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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

33,000+

Available grants

$9.00B

Total funding

$6K

Median grant

33,000+ grants
$9.00B total
$6K median

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32,618 Results based on applied filters

Alieene Vance Memorial Scholarship

Community Foundation Alliance, Inc.
Private
Spencer County, Indiana
US $1,610
The Alieene Vance Memorial Scholarship, established by Don and Mason Foertsch, honors a former employee of Foertsch Construction. This annual, renewable scholarship aims to support children and grandchildren of Foertsch employees in their pursuit of higher education. Eligible applicants are high school seniors with a minimum GPA of 2.5, and renewal is possible for students maintaining good standing in their college programs. Selection is based on academic performance, leadership, and a required essay.
Education - Higher Education Academic Scholarship Programs

New Investigators Research Grant

American Speech Language Hearing Foundation
Private
Canada, United States
US $10,000
The New Investigators Research Grant, offered by the American Speech-Language-Hearing Foundation, supports emerging researchers by funding preliminary studies with a clinical focus in audiology and speech-language pathology. Proposals that incorporate Artificial Intelligence technologies for assessment and treatment are encouraged. Grants of $10,000 are available for one-year projects, fostering innovation and research in communication sciences. Eligible investigators must have completed their doctoral degree within the last five years and must not have received prior external funding.
Communication Disorders

Clinical Research - Independent Research Studies

American Speech Language Hearing Foundation
Private
Canada, United States
US $50,000 - US $75,000
The American Speech Language Hearing Foundation offers Clinical Research Grants aimed at fostering independent research studies that enhance treatment efficacy for communication disorders. These grants support early-career investigators and experienced researchers embarking on new projects. Proposals must demonstrate potential for significant impact, and funding of up to $75,000 over two years is available. This initiative seeks innovative solutions to improve the lives of individuals with communication challenges.
Communication Disorders

Out-of-School Time - Summer Fun & Learning RFP

Max And Marian Farash Charitable Foundation
Private
Monroe County, New York, Ontario County, New York
US $21,000 - US $120,000
The Max And Marian Farash Charitable Foundation invites community organizations to apply for the Out-of-School Time - Summer Fun & Learning RFP. This initiative aims to enhance access to innovative, high-quality summer programs for youth in Monroe and Ontario counties. By supporting diverse out-of-school opportunities, the Foundation seeks to empower young individuals to develop skills, engage with peers and mentors, and enjoy enriching experiences beyond traditional school hours.
After School / Summer Educational Programs

Career Development Grants in American Music

American Musicological Society Inc
Private
Cook County, Illinois
US $800
The Career Development Grants in American Music, offered by the American Musicological Society, provide $800 and free registration to the Annual Meeting for students and educators interested in American music. This initiative aims to enhance knowledge and professional connections through participation in activities at the AMS Annual Meeting in Minneapolis. Applicants must be legal U.S. residents and provide information about their educational status and relevant research interests.
Music

Dallas Athletic Club Scholarship Fund

Communities Foundation of Texas
Private
Texas
Up to US $15,000
The Dallas Athletic Club Scholarship Fund, established by the Communities Foundation of Texas, offers one-year scholarships up to $15,000 for DAC employees and their immediate family members. These funds can be utilized for tuition, books, and housing at accredited colleges, universities, or vocational schools across the U.S. Selection is based on academic achievement and community involvement, ensuring that deserving students have access to quality education and opportunities to thrive.
Education - Higher Education Academic Scholarship Programs

Edwards Lifesciences Foundation Grants

Edwards Lifesciences Foundation
Private
United States
Unspecified amount
The Edwards Lifesciences Foundation Grants program aims to improve the health of underserved communities by supporting initiatives focused on education, screening, and treatment of cardiovascular disease. The Foundation seeks to enhance care access for patients, promote awareness of heart health, and foster community engagement through volunteer opportunities. By 2025, the goal is to positively impact the lives of 2.5 million patients affected by structural heart issues. The program emphasizes collaboration and innovation in healthcare.
Cardiovascular Diseases & Systems

