Best Large Grants for Nonprofit Organizations

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

The J. Warren & Lois McClure Foundation provides invitation-only grants aimed at enhancing postsecondary education opportunities for young Vermonters. By prioritizing equity and systemic change, the foundation supports initiatives that make education more accessible and affordable. Grants range from $10,000 to over $100,000, focusing on scaling Vermont's Free Degree Promise and diversifying the public educator workforce. Organizations serving Vermont's communities are encouraged to apply for funding aligned with these goals.

Notice of Funds Available (RFP): Ohio Developmental Disabilities Council

DSP Workforce Expansion in Excellence Grant

(F) providing training or technical assistance for professionals (including individuals providing education and rehabilitation services), employers, or other individuals who provide services to, employ, or are otherwise substantially involved in the major life functions of, an individual with developmental disabilities.

Independence: People with I/DD will have tools and skills needed to lead self-determined lives.

By expanding pipelines into the DSP field and transportation options annually, people with I/IDD will have valuable support to live the life they want.

• Create new, and expand existing, pipelines into the field of I/DD.
• Development of methods to increase the number and training of DSPs.
• Determine methods to increase the retention of DSPs

The Patricia Kind Family Foundation Grant supports organizations in Philadelphia tackling poverty-related challenges. With a focus on health care, education, and human services, the foundation awards grants typically ranging from $10,000 to $25,000 annually for one to three years. It prioritizes smaller organizations with budgets under $1 million and encourages applications for multi-year general operating support. Site visits are conducted to assess programs in action, ensuring effective and impactful funding.

The Fayette County Community Foundation, part of the Community Foundation of Northeast Iowa, is dedicated to enhancing the welfare of Fayette County residents. It supports diverse initiatives including arts, education, health, and community betterment. Grants prioritize projects that address critical needs, foster collaboration, and promise sustainable benefits. Eligible applicants must be 501(c)(3) nonprofits or government entities, with a focus on charitable projects that uplift the community. Funding is not available for operational costs or religious activities.

The Mortenson Family Foundation is dedicated to expanding opportunities for children and families living in poverty by promoting equitable access to education, social development, and mental health resources. By partnering with nonprofit organizations and public schools, the foundation aims to empower communities through culturally relevant learning practices and strong engagement with families. Their focus on racial equity and sustained support for children from prenatal to 18 years ensures a holistic approach to overcoming the barriers faced by underserved populations.

INDOT Mission

Together, we plan, deliver, and maintain a safe, efficient, and innovative transportation system that:

• Enhances the daily lives of Hoosiers.
• Strengthens Indiana’s economy
• Embraces evolving transportation needs.

Enhanced Mobility of Seniors & Individuals with Disabilities

The Federal Section 5310 grant program is intended to enhance mobility for seniors and persons with disabilities by providing funds for programs to serve the special needs of transit-dependent populations beyond traditional public transportation services.

INDOT does not provide funding to areas over 200,000 population (Lake/Porter counties, South Bend, Fort Wayne, Evansville, Indianapolis, Clark/Floyd counties) should contact their local Metropolitan Planning Organization (MPO). A list of these MPOs can be found at http://www.indianampo.com/inmpo_regions.html

Eligible Activities

Specialized transportation projects planned, designed, and carried out to meet the special needs of seniors and individuals with disabilities when public transportation is insufficient, inappropriate, or unavailable.

The New York State HOME Program is administered by the Housing Trust Fund Corporation’s (HTFC) Office of Community Renewal (OCR) and funds a variety of activities to expand the supply of decent, safe, and affordable housing for low and moderate-income families. 

The Specialized Transportation Program (5310) aims to enhance mobility for seniors and individuals with disabilities through federally funded projects. This program supports various initiatives, including vehicle funding, preventive maintenance, and contracted transportation services. With an 80% federal cost coverage, local funding must cover the remaining 20%. The Ohio Department of Transportation oversees this program, ensuring accessible transportation options in urban and rural areas, thereby addressing the unique needs of transit-dependent populations.

