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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

32,000+

Available grants

$8.25B

Total funding

$6K

Median grant

32,000+ grants
$8.25B total
$6K median

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32,423 Results based on applied filters

Keokuk County Community Endowment Foundation: Major Grant

Keokuk County Community Endowment Foundation (KCCEF)
Association/Society
Keokuk County, Iowa
Up to US $25,000

Keokuk County Community Endowment Foundation

The KCCEF was formed in 2005 as an affiliate of the Community Foundation of Greater Des Moines. The founding members of the organization had a vision to ensure that our county’s charitable programs were supported now, and in the future. We work together with many individuals, families, businesses and organizations to establish endowment funds that will provide grant awards for years to come.

What We Offer

The Keokuk County Community Endowment Foundation is here to assist our county’s organizations contribute to the local quality of life, and one of the ways that is done is through grant funding. KCCEF accepts grant applications to enable projects and programs impacting a wide range of needs in the community. In the past, grants have been awarded for projects involving arts and culture, health & human services, community betterment, historic preservation, and more. Proof of non-profit status, or sponsorship by a government entity is required. 

Major Grant

What We Support

The Keokuk County Community Endowment Foundation will provide grants to improve life in Keokuk County, Iowa by supporting projects relating to: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.

Community Development & Revitalization Educational Access & Equity Arts / Culture Access & Participation +4 more

Hope for Addiction Scholarship

Samba Recovery
Corporate
United States
US $1,000

About Samba RecoverySamba Recovery is dedicated to empowering individuals recovering from alcoholism and drug addiction by restoring confidence and fostering resilience. Through a foundation of compassion, support, and holistic care, we guide individuals toward renewed health and wellness, meaningful relationships, and the discovery of their inner strengths—assisting them to achieve their fullest potential.Hope for Addiction ScholarshipSamba Recovery’s Hope for Addiction Scholarship is an annual $1,000 award dedicated to encouraging more young people to join the fight against addiction by pursuing degrees that directly support individuals and families affected by substance use disorders.

We welcome applications from all eligible students, with special encouragement for those who are in recovery themselves or who have been impacted by addiction within their families.Application requirements:

  • Proof of college enrollment or acceptance
  • Pursuing a degree with the goal of working with individuals and/or families impacted by addiction
  • Completed application form
  • An original 500 to 1000 word essay on how you are planning to use your degree to help individuals and families struggling with addiction, and why helping those affected by substance use disorder is important to you
Addiction & Substance Use Disorders Alcoholism

Community Care Centers of Excellence (INFR8)

California Institute for Regenerative Medicine
Association/Society
Amador County, California, Butte County, California +20 more
Up to US $10,054,000

Community Care Centers of Excellence (INFR8) 

The Community Care Centers of Excellence (CCCE) is a funding program by the California Institute for Regenerative Medicine (CIRM) that aims to expand access to innovative clinical trials and regenerative medicine treatments throughout designated counties in Northern California.

CCCEs will enhance patient access to regenerative medicine treatments by:

  • Expanding the geographic reach of centers capable of conducting clinical trials and delivering approved therapies, and
  • Developing a skilled workforce to support the delivery of regenerative medicine treatments and ensure broad accessibility to California patients.

This initiative addresses a key mandate of the California Stem Cell Research, Treatments, and Cures Initiative of 2020 (Proposition 14), emphasizing the importance of providing access to clinical trials and approved therapies resulting from CIRM-funded research.

Award Details

  • Maximum Award Amount $9,000,000
  • Maximum Award Duration Five years
Health Facilities & Clinics Health Disparities & Social Determinants of Health Stem Cell Research & Clinical Use +2 more

Nationwide Insurance Foundation Grant

Nationwide Insurance Foundation
Corporate
Alachua County, Florida, Bexar County, Texas +12 more
Unspecified amount
The Nationwide Insurance Foundation Grant aims to enhance community quality of life by providing support to nonprofits in areas where many Nationwide members reside. Since 2000, the foundation has donated over $700 million to various organizations, focusing on food security, crisis stabilization, economic empowerment, and children's wellbeing. Grants are available for general operating support, project/program support, and capital support, with a commitment to matching associate contributions.
Crisis Intervention Disaster Relief / Humanitarian Aid Basic Human Needs +3 more

CFGV Community Grants

Community Foundation of the Gunnison Valley
Private
Gunnison County, Colorado
Up to US $7,000
The CFGV Community Grants provide essential funding to nonprofit organizations in Gunnison County, supporting both General Operating and specific Project initiatives. Grants, capped at $7,000, aim to enhance community impact, with first-time applicants encouraged to consult staff prior to applying. Eligible 501(c)(3) organizations can apply for funding that supports their operations, while collaborative projects are also welcomed, ensuring that community needs are effectively addressed through targeted financial support.
Art & Culture Community Development & Revitalization Environment +8 more

Economic Vitality Grant

Nebraska Blue Foundation
Corporate
Nebraska
Up to US $10,000

Nebraska Blue Foundation

Empower. Support. Uplift.