Family Care Grants

Society For Music Theory Inc
Private
Duval County, Florida
Up to US $400
The Society for Music Theory offers Family Care Grants to assist current members with family care expenses incurred while attending the Annual Meeting. These grants aim to promote inclusivity and diversity in the field. Typically, up to four awards are given, each with a maximum of $400. Eligible applicants must be current SMT members facing additional family care costs due to their participation in the meeting.
Music

Gibson Foundation Donation Request

Gibson Gives
Private
United States
Unspecified amount
The Gibson Foundation, now known as Gibson Gives, is dedicated to enhancing lives through music by supporting 501(c)(3) organizations. Their mission is to inspire and amplify the power of music through guitars for all generations. With a commitment to music education and wellness, Gibson Gives is making a positive impact worldwide, ensuring that music continues to shape the lives of musicians and enrich communities. Donations are reviewed monthly, requiring a minimum of four weeks for processing.
Music Education

Division of Boating and Waterways Local Assistance- Boat Launching Facility Grant Program

California Department of Parks and Recreation
State/Local Government
California
Unspecified amount
The Division of Boating and Waterways offers the Boat Launching Facility Grant Program to local agencies in California, aimed at developing and improving public boat launching facilities for motorized vessels. The program funds construction and enhancement of ramps, restrooms, parking, and other necessary infrastructure to ensure better access to California's waterways for recreational boating. Applications are accepted until February 1, 2025, and are open to various local government entities.
Recreational Water Use & Boating

Boston Scientific Medical Student Innovation Fellowship

American Urological Association Inc
Private
Canada, Central America +2 more
Up to US $20,000
The AUA Boston Scientific Medical Student Innovation Fellowship, funded by the American Urological Association, aims to nurture future urologic researchers. This fellowship offers a $20,000 stipend for a 12-month research project, engaging medical students in innovative urology research under expert mentorship. The initiative addresses the pressing need for skilled professionals in the urologic research field, ensuring a robust pipeline of talent dedicated to advancing patient care and scientific discovery in urology.
Urology Diversity, Equity & Inclusion

Leonard Litz Foundation-Silver Connect Initiative

Leonard Litz Foundation
Private
United States
Unspecified amount
The Leonard Litz Foundation-Silver Connect Initiative aims to enhance the quality of life for LGBTQ+ older adults by providing grant funding to nonprofit organizations. This program addresses isolation and barriers faced by seniors, particularly those affected by disability, race, or economic hardship. By supporting community-driven models, Silver Connect promotes dignity, safety, and inclusion, ensuring that LGBTQ+ elders have access to necessary resources and affirming services across the Eastern United States.
Senior Services Aging / Gerontology

AMVETS Veteran, Active Duty & Guard/Reserve Scholarship

Amvets National Service Foundation
Private
United States
Up to US $12,000
The AMVETS Veteran, Active Duty & Guard/Reserve Scholarship provides financial assistance up to $12,000 for qualified U.S. Veterans and active military members pursuing undergraduate degrees. This scholarship is designed to bridge the financial gap after all other federal and state aid has been utilized. Eligibility includes being an honorably discharged veteran or active service member, enrolled in an accredited institution, and demonstrating financial need. AMVETS is dedicated to serving those who have served our country.
Military & Veterans Services Academic Scholarship Programs

Community firearm violence intervention and prevention grants (CFVIP)

Washington State Department of Commerce
State/Local Government
Washington
Up to US $400,000
The Community Firearm Violence Intervention and Prevention Grants (CFVIP) by the Washington State Department of Commerce aim to enhance public safety through targeted initiatives in communities disproportionately affected by gun violence. The program prioritizes youth and young adults at high risk, encouraging evidence-based, culturally relevant strategies. With a funding cap of $8 million, grants range from $400,000 for single organizations to $800,000 for collaborative efforts, fostering community-led solutions to reduce firearm violence.
Gun Violence Prevention

Speech Science Research Grant

American Speech Language Hearing Foundation
Private
Canada, United States
US $10,000
The Speech Science Research Grant, offered by the American Speech-Language-Hearing Foundation, supports new investigators conducting research in speech science. A $10,000 grant will be awarded to eligible researchers, who must have completed their PhD within the last five years. The funding can be utilized for various research-related expenses, fostering innovative studies and honoring the legacy of researcher Dennis Klatt. The next application cycle will be in 2026.
Communication Disorders

