Best Large Grants for Nonprofit Organizations

The Main Street Matters program aims to revitalize downtown areas and surrounding neighborhoods through grants for planning, business support, and aesthetic improvements. Eligible entities include local governments, redevelopment authorities, and nonprofits. Funding supports various projects, such as building rehabilitation and infrastructure improvements, with a minimum 50% match required. This initiative promotes community development, safety, and sustainability, helping districts recover from disasters while fostering vibrant local economies.

The Community Grants Program by the Butler Family Foundation supports organizations focused on environmental stewardship in Minnesota. Grants of $30,000 annually for general support or $20,000 for specific projects are available for 501(c)(3) organizations with budgets over $300,000. The program emphasizes land and water protection, aiming to educate youth on sustainable practices. This initiative seeks to foster community involvement in preserving Minnesota's natural resources.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Food as Medicine Initiative

The Food as Medicine Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to address food insecurity as a critical driver of health outcomes for uninsured and medically underserved patients. Research continues to demonstrate the strong connection between food insecurity and poor health, including increased risk of chronic conditions such as diabetes, hypertension, obesity, and certain cancers. Through this initiative, NAFC will provide $20,000 grants to member free and charitable clinics to implement or expand food insecurity screening and patient-centered interventions that improve access to healthy food and nutrition education as measured by the US Household Food Security Module or Hunger Vital Signs and patient education focused on food as medicine for eligible patients in order to increase the percentage of patients with improved food security scores within one year of project implementation.

Bethany Legacy Foundation

For more than a century, the Bethany name has stood for compassion in action. Today, we carry that legacy forward by uniting the community around innovative, lasting solutions that strengthen well-being across Jefferson County, Indiana.

Bethany Legacy Foundation exists to build a healthier Jefferson County, IN. by listening first, collaborating widely, and investing wisely. Our mission is to bring people together to create sustainable change where it’s needed most.

Grants

Legacy 2030: Our Primary Focus Areas

Our six-year strategic plan aims to create a sustainable community where individuals of all ages can access the necessary resources and services to thrive. A strong workforce is the cornerstone, supported by ensuring youth, adults, and seniors have equitable access to transportation, mental health, and social services to promote well-being and independence. Our efforts and investments will focus on prevention, root causes, and initiatives that create a path to self-reliance.

The following outlines our Focus Areas, goals, and objectives for our Community and the People who live here:

Community

We aim for a Thriving Workforce that makes Jefferson County a desirable place to live and work and attracts and retains top talent.

To achieve this, we seek proposals, projects, and efforts that:

• Expand access and options for quality Childcare to improve outcomes for families and businesses
• Build stability through access to quality, safe and affordable Housing
• Expand Recreation options to promote health, connections, and a high quality of life
• Build skills and knowledge through Professional Development to enhance and advance careers

People

We aim for Strong Youth, Empowered Adults, and Stable Seniors in Jefferson County with the following outcomes if achieved:

• Kids that have a strong foundation and build resilience
• Adults that are healthy, educated, and productive citizens
• Seniors that are independent and Grow Old with Love and Dignity (GOLD)

To achieve this, we seek proposals, projects, and efforts that:

• Build Mental Health resilience and healing through holistic and preventative approaches
• Bridge distances by increasing options and access to Transportation
• Grow Social Services that strengthen and empower individuals and families

BLF uses an open application process to collect and review project ideas that align with BLF Focus Areas There are three types of applications: Long Application; Short Application; and Capacity Building Application.

BLF Grants: Short Application

• For requests of $50,000 or less in total funding, including multi-year requests
• Projects must support BLF Pillars and Focus Areas to be consider for funding
• Only one application form is submitted for review
• Approx 6-week process starting from application submission

The Mayo Clinic Community Contributions Program in Florida focuses on improving access to nutritious food. This grant supports registered 501(c)(3) organizations in northeast Florida, encouraging initiatives that align with community health needs. Eligible projects include health services, education, and youth enrichment, aiming to foster vibrant and sustainable communities. Organizations can apply for funding once per calendar year, with grants designed to enhance community engagement and address food insecurity.

Bridgestone Americas Trust Fund Grants

Empowering People to Move, Live, Work, and Play

Bridgestone has awarded over $60 million to nonprofit organizations in the United States since 1951, and we are committed to continuing our legacy of giving back by supporting communities around the U.S.