Ohio Department of Transportation

With a mission to provide a transportation system that is safe, accessible, well maintained, and positioned for the future, the Ohio Department of Transportation (ODOT) supports the state highway system and promotes transportation initiatives statewide. As a more than $3 billion per year enterprise, ODOT invests the bulk of its resources in system preservation through maintenance, construction, and snow and ice operations.

ODOT's regional district offices and Central Office divisions work together to fulfill the department's mission of providing safe and easy movement of people and goods from place to place.

Specialized Transportation Program (5310)

Program Goal and Description

The Specialized Transportation Program, as authorized by the Federal Transit Administration, 49 USC Section 5310, is intended to enhance mobility for seniors and persons with disabilities by providing Federal Transit Administration funds for programs in small urbanized and rural areas that serve the special needs of transit-dependent populations beyond traditional public transportation services and Americans with Disabilities Act (ADA) complementary paratransit services. The program provides 80% of the cost of capital projects; the remaining 20% must be provided by local funding, which may be derived from other federal (non-U.S. DOT) transportation sources or the Federal Lands Highway Program.

Project Types: Vehicle Funding; Preventive Maintenance (PM) Funding; Mobility Management Funding; Computer Hardware and/or Software & Equipment Funding; Operating Assistance; Contracted Transportation Service Funding

Operating Assistance

The objective of the 5310 operating assistance project is to provide financial support to subrecipients in the day-to-day transportation operations for seniors and persons with disabilities. Operating assistance funding is explicitly intended to be spent on operations. ODOT will reimburse 50% of the operating cost and the subrecipient is required to provide the 50% local match. All of the local match must be provided from sources other than U.S. Department of Transportation funds. To be eligible for Section 5310 operating funds, an applicant must provide open-door services. FTA defines open door as regular, continuing shared ride surface transportation services that is open to the public or open to a segment of the public defined by age or disability.

Funded by the NYC Department of Cultural Affairs (DCLA), this money is for arts and cultural projects that contribute to creative experiences for audiences in Brooklyn. The best proposals share how the project will impact the cultural life of their audience and community.

In 2026, Brooklyn Arts Fund distributed $625,000 to 136 projects across Brooklyn.

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

Microenterprise Development Organizations must demonstrate experience in managing a Revolving Loan Fund, or:

• Certify that it or its employees have received education and training from a qualified microenterprise development training entity so that the applicant has the capacity to manage such a revolving loan fund.
• Demonstrate that it is actively and successfully participating as an intermediary lender in good standing under the U.S. Small Business Administration (SBA) Microloan Program or other similar loan programs as determined by the Administrator.

What kind of funding is available?

• Grants are available to provide technical assistance to rural micro-entrepreneurs or microenterprises, up to $205,000 annually.
  • Funding at the requested level is not guaranteed, and at least 15 percent matching funds are required.

• Loans of $50,000 to $500,000 may be used for establishing a Rural Microloan Revolving Fund managed by the Microenterprise Development Organization.
  • Total aggregate debt is capped at $2.5 million.

What are the loan terms?

• Maximum term is 20 years.
• Two-year payment deferral.
• Must establish a loan loss reserve fund.

What terms are required on loans to ultimate recipients?

• Up to $50,000.
• Fixed interest rate.
• Limited to 75 percent of project cost.

How may the funds be used?

Microlenders may make microloans for qualified business activities and expenses including, but not limited to:

• Working capital.
• Debt refinancing.
• Purchasing equipment and supplies.
• Improving real estate.

In 2025, the Community Foundation of Madison & Jefferson County awarded over $233,000 in scholarships to graduating seniors of the county’s public and private high schools. Nearly 50 different students earned money toward their college costs. Scholarships are available for a variety of applicants. Some are specific to schools, majors, need, or interests.

CFMJC scholarships may be used for tuition and related expenses like fees and required equipment at accredited colleges and universities. Room and board are not covered.

