Best Large Grants for Nonprofit Organizations

Indian Affairs Department

The Indian Affairs Department (IAD) is a Cabinet Level agency within the Executive Branch of the State of New Mexico.

The Indian Affairs Department (IAD) is a cabinetlevel agency within the Executive Branch of the State of New Mexico, leading change through a variety of programs and administration of funding opportunities. IAD investigates and addresses the health, economy, education and legislative impacts affecting Indian conditions and relations in New Mexico.

IAD collaborates with other state agencies, promotes public participation and serves as the clearinghouse for all state programs impacting Indian communities.

The department may hold hearings, conduct meetings, investigate issues and partner with tribal, local, state and federal entities to promote the welfare of New Mexico’s Indian people.

It also contracts with tribal governments, public agencies or private entities to provide services and facilities for Indian communities.

IAD also focuses on matters such as Behavioral Health & Suicide Prevention, Missing and Murdered Indigenous Persons (MMIP), Environmental Justice, Policy & Legislation and more.

Suicide Prevention New Mexico Tribal Citizens & Communities

Purpose

The purpose of this Request for Proposals (RFP) is to strengthen suicide prevention and mental health capacity for Native American citizens in New Mexico through engagement, training and data-driven strategies. The selected vendor will work collaboratively with the New Mexico Indian Affairs Department (IAD) and key partners to coordinate an initiative that integrates suicide prevention education, community assessment and evidence-based mental health training. 

The Cheerful Giver Scholarship, provided by the Community Foundation of the Central Blue Ridge, offers over $300,000 in financial support to students in the Greater Augusta County area pursuing health care-related education. This need-based scholarship is open to high school seniors, current college students, and adult learners, with a preference for those entering the nursing profession. The foundation aims to enhance community well-being through educational opportunities.

The SCAC Individual Artist Fellowships aim to honor the artistic accomplishments of South Carolina's individual artists. With awards of $10,000, these fellowships are competitive and based on artistic merit, achievements, and dedication to the discipline. Eligible applicants must be legal residents of South Carolina, over 18 years old, and not degree-seeking students during the award period. Up to five fellowships are awarded annually, with specific artistic disciplines rotating each year.

Oregon Health Authority

The Oregon Health Authority is at the forefront of lowering and containing costs, improving quality and increasing access to health care in order to improve the lifelong health of people in Oregon.

Mission: Ensuring all people and communities can achieve optimum physical, mental, and social well-being through partnerships, prevention, and access to quality, affordable health care. OHA will transform the health care system in Oregon by: improving the lifelong health of people in Oregon, increasing the quality, reliability, and availability of care for all people in Oregon and lowering or containing the cost of care so it's affordable to everyone.

Land Acquisition (Conservation) Planning Grant

The Drinking Water Source Protection Fund (DWSPF) is designed for the protection of drinking water sources. Drinking water sources include watersheds above a public water supply surface water intake and/or the delineated portion of the aquifer supplying water to public water supply wells or springs. 

Land Acquisition (Conservation) Planning grants are for conservation purposes directed at the preservation of land to protect, restore, or enhance sources of drinking water serving eligible public water systems. Eligible conservation planning projects can include any studies or activities that involve or are related to assessing legal and/or financial feasibility of purchasing land, easements, or similar projects within an identified drinking water source area. 

The Local Government Waste Tire Amnesty Grant Program, administered by CalRecycle, offers $1,500,000 in funding for fiscal year 2025-26 to support local governments in conducting free tire recycling events. These events are designed to help the public and businesses dispose of waste tires conveniently. Up to $40,000 is available for individual applicants, while regional applicants can receive up to $90,000. The program aims to promote responsible waste management and reduce illegal tire dumping.

The Local Enforcement Agency Grant Program, administered by CalRecycle, provides critical funding for Local Enforcement Agencies (LEAs) to enhance solid waste facilities permit and inspection programs. With $1,500,000 available for FY 2025–26, including $96,000 dedicated to LEA training and outreach, this initiative aims to bolster existing budgets and ensure effective waste management. Projects funded will directly contribute to the sustainability and compliance of solid waste operations in California.

