Best Large Grants for Nonprofit Organizations

The New Jersey Department of Health is offering the Rural Health Transformation Grant to enhance chronic disease outcomes in rural communities. This funding opportunity focuses on innovative, sustainable strategies to increase healthcare access, address disparities, and strengthen health systems. Proposed activities include youth violence prevention, education, and community outreach, emphasizing collaboration with local organizations. The grant aims to empower communities by promoting health equity and improving overall health outcomes for residents in underserved areas.

The Sidney R. Baer, Jr. Foundation offers Reintegration Grants aimed at supporting individuals with schizophrenia and bipolar disorder. By focusing on abilities rather than symptoms, the foundation promotes recovery through various programs. Their funding helps organizations that maintain a commitment to mental health, ensuring that recipients receive necessary support, such as scholarships and facility management, to enhance their quality of life. The foundation believes in empowering individuals to actively participate in their recovery journey.

The MD Animal Waste Technology Grants, established by the Maryland Department of Agriculture, support innovative technologies for managing animal waste. These grants aim to reduce nutrient runoff into local waterways and promote sustainable farming practices. By funding projects that transform waste into valuable products or energy, the program not only aids farmers in meeting environmental goals but also enhances their economic viability. This initiative is part of Maryland's commitment to restoring the Chesapeake Bay's health by 2025.

New York State Energy Research and Development Authority

The New York State Energy Research and Development Authority (NYSERDA) offers objective information and analysis, innovative programs, technical expertise, and support to help New Yorkers increase energy efficiency, save money, use renewable energy, and reduce reliance on fossil fuels. A public benefit corporation, NYSERDA has been advancing energy solutions and working to protect the environment since 1975.

Advanced Buildings Program

Buildings require a lot of energy to heat or cool spaces, circulate air, and operate lighting. Currently, about 80 percent of buildings across the State were constructed before energy codes emerged in the 1970s and utilize the burning of fossil fuels for space heating and hot water. Laboratories, startups, and established companies are working on innovative business models and technology to enable building electrification, lowering buildings’ emissions and energy use, or intelligent energy management but they need help getting their innovations to market. 

The current funding opportunity from the End Use Energy Innovation program is focused on accelerating commercialization of innovative buildings solutions through large demonstrations to enable electrification and decarbonization of buildings.

Enabling Innovative Clean Energy Building Solutions Funding Opportunity

The approximately 8 million buildings in NYS are responsible for 60% of the State’s energy consumption, and 32% of the State’s greenhouse gas emissions. Reducing emissions from these buildings will help New York reach its aggressive Climate Act goals.

To tackle emissions from buildings, NYSERDA’s End Use Energy Innovation program has released the Enabling Innovative Clean Energy Building Solutions funding opportunity to help develop energy-efficient building technologies and new business models for New York’s buildings.

How It Works

NYSERDA is requesting proposals for, and anticipates making five $1 million awards under this solicitation, to support the advancement of solutions in these five Topic Areas:

• Building Envelope
• Clean Heating and Cooling
• Intelligent Grid-interactive Building Controls
• Low-GWP Refrigerant Applications and Leak Detection
• Thermal Storage

The Joseph & Vera Long Foundation offers grants targeted at non-profit organizations in Northern California and Hawaii. With larger grants ranging from $60,000 to $150,000 in the Spring and smaller grants from $10,000 to $40,000 in the Fall, the foundation focuses on supporting community-driven initiatives. Eligible organizations must be 501(c)(3) compliant and align with the foundation's priorities, which include environmental conservation, youth development, maternal health, and healthy aging.

The Luther T. McCauley Charitable Trust Grant supports nonprofit organizations that assist the economically disadvantaged, socially marginalized, and those with mental or physical disabilities in El Paso County, Colorado. With a focus on civic activities, community development, education, health research, and social services, the trust aims to enhance the quality of life for these populations. Organizations must meet 501(c)(3) criteria and can apply once a year, with an emphasis on youth support initiatives.