Madison Chautauqua Scholarship for the Arts in Memory of Bob Fourhman

Criteria evaluated:

• Letter of recommendation and artwork samples

Required materials:

• Letter of recommendation from a person knowledgeable about your talent and accomplishments in your art form; and
• An uploaded sample of your work (maximum 3 photos or 1 short video/audio clip)

Scholarship amount:

• $1,200 | 1 scholarship

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

Microenterprise Development Organizations must demonstrate experience in managing a Revolving Loan Fund, or:

• Certify that it or its employees have received education and training from a qualified microenterprise development training entity so that the applicant has the capacity to manage such a revolving loan fund.
• Demonstrate that it is actively and successfully participating as an intermediary lender in good standing under the U.S. Small Business Administration (SBA) Microloan Program or other similar loan programs as determined by the Administrator.

What kind of funding is available?

• Grants are available to provide technical assistance to rural micro-entrepreneurs or microenterprises, up to $205,000 annually.
  • Funding at the requested level is not guaranteed, and at least 15 percent matching funds are required.
• Loans of $50,000 to $500,000 may be used for establishing a Rural Microloan Revolving Fund managed by the Microenterprise Development Organization.
  • Total aggregate debt is capped at $2.5 million.

What are the loan terms?

• Maximum term is 20 years.
• Two-year payment deferral.
• Must establish a loan loss reserve fund.

What terms are required on loans to ultimate recipients?

• Up to $50,000.
• Fixed interest rate.
• Limited to 75 percent of project cost.

How may the funds be used?

Microlenders may make microloans for qualified business activities and expenses including, but not limited to:

• Working capital.
• Debt refinancing.
• Purchasing equipment and supplies.
• Improving real estate.

Berkshire Taconic Community Foundation

Since 1987, we have strengthened communities through philanthropy and leadership. We channel generosity where it is needed, bringing together resources and passion to tackle our region’s most pressing issues and create lasting change.

The Region We Serve

Berkshire Taconic Community Foundation serves Berkshire, Columbia, northeast Dutchess and northwest Litchfield counties. This unique area where New York, Connecticut and Massachusetts meet contains 2,200 square miles of natural beauty and small-town charm that is home to nearly 230,000 people.

Fund for the Northwest Corner

Berkshire Taconic Community Foundation established the Fund for the Northwest Corner in 2000 to improve the quality of life for the residents of northwest Litchfield County, Connecticut: Cornwall, Falls Village, Goshen, Kent, Norfolk, North Canaan, Salisbury, Sharon, and Warren.

For more than two decades, the Fund has supported innovative community-based initiatives that strengthen our communities and create lasting impact.

In 2026, the Fund for the Northwest Corner is launching its first competitive grant cycle, reflecting its commitment to addressing emerging community needs. 

As reductions in state and federal funding intersect with rising demand for essential services, local organizations are adapting quickly. This grant cycle is designed to provide timely support while maintaining close dialogue with the nonprofits serving our towns, ensuring that charitable resources remain aligned with the region’s most pressing priorities.

By combining local insight with Berkshire Taconic Community Foundation’s trusted stewardship and grantmaking infrastructure, Fund for the Northwest Corner deploys resources strategically across critical areas of need.

Together, we aim to strengthen the local safety net and support the well-being of our community members now and into the future.

Types of Support

Requests will be considered for new or existing projects and programs. 

Support may include program expenses, expanded service delivery, staffing, supplies, or other critical costs directly tied to maintaining or strengthening essential services.

Requests may support existing programs, expanded services, or essential operational costs necessary to stabilize and sustain services during this period of increased strain.

Grants are intended to meet the most urgent needs and to be deployed within nine months of the notification deadline. Applicants should demonstrate the capacity to expend funds within this timeframe.

The Foundation

In 1946, The Alfred E. Smith Memorial Foundation was established by Francis Cardinal Spellman to honor the legacy of Alfred Emanuel Smith, New York’s most renowned Catholic governor and the first Roman Catholic to run for President of the United States on a major party ticket.

Our Grants

The Alfred E. Smith Memorial Foundation grants support family services, education, and healthcare.

We understand that although life can be unfair, an investment in those who are less fortunate can help to level the playing field.