The CCCF's Common Ground Program offers Forest Health and Wildfire Resilience Planning & Education Grants aimed at enhancing community wildfire resilience and forest health. Eligible applicants include federal and state agencies, nonprofits, and for-profit organizations. Grants range from $5,001 to $100,000 per year, with a focus on collaborative efforts that strengthen landscapes, conserve agricultural lands, and manage outdoor recreation impacts. The program encourages measurable outcomes and partnerships with organizations like the Colorado State Forest Service.

The Bothin Foundation Grant supports nonprofits with capital investments in social services, youth development, arts, and environmental programs, focusing on those serving disadvantaged children, low-income families, and individuals with disabilities in specific California counties. Eligible projects include building renovations, equipment purchases, and vehicle requests, with a preference for immediate, impactful needs. Organizations must be 501(c)(3) compliant and have a direct service focus, ensuring community benefit and sustainability.

The CCCF Common Ground Program offers Forest Health and Fire Resilience Project Grants aimed at enhancing forest health and community fire resilience. Eligible projects must demonstrate a collaborative approach and provide community value, such as fuel breaks across public and private lands. Funding ranges from $5,001 to $500,000 per year, with a focus on leveraging resources to maximize impact. This initiative supports various organizations in achieving sustainable land management and protecting vital ecosystems.

The JGLR/Elsevier Early Career Scientist Award, presented by the International Association for Great Lakes Research, recognizes the top-ranked paper in the Journal of Great Lakes Research authored by someone within five years of their terminal degree. This prestigious award includes a $750 cash prize and a one-year IAGLR membership. Evaluation criteria focus on originality, contribution, and presentation quality, celebrating significant research in the field of Great Lakes science.

The NH Volunteer Engagement Program offers mini-grants to eligible organizations aimed at enhancing volunteer capacity through training, technology, and program development. Funded by the American Rescue Plan, these grants support projects focused on affordable housing, mental health, and food security in New Hampshire. Organizations can apply for specific needs, with awards ranging from $1,000 to $4,000. Priority will be given to those serving underserved communities and demonstrating a clear need for capacity building.

The Basic Needs Giving Partnership provides single-year grants to support organizations in Northeast Wisconsin that are addressing the root causes of poverty. Their focus is on collaborative initiatives in areas such as early care and education, housing access, mental health, and substance use. By partnering with local communities, they aim to foster equity and enhance economic well-being, while also disrupting systemic barriers that perpetuate poverty.

The Carl and Marilynn Thoma Foundation offers Special Project Funding to support innovative initiatives in the arts, particularly in under-resourced areas. This grant encourages collaborative projects that enhance community engagement and education, focusing on art exhibitions and scholarships in the greater Texas Panhandle. By fostering leadership and creativity, the Foundation aims to empower individuals and organizations to make a lasting impact in the fields of art and art history.

The Cloudsplitter Foundation offers Unrestricted Support Grants, aimed at covering the operating costs of not-for-profits rather than specific projects. Eligible organizations must align with the Foundation's strategic objectives and maintain an established relationship, with grants capped at $5,000 per year. The Foundation, active in the Adirondack region since 1986, prioritizes community building, environmental stewardship, and economic stability, providing vital support to enhance local initiatives and ensure long-term impact.

The Primary Care Residency Expansion Grant Program, authorized by Minnesota Statutes Section 144.1506, aims to establish new primary care residency programs and train eligible residents in Minnesota. This initiative addresses the shortage of primary care physicians, enhancing access to healthcare in rural and underserved communities. Approximately $1.9 million will be available this grant cycle, with awards ranging from $75,000 to $400,000 to support these essential programs.

The Emergency/Medical Workers Behavioral Health Fund aims to support emergency workers facing trauma and anxiety due to their roles. Established by the HealthWell Foundation, it provides financial assistance for treatment-related costs, including copayments for prescription drugs, counseling, and transportation. In 2024, the Foundation awarded over $1.2 billion to underinsured patients, ensuring no one is denied essential healthcare due to financial barriers. This initiative helps address the critical mental health needs of those who serve on the front lines.

