Best Large Grants for Nonprofit Organizations

The Wild Animal Initiative offers Seed Grants to support innovative projects in wild animal welfare research. These grants aim to facilitate early-career researchers and established scientists in testing new techniques and approaches that incorporate welfare assessments into ecological studies. The program emphasizes cost-effective solutions, focusing on improving the welfare of wild animals. Successful proposals will explore diverse themes such as wild fish welfare and near-term welfare interventions to address urgent animal welfare challenges.

The Farm and Ranch Solid Waste Clean Up and Abatement Grant Program, administered by CalRecycle, offers up to $1 million annually for cleaning illegal solid waste sites on agricultural properties. Eligible sites must be zoned for agriculture and demonstrate a need for cleanup to address public health or environmental threats. Applications must include an EPPP Policy by the specified deadlines to ensure compliance with environmental standards.

The Community Planning and Capacity Building Grants, offered by the California Air Resources Board, provide up to $500,000 to assist communities in planning for equitable transportation solutions. These grants focus on early-stage planning, outreach, and workforce development, particularly benefiting Tribal governments, rural communities, schools, and first-time applicants. This funding aims to promote clean transportation initiatives and enhance local readiness.

The Sally Hughes Church Foundation Grant supports non-profit organizations in the Salinas Valley focused on youth development. Grants are awarded annually, typically in September, to organizations that demonstrate a commitment to improving youth well-being, cultural enrichment, and family support. While unsolicited applications are not accepted, interested organizations are encouraged to keep the Foundation informed about their initiatives through regular communications.

National Coastal Wetlands Conservation Grants

The National Coastal Wetlands Conservation Grants Program annually provides grants of up to $1 million to coastal and Great Lakes states, as well as U.S. territories to protect, restore and enhance coastal wetland ecosystems and associated uplands. The Program is funded by revenues collected from excise taxes on sport fishing equipment, electric motors and sonar, import duties on fishing tackle, yachts and pleasure craft, a portion of the gasoline tax attributable to motorboats and small engines, and interest on the fund, under the authority of the Dingell-Johnson Sport Fish Restoration Act of 1950.

Eligible projects include the acquisition of real property interest in coastal lands or waters and the restoration, enhancement, or management of coastal wetlands ecosystems.

OWEB Coastal Wetlands Grants

The U.S. Fish and Wildlife Service (USFWS) National Coastal Wetlands Conservation Grant Program (NCWCGP) was established to acquire, restore, and enhance wetlands in coastal states through competitive matching grants to state agencies. The primary goal of the NCWCGP is the long‐term conservation of coastal wetland ecosystems. Only legislatively approved state agencies may submit applications to the NCWCGP. Since 2013, OWEB has been an approved agency. OWEB serves as the official grantee of the federal award and makes the federal funds available to local conservation and restoration partners through sub-grants. All sub-grants are subject to the Rules and guidelines of OWEB’s grant programs.

Eligible Projects

All projects must ensure long-term conservation.

Eligible projects under the NCWCGP include:

• Acquisition of a real property interest (permanent conservation easement or fee title) in coastal lands or coastal wetlands ecosystems from willing sellers, and/or
• Restoration, enhancement, or management of coastal wetlands ecosystems.

Restoration Grants

OWEB issues a solicitation for Coastal Wetlands Restoration Grant applications in the spring of each year.

The Uplift Grants - Chamber Music Grant, offered by the Community Foundation of Northeast Iowa, supports classical chamber music performances in Black Hawk County. Eligible organizations can apply for grants ranging from $5,000 to $7,390 to enhance cultural programming. The foundation prioritizes projects that demonstrate charitable impact in the community. This initiative aims to foster artistic expression and enrich the local arts scene, benefiting residents through quality musical experiences.

The Trail Accelerator Grants aim to enhance mountain bike trail communities by providing essential planning and design services. With funding between $10,000 to $30,000, these grants support local organizations in creating sustainable trail systems. The initiative encourages projects that increase access and promote community engagement, particularly focusing on diversity and inclusion. Applicants must demonstrate the capacity to match funds, ensuring collaborative efforts to improve trail networks and experiences for all riders.

This funding opportunity aims to support Early Stage Investigators (ESIs) in conducting preclinical HIV/AIDS research using Nonhuman Primate (NHP) models. Eligible applicants must have at least two years of postdoctoral experience and be within ten years of their terminal degree. The initiative aligns with the NIH Strategic Plan for HIV and HIV-Related Research, targeting the reduction of HIV incidence, development of therapies, and advancement in research areas related to HIV.