Nebraskans serving Nebraskans – It’s who we are and what we have done for more than 85 years at Blue Cross and Blue Shield of Nebraska (BCBSNE).

Our customers and employees have lived, worked and played here for generations, and we’re proud to be part of the Cornhusker State’s history. As a local business, we are also invested in the state’s next chapter because your communities are our communities. We share in the successes and challenges facing our state and are dedicated to helping Nebraskans thrive by serving as a champion for health and well-being.  

The Nebraska Blue Foundation, founded in 2024, powers BCBSNE’s philanthropic initiatives. Through the foundation, we support programs improving the health and well-being of Nebraskans and the economic vitality of our state.

The foundation builds on BCBSNE’s rich legacy of uplifting all who call Nebraska home.

Fall Grant Cycle

Overview

For more than 85 years, Blue Cross and Blue Shield of Nebraska (BCBSNE) has been a champion for the health and well-being of our members and the communities we serve. Founded in 2024, the Nebraska Blue Foundation now allows us to concentrate our efforts into pockets of our community that need to be uplifted the most.

The foundation has four priority areas:

The Nebraska Blue Foundation is particularly interested in supporting innovation and pilot projects. As a new foundation, our approach is to be catalytic with our grants – primarily investing in new ideas or programs that could meet a specific need with a one-time investment.

Economic Services & Development Job Creation Workforce Preparation & Job Readiness +1 more

Walking Classroom Grant Program

Alliance For A Healthier Generation
Private
United States
Unspecified amount in in-kind support
The Walking Classroom Grant Program, offered by the Alliance for a Healthier Generation, enables classroom teachers in public schools to receive donated materials for their students. This innovative program promotes physical activity while maintaining instructional time through engaging podcasts. Ideal for grades 3-8, it enhances cognitive function and retention. Schools with the greatest need, both socioeconomically and academically, are prioritized, ensuring that all students can benefit from this unique educational approach.
Academic Success & Enrichment Education - Middle School Education - Elementary School +2 more

New Jersey Office of Faith Based Initiatives: Special Projects

New Jersey Department of State: Office of Faith Based Initiatives
State/Local Government
New Jersey
Up to US $40,000
The New Jersey Office of Faith Based Initiatives (OFBI) aims to enhance the capacity of faith and community-based organizations to address community issues. The program supports diverse projects including civic engagement, food security, and services for seniors, focusing on innovative approaches to create meaningful change. By fostering partnerships and providing resources, OFBI is committed to improving the quality of life for vulnerable populations and facilitating community-driven solutions.
Senior Services Food Access & Hunger Food Security +2 more

See, Test & Treat Grant - Multiyear Funding

College Of American Pathologists Foundation
Private
United States
Up to US $50,000
The See, Test & Treat Grant offers vital funding for cancer screening and health education programs targeting medically underserved communities. This pathologist-led initiative aims to reduce healthcare barriers, empower preventive care, and connect patients with local resources. Eligible organizations can apply for up to $50,000 over three years, fostering sustainable health improvements. The program emphasizes same-day results for screenings and culturally appropriate education, ensuring equitable access to essential healthcare services.
Reproductive Health Breast Cancer Reproductive Education +1 more

TCEF: Texas Grassroots Mini-Grants

Texas Campaign for the Environment Fund
Private
Texas
Up to US $4,000
The Texas Campaign for the Environment Fund offers mini-grants up to $4,000 to grassroots groups addressing environmental issues, particularly in response to the February Deep Freeze. Applications are open to both formal and informal organizations, with a focus on community involvement and strategic action. Grants will prioritize applicants with annual budgets under $50,000. Evaluation criteria include project need, community participation, and the capacity to implement proposed activities.
Environmental Health Environmental Justice & Advocacy Environmental Stewardship +1 more

The Steven Scott Quinn Scholarship Fund

Stark Community Foundation
Private
United States
More than US $500
The Steven Scott Quinn Scholarship Fund, established by the Stark Community Foundation, aims to support Stark County, Ohio residents pursuing higher education in fields such as culinary arts, hospitality, nursing, nutrition, physical therapy, and occupational therapy. This initiative reflects the Foundation's long-standing commitment to enhancing the community through philanthropy and addressing diverse educational needs since its inception in 1963.
Education - Higher Education Vocational & Trade Education Education - High School +5 more

