Best Large Grants for Nonprofit Organizations

The BHHS Legacy Foundation Grant supports initiatives that improve health and quality of life for vulnerable Arizona residents. Since 2001, the Foundation has focused on four key areas: enhancing healthcare access, improving community health, developing the healthcare workforce, and strengthening community ties. Organizations seeking funding must demonstrate a clear health-related need and comply with eligibility criteria, including nonprofit status. This grant is vital for programs aiming to create sustainable health solutions in Arizona.

The IUSCCC Community-Academic Collaborative Program Award invites proposals aimed at addressing cancer burdens in Indiana through evidence-based programs. These initiatives must focus on major cancer types such as lung, breast, and prostate, and include an evaluation component. Community-led projects that engage underserved populations are particularly encouraged. The funding duration is one year, with a budget cap of $15,000. Proposals require prior approval through a Letter of Intent.

The Community Chest Annual Grants provide financial support to nonprofits in New Jersey, focusing on key areas including mental health services, food insecurity, home care, educational enhancement, and racial justice education. Organizations that have been operational for over two years and comply with diversity guidelines are encouraged to apply. Priority will be given to initiatives addressing the needs of vulnerable populations, particularly those impacted by the pandemic. Grants can support a range of programs aimed at fostering community well-being and resilience.

The Community Foundation for Monterey County provides Community Impact Grants to support programs aimed at improving the lives of children, youth, and underserved populations. With an average grant award of $25,000, these grants focus on early childhood education, academic support, and health services. Eligible applicants include 501(c)(3) nonprofits and public agencies in Monterey County. The foundation values innovative, collaborative proposals that demonstrate measurable impact and sustainability.

The City of Muskogee Foundation offers summer grants aimed at enhancing the quality of life in Muskogee through funding for nonprofit organizations, schools, and community projects. Established in 2008, the foundation prioritizes initiatives that promote education, arts, health, and economic development. Grants are awarded based on measurable outcomes and community needs, focusing on job creation, educational empowerment, and health initiatives. This effort fosters collaboration and innovation to create sustainable improvements for residents.

The Trumbull Memorial Health Foundation Grants support innovative health projects in Trumbull County, focusing on mental health, access to care, and community safety. Grants are available to non-profit organizations that directly benefit local residents, with an emphasis on addressing disparities in health outcomes. Eligible applicants include 501(c)3 organizations and government entities, while prioritizing partnerships that align with community health improvement strategies. This rolling application process allows for continuous submissions, ensuring timely funding decisions.

The Four County Community Foundation Grant Program supports innovative projects in education, health, and community services across several Michigan counties. Grants are available for non-profit organizations, schools, and governmental agencies to enhance community welfare. Priority is given to projects that address unmet needs and foster collaboration. Notable programs include the Healthy Seniors/Healthy Youth Grants and the 21st Century Education Grants, which aim to improve the lives of local residents.

The ICCF Community Improvement Grants support projects addressing education, human services, workforce development, and environmental initiatives that benefit Iosco County residents. Eligible organizations include 501(c)(3) non-profits, government entities, schools, and universities. Grants can reach up to $10,000 per cycle, with final reporting required. Notably, projects cannot receive funding for two consecutive cycles and must not promote religious beliefs or support individuals. This program aims to enhance community well-being and sustainability.

The Hope Funds for Cancer Research offers a three-year Postdoctoral Fellowship for innovative research in understanding difficult-to-treat cancers. Candidates with MD, PhD, or equivalent degrees can apply, focusing on novel approaches to cancer mechanisms and treatments. The fellowship provides a stipend starting at $56,000, with annual increases, and a travel grant of $1,500 for conferences. This initiative aims to enhance life expectancy through groundbreaking research in cancer treatment and prevention.

The Appleton-Whittell Research Ranch Fellowship Program supports young scientists conducting research aimed at preserving and enhancing grassland ecosystems in southeastern Arizona. With a focus on conservation, research, and education, the program offers a cash award and housing voucher to facilitate impactful studies on climate change, community engagement, and species conservation. This initiative not only fosters scientific rigor but also encourages a new generation of conservationists dedicated to safeguarding vital ecosystems.

State Farm's Good Neighbor Citizenship Company Grants aim to enhance community safety, development, and education. Focused on long-term impact, they support initiatives in auto and home safety, disaster preparedness, affordable housing, and educational programs. Eligible recipients include nonprofits, educational institutions, and government entities. However, funding is not available for individuals, religious programs, or organizations outside the U.S. By addressing critical community needs, these grants foster safer and more resilient neighborhoods.

The Idaho Environmental Quality Incentives Program (EQIP) offers essential financial and technical assistance to agricultural producers and landowners in Idaho. This voluntary program focuses on implementing conservation practices that enhance natural resources, including soil, water, and air quality. With various initiatives, such as the On-Farm Energy Initiative and Organic Initiative, EQIP addresses specific needs and promotes sustainable agricultural practices. Applications are accepted year-round, ensuring continuous support for conservation efforts.

