Best Large Grants for Nonprofit Organizations

The KeyBank Foundation offers Community Sponsorships to support local organizations in their fundraising efforts. These sponsorships range from $500 to $5,000 and can fund events or provide general operating support. Applications are accepted from January to October, with a decision made within 90 days. Eligible nonprofits must serve areas where KeyBank operates and adhere to strict ineligibility criteria, including no support for individuals or organizations that discriminate based on various identities.

The Community Foundation of Central Missouri (CFCM) promotes community well-being through its Community Support Grants. Since 2010, CFCM has focused on addressing local needs by funding nonprofit projects in areas such as health, education, arts, and community improvement. Eligible organizations must be 501(c)(3) nonprofits or local government entities serving central Missouri. CFCM seeks partnerships that align with its mission to enhance lives and foster sustainable community investments.

The Fund For Siouxland Grant, managed by the Siouxland Community Foundation, supports charitable initiatives in the Siouxland area. With a focus on arts, civic affairs, education, health, and human services, the fund aims to enhance community quality of life. Grants typically do not exceed $5,000, prioritizing projects that demonstrate collaboration, innovation, and broad community impact. The foundation is committed to serving diverse populations and addressing emerging needs without duplicating existing services.

The San Manuel Cares Grant Program, offered by the San Manuel Band of Mission Indians, focuses on empowering communities in the Inland Empire and Indian Country. The program supports educational initiatives, community development, and cultural preservation, emphasizing positive social change. Eligible organizations include 501(c)(3) nonprofits, schools, and local government agencies. Funding is directed towards programs that enhance education, provide basic needs, and promote resilience among underserved populations, fostering a healthier, culturally rich community.

The Loudoun Impact Fund Grant, offered by the Community Foundation for Loudoun and Northern Fauquier Counties, supports organizations that positively impact vulnerable populations in Loudoun County. Grantmakers prioritize projects aiding at-risk children, people with disabilities, and older adults. With donor contributions pooled, the fund aims to address essential needs, health services, and educational support. Interested applicants must be 501(c)(3) nonprofits, schools, or faith-based organizations committed to serving diverse communities.

About the DNR

Preserving and enhancing the natural resources of Wisconsin

In keeping with our mission, the DNR is dedicated to working with Wisconsinites while preserving and enhancing the natural resources of Wisconsin. In partnership with individuals and organizations, DNR staff manage fish, wildlife, forests, parks, air and water resources while promoting a healthy, sustainable environment and a full range of outdoor opportunities.

Wisconsin Forest Landowner Grant Program

The Wisconsin Forest Landowner Grant Program (WFLGP) WFLGP program [PDF] is a cost-share program offered by the Wisconsin Department of Natural Resources (DNR). It is designed to assist woodland owners in protecting and enhancing their woodlands. This program reimburses woodland owners up to 50% of the cost of eligible practices.

Financial Assistance for:

• Tree planting
• Invasive plant control
• Forest Stewardship Plan development
• Forest improvement practices
• Crop tree release

Priority 1 Practices

• Stewardship plan development
• Tree planting/regeneration
• Forest health and improvement
• Soil and water protection and improvement

Priority 2 Practices

• Wetland and riparian protection
• Wildlife habitat enhancement
• Endangered or threatened resources, rare natural community, historic, cultural and archaeological protection, restoration, enhancement and maintenance

The AmeriCorps Competitive Grant (NH) is an initiative by Volunteer NH aimed at fostering community engagement through volunteerism. This grant supports organizations wishing to run full AmeriCorps programs, focusing on applicants with prior AmeriCorps experience. The funding is allocated for three-year intervals, promoting sustainable community solutions. By encouraging local challenges to be addressed through volunteer efforts, Volunteer NH envisions a collaborative environment where communities thrive together.

The Dominion Energy Charitable Foundation supports tax-exempt organizations under IRS Section 501(c)(3) in four key areas: human needs, environmental stewardship, education, and community vitality. Grants typically range from $1,000 to $15,000, with two application cycles each year. Notably, funding is unavailable for organizations without 501(c)(3) status or those located outside Dominion's service areas. This foundation aims to enhance community welfare through targeted support for impactful programs.

The George W. Mergens Foundation Grant supports educational and experiential opportunities for youth, continuing a legacy of over $12 million in funding. Established in 1994 to honor George Mergens, the foundation focuses on enriching the lives of children and adolescents through health, education, and leadership programs. Eligible organizations must be 501(c)(3) nonprofits based in Vermont, primarily serving youth. The foundation aims to partner with groups addressing significant community needs.

