Best Large Grants for Nonprofit Organizations

The Nonpoint Source Program (NPS Program) Grant from the Colorado Department of Public Health and Environment (CDPHE) funds projects aimed at restoring and protecting waterbodies from nonpoint source pollution. This competitive grant opportunity invites submissions for funding under the EPA Clean Water Act Section 319(h). Applicants must enter into cost reimbursement contracts with the State for selected projects, guided by the 2022 Nonpoint Source Management Plan.

The HOKC Good Works Program provides over $2.5 million annually in grants to Kentucky nonprofits, aiding over 3.9 million individuals. Established in 1951, it has distributed $68 million through more than 8,900 grants, relying on the support of over 30,000 active Colonels globally. Eligible nonprofits must be 501(c)(3) organizations based in Kentucky, operational for at least five years, and focused on tangible community benefits, aligning with the program's mission to foster community enhancement and support.

The John's Island Foundation (JIF) offers Core Grants annually to support capital needs of nonprofit agencies in Indian River County. Eligible agencies must be tax-exempt 501(c)(3) organizations that demonstrate a commitment to serving individuals facing challenges related to food, shelter, health, and education. JIF focuses on tangible capital improvements, ensuring that funds are used to enhance community services. This initiative reflects JIF's dedication to fostering a sustainable impact for those in need within the local community.

Grant Applicants

New Hampshire Victim Services Funding Opportunity

A funding opportunity for organizations that provide victim services for the State of New Hampshire is being released through a Request for Proposal through the New Hampshire Department of Justice (NH DOJ). This funding is dedicated to supporting programs for direct services to victims of crime.  

Special consideration will be made for projects that support victims of sexual assault, domestic violence, and child abuse.

The Iowa Farm Bureau offers sponsorships to support events and fundraisers across Iowa, focusing on agriculture, rural communities, and education. Their priorities include promoting health and wellness, fostering youth leadership, and enhancing the viability of farm families. Eligible applicants must be nonprofit organizations with 501(c)(3) status. However, they do not fund projects outside Iowa, political entities, or construction projects. This initiative aims to strengthen community ties and nurture future agricultural leaders.

Department of Education

The Idaho Department of Education is the state agency that supports and strengthens K-12 education in Idaho. By advocating for Idaho’s families, educators, and schools with funding and educational policy alignment, we support and lead academic achievement to ensure every student is prepared with the skills and job readiness to succeed.

21st Century Community Learning Centers

The program supports the creation of community learning centers that provide academic enrichment opportunities during non-school hours for children, primarily those who attend high-poverty and low-performing schools. The program helps students meet challenging state academic standards and local academic standards.

Grant Application

The Idaho Department of Education hosts a request for applications (RFA) for available funds under Title IV, Part B, 21st Century Community Learning Centers, to eligible entities on a competitive basis through a rigorous peer-review process. Competitions are made available as federal funding allows.

The HOKC Good Works Program provides medium grants ranging from $2,500 to $9,999 to support Kentucky nonprofits. With over $2.5 million distributed annually, the program aims to enhance community services in areas such as education, health, and support for low-income individuals. Eligible organizations must be 501(c)(3) nonprofits operating for at least five years within Kentucky. Ineligible entities include religious organizations and most government bodies. This grant initiative has a strong history of impactful contributions to local communities.

The Ribbons of Hope Grant, awarded annually by the Ribbons of Hope Foundation since 2012, aims to enhance the lives of women and children through education, health, economic independence, social well-being, and human rights initiatives. Non-profit organizations with a strong operational history and a commitment to impactful programs are encouraged to apply for this $100,000 grant, which supports both ongoing and self-sustaining projects.

As a 501(c)3 nonprofit organization, our main goals are:

• Bear conservation: Our goal is to conserve all 8 species through diminishing negative interactions via educating the public, providing co-existence strategies, volunteering, partnering with organizations for rehabilitation efforts and giving these animals a voice.
• Habitat preservation: As our organization grows, we will have dedicated spaces of land for these creatures to roam unharmed along with the other animals that live there. As the family grows, so do the Bear Grounds.
• Promoting “bear-awareness”: Bears may look cute – but it is important to practice protocols to ensure the safety of everyone.
• Education: From children to the elderly, we make it our goal to teach everyone about these animals, the roles they play and the importance of bears. We published a children’s book for the kids to learn about bears in a fun and interactive way.

Spectacled Bear Grant

Bear Grounds Coffee Co. is providing its first award toward bear conservation with the Spectacled Bear Grant in 2026. This funding is for research, rehabilitation, spectacled bear or territory conservation efforts only. One applicant will receive $200 to support their project.

Eligible projects include, but are not limited to:

• Scientific research and field studies.
• Wildlife rehabilitation and rescue programs.
• Habitat protection and restoration.
• Community-based conservation initiatives.
• Anti-poaching and human–bear conflict mitigation efforts.
• Sustainable coexistence programs.

The Plymale Foundation Grant, established by Robert E. Plymale in 1963 and now part of the Greater Lynchburg Community Foundation, supports 501(c)(3) organizations in Campbell County and surrounding areas. With approximately $40,000 available annually, grants typically range from $1,000 to $15,000, focusing on social welfare, healthcare, education, and children's needs. The foundation emphasizes funding special projects rather than operating expenses or capital projects.