About Us

Making a Difference, Together

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Life Needs Support

Life Needs Support provides need-based financial assistance to students and young adults from the Greater Milan area who face barriers that may prevent them from completing a degree or skilled trades training program. 

Requests are reviewed on a case-by-case basis. We recognize that unexpected hardships can disrupt educational progress, including expenses related to books and supplies, medical care, transportation, childcare, trade tools.

Applications are evaluated two times each year for awarding in the six months after application and selection.

The Mayo Clinic Community Contributions Program in Rochester provides funding to support initiatives aligned with their mission of advancing patient care, education, and community well-being. Eligible organizations include registered 501(c)(3) entities in Olmsted County, Minnesota. The program supports a variety of causes, such as human services, education, youth enrichment, and diversity. Funding is limited to no more than 20% of an organization's budget, and requests can be made once per calendar year.

The Gould Charitable Foundation Grant supports 501(c)(3) organizations in Boston and Kansas City. The foundation prioritizes innovative projects that can make a significant impact, particularly those with high leveraging potential and long-term benefits. Areas of interest include elder services, environmental stewardship, health care, personal rights, disadvantaged training, children's welfare, and women's issues. Applications are accepted year-round, with a focus on projects that offer valuable community enhancements.

The Citi Foundation's Global Innovation Challenge invites proposals from community organizations worldwide developing innovative employment solutions for low-income youth aged 15 to 24. This initiative aims to enhance youth employability, addressing global unemployment challenges faced by millions. Eligible organizations can apply for funding to support programs such as vocational training, entrepreneurship, and financial education to empower young people. The deadline for application registration is March 4, 2025, at 12 p.m. Eastern Time.

About Us

The mission of the Ohio Developmental Disabilities Council (Ohio DD Council) is to create change that improves independence, productivity and inclusion for people with developmental disabilities and their families in community life. The Ohio DD Council operates under the authority of the federal Developmental Disabilities Assistance and Bill of Rights Act of 2000 (DD Act) and is a part of the Ohio DD Network. The Ohio Department of Developmental Disabilities assists and supports the Ohio DD Council as the federally mandated designated state agency.

All In Play: Empowering Inclusive Sports in K-12 Schools

This grant will support the development and expansion of inclusive K–12 athletic programs that increase access to meaningful participation for students with intellectual and developmental disabilities (I/DD), including those with significant support needs. The goal is to build school and community capacity, not to deliver direct services.

Grantees will implement a train‑the‑trainer model that equips school staff, coaches, and university partners with practical strategies for inclusive sports program design, adaptive coaching, and peer‑to‑peer engagement. Projects must include approaches that prepare trainers to support students across the full spectrum of abilities and to train student peers in disability awareness, communication, and inclusive teamwork.

Funded activities may include developing training materials, delivering trainer sessions, providing technical assistance to schools, building partnerships with university PT/OT programs, and collecting best practices. Projects should emphasize sustainability, replication, and long‑term systems change.

Applicants should demonstrate the ability to:

• Build capacity within schools to design and sustain inclusive athletic programs.
• Train educators, coaches, and university partners to support students with all levels of disability.
• Incorporate structured peer‑engagement models (e.g., buddy systems, mentorship).
• Provide technical assistance that helps schools implement inclusive practices effectively.
• Evaluate training effectiveness and share outcomes.

This grant aligns with ODDC priorities by promoting community inclusion, strengthening local capacity, supporting cross‑disability participation, and fostering collaborative partnerships that lead to lasting systemic change.

The Iredell County Community Foundation Grant Cycle aims to enhance the community by supporting local initiatives in areas such as education, human services, and workforce development. The foundation prioritizes one-time funding for projects that demonstrate collaboration and sustainability. Eligible applicants include 501(c)(3) nonprofits and institutions serving Iredell County residents. Ineligible projects include capital campaigns and direct support for individuals. This grant fosters community growth and engagement through philanthropy.