Bridgestone works with grantseekers that offer solutions to keep society moving forward. Strong partners offer a human-centered approach to societal challenges in one or more of the following areas of focus: 

In addition to our three areas of focus, we will consider applications from organizations that have hosted volunteer or community engagement events with Bridgestone volunteers and organizations that have received funding in previous years. 

The Heinz Endowments, established in 2007, is a prominent philanthropic organization in the U.S. with a focus on southwestern Pennsylvania. It provides approximately $90 million in annual grants across various sectors, including arts, civic participation, and environmental health. Organizations classified as tax-exempt under Section 501(c)(3) are encouraged to apply, while for-profit entities and individuals are ineligible. The Endowments seeks transformative ideas that benefit local communities.

The John C. Bock Foundation supports the preservation and enhancement of natural land areas, particularly those near Lake Mendota, Wisconsin. It aims to educate builders and developers on the importance of conserving mature woodlands and old-growth forests. The Foundation funds educational activities and research while supporting qualified conservation organizations committed to protecting these valuable landscapes. Its mission is centered on public education and the custodianship of natural resources.

Competitive Community Grant- Health & Human Services- Spring Cycle

All people are healthy and safe.

We will support organizations that work to improve the following outcomes in our communities:

• Access to affordable housing
• Food security
• Safety
• Access to health care
• Mental health services
• Healthy neighborhood living conditions
• Senior services

Through direct service, policy advocacy, and/or collaboration efforts, priority strategies will address:

• Affordable housing and shelter for homeless, rent-burdened, and at-risk populations, including eviction prevention
• Access to affordable and high-quality food, including food banks, pantries, and community centers that distribute food and promote healthy eating and work to address “food deserts”
• Efforts to address safety for vulnerable populations, including domestic violence and child abuse prevention, bullying prevention in schools, safety issues specific to immigrant populations, low wage workers and communities of color
• Access to health care, including programs providing un- and under-insured populations with culturally appropriate and equitable access to quality health and wellness programs services. Priority will be given to efforts applying social determinants of health lens to the work
• Mental health services, including school-based services, treatment, prevention, and rehabilitation programs targeting marginalized communities, and groups working on cultural and generational trauma
• Building healthy communities, including built environment and infrastructure, environmental quality (toxins and air/water quality), affordable and reliable transportation, and parks and recreation
• Providing services targeted at senior well-being, including memory care, depression, audiology, dementia, exercise, home care, hospice, and medication guidance.
• Systems change, including public policy, civic engagement, community organizing or public information to improve health and wellbeing of local residents

Grant Sizes

We offer $5,000, $10,000, $15,000, or $20,000 general operating support depending on your annual budget:

• Organizations with an annual budget up to $50,000 may apply for a $5,000 grant;
• Organizations with an annual budget between $50,001 - $150,000 may apply for a $10,000 grant;
• Organizations with an annual budget between $150,001 - $500,000 may apply for a $15,000 grant; and
• Organizations with an annual budget of $500,001 or more may apply for a $20,000 grant.

The Lower Platte North Natural Resources District Grant supports high school students engaged in community-based natural resources projects. With funding up to $1,500, this grant encourages students to plan and implement projects that benefit local ecosystems. Eligible applicants must reside within the district and demonstrate active involvement in initiatives such as FFA supervised agricultural experiences, 4-H projects, or other community engagement efforts. This grant fosters environmental stewardship among youth, promoting sustainable practices in their communities.

The Kaulunani Grant Program, managed by Arbor Day Hawaiʻi, invites proposals for projects that promote the benefits of trees within communities, celebrating Arbor Day on November 2, 2024. Competitive proposals should focus on community capacity building, including workshops on tree planting and care, engaging volunteers, and promoting accessibility to the public. Eligible applicants include non-profits, schools, and community groups from all islands in Hawaiʻi, ensuring projects contribute positively to environmental stewardship.

The Cinnabar Foundation provides Program/Project Grants aimed at enhancing conservation efforts in Montana and the Greater Yellowstone Ecosystem. These grants, ranging from $2,500 to $15,000, support organizations that engage in impactful, grassroots conservation work. Priority is given to projects that align with the Foundation's strategic vision, including climate adaptation, wildlife habitat conservation, public land preservation, and improving air and water quality. Successful applicants will demonstrate measurable outcomes and community engagement.