Grant Procedure

Founded in 1946 to honor the memory of renowned New York Governor and champion of the “little people,” Alfred Emanuel Smith, The Alfred E. Smith Memorial Foundation awards annual grants to organizations that bring hope and support to the poor, sick, and underprivileged within the Archdiocese of New York, regardless of race, creed, or color. Selected organizations are well-managed, financially stable, and propose projects that are worthy, purposeful, and clearly targeted. Charitable efforts are directed primarily toward organizations that serve:

Individuals facing physical, developmental, or emotional challenges who can achieve improved health and well-being through specialized medical and therapeutic services. 

Children and youth affected by poverty or other barriers who can reach their full potential through innovative educational programs and learning opportunities. 

Families and children in need of social support or foster care, whose stability, safety, and long-term prospects can be strengthened through targeted, outcome-driven services. 

The Fund for Women Grant, administered by the Delaware Community Foundation, supports nonprofit organizations dedicated to empowering women and girls in Delaware. This one-year grant provides financial assistance for innovative programs that enhance the potential of women and girls. Eligible applicants must demonstrate 501(c)(3) status and address the specific needs of this demographic. The grant aims to foster self-sufficiency and productive lives, ensuring that women and girls can achieve their full potential.

Lewes-Rehoboth Association of Congregations

The Lewes-Rehoboth Association of Congregations (LRAC) is a 501(c)3 charitable nonprofit corporation established in 1983 as a collaborative effort of local churches to come together to serve those in need in the community. LRAC runs the New Life Thrift Shop which funds grant support for the Community Resource Center and a host of other local ministry partners.

LRAC grants

Our mission is to help those in need, primarily feeding the hungry and housing the homeless. Please be sure your mission addresses food or housing insecurity.

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

What is an eligible area?

• Rural areas outside a city or town with a population of fewer than 50,000 residents. Urbanized areas near a city of 50,000 or more may not be eligible.
• The borrower’s headquarters may be based within a larger city so long as the project service area is located in an eligible rural area.
• The lender may be located anywhere.

 What kind of funding is available? 

Grants are available to provide technical assistance to rural micro-entrepreneurs or microenterprises, up to $205,000 annually. Funding at the requested level is not guaranteed, and at least 15 percent matching funds are required.

Loans of $50,000 to $500,000 may be used for establishing a Rural Microloan Revolving Fund managed by the Microenterprise Development Organization. Total aggregate debt is capped at $2.5 million.

The Curtis and Edith Munson Foundation offers grants focusing on the conservation of natural resources in eastern North America and the Caribbean Basin, particularly in the U.S. Key areas include marine resource management, South Florida ecosystems, and Alabama environmental issues. Grants are site-specific, require a 1:1 match, and are not available for individuals or capital campaigns. Initial inquiries should be submitted by the first or second Friday of April or September.

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

What kind of funding is available? 

Grants are available to provide technical assistance to rural micro-entrepreneurs or microenterprises, up to $205,000 annually. Funding at the requested level is not guaranteed, and at least 15 percent matching funds are required.

Loans of $50,000 to $500,000 may be used for establishing a Rural Microloan Revolving Fund managed by the Microenterprise Development Organization. Total aggregate debt is capped at $2.5 million.

What are the loan terms?

• Maximum term is 20 years.
• Two-year payment deferral.
• Must establish a loan loss reserve fund.

What terms are required on loans to ultimate recipients?

• Up to $50,000.
• Fixed interest rate.
• Limited to 75 percent of project cost.

How may the funds be used?

Microlenders may make microloans for qualified business activities and expenses including, but not limited to:

• Working capital.
• Debt refinancing.
• Purchasing equipment and supplies.
• Improving real estate.

Microenterprise Development Organizations must demonstrate experience in managing a Revolving Loan Fund, or:

• Certify that it or its employees have received education and training from a qualified microenterprise development training entity so that the applicant has the capacity to manage such a revolving loan fund.
• Demonstrate that it is actively and successfully participating as an intermediary lender in good standing under the U.S. Small Business Administration (SBA) Microloan Program or other similar loan programs as determined by the Administrator.

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

Are there other requirements?