The Ohio Coastal Management Assistance Grants provide funding for projects that improve water quality, enhance coastal habitats, and promote public access to Lake Erie. Eligible recipients, including local governments and non-profits, can apply for grants with a required 1:1 non-federal match. Since 1998, over $8 million has been awarded for 155 projects, with total investments exceeding $13 million. These grants support vital coastal planning, education, and habitat restoration efforts.

The Community Grant: Operating Support Grant by the Greater Worcester Community Foundation aims to enhance the vibrancy of Worcester County by funding organizations aligned with focus areas such as Health & Wellbeing, Arts & Creativity, Youth & Families, and Basic Needs. This initiative encourages nonprofits to adopt equitable practices and engage community voices, while offering flexible funding options based on organizational budgets. The grant seeks transformative partnerships that address systemic barriers and foster community-driven solutions.

The Keystone Savings Foundation Grant supports non-profit organizations in the Lehigh Valley, focusing on education, health services, arts, community development, and economic revitalization. Grants of $25,000 or more are reviewed annually, with applications due by August 15. Organizations must be 501(c)(3) compliant and can apply for funding in various categories, but restrictions apply to consecutive funding years. The foundation does not support certain fundraisers or debt reduction efforts.

The Semi-Annual Competitive Grant from the Robert G III and Maude Morgan Cabell Foundation supports capital projects for tax-exempt organizations in Virginia. Established in 1957, the foundation emphasizes strategic grants that inspire community engagement and leverage donor generosity. Eligible nonprofits, particularly in the Richmond area, can apply for matching funds to enhance cultural arts, education, and social services. The foundation's goal is to address philanthropic needs while fostering long-term community development.

The Holle Family Foundation Grant supports nonprofits in central Alabama that address societal needs, promote leadership, and celebrate culture. It aims to empower vulnerable populations, foster youth leadership through service, and enhance community appreciation of art and history. Grants are focused on specific needs such as educational opportunities and physical improvements for nonprofits. The Foundation prioritizes innovative solutions to community challenges and looks for measurable impacts from its funding.

The Glaser Foundation Grants focus on direct services primarily for children and the elderly. They support innovative medical research, programs for children with disabilities, education initiatives, and services for economically disadvantaged seniors. Additionally, they address challenges faced by families from disadvantaged backgrounds and at-risk youth. Organizations must be 501(c)(3) public charities operating in Western Washington, particularly King County, to apply. The foundation prefers direct line services over large capital campaigns.

The Butler Family Foundation Community Grant provides two-year funding to 501(c)(3) organizations in Minnesota focused on arts, environment, and human services. Grants support general operations or specific projects, with minimum awards of $30,000 for operating costs and $20,000 for program support. Priority is given to organizations serving urban areas of St. Paul and Minneapolis, promoting community arts, environmental stewardship, and essential services for vulnerable populations, particularly youth and families.

The Healthy & Thriving Communities Grant aims to enhance health equity and well-being in Broward County by fostering a culture of health for all populations. This initiative addresses social determinants of health such as access to nutritious food and mental health resources, essential for reducing health disparities. It emphasizes community involvement and sustainable practices, promoting better health outcomes through education, environmental sustainability, and health literacy programs, ultimately striving for a resilient and thriving community.

The Denver Foundation's Community Grants Program supports diverse organizations in Metro Denver, focusing on reducing disparities and promoting equity for underserved communities, including those living in poverty, immigrants, and people of color. The foundation prioritizes funding in areas such as economic opportunity, youth well-being, environment, and housing, investing in initiatives that foster a just and vibrant community. For more information, please visit their FAQs.

North Carolina Sea Grant

Under executive director Susan White, North Carolina Sea Grant works with local, state, and national policymakers and scientists to co-produce critical projects in four focus areas: healthy coastal ecosystems, resilient communities and economies, sustainable fisheries and aquaculture, and environmental literacy and workforce development. 

With significant returns on investment for coastal North Carolina, we forge partnerships and support research, education, and outreach. Funding opportunities include grants for established scientists and specialists, fellowships to develop the next generation of researchers and policymakers, and special collaborations that fuse community and academic expertise.