Nick Van Pernis Scholarship Fund

Hawai'i Community Foundation
Private
Hawaii
Unspecified amount
The Nick Van Pernis Scholarship Fund, established in memory of Nick Van Pernis, supports students from Hawaii's west side pursuing degrees in Marine Science, Biotechnology, Health Sciences, or Early Childhood Education. Eligible applicants must demonstrate financial need, maintain a minimum GPA of 2.0, and engage in community service. Preference is given to prior recipients who continue to meet requirements. This fund aims to empower students to positively impact the lives of Hawaii residents through their chosen careers.
Marine Biology Biotechnology Anatomy +4 more

Helpful Harvest Grant Round

The Community Foundation of Herkimer & Oneida Counties
Private
Herkimer County, New York, Oneida County, New York
Unspecified amount

About The Community Foundation

The Community Foundation of Herkimer and Oneida Counties is a community-based social impact investor whose mission is to engage, invest, and lead—working toward a vision of community vibrancy with opportunity for all. Our team of experienced staff and dedicated trustees is committed to boldly leading and supporting transformational community investments. We channel charitable contributions from donors through nonprofit partners that are meeting current community needs and steward community resources responsibly to ensure greater capacity for the future.

Helpful Harvest Grant Round

The Community Foundation of Herkimer and Oneida Counties will host its Helpful Harvest Grant Round to help Herkimer and Oneida County nonprofits address food insecurity this holiday season. The Community Foundation is seeking applications from human service organizations whose primary operation is a food pantry, soup kitchen or shelter that provides pantry items or meals to residents.

Basic Human Needs Food Delivery & Distribution Services Food Security

AWWA Scholarship Program - Roberts Filter Group – Charles “Chick” Roberts Scholarship

American Water Works Association (AWWA)
Association/Society
Pennsylvania
US $5,000
The AWWA Scholarship Program, specifically the Charles 'Chick' Roberts Scholarship, offers $5,000 to a Pennsylvania student pursuing studies in water technologies. This initiative by the American Water Works Association underscores the importance of nurturing future professionals in the water industry. AWWA, the largest organization for water supply experts, is dedicated to supporting students who aim to make significant contributions to this vital field.
Water Resource Management Academic Scholarship Programs

AWWA Scholarships Program - Mueller Water Products Continuing Education Scholarship

American Water Works Association (AWWA)
Association/Society
North America
US $5,000
The AWWA Scholarships Program, led by the American Water Works Association, aims to support the future of the water industry by investing in students. The Mueller Water Products Continuing Education Scholarship awards $5,000 to an undergraduate student employed by a water utility, emphasizing the importance of practical experience in education. This scholarship not only aids financial needs but also encourages students to pursue careers in water supply, fostering growth in this vital sector.
Water Resource Management Academic Scholarship Programs

AWWA Scholarship Program - Veolia Water Technologies & Solutions Vernon D. Lucy III Scholarship

American Water Works Association (AWWA)
Association/Society
North America
US $5,000
The AWWA Scholarship Program, specifically the Veolia Water Technologies & Solutions Vernon D. Lucy III Scholarship, offers a $5000 award to undergraduate students pursuing careers in the water sector. Established by the American Water Works Association, this scholarship honors the mentorship of Vernon D. Lucy III and aims to support the next generation of water industry professionals. Eligible candidates must demonstrate interest in water-related fields, underscoring AWWA's commitment to fostering future leaders.
Water Resource Management Academic Scholarship Programs

Leonard & Helen R. Stulman Charitable Foundation Grants

Leonard And Helen R Stulman Charitable Foundation Inc
Private
Maryland
Unspecified amount
The Leonard & Helen R. Stulman Charitable Foundation Grants provide funding ranging from $25,000 to $150,000 to support initiatives in mental health, aging, and health care. The foundation prioritizes projects in greater Baltimore and Maryland, focusing on underserved populations and evidence-based practices. Organizations must qualify as public charities and adhere to non-discrimination policies. The foundation does not fund capital projects, K-12 education, scholarships, or conferences.
Mental Health & Psychiatric Diseases Senior Services Aging / Gerontology +3 more

Rural Residency Training Grant Program

Minnesota Department of Health
State/Local Government
Minnesota
Up to US $225,000
The Rural Primary Care Residency Training Grant Program aims to enhance primary care residency training in rural Minnesota. With funding between $1.5 to $2 million, it supports planning, accreditation, and training. Grants of up to $225,000 per resident per year are available for sustainable projects. To qualify, programs must demonstrate ACGME accreditation and provide evidence of resident training. This initiative is vital for strengthening the rural physician workforce and improving healthcare access in underserved areas.
Aging / Gerontology Children’s Health & Pediatrics Mental Health & Psychiatric Diseases +3 more