The Weatherization Assistance Program (WAP) by the U.S. Department of Energy provides essential services to improve energy efficiency in homes, particularly for low-income households. Eligible participants include those below 200% of the poverty level, renters, and homeowners. The application process involves determining eligibility, identifying local providers, and submitting necessary documentation. By helping families save on energy costs and enhancing comfort, WAP plays a crucial role in supporting vulnerable communities.

The ESVCF Community Grants Program supports capital projects and ongoing programs that positively impact residents of the Eastern Shore of Virginia. Grants of up to $50,000 are available for initiatives in areas such as arts, education, health, and community welfare. Eligible applicants must be 501(c)(3) organizations that directly benefit local communities, with a focus on sustainable outcomes and collaboration. Priority is given to projects that demonstrate significant community benefits and innovative solutions.

The AAO-HNSF Bobby R. Alford Endowed Research Grant offers $30,000 for one year to support innovative research in otolaryngology. This grant aims to facilitate the career development of young investigators and promote research that may lead to significant advancements in understanding diseases of the head and neck. Eligible projects should have direct clinical significance for patients and can include basic, translational, and clinical research.

The Ferguson Cares Grant is an essential aspect of Ferguson's Sustainability strategy, focusing on social challenges and community wellbeing. This grant supports nonprofit organizations in the U.S. dedicated to affordable housing, skilled trades workforce development, clean water access, and enhancing local economic quality of life. Ferguson aims to create lasting partnerships that drive positive impact within their operational regions, reflecting their commitment to social responsibility and community support.

The Beaufort-Hyde Community Foundation Grant, established in 2001, is an initiative of the North Carolina Community Foundation aimed at enhancing community life in Beaufort and Hyde counties. It provides annual grants to local nonprofit organizations that address community needs. Eligible applicants include 501(c)(3) organizations, local governments, and faith-based entities for social outreach, while ensuring no discrimination in services. The foundation fosters economic access and supports initiatives that promote community welfare.

About GCAC

The Greater Columbus Arts Council supports artists and arts organizations through a spectrum of grant programs, workshops, networking events and services. GCAC also shares a host of resources such as calls for artists, job opportunities, nonprofit board openings and listings of spaces for rent. Subscribe to our newsletters to stay up-to-date on GCAC grant deadlines, workshops and events.

Legal Grant & Lawyer Referral Program

GCAC recognizes that artists confront a range of legal matters critical to their career sustainability and the protection of their creative works. In 2026, GCAC is offering a grant to assist with some legal expenses related to an artist’s art practice and art business. In addition, GCAC established a Lawyer Referral Service with attorneys who guarantee to provide our legal program grantees a flat fee of $300 per eligible legal service.

Purpose:

Assist artists with protecting their artwork and art business.

This Grant is open to:

Individuals who work in the following disciplines: dance, fashion, film, literary, music, theater, visual and multidisciplinary arts who meet GCAC’s definition of a working artist.

Award Amount:

$300 to pay an attorney for eligible services

The Andrew McMorris Foundation offers Fine Arts Grants to honor the vibrant spirit of Andrew McMorris, a multi-talented artist and aspiring pilot. These grants aim to support K–12 students who embody creativity, passion, and enthusiasm for the arts. By providing financial assistance, the Foundation encourages young artists to explore their talents and pursue their dreams, fostering a community that celebrates kindness, adventure, and artistic expression, just as Andrew did.

The TCA Texas Arts Respond Project Grant, offered by the Texas Commission on the Arts, supports innovative arts projects that enhance education, health, economic development, public safety, and environmental awareness in Texas. Eligible applicants include various arts organizations and institutions that comply with specific regulations. This competitive grant program aims to foster creativity and community engagement, ultimately contributing to the state's cultural and economic vitality.

The Illinois Climate Pollution Reduction Grant's Community Geothermal Planning and Pilots Phase One Grants aim to accelerate the deployment of community-scale geothermal energy systems. The initiative focuses on reducing carbon pollution by over 15,000 metric tons by 2030 and serving 1,100 households. With funding for planning and design of projects, this program seeks to create replicable and cost-effective geothermal solutions that contribute to significant greenhouse gas reductions, fostering sustainable energy practices in Illinois.