The Emerging Scholars Award, offered by the Civitan International Research Center, provides crucial funding for graduate students and postdoctoral fellows engaged in neurodevelopmental research. This initiative aims to enhance understanding of brain development and related disorders. Proposals are invited from UAB campus for innovative research projects that explore normal and abnormal brain development, cognition, and the impact of environmental toxins. This program is supported by generous donations and matching funds from various organizations.

The Agricultural Conservation Easement Program (ACEP) helps landowners, land trusts, and other entities protect, restore, and enhance wetlands or protect working farms and ranches through conservation easements.

The Agricultural Conservation Easement Program (ACEP) protects the agricultural viability and related conservation values of eligible land by limiting nonagricultural uses which negatively affect agricultural uses and conservation values, protect grazing uses and related conservation values by restoring or conserving eligible grazing land, and protecting and restoring and enhancing wetlands on eligible land.

ACEP has two components:

• Agricultural Land Easements (ALE) help private and tribal landowners, land trusts, and other entities such as state and local governments protect croplands and grasslands on working farms and ranches by limiting non-agricultural uses of the land through conservation easements.

• Wetland Reserve Easements (WRE) help private and tribal landowners protect, restore and enhance wetlands which have been previously degraded due to agricultural uses.

Additionally, through ACEP, USDA offers the Wetland Reserve Enhancement Partnership (WREP), a voluntary program through which NRCS enters into agreements with eligible partners to leverage resources to carry out high priority wetland protection, restoration, and enhancement and to improve wildlife habitat.

The Sonnentag Foundation Grant supports organizations in cities where County Materials Corporation operates, focusing on four key areas: Hunger & Homelessness Support, Service Members & Veterans Support, Sexual Abuse & Domestic Assault Services, and Mentoring & Skills Building. Eligible applicants must be 501(c)(3) recognized organizations that serve the broader community. The foundation aims to empower vulnerable populations, including veterans, to lead fulfilling lives and provide essential services for healing and personal development.

The Giving Tree – Early Literacy Grants, offered by the Arkansas Community Foundation, aim to enhance early literacy among children. These grants support initiatives that engage parents, improve school readiness, bolster classroom instruction, and address attendance issues. They are designed for 501c3 nonprofits, schools, and government entities. By focusing on various aspects of early education, these grants seek to ensure that every child in Arkansas has the resources and support necessary to thrive academically.

The Special Emphasis Limited Project Grant from the American Society of Colon and Rectal Surgeons aims to address health disparities in colorectal surgery. It focuses on improving care for racial/ethnic minorities, women, LGBTQ+ populations, and individuals with disabilities. Proposals should concentrate on patient-oriented interventions and may explore quality improvement, access to services, and enhancing workforce diversity. Funding of up to $20,000 is available for innovative projects that promote equity in colorectal healthcare.

The Community Grants for Educational Success aim to enhance educational achievement for underperforming children and youth in South Hampton Roads. By supporting innovative programs, the grant focuses on preparing students for kindergarten, preventing dropouts, and facilitating transitions to higher education. The initiative emphasizes the importance of education in fostering economic development and personal prosperity, aiming for measurable outcomes like improved graduation rates and increased enrollment in post-secondary education.

The Joan Rajkovich McGarry Family Education Endowment Grant focuses on enhancing family and consumer sciences in Grand Traverse and Leelanau Counties. Dedicated to improving nutrition and physical activity, it supports innovative, evidence-based programs for children and families, particularly addressing obesity. Eligible applicants include 501(c)(3) organizations, educational institutions, and governmental entities. Applications are accepted annually in the fall, prioritizing creative proposals that align with Michigan State University Extension resources.

The Williamsburg Health Foundation (WHF) offers the Responsive Grant to enhance health in Greater Williamsburg. This private foundation supports nonprofit organizations and government agencies focused on improving opportunities for uninsured and underinsured populations. Priority is given to proposals that align with WHF's mission, demonstrate collaboration, and create stronger health systems. For more details, visit their Strategic Plan online.

Who We Are

The organization is a non-profit 501 (c)(3) Charitable Trust supported by members of the NH Beverage Association, the Beverage Distributors of New Hampshire Association and the New Hampshire Grocers Association. This collaborative effort by food and beverage companies has developed comprehensive programs to address, litter issues, recycling challenges, environmental awareness and education.

What We Do

We accomplish these goals by offering municipal recycling grants and signs, anti-litter programs and technical assistance to recycling programs. New Hampshire communities are eligible to apply for funding to assist with the purchase of recycling equipment. This includes monies to purchase curbside collection bins, balers, crushers, roll-off containers and other equipment that will help a community achieve higher diversion rates.

Municipal Recycling and Storage Equipment Grants

New Hampshire communities are eligible to apply for funding to assist with the purchase of recycling equipment. Grant applications are considered on an individual basis and funding may be up to 20% of the purchase price of the equipment. While we will not help with the purchase of land, studies or buildings, we do help fund the purchase of balers, crushers, roll-off containers and other equipment that will help a community achieve higher diversion rates.

