aims to strengthen the rheumatology workforce, ensuring better care for patients with musculoskeletal diseases.
Musculoskeletal Diseases Immune System Diseases Arthritis +1 more

Medical and Graduate Student Preceptorship

Rheumatology Research Foundation
Private
United States
US $4,000
The Medical and Graduate Student Preceptorship provides a unique opportunity for students to engage in rheumatology through either clinical or research experiences lasting 4 to 8 weeks. Participants will observe practices in a shadowing role, gaining invaluable insights without direct patient management. The program supports students with financial awards of $2,000 or $4,000, depending on the duration of their preceptorship, and includes additional funds for travel expenses to attend professional conferences.
Musculoskeletal Diseases Immune System Diseases Arthritis +1 more

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.