Best Large Grants for Nonprofit Organizations

The Mid-Atlantic Environmental Justice Fund - Track II focuses on enhancing tree canopy to improve public health and environmental resilience in disadvantaged communities. This initiative aims to address air pollution, stormwater management, and ecological challenges through community-driven tree planting and maintenance projects. Supported by the Chesapeake Bay Trust and various local organizations, this program emphasizes participatory decision-making and requires community recommendations for project proposals, fostering local engagement and sustainability.

The Greater Green Bay Community Foundation offers grants aimed at enhancing community life through diverse funding priorities, including arts, education, health, and environmental conservation. These grants support non-profits and governmental bodies serving Brown, Kewaunee, and Oconto counties, focusing on innovative solutions to pressing local needs. Eligible applicants must be 501(c)(3) organizations and are encouraged to address issues such as poverty, youth development, and community improvement. Notably, grants do not support religious activities or fundraising events.

The NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01) aims to support clinical trials that evaluate interventions for communication disorders. This funding opportunity encourages collaboration between NIDCD Project Scientists and investigators, focusing on trials that require FDA oversight, establish efficacy, or pose risks of harm. By fostering well-designed studies, the NIDCD seeks to advance treatment and prevention strategies in the field of communication disorders.

The KCF Capital Grant provides funding for building renovations, new constructions, land acquisition, and equipment purchases for eligible organizations in Kalamazoo County. With an annual commitment of $500,000, KZCF aims to support three to five organizations with a minimum request of $100,000. This grant does not impact eligibility for other KZCF grants, allowing organizations to explore various funding opportunities to enhance community resources and infrastructure.

Request for Applications

Modification of Existing Clinical Facilities for Mental Health Crisis

The Nebraska Department of Health and Human Services (DHHS), Division of Behavioral Health (DBH) is issuing this Request for Applications (RFA) for the purposes of entering into a grant agreement and awarding federal funds through the Rural Health Transformation Program (RHTP) 5.3, to provide funding for equipment and enhancements to hospitals and behavioral health providers to expand crisis response, stabilization, and substance use withdrawal services in rural areas. Through this RFA, eligible and qualified rural entities will receive funding for equipment and minor building alterations and renovation projects in an existing building or facility.

Objective

DHHS is seeking interested providers who can support the RHTP Nebraska Behavioral Health initiative through creating a sustainable, community-based emergency behavioral health system that improves outcomes, reduces costs, and strengthens the State’s behavioral health continuum of care. Potential grantees would look to increase crisis stabilization, crisis response and substance use withdrawal management capacity by retrofitting existing areas or purchasing needed equipment in rural hospitals, community health centers, rural emergency hospitals (REHs), and tribal health facilities.

Through minor facility modifications and equipment enhancements, existing clinical spaces will be adapted to serve individuals experiencing behavioral health or substance use crises.

DHHS is making the full amount of $5,500,000 available for grants under this RFA. A total award of funds requested by the applicant is not guaranteed but is subject to the number of applications received, the actual money appropriated to DHHS, and at DHHS’ discretion.

The McGlothlin Foundation Grant supports philanthropic initiatives in higher education, healthcare, and the arts, focusing primarily on projects in Southwest Virginia, Eastern Kentucky, and Northeast Tennessee. The foundation prioritizes proposals from tax-exempt non-profits, especially for capital projects and programmatic needs. While there are no fixed grant sizes, organizations are encouraged to apply after prior awards have concluded. The foundation does not fund individuals or political activities, ensuring its resources enhance community infrastructure and cultural development.

The NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) support small businesses in conducting clinical trials for NIH-funded projects. This initiative encourages partnerships with investors to assist in the commercialization of innovations in neurological disorders. Applicants must submit a comprehensive Commercialization Plan detailing anticipated funding. The program aims to promote effective transitions from research to market, enhancing the development of drugs, devices, and therapies for neurological conditions.

The Fund for Change Grants support organizations advocating for social change, focusing on underserved communities. With an average grant size of $10,000-25,000, it funds initiatives in housing, behavioral health, criminal justice reform, and environmental justice. Eligible organizations can apply annually, but multi-year commitments are not available. The fund does not support capital campaigns, indirect costs, endowments, or individual scholarships, ensuring that funds are directed towards direct program expenses.

The Arts Projects – Organisations Grants program, funded by the Australia Council for the Arts, supports diverse activities that enhance the arts sector and engage communities. With grants ranging from $20,000 to $100,000, eligible organizations can propose various initiatives including professional development, creative collaborations, and community engagement projects. Applications are open to organizations that benefit practicing Australian artists and audiences, fostering artistic innovation and cultural exchange.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required) invites applications for high-risk clinical trials that involve multiple centers and aim to change clinical practice or public health. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline, with various deadlines set from February 2025 to October 2026. Planning activities must be completed before submission, and consultation with NIDDK staff is advised.

Overview

The Tower Foundation is a family foundation that helps children, adolescents, and young people affected by intellectual disabilities, learning disabilities, mental health issues, and/or substance use disorders. Our goal is to improve the lives of young people in our geographic footprint of Erie and Niagara Counties in Western New York, and Barnstable, Dukes, Essex, and Nantucket Counties in Eastern Massachusetts.