North Carolina Team Competition for Resilience Research

This funding opportunity, supported by North Carolina Sea Grant, provides awards to teams of North Carolina-based graduate and undergraduate students led by a PhD student. Winning teams will conduct hypothesis-based research projects that contribute to more resilient habitats and communities across North Carolina.

Research Focus Areas

Proposals must address at least one core aspect of resilience in North Carolina:

• Ecosystem Resilience
• Community Resilience
• Economic Resilience

The Doheny Foundation Grant Program supports nonprofit organizations in Greater Los Angeles that align with its mission and four focus areas: Social Welfare, Health and Wellness, Education, and Religion. Eligible applicants must be registered 501(c)(3) organizations and can only apply once per year. The Foundation emphasizes initiatives that enhance the lives of vulnerable populations and promote economic self-reliance, while avoiding funding for specific exclusions such as political activities or work outside the U.S.

The Aquatic Stewardship Grant Program, managed by the Ohio Department of Natural Resources, aims to enhance aquatic stewardship through engaging educational experiences. Eligible organizations, including schools and conservation groups, can apply for up to $7,500 per fiscal year for projects that promote hands-on aquatic education. Key criteria include the necessity for educational components in fishing activities and a commitment to inclusivity for all participants.

State Farm's Good Neighbor Citizenship Company Grants aim to enhance community safety, development, and education. Focused on long-term impact, they support initiatives in auto and home safety, disaster preparedness, affordable housing, and educational programs. Eligible recipients include nonprofits, educational institutions, and government entities. However, funding is not available for individuals, religious programs, or organizations outside the U.S. By addressing critical community needs, these grants foster safer and more resilient neighborhoods.

The BHHS Legacy Foundation Grant supports initiatives that improve health and quality of life for vulnerable Arizona residents. Since 2001, the Foundation has focused on four key areas: enhancing healthcare access, improving community health, developing the healthcare workforce, and strengthening community ties. Organizations seeking funding must demonstrate a clear health-related need and comply with eligibility criteria, including nonprofit status. This grant is vital for programs aiming to create sustainable health solutions in Arizona.

World Wildlife Fund

Since our founding in 1961, WWF has been committed to protecting nature and its resources. We understand that nature is our planet’s greatest asset, intrinsically linked to human survival — and that it needs our help. Our work to reverse nature loss and conserve biodiversity has never been more urgent.

As the world’s leading conservation organization—with offices on six continents and in nearly 100 countries—our global reach includes the world’s most critical forests, river systems, wetlands, savannas, and ocean habitats. By conserving these places and supporting sustainable livelihoods within them, we can keep the Earth in balance for people, wildlife, and the planet.

Environmental and Social Impact Grant

WWF’s Russell E Train Education for Nature Program (EFN) invites proposals focused on collaborative capacity building related to (i) environmental and social impacts and risks of development projects on ecosystems and their services and (ii) enhancing inclusive conservation and sustainable development. The Environmental and Social Impact Grant aims to provide competitive financial support to teams and institutions working in Kenya, Tanzania, and Madagascar focusing on enhancing capacities to address environmental and social impact assessment capacity building needs with an emphasis on local communities and local practitioners.

The proposals should target diverse audiences involved in addressing social and environmental issues associated with the execution and management of conservation and development initiatives, particularly with a focus on WWF key goals including climate, food, forests, freshwater, oceans, and wildlife.

Amgen is a leading biotechnology company dedicated to advancing medicine through Independent Medical Education (IME). It funds accredited educational programs that empower healthcare providers to enhance patient care. IME funding supports critical areas such as oncology, bone health, cardiovascular education, and more. Amgen's commitment ensures that these educational activities remain unbiased and compliant with applicable guidelines, fostering innovation and improved health outcomes for patients worldwide.

The IUSCCC Community-Academic Collaborative Program Award invites proposals aimed at addressing cancer burdens in Indiana through evidence-based programs. These initiatives must focus on major cancer types such as lung, breast, and prostate, and include an evaluation component. Community-led projects that engage underserved populations are particularly encouraged. The funding duration is one year, with a budget cap of $15,000. Proposals require prior approval through a Letter of Intent.

The Four County Community Foundation Grant Program supports innovative projects in education, health, and community services across several Michigan counties. Grants are available for non-profit organizations, schools, and governmental agencies to enhance community welfare. Priority is given to projects that address unmet needs and foster collaboration. Notable programs include the Healthy Seniors/Healthy Youth Grants and the 21st Century Education Grants, which aim to improve the lives of local residents.