The Conservation Partners Legacy Grant Program, managed by the Minnesota Department of Natural Resources, offers competitive grants ranging from $5,000 to $500,000 for projects that restore, protect, or enhance vital habitats like prairies and wetlands. Applicants must provide a 10% match of non-state funds and the total project cost cannot exceed $1,000,000. Focused on habitat benefits, the program emphasizes conservation easements and public ownership for funded projects.

The Building Community Power Fund, launched by HealthSpark Foundation, aims to empower nonprofit organizations in Montgomery County, PA, by enhancing their advocacy efforts. With a budget of approximately $140,000 for 2025, the fund will support initiatives that foster civic engagement, social equity, and community empowerment. Grants of up to $20,000 will be available to help organizations integrate advocacy into their missions, ensuring they can effectively address community needs and influence policies that impact health and well-being.

The Bank of America Charitable Foundation focuses on improving economic mobility and social progress through partnerships with nonprofits. It prioritizes basic needs, income creation, stable housing, and community empowerment. By supporting vulnerable populations, the foundation aims to enable individuals to achieve their goals and contribute positively to their communities. The foundation emphasizes sustainable progress, ensuring that all community members have access to essential resources and opportunities for growth.

The Mishler Brown Fund Grant, managed by the Community Foundation of Elkhart County, supports nonprofits dedicated to agriculture and historic preservation. Applications are accepted annually from October 1 to December 31, with funds awarded in January. Organizations must have a 501(c)(3) status but do not need to be located in Elkhart County. The fund honors Helen Mishler's legacy by preserving farming heritage, including her family's historic homestead.

The ASTRO-LUNGevity Residents/Fellows in Radiation Oncology Seed Grant aims to enhance the research careers of residents and fellows focused on radiation oncology, specifically benefiting lung cancer patients. This initiative supports basic, translational, and clinical research endeavors. With a maximum award amount of $50,000 for one year, it provides essential funding to foster innovative projects that can lead to significant advancements in lung cancer treatment.

The OK Southern Pine Beetle Prevention Cost-Share Grant Program aims to assist landowners in eastern Oklahoma in managing their pine forests, particularly those at risk from the Southern Pine Beetle (SPB). The program provides financial support for practices that promote healthy forest conditions and reduce infestation risks. Priority is given to landowners in LeFlore, McCurtain, and Pushmataha counties, but funding is also available for high-risk stands outside these areas, ensuring comprehensive protection against SPB threats.

NC 21st Century Community Learning Centers (CCLC) Program

Purpose of Program

The 21st CCLC program is authorized under Title IV, Part B of the Elementary and Secondary Education Act (ESEA). The program provides before and after-school, weekend, and summer school academic enrichment opportunities for children attending low-performing schools to help them meet local and state academic standards in subjects such as reading, mathematics, and science. In addition, programs may provide activities for youth development, drug and violence prevention, art, music, technology, character education, counseling, and recreation to enhance the program's academic components. The program also supports a component for family literacy and community outreach.

Overview

The 21 st Century Community Learning Centers (CCLC) Program is authorized under Title IV, Part B, of the Elementary and Secondary Education Act (ESEA) of 1965 as amended by the Every Student Succeeds Act (ESSA) of 2015. The purpose of the 21st CCLC program is to provide federal funds to establish or expand community learning centers that operate during out-of-school hours with three specific purposes:

• Provide opportunities for academic enrichment, including providing tutorial services to help students (particularly students in high poverty areas and those who attend low-performing schools) meet state and local student performance standards in core academic subjects such as reading and mathematics.
• Offer students a broad array of additional services, programs, and activities, such as: youth development activities; service learning; nutrition and health education; drug and violence prevention programs; counseling programs; arts, music, physical fitness and wellness programs; technology education programs; financial literacy programs; environmental literacy programs; mathematics, science, career and technical programs; internship or apprenticeship programs; and other ties to an in-demand industry sector or occupation for high school students that are designed to reinforce and complement the regular academic program of participating students.
• Offer families of students served by 21 st CCLCs opportunities for active and meaningful engagement in their children’s education, including opportunities for literacy and related educational development.