The RE/MAX Equity Group Foundation Grant aims to support small, local, and grassroots charitable organizations in the Portland metro and SW Washington areas. With contributions ranging from $500 to $2,500, the foundation focuses on tangible needs such as food, clothing, and medical services. Priority is given to organizations that support children and families, demonstrating low operating expenses and direct community engagement to maximize impact.

The 2025-2026 Perkins V grant aims to enhance career and technical education (CTE) for secondary students by developing their academic and employability skills. It focuses on integrating rigorous academic and technical instruction, increasing flexibility in service provision, and building partnerships among educational institutions and industries. Additionally, the program seeks to support underrepresented populations, ensuring they gain the necessary skills for competitive employment in high-demand fields.

The Rubberized Pavement Grant Program in California, administered by CalRecycle, aims to divert waste tires from landfills and promote recycled-content products. This initiative encourages the use of rubberized pavement through two project types: Rubberized Asphalt Concrete Hot-Mix and Rubberized Chip Seal. Grants of up to $375,000 are available for individual applicants, with a maximum of $525,000 for regional applications, and $750,000 for tribal grants, fostering sustainable practices in construction.

The Community Wellness Grant Cycle, managed by the Community Foundation Serving Western Virginia, focuses on supporting programs that address the essential needs of vulnerable populations. It prioritizes initiatives that provide food assistance, affordable housing, homelessness prevention, and essential supplies. Organizations eligible for funding must be located in and serve specific cities and counties in the region, promoting collaborative efforts to enhance community well-being. This initiative aims to create a thriving environment for all community members.

The Ralph J. Torraco Scholarship for Therapy Sciences, provided by the UNICO Foundation, awards two scholarships valued at $2,500 each to full-time students pursuing degrees in Therapy Sciences, including physical therapy, occupational therapy, audiology, and speech-language pathology. Eligible candidates must be U.S. citizens with a minimum GPA of 3.0 and continue their studies in the 2026-2027 academic year. This scholarship promotes educational advancement within the community.

The William Penn Foundation aims to enhance caregiver support for 15,000 pregnant and parenting families in Philadelphia by 2035. The initiative recognizes the critical link between caregivers' well-being and children's development. It seeks to empower families through community-based programs that promote early learning and parenting skills. The focus includes vulnerable populations such as grandparents and immigrant families, ensuring access to resources that enable children to thrive. Progress will be measured through comprehensive grantee reporting.

The Manning Family Foundation offers rolling grants to 501(c)(3) nonprofits in Charlottesville, Virginia, focusing on health, education, and financial literacy. Established in 2003, the foundation emphasizes support for at-risk youth and disadvantaged communities. Their local giving initiative aims to foster a thriving community where culture flourishes and families prosper, while also providing essential free physical and mental health services to those in need.

The District of Columbia Department of Energy and Environment (DOEE) aims to replace diesel vehicles with zero-emission equivalents to enhance community health. The grant supports replacing medium- and heavy-duty vehicles registered in the District, with available funding totaling $2,396,457. Non-governmental organizations, faith-based groups, universities, and private enterprises are encouraged to apply for rebates on vehicle replacement costs, promoting a cleaner environment and reduced NOx emissions.

The Oregon State Weed Board Grant Program, administered by the Oregon Department of Agriculture and OWEB, focuses on controlling noxious weeds to protect water quality and restore watershed health. Eligible applicants include tribes, colleges, and conservation districts, with an emphasis on integrated weed management strategies. Projects must prioritize on-the-ground control efforts and demonstrate clear site management objectives. This funding opportunity aims to enhance fish and wildlife habitats and support native salmonid populations.

The Banner-ASU Neuroscience Scholars Program offers a unique eight-week training opportunity for top undergraduate and graduate students in science and social science. Participants engage in hands-on research alongside leading scientists in the Greater Phoenix area, focusing on neurodegenerative diseases. The program includes mentorship, educational seminars, and a stipend of $4,000 upon completion. Scholars present their findings at a formal symposium, enhancing their professional skills and academic credentials.