Recycling Equipment grant applications are accepted on a rolling schedule, with current applications being considered every two months and up to 9 months given to allow communities to purchase and install suitable equipment. Grants are paid as a reimbursement to communities after they have purchased the equipment. Equipment purchased with NHtB grant money must be used exclusively for recycling. Communities that discontinue their recycling programs must either repay NHtB or, where applicable, work with NHtB to transfer that equipment to another community for use in recycling.

The Zero-Emissions Access Program Grant (WA) aims to fund zero-emission carshare pilot programs in underserved communities with limited public transportation access. Grants range from $50,000 to $200,000, requiring applicants to match at least 10% of project costs. This initiative, supported by Washington's Climate Commitment Act, promotes clean transportation options to enhance mobility in areas facing high emissions.

2026 CityArts Program Overview

The City of Chicago Department of Cultural Affairs and Special Events (DCASE) supports artists and cultural organizations, invests in the creative economy, and expands access and participation in the arts throughout Chicago’s 77 neighborhoods. The CityArts Program aims to support a diverse group of arts and culture nonprofits reflective of the city of Chicago and its cultural landscape through flexible and strategic grant funding. Chicago arts and culture nonprofits of all sizes and artistic disciplines can apply for CityArts grants.

In 2026, the CityArts Program will offer two types of grants:

• General Operating Grants for Arts & Culture Organizations
• Project Grants for Arts & Culture Organizations

There will be separate applications and review processes for each type.

Eligible organizations may apply for both a general operating grant AND a project grant in 2026. Some past grantees that cannot apply for general operating support in 2026 may be eligible to apply for project funding if otherwise eligible. Refer to Eligibility Criteria below and in CityArts guidelines for more details.

General Operating:

Flexible support for Chicago-based arts and culture nonprofits of all sizes. General operating support funds may be used for artistic, administrative and/or program activities including expenses such as salaries, marketing, insurance, supplies, professional services, fees and training.

Mission

The mission of the Mississippi Wildlife, Fisheries, Parks and Marine Foundation is to provide financial support to the Mississippi Department of Wildlife, Fisheries and Parks and to the Mississippi Department of Marine Resources. This support is provided to assist these two agencies in regard to their efforts involved with the conservation and protection of Mississippi’s natural resources and provide supplemental financial assistance as available and necessary.Focus Areas

• Wildlife,
• Fisheries,
• Parks,
• Conservation,
• Natural Resources, and
• related fields

The NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional) supports innovative, hypothesis-driven clinical studies with a focus on diseases relevant to NIDDK. This initiative facilitates early peer review and assessment of study designs while providing essential support for operational documents. Applicants are encouraged to consult with NIDDK staff before submission to enhance the chances of success.

The Grants for Rural and Native Alaskan Villages program is designed to provide essential drinking water and waste disposal systems to remote Alaskan villages. By addressing dire sanitation conditions, the program ensures access to clean water and improves public health in communities that are often isolated. Funded by USDA Rural Development, these grants cover up to 75% of project costs, promoting sustainable infrastructure in areas facing unique challenges due to geography and climate.

Baltimore Community Foundation

Mission: Inspire donors to achieve their charitable goals from generation to generation and to improve the quality of life in the Baltimore region through grantmaking, enlightened civic leadership, and strategic investments.

Baltimore City Community Grants Program

The Baltimore Community Foundation (BCF) is proud to administer the Baltimore City Community Grants Program in partnership with The Harry and Jeanette Weinberg Foundation. These grants are designed to support nonprofits that provide direct services to low-income Baltimore City residents, with a focus on creating paths to stability and opportunity. 

Through this program, we aim to strengthen the capacity of community-based organizations aligned with the Weinberg Foundation’s five focus areas: Housing, Health, Jobs, Education, and Aging.

Focus Areas

• Housing: Improving stability by helping people access safe and affordable housing.
• Health: Promoting health and well-being
• Jobs: Creating paths to jobs and careers
• Education: Helping youth succeed in school and beyond
• Aging: Ensuring individuals are able to age with respect, dignity, and support.

Grants are one-time, unrestricted or project-based depending on organizational needs and proposed use.

The Dennis and Phyllis Washington Foundation provides essential funding to nonprofit organizations that improve the lives of economically and socially disadvantaged individuals. Since 1988, the foundation has supported various initiatives, including education, health services, and community programs. It emphasizes direct services with low administrative costs, ensuring that funds have a meaningful impact. Organizations applying must demonstrate a commitment to serving at-risk youth and families, particularly in Montana and select areas where The Washington Companies operate.

The Julie Hayes Performing Arts Grants aim to support organizations dedicated to the performing arts, including dance, music, opera, and theatre, in Gilroy and surrounding areas. This grant prioritizes programs that demonstrate community impact, sustainability, and strong local involvement. Eligible applicants must be established organizations with a board and financial controls, ensuring accountability. The Foundation avoids funding capital improvements and budget shortfalls, focusing instead on projects that benefit the wider community without discrimination.