Southern Lowcountry Grants: Winthrop Family Fund Grant

Coastal Community Foundation of South Carolina
Private
Allendale County, South Carolina, Hampton County, South Carolina
Up to US $5,000
The Winthrop Family Fund Grant, hosted by the Coastal Community Foundation of South Carolina, offers financial support to nonprofit organizations in Allendale and Hampton counties. Applications are accepted through an online portal, with deadlines set for February 1st each year. This grant prioritizes initiatives in education, health, and environmental conservation, empowering local nonprofits to address diverse charitable needs within their communities.
Environmental Conservation Education Health & Medicine +3 more

Illinois Community Canopy: Tree Removal Grant Program

Trees Forever
Private
Illinois
Up to US $25,000 in in-kind support
The Illinois Community Canopy: Tree Removal Grant Program, funded by Trees Forever, aims to assist communities in managing their tree canopies by providing grants for the removal of dead, dying, or damaged trees. This initiative is crucial for safety and environmental health, especially in areas affected by the Emerald Ash Borer and natural disasters. Eligible communities can also apply for tree planting grants to replace the removed trees, fostering a sustainable urban ecosystem.
Forestry Disaster Relief / Humanitarian Aid

Junior Board Grants

Frieda C Fox Family Foundation
Private
Los Angeles County, California, Santa Clara County, California
Up to US $10,000
The Junior Board Grants by the Frieda C. Fox Family Foundation aim to empower nonprofit organizations in Los Angeles County focused on maximizing youth potential. While the grant amounts can reach up to $10,000, priority is given to organizations with a strong operational history and a budget under $10 million. Applications are currently closed, but organizations that meet the criteria are encouraged to reach out for future opportunities.
Youth Services STEM / STEAM Education Youth Development & Leadership +3 more

Jack Buell Forest Education Grant

Idaho Forest Products Commission
State/Local Government
Idaho
Up to US $1,000
The Jack Buell Forest Education Grant, offered by the Idaho Forest Products Commission, aims to enhance forest education for Idaho's youth. Grants up to $1,000 are available for projects encouraging hands-on learning experiences in forests or related facilities. Eligible applicants include teachers and educators working with youth. Applications open on August 1 and close on October 15, with all projects required to be completed by July 31.
Forestry Education - K through 12

FCP Capital Improvement Grants

Foundations Community Partnership
Private
Bucks County, Pennsylvania
Up to US $15,000
The FCP Capital Improvement Grants provide funding up to $10,000 for non-profit organizations in Bucks County, PA, focusing on structural enhancements for facilities serving special needs children and families. The application process includes a Letter of Inquiry and a full application, with deadlines in October and April. Recipients must submit a final report after 12 months, ensuring transparency and accountability. This initiative aims to enhance community resources and support.
Children With Disabilities Children’s Mental Health Family Services +2 more

Partnership in Youth Services Grants (PYS)

Foundations Community Partnership
Private
Bucks County, Pennsylvania
Up to US $5,000
The Partnership in Youth Services Grants (PYS) program provides funding of up to $5,000 to non-profit organizations in Bucks County, PA, that address community issues and improve the lives of children and families. This program prioritizes first-time applicants and those who have not applied in the last five years, ensuring support for organizations dedicated to the behavioral health and human service needs of the community.
Youth Services Family Services Children’s Mental Health +2 more

Graduate Student Water Resources Fellowship Program

Montana Water Center
State/Local Government
Montana
US $5,000
The Montana Water Resources Graduate Student Fellowship Program, managed by the Montana Water Center, offers funding opportunities for graduate students engaged in water resource research. Each year, the program provides 3-6 fellowships of $2500 to support various research-related expenses. Eligible applicants must be current graduate students at a Montana institution. The program particularly encourages indigenous students to apply and explore additional funding through related initiatives.
Water Resource Management Education - Higher Education

Faculty Seed Grant

Montana Water Center
State/Local Government
Montana
Up to US $25,000
The Faculty Seed Grant, offered by the Montana Water Center, aims to foster innovative water-related research among faculty and students within the Montana University System. With a total funding of $50,000, the program invites proposals that focus on critical issues such as climate change and water management. Priority is given to early-career faculty and collaborative projects with USGS. This initiative seeks to enhance knowledge of Montana's water resources and promote student involvement.
Water Resource Management Education - Higher Education

Mechanicsburg Area Foundation Grant

The Foundation for Enhancing Communities
Private
Cumberland County, Pennsylvania
Up to US $12,000
The Mechanicsburg Area Foundation Grant supports nonprofit organizations in Mechanicsburg, PA, focusing on critical areas such as arts, education, and health. With grants up to $12,000, MAF prioritizes projects that demonstrate measurable success and sustainability. Applicants must be 501(c)(3) organizations serving zip codes 17050 and 17055. This grant aims to enhance community quality of life through innovative solutions, making a significant impact on local families and individuals in need.
Health & Medicine Art & Culture Community Development & Revitalization +7 more

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.