The Forestland Preservation Grant Program in Washington provides financial support for the acquisition of conservation easements to protect forests from development. This initiative, part of the Washington Wildlife and Recreation Program, aims to maintain timber production while promoting ecological benefits and public access. Eligible applicants can request funding up to $500,000 for projects that ensure sustainable forest management and habitat enhancement, contributing to the conservation of vital natural resources.

Foundation for Delaware County

Our Mission

To ensure an equitable, vibrant future for Delaware County by promoting generosity, inspiring participation and partnership across our communities, and improving the quality of life for all.

The Foundation for Delaware County works with individuals, private foundations, nonprofits, and businesses to move Delaware County forward.

Partners in Giving RFP

This collaborative effort between The Community’s Foundation (TCF) and The Foundation for Delaware County (the Foundation) is designed to support nonprofits serving Delaware County by reducing duplication, improving access to resources, and creating a more seamless funding experience. Through greater alignment of processes, shared expertise, and coordinated opportunities, nonprofits can more easily navigate support systems, strengthen their organizational capacity, while maximizing the collective benefit to the community.

Rather than duplicating efforts, TCF and the Foundation will work side-by-side to identify where joint action can yield greater results, whether through shared tools that make grant applications more accessible, coordinated timelines that reduce administrative burden for grantee partners, or aligned funding priorities that direct resources toward the community’s highest needs.

This approach fosters stronger relationships between the two foundations and with the nonprofit sector, builds mutual understanding of local challenges and opportunities, and reinforces the shared commitment to equitable, high-impact philanthropy in Delaware County.

This spirit of partnership is reflected in specific initiatives that make it easier for nonprofits to engage with both foundations and focus more of their energy on delivering impact.

Funding Priorities

For the 2026 Partners in Giving Grant cycle, this collective effort will consider awarding grant funds to organizations that focus on community development, health, hospice and homecare, support for cancer survivors, and youth development.

Eligible organizations may apply for funding under any of the funding priorities, selecting one area that aligns most closely with their mission and proposed activities. The application should demonstrate outcomes within at least one of the following types of outcomes:

Types of Outcomes

Safety Net – Provide basic assistance to ensure well-being and prevent dire outcomes for individuals facing economic hardship, health issues, or other challenges.

Preventive – Intervene before problems arise, reducing factors that lead to negative outcomes and enhancing protective factors that contribute to well-being and success. This can include Out-Of-School Time programming.

Systems Change – Target the root causes of social issues to change structures, such as public policies and regulations that enable systems to function better.

Organizational Development – Strengthen effectiveness and capacity through planned change in an organization’s processes, systems, structures, or leadership.

Eligible organizations may submit one application to support their efforts in advancing the funding priorities above. Organizations can apply for a single year only.

Partners in Giving: Health

The 2026 Partners in Giving initiative will consider awarding grants of up to $10,000 to organizations that improve the health and well-being of children, families, and vulnerable populations living in Delaware County, including through LGBTQIA+ inclusive and affirming approaches. Funding may support health education, prevention, supportive services, coordination, and advocacy efforts that strengthen access to behavioral health (including mental health), health care, maternal and child health services, preventive care, nutrition, and food security, with an emphasis on improving outcomes for low-income and historically marginalized communities.

All grant proceeds must be used to provide programs and services in and for Delaware County residents.

The Noxious Weed Management Fund Grant, offered by the Colorado Department of Agriculture, aims to support the eradication and containment of state-listed noxious weeds. This grant provides vital financial resources to cooperatively manage these invasive species, ensuring measurable outcomes across Colorado. It particularly focuses on assisting newly established weed management programs in regions that require additional support, fostering sustainable agricultural practices and protecting native ecosystems.

The Department awards grants from State appropriations, federal awards, and other funding sources. Since the award and appropriation of these funds do not always conform to the State Fiscal Year, the information included in this directory is based on anticipated grant awards that will begin in the period from July 1 through June 30 of each State Fiscal Year. The ability of the Department to make grant awards is expressly dependent upon the availability of funds appropriated by the State Legislature from State and/or federal revenue or such other funding sources as may be applicable.

Stillbirth Awareness Campaign NOFA

The grant will be used to develop and maintain a state-wide, evidence-based, stillbirth prevention public health campaign that increases awareness of stillbirth prevention measures and decrease New Jersey's high stillborn rate.