Microenterprise Development Organizations must demonstrate experience in managing a Revolving Loan Fund, or:

• Certify that it or its employees have received education and training from a qualified microenterprise development training entity so that the applicant has the capacity to manage such a revolving loan fund.
• Demonstrate that it is actively and successfully participating as an intermediary lender in good standing under the U.S. Small Business Administration (SBA) Microloan Program or other similar loan programs as determined by the Administrator.

What kind of funding is available?

• Grants are available to provide technical assistance to rural micro-entrepreneurs or microenterprises, up to $205,000 annually.
  • Funding at the requested level is not guaranteed, and at least 15 percent matching funds are required.
• Loans of $50,000 to $500,000 may be used for establishing a Rural Microloan Revolving Fund managed by the Microenterprise Development Organization.
  • Total aggregate debt is capped at $2.5 million.

What are the loan terms?

• Maximum term is 20 years.
• Two-year payment deferral.
• Must establish a loan loss reserve fund.

What terms are required on loans to ultimate recipients?

• Up to $50,000.
• Fixed interest rate.
• Limited to 75 percent of project cost.

How may the funds be used?

Microlenders may make microloans for qualified business activities and expenses including, but not limited to:

• Working capital.
• Debt refinancing.
• Purchasing equipment and supplies.
• Improving real estate.

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

Microenterprise Development Organizations must demonstrate experience in managing a Revolving Loan Fund, or:

• Certify that it or its employees have received education and training from a qualified microenterprise development training entity so that the applicant has the capacity to manage such a revolving loan fund.
• Demonstrate that it is actively and successfully participating as an intermediary lender in good standing under the U.S. Small Business Administration (SBA) Microloan Program or other similar loan programs as determined by the Administrator.

 What kind of funding is available?

• Grants are available to provide technical assistance to rural micro-entrepreneurs or microenterprises, up to $205,000 annually.
  • Funding at the requested level is not guaranteed, and at least 15 percent matching funds are required.
• Loans of $50,000 to $500,000 may be used for establishing a Rural Microloan Revolving Fund managed by the Microenterprise Development Organization.
  • Total aggregate debt is capped at $2.5 million.

What are the loan terms?

• Maximum term is 20 years.
• Two-year payment deferral.
• Must establish a loan loss reserve fund.

What terms are required on loans to ultimate recipients?

• Up to $50,000.
• Fixed interest rate.
• Limited to 75 percent of project cost.

How may the funds be used?

Microlenders may make microloans for qualified business activities and expenses including, but not limited to:

• Working capital.
• Debt refinancing.
• Purchasing equipment and supplies.
• Improving real estate.

The SCORCH Program: Phase 2 aims to enhance the understanding of single cell biology in the context of HIV and Substance Use Disorder (SUD). Building on previous research, this initiative will explore new single cell approaches to investigate the interactions between SUD and HIV progression at various biological levels. By leveraging advanced techniques, the program seeks to identify candidate mechanisms and potential therapeutic targets, ultimately contributing to innovative solutions for SUDs and HIV-related challenges.

The Wells County Foundation offers grants to support non-profit organizations that enhance the quality of life in Wells County. Funding is available for projects in various sectors, including arts, education, and health. The Foundation prioritizes proposals that demonstrate significant community impact, innovation, and collaboration with local organizations. Eligible applicants include charitable organizations that do not discriminate based on race, gender, or religion. This initiative aims to foster community development and provide ongoing support for impactful projects.

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

What is an eligible area?

• Rural areas outside a city or town with a population of fewer than 50,000 residents. Urbanized areas near a city of 50,000 or more may not be eligible.
• The borrower’s headquarters may be based within a larger city so long as the project service area is located in an eligible rural area.
• The lender may be located anywhere.

Check eligible addresses for Business Programs here.

 What kind of funding is available? 

Grants are available to provide technical assistance to rural micro-entrepreneurs or microenterprises, up to $100,000 annually. Funding at the requested level is not guaranteed, and at least 15 percent matching funds are required.

Loans of $50,000 to $500,000 may be used for establishing a Rural Microloan Revolving Fund managed by the Microenterprise Development Organization. Total aggregate debt is capped at $2.5 million.