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32,000+
Available grants
$8.25B
Total funding
$6K
Median grant
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Middendorf Foundation Environment GrantsThe Middendorf Foundation was founded in 1953 by J. William Jr. and Alice Carter Middendorf to support institutions and projects in their areas of interest within the State of Maryland. Their focus included: education, healthcare, social services, the environment, historic preservation and arts & culture.Since the 1970’s, the Foundation has been aware of emerging environmental issues regarding air and water pollution, loss of wilderness and the extinction of wildlife. Over the decades, the Foundation has supported a broad array of environmental interests. Supporting the urgent need to resolve environmental issues including addressing pollution and the extinction of wildlife.The Foundation prioritizes one-time costs such as capital campaigns for building, equipment, and/or technology with the lifespan of 7+ years.Use of Funds:
All grant funds must be used within one year of receiving the award.
About Patient Advocate Foundation
Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.
Who we are and our impact
Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.
Multiple sclerosis (MS) health equity
Help with healthcare costs for multiple sclerosis (health equity)
This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.
Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code.
About the disease
Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.
About Patient Advocate Foundation
Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.
Who we are and our impact
Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.
Multiple sclerosis (MS)
Help with healthcare costs for Multiple sclerosis (MS)
This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.
About the disease
Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.
About Patient Advocate Foundation
Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.
Who we are and our impact
Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.
Eosinophilic esophagitis
Help with healthcare costs for eosinophilic esophagitis
This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.
About the disease
Eosinophilic Esophagitis (EoE) is a disorder of the esophagus and is increasingly recognized as a major cause of swallowing difficulties in children and adults. It is a chronic disease of the immune system and can be triggered by a food allergy, acid reflux, or an airborne allergy. An allergic trigger causes the immune system to overact which causes many white blood cells, or eosinophils, to collect in the esophagus. This causes the esophagus to become inflamed and not contract properly. The esophagus can also narrow and develop rings or abscesses. This condition can become worse over time.
Boone County Community Foundation
The Boone County Community Foundation was formed in 2005 to coordinate and provide philanthropic support for community betterment projects in Boone County. The foundation is made up of community minded individuals who have the ability to assess community needs, implement asset development, evaluate area grant applications, encourage partnerships and initiate activities to enhance Boone County.
Mission: The Boone County Community Foundation is a charitable foundation created by and for local citizens to improve the quality of life right here in our communities. We are here to help donors make a positive, local impact by offering a variety of giving tools to help people achieve their charitable giving goals and do good work in our communities that lasts forever.
Grants
Each year the foundation makes grant awards to worthwhile projects located in the county that are identified through a community grants application process. Our foundation’s areas of emphasis include: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.
Three types of grants based on grant amount: Simple Grant; Standard Grant and Impact Grant
Impact Grant
$15,001 and up
Tobacco-Related Disease Research Program
A portion of California's tobacco product excise taxes are used to fund research grants. These grants are administered by TRDRP.
As one of three state agencies that work together towards a tobacco-free California, we aim to eliminate commercial tobacco use and tobacco-related diseases and to improve the health and well-being of all Californians. TRDRP works with the California Department of Public Health and Department of Education under the guidance of the Tobacco Education and Research Oversight Committee to ensure collaboration across all sectors of California's tobacco control community.
TRDRP is administered by the Research Grants Program Office (RGPO) at the University of California, Office of the President.
Student Research Award Supplement
Purpose
Student Research Award Supplement (SRAS) are intended to foster undergraduate and master’s student research and allow active research training and mentoring by providing supplemental funding to existing TRDRP awards, in order to bring new workforce into the stated TRDRP research priority areas.
Summary:
Baltimore Community Foundation
Mission: Inspire donors to achieve their charitable goals from generation to generation and to improve the quality of life in the Baltimore region through grantmaking, enlightened civic leadership, and strategic investments.
Kaiser Permanente’s Social Health Impact Fund
Unmet social needs such as lack of food, housing, or transportation are barriers to health and well-being. Addressing these needs is an integral part of quality care. As an integrated health system committed to total health, Kaiser Permanente not only provides excellent medical care and support for mental health and wellness, we are also addressing the social health needs of our members and communities. To help address unmet social needs, Kaiser Permanente, in partnership with Unite Us, has deployed the Mid-Atlantic Community Network – a social service resource locator that integrates clinical and social care and is supported by data integration and partnership with community.
2026 Veterans and Nature Grant
Supporting the health, well-being, and community connection of America's veterans
The National Environmental Education Foundation (NEEF) is pleased to announce grant funding supported by the American Medical Association (AMA) to expand access to nature-based experiences that support the health, well-being, and community connection of America's veterans. AMA has partnered with NEEF to bring an evidence-based health perspective to this effort, underscoring the growing body of research linking time in nature to improved physical and mental health outcomes.
Background
A Pew Research Center survey found that roughly one in four veterans say the transition back to civilian life was at least somewhat difficult. This is especially true for those who return home with stress or trauma. The National Alliance on Mental Illness estimates 11-20% of veterans are believed to experience post-traumatic stress disorder (PTSD) each year.
Nature offers profound restorative benefits for veterans navigating the challenges of post-service life. Time spent outdoors — whether hiking, fishing, camping, or simply sitting among trees — has been shown by numerous studies to reduce symptoms of PTSD, anxiety, and depression, conditions that affect veterans at disproportionately high rates.
Quieting hypervigilance, allowing space for reflection, fostering camaraderie, and reducing isolation are all mental and physical benefits that be found through outdoor recreation. Using America’s public lands to do so provides a powerful and accessible path forward.
Overview
Through the 2026 Veterans and Nature grant, NEEF aims to expand access to nature-based experiences that support veteran health, well-being, and community connection by
The grant will provide up to $10,000 per grantee for projects on federal, state, local, or nonprofit public lands that address physical and mental health in veteran communities.
Examples of project types include outdoor activities, such as hiking, biking, climbing, or fishing; wellness activities, such as forest bathing or meditation; environmental education, such as community science; adaptive programming; and conservation volunteering. Projects are not limited to those listed here.
Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.
Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.
How common are grants in this category?
Quite common — grants in this category are more prevalent than in others.
Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?
Most grants are due in the first quarter.
What's the typical grant amount funded for Large Grants for Nonprofit Organizations?
Grants are most commonly $34,887.
Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.
Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.
Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.
Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.
Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.
To improve the chances of receiving large grants, nonprofits should:
Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.
Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.