The Tower Foundation believes every young person should have the chance to achieve their personal goals, regardless of the challenges they face. Individuals who live with one or more of these issues may be overlooked or stigmatized, creating additional challenges. We also know that some young people face more challenges than others because of systemic inequalities. The convergence of our focus areas with racism, ableism, sexism, and other types of discrimination warrants the Foundation’s attention because as we know, people do not live single-issue lives.

The Tower Foundation sees its role as more than just a funder. These issues are near and dear to us because we have members of our family who live with one or more of the issues. These are individuals who are resilient—persevering despite the challenges they face— and who should be valued by our communities. The Tower Foundation envisions a future in which equitable communities include, accept and value these young people.

Strengthening Partner Capacity Grants

The Foundation seeks to fund requests that, “build and/or strengthen the systems, structures, cultures, skills, resources, and power that organizations need to serve their communities.” Strengthening Partner Capacity grants are available for board/leadership development; diversity, equity, inclusion; evaluation/evaluation design; organizational development; professional development; program design and planning (not service delivery); small capital projects/equipment purchases; staff mental wellness support; technology planning/purchasing; and other ideas that help organizations better serve their communities as described above. 

The Music Therapy Impact Fund Grant offers funding for music interventions aimed at addressing the spiritual, developmental, and physical needs of individuals in Butte County. This grant operates on a first-come, first-served basis, ensuring that anyone who submits a request form can receive support, as long as funds are available. The program focuses on assisting individuals with Parkinson’s disease, hospice and palliative care, and at-promise youth, striving to maintain low or no costs for participants.

Executive Summary

The New Jersey Department of Health (NJDOH), Division of Health Promotion – Community Health and Wellness Unit (CHWU) addresses leading causes of death and disability from chronic disease and illness. The core mission of the CHWU is to prevent premature death and disability from chronic disease, to understand the risk factors of chronic disease, and to promote healthy behaviors through leadership efforts that address evidence-based policies, systems, and environmental change. To achieve this mission, the CHWU has cultivated a robust group of partners – clinicians, academicians, community advocates, patients, consumer representatives, business leaders and government agencies – across the state of New Jersey to reach high burden populations and communities and complete funded work. Improved quality of life and extended years of healthy living for New Jersey residents are the overall outcomes for all activities undertaken through CHWU programs and services.

The Community Health and Wellness Unit’s – Colorectal Cancer Screening and Prevention Program announces the availability of State Fiscal Year (SFY) 2026 funding and technical assistance for primary care clinics operating in Cumberland, Cape May, Gloucester, Monmouth, Hunterdon, Somerset and Essex counties whose colorectal cancer (CRC) screening prevalence is between 25% and 55%, to implement evidence-based interventions (EBIs) and quality improvement (QI) processes to increase CRC screening in eligible and priority populations. This RFA seeks to increase CRC screening among populations aged 45 to 75 years that have lower colorectal cancer screening prevalence. The NJDOH-CCSPP is seeking up to four (4) primary care clinics to adopt strategies that utilize multi-component EBIs to increase CRC screening and to partner with NJDOH-CCSPP by accepting technical assistance, and support for data collection and evaluation activities.

Funded entities must demonstrate capacity and readiness to implement the program by completing the following:

• Engage in a formal readiness assessment of funded entities’ capacity to implement EBIs. This assessment will be used to select EBIs that will support improved CRC screening.
• Implement multicomponent interventions that combine a minimum of three (3) evidence-based interventions (EBI), as recommended in The Community Guide. These EBIs must focus on different areas of the clinical system (which will increase demand, access, and delivery of screening recommendations). The EBIs of priority for this work includes patient reminders, provider reminders and feedback, reducing structural barriers, and patient navigation.
• Provide high-quality, clinic-level data, including baseline and annual CRC screening prevalence, aggregate data on stool-based tests provided to and returned by patients, and aggregate data on follow-up colonoscopies. Emphasis will be on the capacity to collect data and track the entire CRC screening process patients undergo.
• Support completion of stool tests and colonoscopies, including tracking and follow-up of colonoscopies for positive stool tests

In addition to funding and technical assistance, each awardee will have the opportunity to utilize a free patient navigation service supported by NJDOH. The navigators will be deployed to the awardees primary care clinics site and will provide direct patient referrals and outreach via electronic health records (EHR). Leveraging innovative tools, including a patient chat text concierge, the patient navigators will enhance patient engagement, reduce barriers, and empower informed decision-making. Navigators will also coordinate care, track outcomes, schedule screenings, and ensure timely follow-up to promote comprehensive, equitable colorectal cancer prevention and care.

The Keith Haring Foundation offers grants primarily to support non-profit organizations that provide educational opportunities for underprivileged youth and those affected by HIV/AIDS. Established by the artist Keith Haring in 1989, the foundation focuses on initiatives that foster self-sufficiency among vulnerable populations in New York City and the Southeastern US. It invites applications from organizations dedicated to promoting Haring's legacy through arts and culture, ensuring impactful, evidence-based programming.