Independent, Unsupported, or Undersupported Scholar Travel Grant

Society For Music Theory Inc
Private
Duval County, Florida
Up to US $400
The Independent, Unsupported, or Undersupported Scholar Travel Grant, offered by the Society for Music Theory, supports scholars facing financial difficulties in attending the SMT Annual Meeting. Open to non-SMT members, the grant prioritizes adjunct instructors and independent scholars without funding access. Typically, up to five grants are awarded, each providing a maximum of $400. This initiative promotes inclusivity and diversity within the music theory community, enhancing engagement in this vital scholarly field.
Music

Calvin H. & Elizabeth L. Topliff Scholarship

Marion Community Foundation
Private
United States
Unspecified amount

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Calvin H. & Elizabeth L. Topliff Scholarship

Georgia Mathews, mother to Marion Community Foundation board member, Spencer Mathews, created this endowed scholarship in 2023 in honor of her parents. The scholarship will be awarded to Marion County students who are pursuing a career in either education or engineering, with special consideration for students who will be attending Ohio Northern University, which is where Georgia’s parents met.

Betty Beatty Topliff was born in Pittsburgh but ended up in Marion after meeting Calvin at Ohio Northern and moving to his hometown of Marion. Betty (1928-2022) was a dedicated teacher for 30 years, most recently at Ridgedale High School. Calvin (1924-2009) was an Army veteran who served in Europe during WWII and was awarded the Bronze Star. Calvin retired from the marketing department of Ohio Edison Marion Division after 36 years of service.

Following retirement, Calvin and Betty were Florida snowbirds, but Betty returned to Marion after Calvin’s death to be with her beloved children, grandchildren, and great grandchildren.

Academic Scholarship Programs Engineering Education

Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed) (353758)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH Independent Scientist Award (K02) supports the development of outstanding scientists by providing three to five years of salary support and protected time for newly independent researchers. This funding opportunity is specifically for applicants proposing research that does not involve leading an independent clinical trial, allowing them to gain experience in trials led by others. Key deadlines for applications span from June 2024 to February 2027.
Medical Education & Professional Training Science Health & Medicine

Indiantown Community Trust Fund Program

Village of Indiantown
State/Local Government
Martin County, Florida
Unspecified amount

In July of 1991 Martin County Board of County Commissioners entered into a planned unit development (PUD) agreement for the development of the Indiantown Cogeneration Project. A condition of the PUD agreement required the establishment of the Indiantown Community Trust Fund with the interest from the trust fund used for projects which benefit the Indiantown community and have a general synergy with the Indiantown Cogeneration Project. The trust fund has been accruing interest since October 21, 1992. The committee annually reviews applications for proposed projects and makes recommendations for funding for the projects from the accrued interest of the trust fund subject to final approval by the Village Council.The trust income shall be used solely for projects benefiting Indiantown. Examples of such projects include, but are not limited to:

  • General training programs for local residents;
  • Day care facilities;
  • Recreation facilities;
  • Community center;
  • General community beautification projects; and
  • ‘Seed money’ for use in community programs for matching fund programs.
Community Services Recreation Greening & Beautification

Nature Awards for Inspiring Women in Science: Science Outreach Category

Springer Nature Limited
Corporate
Afghanistan, Algeria +95 more
Up to US $50,000
The Nature Awards for Inspiring Women in Science, particularly in the Science Outreach category, honors initiatives that empower girls and young women in STEM fields. With a focus on engagement and retention, the awards aim to celebrate projects that encourage participation in natural sciences, technology, engineering, mathematics, and medicine. Winners will receive significant cash prizes and opportunities for mentorship, creating pathways for future generations of women in science.
Engineering Mathematics Science +2 more

Zuckerman Postdoctoral Scholars Program: Joint North American-israel Postdoc Track

Mortimer B Zuckerman Foundation
Private
Canada, Israel +1 more
Up to US $126,000
The Zuckerman Postdoctoral Scholars Program fosters collaboration between leading scientific institutions in the U.S. and Israel by attracting top postdoctoral researchers. With a focus on STEM leadership, this program offers a unique two-year scholarship, allowing scholars to conduct research at participating Israeli universities and North American institutions. The initiative aims to strengthen academic ties, enhance research capabilities, and support the return of talented Israeli scholars to their home institutions, ultimately enriching the global scientific community.
Engineering Mathematics Science +1 more