The Department of Natural Resources’ Watershed and Climate Services Grants Gateway

The Maryland Department of Natural Resources, Watershed & Climate Services (WCS) is committed to providing technical and financial assistance to Maryland’s communities that are challenged by intense storms, changing sea levels and increasing flooding, while balancing growing populations, economic growth, and increased tourism and recreation. These trends make the already challenging task of restoring the Chesapeake Bay, safeguarding people and infrastructure and managing natural resources even more complex.

Grants Gateway provides a resource for partners seeking technical and financial support for projects that foster healthy and resilient ecosystems, communities, and economies. Grants Gateway provides a centralized hub to streamline the grant application process for governments, academic institutions, and non-governmental organizations.

Eligible projects across six programs (as above) will improve water quality, restore local waterways, increase community flood planning, develop the next generation of environmental stewards, improve shorelines, and plan for beneficial reuse.

Chesapeake and Atlantic Coastal Bays Trust Fund (Outcome 1)

There are two tracks including the traditional competitive grant program and the Pay for Performance track.

Pay for Performance Track

In addition to the traditional competitive grant program, the Trust Fund is soliciting pay for performance contracts that provide the following:

• Cost per lb or outcome and cost per unit of implementation that is more cost effective than traditional grant values, as seen in the Trust Fund Table. Maryland DNR may select to not fund proposals as Pay for Performance if found to be less cost effective than traditional grant mechanisms.

• Reduced risk to state as payments commence once the project is installed and verified, with subsequent payments offered once project is verified to be functioning and sustained

• Innovative projects and/or projects of scale: Large scale restoration where implementation units exceed traditional grant acreages; Additionally, the state is interested in supporting holistic projects that maximize co-benefits; Innovative BMPs with a quantifiable reduction in nutrient and/or sediment pollution or increase in co-benefits

• Measurement of goal attainment (%) - Measure of success is more specific than implementation units and must include measurement of hydric soils, plant survivability, canopy cover, plant density or other indicators that measure performance.

• Long-term sustainability of performance measures achieved through expected project lifespan, monitoring, easements/landowner agreements, operation and maintenance and/or adaptive management plans

Pre-Proposal Meetings are required for all Pay for Performance Proposals; site visits are required for stream restoration projects and strongly encouraged for other restoration practices.

The WSFS Foundation Grant aims to support nonprofit organizations focused on enhancing community investment, providing affordable housing, and promoting education and leadership development. The foundation emphasizes initiatives that are innovative and sustainable, fostering diversity and inclusion. Eligible organizations must align with the foundation's vision and demonstrate a commitment to non-discrimination. This grant encourages programs that improve the quality of life and economic well-being within the communities it serves.

The Department of Natural Resources’ Watershed and Climate Services Grants Gateway

The Maryland Department of Natural Resources, Watershed & Climate Services (WCS) is committed to providing technical and financial assistance to Maryland’s communities that are challenged by intense storms, changing sea levels and increasing flooding, while balancing growing populations, economic growth, and increased tourism and recreation. These trends make the already challenging task of restoring the Chesapeake Bay, safeguarding people and infrastructure and managing natural resources even more complex.

Grants Gateway provides a resource for partners seeking technical and financial support for projects that foster healthy and resilient ecosystems, communities, and economies. Grants Gateway provides a centralized hub to streamline the grant application process for governments, academic institutions, and non-governmental organizations.

Eligible projects across six programs (as above) will improve water quality, restore local waterways, increase community flood planning, develop the next generation of environmental stewards, improve shorelines, and plan for beneficial reuse.

Chesapeake and Atlantic Coastal Bays Trust Fund (Outcome 1)

There are two tracks including the traditional competitive grant program and the Pay for Performance track.

Traditional Competitive Grant Program

What kind of projects are supported by the Trust Fund?

Implementation-ready restoration proposals can be submitted under this funding source. Example projects can include, but are not limited to: wetland restoration, afforestation and other tree planting projects, riparian buffer restoration, stormwater best management practices, stream restoration, meadow plantings, and agricultural best management practices.

Projects must address water quality in the Chesapeake Bay or Atlantic Coastal Bays by reducing non-point source pollution, namely nitrogen, phosphorus and sediment. Projects should be cost-effective, located in targeted areas, and be implementation-ready. Competitive projects will be large-scale, multi-partnered efforts with demonstrable water quality benefits. Proposed projects should demonstrate the ability to construct within 12 months of award. Additionally, the state is interested in supporting projects that provide desirable co-benefits (Maryland Code, Natural Resources § 8-2A-04), including:

• The restoration of aquatic resources, such as seagrass beds or oyster reefs;
• Climate resilience;
• Carbon sequestration;
• Creation of wildlife habitat;
• Local employment opportunities;
• The improvement or provision of recreational opportunities; or
• Environmental justice benefits;

Funding is only available for projects located in the Maryland portions of both the Chesapeake Bay Watershed and the Atlantic Coastal Bays. Tree planting projects are eligible for all of Maryland. Public and private lands are eligible. Site visits are required for all stream restoration projects.