Estimate amount of money in the grant program

• $99,700

The Combat Cancer Prevention and Screening Grant aims to enhance the health of rural Iowans by providing essential screening test kits and telehealth equipment for early cancer detection. It focuses on raising awareness about cancer risk factors through media outreach and decreasing radon gas exposure via home test kits and mitigation support. This initiative is part of the Iowa Healthy Hometowns Project, funded by the Centers for Medicare & Medicaid Services' Rural Health Transformation Program.

The Appalachian Landscapes Project Capital Grant, offered by the Open Space Institute, supports vital conservation initiatives aimed at preserving biodiversity and enhancing landscape connectivity. Established in 1974, the OSI has protected over 2.5 million acres in the Eastern US and Canada, focusing on land that ensures clean drinking water and wildlife habitats. This grant is specifically for projects within the Appalachian Landscapes Project service area, promoting sustainable community benefits.

The Disaster Distress Helpline (DDH) offers 24/7 crisis counseling to individuals in the U.S. and its territories facing emotional distress from disasters. Managed by SAMHSA, the helpline aims to enhance and strengthen access to crucial support services year-round, ensuring that those affected by natural or human-caused disasters receive the help they need to mitigate behavioral health impacts.

The Nonpoint Source Pollution Control Grant Program, funded by the California State Water Board through the Clean Water Act Section 319(h), supports projects aimed at reducing nonpoint source pollution. Funded initiatives include livestock management, forest road improvements, stream restoration, and agricultural best practices to protect water quality. Approximately $4 million is awarded annually to enhance impaired waters and safeguard high-quality ecosystems, ensuring sustainable management of California's water resources.

The California Department of Food and Agriculture's Pierce's Disease and Glassy-winged Sharpshooter Board provides vital funding for research and outreach projects aimed at protecting vineyards from serious pests and diseases. Focus areas include Pierce's disease, grapevine red blotch, and various insect threats, with awards ranging from $4,300 to $383,000. The program encourages multi-disciplinary projects that deliver practical solutions to enhance the sustainability of California's winegrape industry.

The Water Quality Combined Funding Program in Washington aims to enhance and safeguard water quality through a competitive funding process. It supports various projects, including wastewater management and stormwater control, while offering technical assistance to applicants. The program combines multiple funding sources, ensuring comprehensive financial support tailored to project needs. Eligible entities include counties, cities, tribal governments, and nonprofit organizations. The initiative reflects a commitment to improving environmental sustainability across the state.

The Kings County Conservation Futures Grant provides essential funding for the Land Conservation Initiative, aimed at preserving vital natural and urban green spaces. This grant supports projects like parks, community gardens, and habitat restoration, particularly in underserved areas. Eligible recipients include local governments and qualified nonprofits. The initiative seeks to enhance community access to open spaces, ensuring that all residents can benefit from nature and recreational opportunities.

The Lake Fork Community Foundation supports the citizens of Hinsdale County through grants focused on educational assistance, care for the needy, and community beautification. Established in 1994, this private foundation encourages collaboration among organizations and seeks to maximize community impact. Eligible applicants must be IRS-recognized tax-exempt entities, ensuring funds reach those who can best serve the community's needs. Grants prioritize innovative projects that leverage additional resources and promote local engagement.

The Amazon Loudoun County Community Fund Grant, a $150,000 initiative by Amazon and the Community Foundation for Loudoun and Northern Fauquier, aims to empower local nonprofits and organizations. This program supports transformative projects that enhance inclusion, resilience, and community well-being in Loudoun. Grants ranging from $500 to $10,000 will address critical areas such as health, food security, and homelessness, fostering a strong and connected community for residents.

The Fort Orange Garden Club Centennial Endowed Scholarship is designed for third- and fourth-year undergraduate or current graduate students majoring in plant sciences, conservation, environmental sciences, or landscape architecture. Scholarship recipients must demonstrate financial need and reside in specific counties in New York, including Albany and Schenectady, fostering academic growth while contributing to environmental stewardship.

The Habitat Conservation Trust Foundation offers Fish & Wildlife Grants to support projects focused on native freshwater fish, wildlife, and their habitats. These grants aim to achieve significant conservation outcomes and encourage habitat enhancement and restoration. Eligible applicants include governments, First Nations, and NGOs, with a priority on projects that yield tangible results. Additionally, seed grants of up to $5,000 are available for preliminary project planning, facilitating the development of full proposals within two years.