The competitive grant opportunity will be processed through the CCIP system. Grant amounts will range from $50,000 to $500,000 depending on 1) needs identified in the community and schools; 2) scope of the program; 3) proposed number of students served; and 4) program design. Depending on funding availability, grant awards may continue for up to three years (through Summer 2027).

The Detlev and Mary Ellen Preissler Fund for the Arts, Music, Design, and Nature supports arts education in Jefferson, Berkeley, and Morgan County. Grants from $1,000 to $10,000 are available for 501(c)(3) nonprofits and public schools that focus on inspiring children through art, music, design, and nature. Eligible applicants are encouraged to propose specific programs that enhance children's learning experiences, particularly those integrating nature into their curriculum.

The Minister’s Special Licence Resident Draw Grants support conservation projects that enhance wildlife and their habitats in Alberta. Funded by Alberta hunters and anglers, these grants have raised millions since 1995. Eligible applicants include individuals and organizations committed to wildlife health and habitat enhancement, with no maximum funding limit. Notably, projects must occur within Alberta, ensuring local impact. This initiative promotes responsible hunting education and fosters community involvement in conservation efforts.

The WHEDA Housing Grant Program, established by the WHEDA Foundation in 1983, supports organizations improving housing for individuals with complex needs in Wisconsin. The Foundation aims to enhance housing opportunities for vulnerable populations, including those with disabilities and experiencing homelessness. With $2,000,000 in grants, the program focuses on developing housing facilities that address crises faced by residents. Eligible applicants include nonprofits, local governments, and community development authorities.

The RRGL Emergency Grant provides crucial funding for urgent projects in Montana that threaten the management of renewable resources. With a budget of $300,000, grants up to $30,000 are available for projects that cannot wait for legislative approval. Eligible entities include state and local governments, while funds can cover various water-related emergencies. This program supports conservation efforts and ensures the sustainable use of water resources, promoting the economic and social well-being of Montana's citizens.

The Betty Scalice Foundation Grant supports music programs in San Diego County, particularly in North County. It encourages applications from nonprofit and school-based initiatives that offer music education, community concerts, and affordable musical instruments. Eligible organizations must be 501(c)3 charities or fiscally sponsored entities. The foundation prioritizes projects that promote music appreciation while excluding those that focus on chamber music, training musicians, and other specific activities. This grant aims to enhance community engagement through music.

The Amy Ellen Polk Memorial Scholarship, offered by the American Association of Birth Centers Foundation, supports individuals developing freestanding birth centers. This scholarship honors Amy Ellen Polk, a passionate advocate for birthing centers. Recipients receive tuition for the 'How to Start a Birth Center Workshop' and an additional $500 for travel if attending in person. Eligible applicants must demonstrate financial need and cannot have attended the workshop in the last three years.

The GCI Suicide Prevention Grant, offered by The Alaska Community Foundation in partnership with GCI, aims to reduce suicide rates in Alaska by supporting projects that promote mental wellness and community connections. Eligible organizations include 501(c)(3) nonprofits, tribal entities, and schools. The grant prioritizes initiatives that address generational trauma, veteran connectedness, and youth engagement, particularly in rural areas. Funding will enhance community support systems and encourage sustainable programs.

Incyte Corporation offers charitable contributions to organizations aligned with its mission to improve the lives of patients with cancer and other diseases. Eligible entities include medical schools, associations, not-for-profits, advocacy groups, and hospitals. Requests should focus on healthcare and comply with relevant guidelines. Organizations must enter a written agreement to receive funding, and requests should be submitted at least 60 days prior to the decision deadline.

The Workforce Innovation Opportunity Act (WIOA) Youth Funding aims to support marginalized youth aged 18-24 facing barriers to education, training, and employment. Managed by the Office of Workforce Development in collaboration with local organizations, this grant provides funding for up to three years to create a coordinated system that helps youth transition into career-oriented opportunities. Key focus areas include evidence-based policies, partnerships, and access to essential services to ensure successful outcomes for participants.

The Fund for Lake Michigan Grant supports initiatives aimed at enhancing the health of Lake Michigan through projects that yield both immediate and long-term benefits. Eligible applicants include non-profits, government agencies, and educational institutions focusing on water quality improvement. Grants range from $700,000 to $900,000 quarterly, with priorities on projects that directly impact water quality and promote sustainable practices. This grant fosters economic growth while ensuring the preservation of vital water resources.