NIJ FY 2026 Crime and Justice Research

US Department of Justice: National Institute of Justice (NIJ)
Federal Government
American Samoa, Guam +4 more
Up to US $5,000,000
The NIJ FY 2026 Crime and Justice Research funding opportunity invites applications for innovative research aimed at enhancing the effectiveness of the adult criminal justice system. It comprises two main categories: one focuses on new programs and strategies to improve workforce readiness, while the other assesses the impact of the COPS De-escalation Training Program. This initiative seeks to foster safety and operational improvements within law enforcement.
Crime & Justice Community / Public Safety Emerging Technology Development

Zuckerman Postdoctoral Scholars Program: Israeli University Postdoc Track

Mortimer B Zuckerman Foundation
Private
Israel
Up to US $126,000
The Zuckerman Postdoctoral Scholars Program supports exceptional researchers from the U.S. and Canada to conduct postdoctoral studies at prestigious Israeli universities. This initiative aims to foster scientific collaboration and innovation between leading academic institutions in the U.S. and Israel. Selected scholars benefit from unique workshops and networking opportunities, enhancing their research capabilities and contributing to Israel's reputation in STEM fields. With a scholarship of $63,000 per academic year for two years, this program empowers the next generation of STEM leaders.
Engineering Mathematics Science +1 more

Traditional Grants

William G. and Marie Selby Foundation
Private
Charlotte County, Florida, DeSoto County, Florida +2 more
US $10,000 - US $50,000

The Selby Mission

By investing in people through academic scholarships and supporting capital projects of local organizations, we look beyond what is and enable change for what can be.

Traditional Grants

The William G. and Marie Selby Foundation awards “traditional grants” twice each year.

Organizations with budgets greater than $300,000 that primarily serve Sarasota, Manatee, Charlotte and DeSoto counties have the opportunity to apply.

The Selby Foundation invests in capital support that will help nonprofits achieve more for those they serve.

Community Services Economic Services & Development Community Development & Revitalization

Louise Tuller Miller Trust Grant

Louise Tuller Miller Trust
Private
Grand Traverse County, Michigan, Lapeer County, Michigan +5 more
Unspecified amount
The Louise Tuller Miller Trust Grant offers funding exclusively for charitable organizations in Metropolitan Detroit and Traverse City, Michigan. This private grant supports various program areas including education, religious initiatives, scientific research, and animal welfare. To qualify, organizations must be recognized as tax-exempt under section 501(c)(3) of the IRS. Note that individuals are not eligible to apply for this grant, ensuring support is directed solely to nonprofit entities.
Education Religion & Spirituality Science +1 more

Robert G. Campbell Community Fund

The Community Foundation of Southern Wisconsin
Private
Iowa County, Wisconsin
Unspecified amount
The Robert G. Campbell Community Fund, managed by the Community Foundation of Southern Wisconsin, is an unrestricted endowment dedicated to enhancing the quality of life in Iowa County, WI. Focused on supporting seniors, it funds projects that provide recreational opportunities, quality of life improvements, and community events honoring senior contributions. Annually, a portion of the fund's earnings is allocated to grants for the elderly, historic preservation, the arts, the environment, and education, fostering community enrichment.
Community Services Recreation Senior Services

Independent Scientist Award (Parent K02 - Independent Clinical Trial Required) (353756)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH Independent Scientist Award (K02) aims to support the development of independent scientists and enhance their research capabilities. This award offers salary support and protected time for three to five years, specifically for those leading independent clinical trials or feasibility studies. Applicants must demonstrate a need for focused research to advance their careers. Key deadlines for applications span from June 2024 to February 2027, catering to various submission types including standard and AIDS-related grants.
Medical Education & Professional Training Science Health & Medicine

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.34B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.7%
Q2
24.7%
Q3
23.5%
Q4
22.1%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $32,500.

$0 $0 Min.
$32,500 $32.5 K Median
$633,837 $633.8 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.7% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $32,500, while the average grant awarded is $633,837. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.