The Saint Paul & Minnesota Foundation's Community Solutions Grant Program aims to enhance the quality of life in the East Metro by supporting organizations and initiatives that are shaped by and benefit local residents. Through general operating, project, and capital support, the program prioritizes funding for community and economic development, health and human services, and youth and education initiatives, fostering sustainable growth in Dakota, Ramsey, and Washington counties.

The Altman Foundation Grant invites organizations with 501(c)(3) status in New York City to submit Letters of Inquiry for health-related projects. This funding focuses on improving access to quality healthcare for underserved populations, enhancing the capacity of local service providers, and addressing structural barriers to health equity. New grants are currently limited, and only health-related LOIs will be accepted. Eligible applicants should review specific interests outlined by the Foundation before applying.

The Doheny Foundation Grant Program supports nonprofit organizations in Greater Los Angeles that align with its mission and four focus areas: Social Welfare, Health and Wellness, Education, and Religion. Eligible applicants must be registered 501(c)(3) organizations and can only apply once per year. The Foundation emphasizes initiatives that enhance the lives of vulnerable populations and promote economic self-reliance, while avoiding funding for specific exclusions such as political activities or work outside the U.S.

The Georgia Power Grant supports 501(c)(3) organizations, providing funding to empower local communities in Georgia. Grant requests of up to $25,000 are reviewed on an ongoing basis, while larger requests require board approval. The foundation prioritizes Georgia-based initiatives that enhance the quality of life for residents. Notably, grants are not available for individuals, political campaigns, or organizations that discriminate based on race, gender, or other factors. This commitment reflects over 130 years of community support.

The Sun Club Sustainability Grant, offered by Green Mountain Energy, empowers U.S.-based nonprofits to implement sustainability initiatives. Established in 2002, this grant supports diverse projects, including clean transportation, renewable energy, and resource conservation. Organizations must demonstrate three years of tax-exempt status and a commitment to community impact. Awards range from $50,000 to $400,000, focusing on measurable environmental, social, and financial benefits. Join us in fostering a greener future through innovative solutions and community engagement.

Amgen is a leading biotechnology company dedicated to advancing medicine through Independent Medical Education (IME). It funds accredited educational programs that empower healthcare providers to enhance patient care. IME funding supports critical areas such as oncology, bone health, cardiovascular education, and more. Amgen's commitment ensures that these educational activities remain unbiased and compliant with applicable guidelines, fostering innovation and improved health outcomes for patients worldwide.

The Denver Foundation's Community Grants Program supports diverse organizations in Metro Denver, focusing on reducing disparities and promoting equity for underserved communities, including those living in poverty, immigrants, and people of color. The foundation prioritizes funding in areas such as economic opportunity, youth well-being, environment, and housing, investing in initiatives that foster a just and vibrant community. For more information, please visit their FAQs.

The Charity of the Month Grant Program by Bashas' invites local charitable organizations registered under IRS 501(c)(3) to apply for support. This initiative fosters community involvement through customer donations at checkout, helping various causes and promoting generosity. Bashas' is dedicated to enhancing local charities and encourages participation from eligible organizations to benefit from this unique opportunity. Join us in making a difference in our community.

The Greater Worcester Community Foundation's Community Grant Program provides essential funding for organizations in Worcester County, awarding grants between $2,500 and $25,000. This program supports innovative projects across five focus areas: Arts & Creativity, Basic Needs, Economic Opportunity, Health & Wellbeing, and Youth Development. Organizations must demonstrate community engagement and operational integrity while addressing pressing local needs. This funding opportunity aims to foster collaboration and sustainable development within the region.

The AmeriCorps Formula Grant NE aims to strengthen communities in Nebraska through national service and volunteering. ServeNebraska mobilizes individuals to address critical needs in education, health, and economic opportunity. The 2024 funding initiative prioritizes partnerships that engage AmeriCorps members in evidence-based interventions to tackle local challenges, while emphasizing racial equity and community representation. By investing in diverse organizations, AmeriCorps enhances civic engagement and fosters a culture of service across the nation.

The CD Education Mini-Grants program, funded by the Montana Department of Natural Resources and Conservation, aims to support local conservation districts in their educational efforts. Grants ranging from $1,000 to $5,000 are available for projects that promote conservation education among youth and adults. Eligible projects include workshops, field trips, and resource development, all aimed at fostering a deeper understanding of natural resource management in Montana.

The UWCNM Community Grants aim to support agencies that tackle systemic issues affecting families and children in central New Mexico. By prioritizing education, housing stability, and health, the grants enhance community stability and educational outcomes. Eligible agencies must be 501(c)(3) nonprofits in good standing and demonstrate financial sustainability. The program encourages collaborative efforts and capacity building to foster deeper impact across various sectors, ultimately leading to a stronger, thriving community.