The KCF Annual Responsive Grant supports organizations in Kalamazoo County with projects that align with community impact priorities, such as wealth, housing, education, and vibrant neighborhoods. It is ideal for first-time applicants, new organizations, and ongoing partners who haven’t received multiyear awards. Grants range from $5,000 to $50,000, empowering organizations to enhance their operations and community connections.

Nebraska Medical Center supports non-profit organizations aiming to serve vulnerable populations and address major health issues like cancer, mental health, and prenatal care. They prioritize funding for initiatives aligned with community health improvement, specifically benefiting underserved groups. Eligible applicants must be IRS-designated 501(c)(3) organizations and submit proposals 60 days prior to events. However, they do not fund activities related to debt retirement, scholarships, or religious programming.

The Competitive Grants program by the Community Foundation for Brevard empowers local nonprofits to address pressing community needs through targeted funding in areas like education, health, and environmental stewardship. With a focus on supporting organizations that enrich community life, this initiative fosters collaboration and innovation. Grants are available to eligible nonprofits that have been operational for at least two years and meet specific criteria. This funding aims to enhance the quality of life in Brevard County and promote sustainable community development.

The Community Memorial Foundation offers the CMF Responsive Grants program to support 501(c)(3) nonprofits working to improve health in the western suburbs of Chicago. Organizations eligible for funding must align with the Foundation's mission and address community needs, particularly for underserved populations. Grants are awarded bi-annually, and priority is given to programs that enhance health equity and access to care. This initiative aims to transform the region into the healthiest community in the country.

The Episcopal Presbyterian Health Trust Grant, managed by the St. Louis Community Foundation, focuses on enhancing health care access and addressing chronic diseases. Grants are awarded biannually, prioritizing maternal and infant health in the second cycle. Organizations are encouraged to submit one Letter of Intent (LOI) annually, ensuring their proposals align with the funding priorities to foster sustainable health solutions in the community.

The Next Gen Council Grant Program, supported by the Reser Family Foundation, focuses on funding organizations in Oregon that provide essential services such as mental health counseling, addiction support, and educational mentorship. Eligible applicants must be established 501c3 organizations with a history of community service and measurable success. This initiative honors the legacy of the Reser Family by addressing pressing community needs and fostering collaborative partnerships.

The Seherr-Thoss Foundation Grant, established in 1991, primarily supports cultural, educational, health-related, religious, and civic initiatives within the Town of Litchfield, Connecticut. The foundations, initiated by Sonia and Hans Seherr-Thoss, have funded numerous local projects, including capital improvements for community organizations and essential equipment for volunteer services. They welcome applications from exempt organizations that align with their mission to enhance the community's well-being and preserve its heritage.

The AgEnhancement Grant, awarded by Farm Credit East and CoBank, provides funding between $500 to $10,000 annually to support projects that enhance agriculture, commercial fishing, and forest products in the Northeast. Since 1996, over $3.5 million has been distributed to various organizations. The program seeks initiatives that promote diversity and provide opportunities for all-sized farms, ensuring long-term benefits to the community and industry.

The Crail-Johnson Foundation focuses on enhancing the well-being of children and families in Los Angeles through grants aimed at Health, Human Services, and Education. It supports non-profit organizations that provide essential services, prioritizing communities such as San Pedro and Watts. The Foundation emphasizes mental health, access to care, and innovative programs for disadvantaged youth. Grants are typically one-year, with a focus on systemic change and proven approaches to community health and education.

The Kars4Kids Small Grant Program aims to support educational initiatives globally, impacting the lives of children. This program welcomes applications from IRS-recognized nonprofit organizations focused on youth development, mentorship, and education. Grants typically range from $500 to $2,000, depending on mission alignment and available funds. Kars4Kids, a national Jewish nonprofit, is dedicated to nurturing productive community members through educational and mentoring opportunities.

The HEAL Initiative aims to combat the opioid crisis through action-oriented research that enhances the translation of addiction epidemiology, prevention, treatment, and recovery services into practice. It prioritizes scalable, evidence-based approaches targeting various levels, including individual and community. The initiative supports a range of methods for research deployment, emphasizing collaboration between researchers and decision-makers to improve outcomes for those affected by addiction and related chronic pain.

The Comcast NBCUniversal Foundation offers Local Impact Grants to nonprofit organizations in 11 markets, providing $225,000 to support local programs addressing community issues. Eligible organizations must be 501(c)(3) nonprofits with a revenue exceeding $100,000 and must operate in one of the specified television markets. The grants aim to empower youth through education, promote diverse storytelling, and enhance community engagement. This initiative underscores Comcast's commitment to fostering inclusion and equitable opportunities for underserved communities.

The RIF Community Priority Grants, initiated by the Rhode Island Foundation, aim to enhance community well-being through targeted support to 501(c)(3) nonprofit organizations in Rhode Island. These grants focus on addressing six identified community priorities, promoting diversity, equity, inclusion, and access. By fostering collaboration and understanding community needs, the program seeks to empower local organizations to effectively respond to systemic inequities and support thriving communities for a better Rhode Island.