The Antone & Edene Vidinha Charitable Trust Grant supports 501(c)(3) organizations on Kauai, focusing on churches, hospitals, health organizations, and educational scholarships for Kauai students. This trust aims to enhance the lives of residents through various capital projects and tuition aid programs. Grants are not awarded to individuals or for ongoing maintenance projects, ensuring funds directly benefit the community.

The Archdiocese of Milwaukee Catholic Community Foundation is offering the Fall Education, Lay Leadership, and Community Grant Cycle, aimed at supporting Catholic education and community initiatives. Grants are available for organizations that align with the Foundation's focus areas, including education, leadership development, and community-building. Eligible organizations must be listed in the Official Catholic Directory or have a mission consistent with the church. Note that multi-year grants are rarely funded.

City of Boston Racial Justice Initiatives

The City aims to make sure all of us have access and support to thrive from childhood to retirement. We're focused on community impact, comprehensive policy advocacy, and systemic inequities.

Program Description 

This program seeks to build a solid foundation increasing participation in civil life for all residents, recognizing that historically underserved populations disproportionately face barriers to exercising their rights, whether at the ballot box, in housing, in accessing government services in their own language, or in navigating systems not designed with their needs in mind. 

This grant funds community organizations to build residents' knowledge of their civil rights and connect them to existing City, state, and federal resources, closing the awareness gap that leaves many residents unaware of protections and services that already exist. This grant funds education, outreach, and/or referral, not direct service delivery. Since City and State departments already provide fair housing enforcement, language access services, disability accommodations, or election administration, funded organizations will build awareness of and connect residents to those existing resources, rather than duplicating them, closing the gap between residents and the protections and services already available to them.

Funded program activities include:

Organizations may propose programming in one or more of the following eligible areas, based on their expertise and the needs of the communities they serve. Programming is not required to address every area, but proposed activities must fall under at least one eligible area.

• Civil Rights Education & Navigation: Know Your Rights workshops; referrals to and distribution of appropriate City, state, and federal civil rights resources and publicly available information, including printed and digital materials, without providing individualized legal advice or representation or creating new materials; and youth engagement programming, community forums, and leadership-development sessions.
• Voting Rights & Civic Access: Nonpartisan voter registration and education in low-turnout precincts, using existing City and state-approved voter information and multilingual materials.
• Fair Housing & Anti-Discrimination: Education regarding fair housing protections, discrimination, available resources, and pathways for reporting to the appropriate City and state agencies.
• Language Access: Community education regarding residents' ability to access government information, programs, and services in languages other than English, and connection to existing City and state language access resources.
• Disability Rights & Accessibility: Education regarding accessibility protections, reasonable accommodations, and accessible government programs and services, and connection to existing City and state disability resources.

The Brownfield Cleanup Program in New York aims to facilitate the cleanup and redevelopment of brownfield sites, thereby revitalizing economically distressed communities. By providing tax incentives and removing barriers, the program encourages private-sector investment in urban areas. Eligible properties are those with contaminants exceeding safety standards. However, sites classified as hazardous waste or under enforcement actions are ineligible. This initiative represents a significant step towards sustainable urban development.

The Sunburst Community Foundation Grant supports charitable projects that enhance the quality of life in the Sunburst area. Eligible applicants include 501(c)(3) organizations, governmental units, or those with a fiscal sponsor. Projects can focus on humanities, social services, public safety, or civic improvements. Preference is given to those with matching funds, ensuring a stronger impact on community development. This grant aims to empower local initiatives and foster lasting community legacies.

The Tom and Helen Tonkin Foundation Grant supports charitable, educational, and religious organizations that benefit the youth of Wyoming, particularly those in Casper facing challenges due to illness, injury, or poverty. Annually, the foundation awards 5 to 15 grants ranging from $2,000 to $50,000, with a preference for local organizations. This initiative aims to empower young individuals aged 6-21 by providing essential resources and support.